IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MAPT Ensembl ENSG00000186868 Chromosome 17 Start 41327624 End 41461547
Description Microtubule-associated protein tau (Neurofibrillary tangle protein)(Paired helical filament-tau)(PHF-tau) [Source:UniProtKB/Swiss-Prot;Acc:P10636]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6893
     Entrez Gene : 4137
     UCSC : uc010dau.2
     GeneCards : 6893
     RefSeq : NM_001123066
     CCDS : CCDS11499.1
     Uniprot : Q5CZI7
     Interpro : Q5CZI7
     OMIM : 157140
     GeneTests : MAPT
     CGAP : MAPT
     PMID : 7936241

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  113_i_at  0.30  1.93e-1  2.84e-1  0.95  2.95e-3  7.96e-3
 HG_U95  114_r_at  -0.05  7.69e-1  8.33e-1  -0.50  3.82e-3  9.96e-3
 HG_U95  310_s_at  -0.03  8.54e-1  8.97e-1  -0.16  5.19e-1  6.19e-1
 HG_U95  331_at  -0.01  9.68e-1  9.77e-1  -0.35  1.28e-1  2.02e-1
 HG_U95  38629_at  0.31  9.86e-4  3.10e-3  0.23  1.51e-1  2.32e-1
 HG_U133A  203928_x_at  0.08  5.31e-1  5.83e-1  2.64  2.92e-64  8.50e-64
 HG_U133A  203929_s_at  0.29  1.57e-2  2.37e-2  1.16  2.37e-25  3.72e-25
 HG_U133A  203930_s_at  0.03  7.99e-1  8.29e-1  3.38  5.28e-86  2.48e-85
 HG_U133A  206401_s_at  0.23  9.90e-2  1.30e-1  1.68  3.77e-17  5.26e-17
 HG_U133_Plus2  203928_x_at  0.19  1.29e-1  1.90e-1  0.50  7.48e-5  1.70e-4
 HG_U133_Plus2  203929_s_at  0.37  4.15e-2  7.15e-2  0.62  1.83e-3  3.37e-3
 HG_U133_Plus2  203930_s_at  -0.16  4.24e-1  5.14e-1  0.51  1.44e-2  2.29e-2
 HG_U133_Plus2  206401_s_at  -0.06  6.97e-1  7.63e-1  0.20  2.44e-1  2.99e-1
 HG_U133_Plus2  225379_at  -0.73  8.69e-6  3.35e-5  -1.24  2.43e-12  1.41e-11
 Stanford  19419  -0.15  6.24e-1  7.74e-1  -0.20  5.58e-1  7.58e-1
 Agilent_HS_21.6K  10895  0.01  6.05e-1  7.56e-1  0.02  4.04e-1  5.63e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203928_x_at  -0.00  9.89e-1  9.99e-1  -0.12  6.93e-1  1.00e+0
 HG_U133A  203929_s_at  0.81  1.22e-1  7.90e-1  0.09  7.54e-1  1.00e+0
 HG_U133A  203930_s_at  0.33  4.49e-1  9.14e-1  -0.04  8.87e-1  1.00e+0
 HG_U133A  206401_s_at  0.15  7.87e-1  9.81e-1  -0.53  6.16e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 113_i_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 114_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 310_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 331_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38629_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203928_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203929_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203930_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206401_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203928_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203929_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203930_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206401_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225379_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19419    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10895    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mapt adenomatous polyposis coli (apc) Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples ex 11836553 Human
microtubule-associated protein tau adenomatous polyposis coli (apc) Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples ex 11836553 Human
mapt neuroblastoma Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples ex 11836553 Human
microtubule-associated protein tau neuroblastoma Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples ex 11836553 Human
microtubule-associated protein tau gastrointestinal stromal tumors Expression of microtubule-associated protein tau by gastrointestinal stromal tumors. 11727254 Human
microtubule-associated protein tau human neuroblastoma Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. 7925819 Human
the tau gene neuroblastoma The sequence of a high molecular weight (HMW) tau cDNA cloned from a neuroblastoma N115 library contains, in addition to the C- and N-terminal and middle regions present in the low molecular weight mouse brain tau proteins, a 711-bp nonhomologous domain ( 8360688 Human
the tau protein neuroblastoma A possible consequence of expressing a higher proportion of the tau protein containing four tubulin-binding motifs could be an increase in microtubule stability of differentiated neuroblastoma cells. 1544466 Human
microtubule-associated protein tau embryonal carcinoma Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells. 1560239 Mouse
microtubule-associated protein tau embryonal carcinoma Expression of the genes encoding the beta/A4 amyloid protein precursor (APP) and microtubule-associated protein tau was studied in an embryonal carcinoma cell line (P19) that differentiates in vitro into cholinergic neurons after treatment with retinoic a 1560239 Human
microtubule-associated protein tau neuroblastoma Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells. 1433385 Human
microtubule-associated protein tau neuroblastoma NB2a/d1 neuroblastoma cells constitutively express multiple isoforms of the microtubule-associated protein tau and incorporate this protein into the axonal neurites elaborated during serum deprivation. 1433385 Human
ftdp-17 neuroblastoma To examine the molecular mechanisms responsible for aberrant splicing of the tau gene containing mutations linked to FTDP-17, we performed Exon trapping and binding assay using tau exon 10 pre-mRNA and nuclear extracts of neuroblastoma cell lines and in v 15009090 Human
microtubule-associated protein tau neuroblastomas Nucleolar localization of the microtubule-associated protein tau in neuroblastomas using sense and anti-sense transfection strategies. 9295144 Human
microtubule-associated protein tau breast cancer Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer. 15914550 Human
the tau gene neuroblastoma To examine the molecular mechanisms responsible for aberrant splicing of the tau gene containing mutations linked to FTDP-17, we performed Exon trapping and binding assay using tau exon 10 pre-mRNA and nuclear extracts of neuroblastoma cell lines and in v 15009090 Human
the tau protein pd We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. 11391737 Human

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