IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FMNL1 Ensembl ENSG00000184922 Chromosome 17 Start 40655075 End 40680464
Description Formin-like protein 1 (Leukocyte formin)(CLL-associated antigen KW-13) [Source:UniProtKB/Swiss-Prot;Acc:O95466]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1212
     Entrez Gene : 752
     UCSC : uc002iin.2
     GeneCards : 1212
     RefSeq : NM_005892
     CCDS : CCDS11497.1
     Uniprot : O95466
     Interpro : O95466
     OMIM : 604656
     GeneTests : FMNL1
     CGAP : FMNL1
     PMID : 9799091

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37100_at  -0.31  4.28e-3  1.12e-2  -0.65  2.43e-6  1.40e-5
 HG_U133A  204789_at  -0.49  1.73e-5  3.91e-5  0.98  1.19e-17  1.67e-17
 HG_U133_Plus2  1569257_at  -0.69  4.09e-8  2.29e-7  -1.06  2.82e-12  1.63e-11
 HG_U133_Plus2  204789_at  -0.64  1.14e-7  6.00e-7  -1.16  3.99e-12  2.26e-11
 Agilent_HS_21.6K  4562  -0.12  3.96e-1  5.82e-1  -0.23  1.18e-2  4.09e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204789_at  0.68  5.15e-2  7.08e-1  -0.34  3.09e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37100_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204789_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1569257_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204789_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4562    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
leukocyte formin lymphoid malignancies Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt. 14592423 Human
fmnl1 large-cell carcinoma FMNL1 mRNA was expressed in natural killer cells, Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma, FMNL2 mRNA in several normal tissues, diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblas 12684686 Human
fmnl1 pancreatic cancer FMNL1 mRNA was expressed in natural killer cells, Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma, FMNL2 mRNA in several normal tissues, diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblas 12684686 Human
fmnl1 burkitt lymphoma FMNL1 mRNA was expressed in natural killer cells, Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma, FMNL2 mRNA in several normal tissues, diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblas 12684686 Human
fmnl1 prostate cancer FMNL1 mRNA was expressed in natural killer cells, Burkitt lymphoma, pancreatic cancer, prostate cancer, and lung large cell carcinoma, FMNL2 mRNA in several normal tissues, diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblas 12684686 Human
fmnl1 metastasis FMNL1, FMNL2 and FMNL3 might be implicated in polarity control, invasion, migration, or metastasis through regulation of the Rho-related signaling pathway. 12684686 Human

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