IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NMT1 Ensembl ENSG00000136448 Chromosome 17 Start 40494206 End 40541903
Description Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97)(Peptide N-myristoyltransferase 1)(Myristoyl-CoA:protein N-myristoyltransferase 1)(NMT 1)(Type I N-myristoyltransferase) [Source:UniProtKB/Swiss-Prot;Acc:P30419]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7857
     Entrez Gene : 4836
     UCSC : uc002ihz.2
     GeneCards : 7857
     RefSeq : NM_021079
     CCDS : CCDS11494.1
     Uniprot : P30419
     Interpro : P30419
     OMIM : 160993
     GeneTests : NMT1
     CGAP : NMT1
     PMID : 1570339

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38999_s_at  0.08  2.57e-1  3.58e-1  0.22  1.79e-2  3.81e-2
 HG_U95  39000_at  0.05  3.82e-1  4.88e-1  0.13  1.59e-1  2.41e-1
 HG_U133A  201157_s_at  0.38  3.99e-14  2.01e-13  0.82  5.03e-26  7.98e-26
 HG_U133A  201158_at  0.86  1.02e-9  3.56e-9  3.31  1.39e-61  3.85e-61
 HG_U133A  201159_s_at  0.51  5.94e-9  1.92e-8  4.18  1.35e-109  1.19e-108
 HG_U133_Plus2  201157_s_at  0.17  3.21e-3  7.43e-3  0.45  1.26e-10  5.99e-10
 HG_U133_Plus2  201158_at  0.12  6.78e-2  1.10e-1  0.20  1.39e-2  2.21e-2
 HG_U133_Plus2  201159_s_at  0.19  2.25e-1  3.05e-1  0.10  6.13e-1  6.66e-1
 Stanford  4567  0.59  2.83e-2  1.26e-1  0.54  4.81e-2  1.66e-1
 Stanford  7626  0.68  3.28e-3  3.14e-2  0.26  2.82e-1  5.23e-1
 Agilent_HS_21.6K  10340  0.05  1.27e-1  2.77e-1  0.17  7.44e-4  4.24e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201157_s_at  0.19  2.70e-1  8.63e-1  0.04  7.16e-1  1.00e+0
 HG_U133A  201158_at  -0.51  2.14e-1  8.38e-1  0.03  9.41e-1  1.00e+0
 HG_U133A  201159_s_at  0.33  2.60e-1  8.59e-1  -0.21  2.27e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38999_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39000_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201157_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201158_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201159_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201157_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201158_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201159_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4567    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7626    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10340    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nmt epithelial neoplasms We have reported for the first time in rats treated with azoxymethane that NMT activity was higher in colonic epithelial neoplasms than in normal colonic tissue and that an increase in NMT activity appeared at an early stage in colonic carcinogenesis. 12239600 Rat
nmt tumors Increased NMT activity was also confirmed in human colonic tumors compared to normal tissue. 12239600 Human
nmt colorectal tumors Furthermore, colorectal tumors displayed increased immunohistochemical staining for NMT compared to normal mucosa in the cytoplasm. 12239600 Human
nmt gallbladder carcinoma In addition, gallbladder carcinoma showed moderate to strong cytoplasmic positivity for NMT with increased intensity in the invasive component whereas the normal gallbladder mucosa showed weak to negative cytoplasmic staining for this enzyme. 12239600 Human
nmt cancer It is conceivable therefore that NMT can be used as a potential marker for the early detection of cancer. 12239600 Human
nmt neoplasms Of particular note is the very recent discovery of cytotoxic compounds in the laboratories of the authors which inhibit NMT and may offer a novel approach for the evolution of candidate antineoplastic agents which display greater potencies towards neoplas 12239600 Human
nmt gall-bladder cancer Earlier, we have demonstrated that NMT activity is elevated in colon and gall bladder cancer. 14751229 Human
nmt cancer Attenuation of NMT activity may prove a novel therapeutic protocol for cancer. 14751229 Human
nmt colon cancer This review describes the basic enzymology, molecular cloning and regulation of NMT activity in various pathophysiological processes such as colon cancer and diabetes. 10718634 Human
nmt invasive carcinomas To investigate whether, through Src, NMT contributes to the pathogenesis of gallbladder carcinoma, the authors investigated expression of NMT and p53 in in situ and invasive carcinomas. 10813869 Human
nmt gallbladder carcinoma To investigate whether, through Src, NMT contributes to the pathogenesis of gallbladder carcinoma, the authors investigated expression of NMT and p53 in in situ and invasive carcinomas. 10813869 Human
nmt gallbladder carcinoma METHODS: One hundred cases of documented gallbladder carcinoma were reviewed, and 30 cases were selected randomly to evaluate expression of NMT and p53 by immunohistochemistry in both in situ and in invasive tumor components. 10813869 Human
nmt tumor METHODS: One hundred cases of documented gallbladder carcinoma were reviewed, and 30 cases were selected randomly to evaluate expression of NMT and p53 by immunohistochemistry in both in situ and in invasive tumor components. 10813869 Human
nmt gallbladder carcinoma RESULTS: Eighteen cases (60%) of gallbladder carcinoma showed moderate to strong cytoplasmic positivity for NMT with increased intensity in the invasive component, and 12 cases (40%) were negative. 10813869 Human
nmt tumors Amplification of intron-8 in normal gallbladder mucosa and invasive carcinoma were similar in intensity, suggesting the absence of NMT gene amplification in these tumors. 10813869 Human
nmt invasive carcinoma Amplification of intron-8 in normal gallbladder mucosa and invasive carcinoma were similar in intensity, suggesting the absence of NMT gene amplification in these tumors. 10813869 Human
nmt tumors CONCLUSIONS: The increased expression of NMT in these tumors could be due to transcriptional activation. 10813869 Human
nmt tumors Tumors with increased expression of NMT and p53 were associated with poor clinical outcomes as evidenced by their mean survival times. 10813869 Human
nmt gallbladder carcinoma NMT is likely to play a pathogenic role in gallbladder carcinoma. 10813869 Human
nmt epithelial neoplasms Earlier, we have reported that N-myristoyltransferase (NMT) activity is higher in colonic epithelial neoplasms than in normal appearing colonic tissue and that increase in NMT activity appears at an early stage in colonic carcinogenesis [Magnuson, B., Raj 10891381 Human
nmt adenocarcinomas 87, 1630-1635]. In this study, we demonstrate increased NMT mRNA in well-differentiated adenocarcinomas. 10891381 Human
nmt human colon cancer NMT and c-Src mRNA levels were generally elevated in a subset of human colon cancer cell lines. 10891381 Human
nmt epithelial neoplasms Earlier, we demonstrated that NMT is more active in colonic epithelial neoplasms than in corresponding normal-appearing colonic tissue. 14633729 Human
nmt gallbladder carcinoma Furthermore, an increased expression of NMT was also observed in gallbladder carcinoma. 14633729 Human
nmt colorectal adenocarcinomas Recently we reported that the enzyme that catalyzes this modification, N-myristoyltransferase (NMT), is elevated in colorectal adenocarcinomas [Magnuson, B. A., Raju, R. V. S., Moyana, T. N., and Sharma, R. K. 9281363 Human
nmt colorectal adenocarcinomas 87, 1630-1635]. The purpose of the present study was to investigate whether the elevated activity of NMT in colorectal adenocarcinomas is due to an increase in the production of NMT or a change in the structure of the preexisting enzyme. 9281363 Human
nmt adenocarcinomas The expression of NMT in normal colonic mucosa and adenocarcinomas from human colorectal surgical specimens was studied by immunoblotting, and its localization was confirmed by immunohistochemistry. 9281363 Human
nmt colorectal adenocarcinomas In both normal mucosa and colorectal adenocarcinomas, NMT with a molecular mass of 48.5 kDa was identified with anti-human NMT and anti-peptide antibody. 9281363 Human
nmt colorectal tumors However, the expression of NMT was found to be higher in the colorectal tumors. 9281363 Human
nmt colorectal adenocarcinomas These findings represent the first description of NMT overexpression in colorectal adenocarcinomas. 9281363 Human
nmt cervical carcinoma Most of the in vitro NMT activity (60-85%) in isoosmotic cell homogenates of human lymphoblastic leukemia (i.e. CEM and MOLT-4) and cervical carcinoma (i.e. HeLa) cells was shown to be associated with the ribosomal subcellular fractions by differential ce 9353336 Human
nmt lymphoblastic leukemia Most of the in vitro NMT activity (60-85%) in isoosmotic cell homogenates of human lymphoblastic leukemia (i.e. CEM and MOLT-4) and cervical carcinoma (i.e. HeLa) cells was shown to be associated with the ribosomal subcellular fractions by differential ce 9353336 Human
nmt cancer PNMT and/or NMT activity were present in red blood cells (RBCs), and cancer cell lines. 7769131 Human
nmt murine leukemia The activity catalyzed by N-myristoyl transferase (NMT) is described for the first time in microsome-rich fractions from the murine leukemia cell line L1210, rat brain and mouse liver as biological sources. 1915371 Rat
nmt colonic tumors Increased NMT activity was also confirmed in human colonic tumors compared to normal tissue. 12239600 Human
nmt human colon cancer In this study, we examined the levels of expression of MetAP2, NMT, and NMT inhibitor protein 71 (NIP71) in human colon cancer cell lines (HCCLs). 15336565 Human
nmt colon cancer Further studies directed to revealing the role of HSC70 in the regulation of NMT may lead to the development of gene based therapies of colon cancer. 15156568 Human
nmt gallbladder carcinomas Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas 15756927 Human
nmt epithelial neoplasms Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas 15756927 Human
nmt brain tumors Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas 15756927 Human
nmt brain tumors For the first time, we have demonstrated that NMT has the potential to be used as a marker of human brain tumors. 15756927 Human
nmt pd Further studies of NMT activity in human PD cases and patients with cardiomyopathy of unknown cause may provide valuable information in these disorders. 15870904 Human
nmt epithelial neoplasms Previously, we reported that NMT activity is higher in colonic epithelial neoplasms than in normal-appearing colonic tissue and that the increase in NMT activity appears at an early stage in colonic carcinogenesis. 16043893 Human
nmt gallbladder carcinoma Furthermore, we observed that NMT expression is elevated in colorectal and gallbladder carcinoma. 16043893 Human
nmt colonic tumors In our laboratory, an endogenous NMT inhibitor protein (NIP71) was discovered from bovine brain that inhibited NMT activity in rat colonic tumors. 16043893 Human
nmt colorectal cancer Further work may elucidate the role of HSC70 and/or enolase in the regulation of NMT, which may lead to the development of a gene-based therapy of colorectal cancer. 16043893 Human
nmt1 gallbladder carcinomas Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas 15756927 Human
nmt1 epithelial neoplasms Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas 15756927 Human
nmt1 brain tumors Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas 15756927 Human
nmt1 tumor Finally, intratumoral injection of siRNA for NMT1 or for both NMT1 and NMT2 inhibited tumor growth in vivo, whereas the same treatment with siRNA for NMT2 or negative control siRNA did not. 16123142 Human
nmt1 tumor Overall, the data indicate that NMT1 and NMT2 have only partially overlapping functions and that NMT1 is critical for tumor cell proliferation. 16123142 Human

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