IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CRHR1 Ensembl ENSG00000120088 Chromosome 17 Start 41217449 End 41268973
Description Corticotropin-releasing factor receptor 1 Precursor (CRF-R)(CRF1)(Corticotropin-releasing hormone receptor 1)(CRH-R 1) [Source:UniProtKB/Swiss-Prot;Acc:P34998]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2357
     Entrez Gene : 1394
     UCSC : uc002ijm.2
     GeneCards : 2357
     RefSeq : NM_001145146
     CCDS : CCDS42350.1
     Uniprot : P34998
     Interpro : P34998
     OMIM : 122561
     GeneTests : CRHR1
     CGAP : CRHR1
     PMID : 7590738

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40650_r_at  -0.05  8.02e-1  8.59e-1  -0.96  4.32e-4  1.47e-3
 HG_U95  40651_s_at  0.44  8.01e-6  4.26e-5  0.38  1.34e-2  2.97e-2
 HG_U133A  208593_x_at  -0.10  8.72e-2  1.15e-1  0.82  4.20e-26  6.67e-26
 HG_U133A  211897_s_at  -0.22  1.45e-1  1.84e-1  2.85  1.69e-60  4.61e-60
 HG_U133A  214619_at  -0.16  1.86e-1  2.30e-1  -2.20  3.47e-23  5.27e-23
 HG_U133_Plus2  208593_x_at  0.29  7.48e-2  1.19e-1  0.80  1.32e-5  3.32e-5
 HG_U133_Plus2  211897_s_at  0.49  8.24e-3  1.72e-2  -0.06  7.63e-1  8.01e-1
 HG_U133_Plus2  214619_at  0.14  3.82e-1  4.73e-1  0.36  4.36e-2  6.32e-2
 Stanford  793  -0.15  5.80e-1  7.42e-1  0.25  5.27e-1  7.37e-1
 Agilent_HS_21.6K  18831  0.00  9.42e-1  9.68e-1  -0.01  6.33e-1  7.54e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208593_x_at  -0.27  1.90e-1  8.25e-1  0.02  8.68e-1  1.00e+0
 HG_U133A  211897_s_at  -0.70  1.16e-1  7.84e-1  -0.34  2.82e-1  1.00e+0
 HG_U133A  214619_at  -0.93  5.92e-3  6.53e-1  -0.06  8.42e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40650_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40651_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208593_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211897_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214619_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208593_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211897_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214619_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 793    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18831    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
crf1 retinoblastoma Potential G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) mediation of homologous desensitization of corticotropin-releasing factor type 1 (CRF1) receptors was investigated in human retinoblastoma Y-79 cells. 11247813 Human
crfr1 retinoblastoma The photoactivatable CRF antagonists were tested for their ability to displace 125I-labeled Tyr0 ovine CRF ([125I-labeled Tyr0]oCRF) in binding experiments and to inhibit oCRF-stimulated adenylate cyclase activity in human embryonic kidney (HEK) 293 cells 10806401 Human
crf1 human neuroblastoma Functional, endogenously expressed corticotropin-releasing factor receptor type 1 (CRF1) and CRF1 receptor mRNA expression in human neuroblastoma SH-SY5Y cells. 10456290 Human
crf1 human neuroblastoma We identified CRF1 receptors functionally coupled to cAMP formation in human neuroblastoma SH-SY5Y cells. 10456290 Human
crf1 neuroblastoma We conclude that neuroblastoma SH-SY5Y cells are endowed with native CRF1 receptors positively coupled to cAMP formation. 10456290 Human
crf1 tumor This was shown in two ways: by the presence of relatively high levels of CRF1 receptor mRNA in W256 cells, and by the fact that the tumor growth inhibitory and differentiation inducing effects of hCRF in vitro were abolished by the CRF receptor antagonist 9575420 Rat
crf-r human corticotropic adenoma (hca) To investigate the expression of CRF receptor (CRF-R) in human corticotropic adenoma (hCA) cells, we analyzed messenger RNA (mRNA) levels of type-1 CRF-R (CRF-R1). 9100600 Human
crf1 cancers Expression of CRF1 and CRF2 receptors in human cancers. 12843181 Human
crf1 retinoblastoma Protein kinase C (PKC)-mediated desensitization of the corticotropin releasing factor type 1 (CRF1) receptor was investigated in human retinoblastoma Y79 and transfected COS-7 cells. 12734388 Human
crf1 retinoblastoma Because stimulation of Y79 cells with CRF resulted in large ( approximately 30-fold) increases in intracellular cAMP accumulation without changing inositol phosphate levels, the CRF1 receptor expressed in retinoblastoma cells couples to Gs, but not to Gq, 12734388 Human
crf1 neuroblastoma Cell-type specific calcium signaling by corticotropin-releasing factor type 1 (CRF1) and 2a (CRF2(a)) receptors: phospholipase C-mediated responses in human embryonic kidney 293 but not SK-N-MC neuroblastoma cells. 15450949 Human
crfr1 adenocarcinoma Transient expression of constructs containing sequentially deleted 5'-flanking sequences of CRFR1 fused to luciferase, revealed the minimal promoter sequence 370 bp in size, as shown by assays in neuroblastoma (SH-5YSY), teratocarcinoma (NT2), and ad 15142984 Human
crfr1 neuroblastoma Transient expression of constructs containing sequentially deleted 5'-flanking sequences of CRFR1 fused to luciferase, revealed the minimal promoter sequence 370 bp in size, as shown by assays in neuroblastoma (SH-5YSY), teratocarcinoma (NT2), and ad 15142984 Human
crfr1 teratocarcinoma Transient expression of constructs containing sequentially deleted 5'-flanking sequences of CRFR1 fused to luciferase, revealed the minimal promoter sequence 370 bp in size, as shown by assays in neuroblastoma (SH-5YSY), teratocarcinoma (NT2), and ad 15142984 Human

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