IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ITGB3 Ensembl ENSG00000056345 Chromosome 17 Start 42686207 End 42745076
Description Integrin beta-3 Precursor (Platelet membrane glycoprotein IIIa)(GPIIIa)(CD61 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P05106]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6156
     Entrez Gene : 3690
     UCSC : uc002ilj.2
     GeneCards : 6156
     RefSeq : NM_000212
     CCDS : CCDS11511.1
     Uniprot : P05106
     Interpro : P05106
     OMIM : 173470
     GeneTests : ITGB3
     CGAP : ITGB3
     PMID : 2454952

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1176_at  0.18  2.59e-1  3.60e-1  -0.38  1.35e-1  2.11e-1
 HG_U95  37952_at  0.11  5.38e-1  6.38e-1  0.02  9.25e-1  9.49e-1
 HG_U95  852_at  0.58  4.91e-3  1.27e-2  0.35  2.41e-1  3.39e-1
 HG_U133A  204625_s_at  0.00  9.68e-1  9.74e-1  1.47  3.81e-34  6.76e-34
 HG_U133A  204626_s_at  -0.00  9.84e-1  9.86e-1  1.97  4.73e-24  7.29e-24
 HG_U133A  204627_s_at  0.92  6.68e-7  1.75e-6  4.53  4.70e-94  2.72e-93
 HG_U133A  204628_s_at  0.31  2.91e-4  5.70e-4  2.84  1.19e-76  4.45e-76
 HG_U133A  211579_at  0.03  8.45e-1  8.69e-1  -1.59  4.38e-12  5.67e-12
 HG_U133A  215240_at  -0.02  9.03e-1  9.18e-1  2.38  2.99e-57  7.71e-57
 HG_U133A  216261_at  0.27  1.09e-4  2.26e-4  -1.11  1.21e-11  1.56e-11
 HG_U133_Plus2  204625_s_at  0.21  2.70e-1  3.55e-1  0.23  2.15e-1  2.67e-1
 HG_U133_Plus2  204626_s_at  0.86  1.05e-6  4.73e-6  1.02  7.14e-6  1.87e-5
 HG_U133_Plus2  204627_s_at  0.07  7.50e-1  8.07e-1  -0.34  1.51e-1  1.95e-1
 HG_U133_Plus2  204628_s_at  0.11  4.40e-1  5.30e-1  0.09  5.25e-1  5.83e-1
 HG_U133_Plus2  211579_at  0.37  5.35e-2  8.93e-2  1.16  1.77e-8  6.48e-8
 HG_U133_Plus2  215240_at  0.50  1.15e-2  2.30e-2  0.42  3.13e-2  4.66e-2
 HG_U133_Plus2  216261_at  0.43  2.80e-3  6.57e-3  0.64  4.42e-6  1.19e-5
 Stanford  7389  1.24  2.89e-2  1.27e-1  0.73  1.85e-1  4.05e-1
 Stanford  14158  0.14  6.24e-1  7.74e-1  0.28  3.37e-1  5.76e-1
 Stanford  19981  0.95  5.31e-2  1.62e-1  0.59  1.45e-1  3.49e-1
 Agilent_HS_21.6K  871  -0.04  6.50e-1  7.88e-1  -0.11  6.73e-3  2.60e-2
 Agilent_HS_21.6K  15936  0.04  7.49e-2  1.93e-1  0.02  2.66e-1  4.20e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204625_s_at  -0.71  9.98e-2  7.73e-1  0.21  4.01e-1  1.00e+0
 HG_U133A  204626_s_at  0.46  1.02e-1  7.76e-1  0.14  4.47e-1  1.00e+0
 HG_U133A  204627_s_at  -0.49  4.93e-1  9.26e-1  -0.54  1.70e-1  1.00e+0
 HG_U133A  204628_s_at  -0.28  3.70e-1  8.96e-1  -0.08  4.63e-1  1.00e+0
 HG_U133A  211579_at  0.62  1.63e-1  8.15e-1  0.63  1.17e-1  1.00e+0
 HG_U133A  215240_at  -0.40  3.90e-1  8.96e-1  -0.08  7.13e-1  1.00e+0
 HG_U133A  216261_at  -0.24  2.61e-1  8.60e-1  -0.02  9.33e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1176_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 37952_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 852_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204625_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204626_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204627_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204628_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211579_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215240_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216261_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204625_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204626_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204627_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204628_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211579_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215240_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216261_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7389    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14158    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19981    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 871    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15936    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd61 human tumors Immunohistochemical analysis of beta3 integrin (CD61): expression in pig tissues and human tumors. 11962738 Human
gpiiia tumour A monoclonal antibody (JM2E5) specific for the integrin beta3 chain, or CD61 or GPIIIa subunit, has been employed to determine the expression of the canine homologue CD41/CD61 or CD51/CD61 complex on different canine cells in peripheral blood lymphocytes, 11297034 Human
cd61 tumour A monoclonal antibody (JM2E5) specific for the integrin beta3 chain, or CD61 or GPIIIa subunit, has been employed to determine the expression of the canine homologue CD41/CD61 or CD51/CD61 complex on different canine cells in peripheral blood lymphocytes, 11297034 Human
cd61 tumour The canine homologue CD41/CD61 or CD51/61 was present on peripheral blood lymphocytes, monocytes, granulocytes, breast tumour cells and spleen cells as well as on platelets and it was absent from erythrocytes and lymph-node cells. 11297034 others
gpiiia polycythaemia vera We have previously demonstrated that platelets in polycythaemia vera (PV) exhibit decreased aggregation after stimulation with platelet activating factor (PAF) and reduced expression of GPIIIa on both resting and stimulated platelets. 11092463 Human
cd61 colon tumor Cell colony density was evaluated basally (endothelial plus colon tumor cells) and following the addition of: purified vWF, vWF plus vWF-blocking antibodies, antibodies against various integrins and adhesion molecules (alpha2 b integrin, beta1 integrin, b 11100896 Human
cd61 acute megakaryoblastic leukemia We report a case of acute myeloid leukemia which we have classified as acute megakaryoblastic leukemia because of intracytoplasmic expression of CD61. 10550559 Human
cd61 acute myeloid leukemia We report a case of acute myeloid leukemia which we have classified as acute megakaryoblastic leukemia because of intracytoplasmic expression of CD61. 10550559 Human
cd61 acute leukemias Our findings suggest that cytoplasmic expression of CD61 may precede the cell-surface expression of this antigen and should therefore be investigated in all cases of acute leukemias with undifferentiated morphology and negative cytochemistry to set apart 10550559 Human
cd61 kasabach-merritt syndrome Kasabach-Merritt syndrome: identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61. 10571842 Human
cd61 tufted angioma Kasabach-Merritt syndrome: identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61. 10571842 Human
cd61 tumor In this case we directly demonstrated platelet trapping in the vascular lumen of the tumor by an immunohistochemical technique using a monoclonal antibody against CD61, a marker of platelets and megakaryocytes. 10571842 Human
gpiiia chronic myelogenous leukemia Using GPIIIa as a marker to recognize megakaryocytes in the bone marrow, we have estimated GPIIIa expression by flow cytometry in megakaryocyte populations from normal individuals and from patients with chronic myelogenous leukemia, immune thrombocytopeni 10697532 Human
gpiiia polycythemia vera Using GPIIIa as a marker to recognize megakaryocytes in the bone marrow, we have estimated GPIIIa expression by flow cytometry in megakaryocyte populations from normal individuals and from patients with chronic myelogenous leukemia, immune thrombocytopeni 10697532 Human
gpiiia human erythroleukemia (hel) In this report we describe the structure of the human beta subunit GPIIIa deduced from an analysis of 4.0 kb of overlapping cDNA sequences isolated from a human erythroleukemia (HEL) cell cDNA expression library. 2452834 Human
gpiiia human erythroleukemia (hel) Human erythroleukemia (HEL) cells synthesize both GPIIb and GPIIIa. 3165296 Human
gpiiia human leukemia To gain a better understanding of the genetic basis for GpIIb and GpIIIa synthesis, we studied their synthesis by two human leukemia cell lines, HEL and K562. 3548842 Human
gpiiia hyperplasia Glycoprotein IIIa (GPIIIa) has a key role in the aggregation of thrombocytes, and it also mediates intimal hyperplasia after endothelial injuries; the possible association of the Pl(A1/A2) polymorphism of the gene for GPIIIa with coronary thrombosis and w 10521390 Human
cd61 cancer In a feasibility clinical study, 10 cancer patients (8 with breast cancer and 2 with non-Hodgkin's lymphoma) undergoing autologous peripheral blood progenitor cell (PBPC) transplant received MP generated ex vivo (range, 1 to 21 x 10(5)/kg CD61 cells) 9108385 Human
cd61 breast cancer In a feasibility clinical study, 10 cancer patients (8 with breast cancer and 2 with non-Hodgkin's lymphoma) undergoing autologous peripheral blood progenitor cell (PBPC) transplant received MP generated ex vivo (range, 1 to 21 x 10(5)/kg CD61 cells) 9108385 Human
cd61 non-hodgkin's lymphoma In a feasibility clinical study, 10 cancer patients (8 with breast cancer and 2 with non-Hodgkin's lymphoma) undergoing autologous peripheral blood progenitor cell (PBPC) transplant received MP generated ex vivo (range, 1 to 21 x 10(5)/kg CD61 cells) 9108385 Human
cd61 myeloma We investigated the expression of adhesion molecules including LFA-1 alpha (CD11a), Mac-1 (CD11b), LFA-1 beta (CD18), VLA-beta 1 (CD29), H-CAM (CD44), VLA-4 (CD49d), VLA-5 (CD49e), ICAM-1 (CD54), N-CAM (CD56), LFA-3 (CD58), VNR-beta (CD61), and LECAM-1 (C 8797890 Human
cd 61 hepatocellular carcinoma (hcc) This study described the distribution, pattern and intensity of cytokine TGFa, adhesion molecules CD 34 and CD 44 and integrins a2, a3, CD 29 (beta 1 chain) and CD 61 (beta 3 chain) in hepatocellular carcinoma (HCC), metastatic liver tumors and hepatic ci 7539239 Human
cd 61 metastatic liver tumors This study described the distribution, pattern and intensity of cytokine TGFa, adhesion molecules CD 34 and CD 44 and integrins a2, a3, CD 29 (beta 1 chain) and CD 61 (beta 3 chain) in hepatocellular carcinoma (HCC), metastatic liver tumors and hepatic ci 7539239 Human
gpiiia acute megakaryoblastic leukemia AP3, a MoAb reactive with platelet glycoprotein (GPIIIa), was specific for acute megakaryoblastic leukemia. 3297208 Human
gpiiia human erythroleukemia (hel) Both GPIIb and GPIIIa are synthesized by a human erythroleukemia (HEL) cell line. 3479442 Human
gpiiia human leukemia To characterize synthesis of these two proteins, RNA isolated from a human leukemia cell line that contains GPIIb and GPIIIa was translated in a wheat germ cell-free system. 3006053 Human
cd61 myelodysplasia Furthermore, in myelodysplasia 25% of the CD61 positive cells were micromegakaryocytes as opposed to less than 10% in normal or reactive marrows. 1699866 Human
gpiiia melanoma The second integrin shares the same beta subunit (beta 3 or GPIIIa), but has a distinct alpha subunit that comigrates with the alpha subunit (alpha v) of the vitronectin receptor (VnR) on endothelial cells and reacts with a monoclonal antibody, LM142, whi 2478219 Human
gpiiia megakaryoblastic leukemia Immunogold labeling for the GpIIIa platelet glycoprotein (CD61) was used in cases where the light microscopy of blood films revealed possible megakaryoblastic leukemia. 8819897 Human
cd61 megakaryoblastic leukemia Immunogold labeling for the GpIIIa platelet glycoprotein (CD61) was used in cases where the light microscopy of blood films revealed possible megakaryoblastic leukemia. 8819897 Human
cd61 primary malignant melanomas In order to evaluate the significance of adhesion molecules expressed on melanocytic tumours for progression and prognosis in vivo, we studied integrin expression (VLA-1 to VLA-6, CD18, CD51, CD61) on 10 naevi, 40 primary malignant melanomas, and 11 metas 8105045 Human
cd61 metastases In order to evaluate the significance of adhesion molecules expressed on melanocytic tumours for progression and prognosis in vivo, we studied integrin expression (VLA-1 to VLA-6, CD18, CD51, CD61) on 10 naevi, 40 primary malignant melanomas, and 11 metas 8105045 Human
cd61 tumours In order to evaluate the significance of adhesion molecules expressed on melanocytic tumours for progression and prognosis in vivo, we studied integrin expression (VLA-1 to VLA-6, CD18, CD51, CD61) on 10 naevi, 40 primary malignant melanomas, and 11 metas 8105045 Human
cd61 melanomas Statistical analysis (Wilcoxon rank test, Scheffe test) revealed significant differences in the expression of VLA-1 (P < 0.0001), VLA-2 (P = 0.0001), VLA-5 (P = 0.0093), VLA-6 (P = 0.0232), and CD61 (P = 0.0002) between naevi and primary melanomas. 8105045 Human
cd61 myelodysplastic syndrome The use of CD61 antibodies, which recognize megakaryocytic cells at all stages of maturation, confirmed that these patients had a higher number of these cells than either normal subjects or patients affected by myelodysplastic syndrome (MDS) without fibro 1712222 Human
cd61 myeloproliferative disorders Most of the CD61 positive cells featured cytoplasmic differentiation markers such as alpha granules and demarcation membranes, further confirming the presence of circulating megakaryocythemia, a phenomenon described many years ago in various myeloprolifer 8819897 Human
cd61 breast tumour A monoclonal antibody (JM2E5) specific for the integrin beta3 chain, or CD61 or GPIIIa subunit, has been employed to determine the expression of the canine homologue CD41/CD61 or CD51/CD61 complex on different canine cells in peripheral blood lymphocytes, 11297034 Human
cd61 breast tumour The canine homologue CD41/CD61 or CD51/61 was present on peripheral blood lymphocytes, monocytes, granulocytes, breast tumour cells and spleen cells as well as on platelets and it was absent from erythrocytes and lymph-node cells. 11297034 others
cd61 necrosis Two observers graded the extent of CD61 staining in PC and GC from 0 (none) to 2+ (>50%) in 15 renal allograft biopsy specimens with AHR and compared these with tissues from allografts with acute cellular rejection (ACR) (n = 23); acute calcineurin inhibi 12827606 Human
cd61 necrosis PC CD61 was observed in 11 of 11 foci of necrosis due to AHR, RVT, and ischemia. 12827606 Human
cd61 necrosis OBJECTIVE: To analyze the relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation. 12826159 Human
cd61 necrosis RESULTS: The expression levels of CD61, CD63, and PAC-1 on platelet surfaces significantly increased (P <.05) among patients with acute rejection, as compared with those with normal graft function or acute tubular necrosis. 12826159 Human
cd61 necrosis CONCLUSIONS: The pretransplant expression levels of CD61, CD63, and PAC-1 on platelet surface were significantly higher among patients with acute rejection, suggesting that this complication rather than acute tubular necrosis may be related to platelet ac 12826159 Human
cd61 leukemia Immunophenotyping of the first leukemia sample revealed a mixed lineage leukemia immunophenotype with positivity for terminal deoxynucleotidyl transferase (TdT), CD13 and CD19; the second sample revealed solely myeloid characteristics with positivity for 15863212 Human
cd61 lung carcinoma The aim of this study was to analyze the expression of ADAM15 and its potential ligand, integrin alpha(v)beta3 (CD51/CD61), in lung carcinoma cell lines and tissues. 15756594 Human
cd61 melanoma Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium. 15897908 Human
cd61 tumor The expression of the alphavbeta3 integrin (CD51/CD61) on human melanoma cells has been shown to be associated most closely with tumor progression and metastases formation in melanoma. 15897908 Human
cd61 melanoma The expression of the alphavbeta3 integrin (CD51/CD61) on human melanoma cells has been shown to be associated most closely with tumor progression and metastases formation in melanoma. 15897908 Human
cd61 metastases The expression of the alphavbeta3 integrin (CD51/CD61) on human melanoma cells has been shown to be associated most closely with tumor progression and metastases formation in melanoma. 15897908 Human
gp3a prostatic cancer [Prognostic implications of GP3a glucoprotein gene PLA1/PLA2 allele in prostatic cancer: pilot results of the study] We studied the role of integrins, primarily, the role of allele distribution of GP3a gene in development of prostatic cancer (PC) and asse 16158739 Human
gpiiia breast tumour A monoclonal antibody (JM2E5) specific for the integrin beta3 chain, or CD61 or GPIIIa subunit, has been employed to determine the expression of the canine homologue CD41/CD61 or CD51/CD61 complex on different canine cells in peripheral blood lymphocytes, 11297034 Human
gpiiia essential thrombocythemia In a prospective study of 86 patients with polycythemia vera (43 patients) or essential thrombocythemia (43 patients), we examined the possible role of polymorphisms of platelet adhesion receptors [glycoprotein (GP) Ibalpha, GPIa, GPIIIa) and clotting fac 15166939 Human
gpiiia polycythemia vera In a prospective study of 86 patients with polycythemia vera (43 patients) or essential thrombocythemia (43 patients), we examined the possible role of polymorphisms of platelet adhesion receptors [glycoprotein (GP) Ibalpha, GPIa, GPIIIa) and clotting fac 15166939 Human
gpiiia polycythemia vera However, among patients with polycythemia vera, the presence of the PlA2 allele of GPIIIa was associated with an increased risk of arterial thrombosis. 15166939 Human
integrin beta 3 carcinoma Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. 1374415 Human
integrin beta 3 human erythroleukaemia (hel) A cDNA for integrin beta 3 isolated from a human erythroleukaemia (HEL) cell library contained a 340 bp insert at position 1281. 8198553 Human
integrin beta 3 melanoma Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. 7542248 Human
integrin beta 3 melanoma Transfection of CS-1 melanoma cells with a cDNA encoding the wild-type integrin beta 3 subunit, results in de novo alpha v beta 3 expression and cell attachment, spreading, and migration on vitronectin. 7542248 Human
integrin beta 3 melanoma These findings demonstrate that the NPXY motif within the integrin beta 3 cytoplasmic tail is essential for alpha v beta 3-dependent post-ligand binding events involved in cell migration and the metastatic phenotype of melanoma cells. 7542248 Human
integrin beta 3 metastasis Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis. 8806594 Human
integrin beta 3 melanoma Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis. 8806594 Human
integrin beta 3 human erythroleukemia (hel) Among the four overlapping cell-permeable peptides, only the peptide carrying residues 747-762 of the carboxyl-terminal segment of integrin beta 3 inhibited adhesion of human erythroleukemia (HEL) cells and of human endothelial cells (ECV) 304 to immobili 8876221 Human
integrin beta 3 pulmonary metastasis Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma. 11299820 Human
integrin beta 3 colorectal carcinoma Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma. 11299820 Human
integrin beta 3 primary tumors Fifty-one primary tumors and 22 lung metastases were examined for immunohistochemical detection of integrin beta 3. 11299820 Human
integrin beta 3 lung metastases Fifty-one primary tumors and 22 lung metastases were examined for immunohistochemical detection of integrin beta 3. 11299820 Human
integrin beta 3 metastasis Indeed, vascular integrin beta 3 index was significantly higher in tumors of patients with lung metastasis than in those without lung metastasis. 11299820 Human
integrin beta 3 tumors Indeed, vascular integrin beta 3 index was significantly higher in tumors of patients with lung metastasis than in those without lung metastasis. 11299820 Human
integrin beta 3 primary tumors In the patients with lung metastases, vascular integrin beta 3 index was significantly lower in lung metastases than in primary tumors. 11299820 Human
integrin beta 3 lung metastases In the patients with lung metastases, vascular integrin beta 3 index was significantly lower in lung metastases than in primary tumors. 11299820 Human
integrin beta 3 metastasis It was immunohistochemically proved that integrin beta 3 is an important vascular endothelial cell market for lung metastasis. 11299820 Human
itgb3 breast cancer No association of breast cancer risk with integrin beta3 (ITGB3) Leu33Pro genotype. 15970922 Human
itgb3 breast cancer To pursue a borderline increased risk of breast cancer for carriers of two integrin beta(3) (ITGB3) 33Pro alleles found in a recent prospective study, we conducted a case-control study of 1088 women with breast cancer and 4815 female controls. 15970922 Human
cd-61 tumor We quantified the percentage of tumor area stained with beta3 integrin Ab CD-61 using an image analyzer. beta3 integrin expression was detected in 107/160 primary melanomas (69%). beta3-integrin-positive (beta3+) tumors were thicker (mean 2.98 +/- 0.3 mm) 8661192 Human
cd61 mds The use of CD61 antibodies, which recognize megakaryocytic cells at all stages of maturation, confirmed that these patients had a higher number of these cells than either normal subjects or patients affected by myelodysplastic syndrome (MDS) without fibro 1712222 Human
cd-61 melanomas We quantified the percentage of tumor area stained with beta3 integrin Ab CD-61 using an image analyzer. beta3 integrin expression was detected in 107/160 primary melanomas (69%). beta3-integrin-positive (beta3+) tumors were thicker (mean 2.98 +/- 0.3 mm) 8661192 Human
cd-61 tumors We quantified the percentage of tumor area stained with beta3 integrin Ab CD-61 using an image analyzer. beta3 integrin expression was detected in 107/160 primary melanomas (69%). beta3-integrin-positive (beta3+) tumors were thicker (mean 2.98 +/- 0.3 mm) 8661192 Human
itgb3 breast cancer To analyze the role of ITGA2 and ITGB3 polymorphisms for breast cancer risk and prognosis, we performed a case-control study including 500 female breast cancer patients and 500 healthy female age-matched control subjects. 16317580 Human
itgb3 female breast cancer To analyze the role of ITGA2 and ITGB3 polymorphisms for breast cancer risk and prognosis, we performed a case-control study including 500 female breast cancer patients and 500 healthy female age-matched control subjects. 16317580 Human
itgb3 breast cancer The ITGB3 176T>C polymorphisms was not associated with breast cancer susceptibility. 16317580 Human
itgb3 metastasis In a Cox-regression analysis, carriers of the homozygous ITGB3 176-CC genotype had a higher risk for metastasis (relative risk 2.3; 95% CI 1.3-4.2; p=0.005). 16317580 Human
itgb3 breast cancer We conclude that functional polymorphisms in integrin genes ITGA2 and ITGB3 influence the development and progression of breast cancer, respectively. 16317580 Human
cd61 leukemia The megakaryocytic nature of the leukemia has to be proven by ultrastructural demonstration of platelet peroxidase or by immunological demonstration of CD61, CD42, CD41 on the surface of the leukemic blasts. 7496359 Human
cd61 cml (2) Compared to non-CML controls, CML specimens at diagnosis showed an increased reticulin fibrosis and a decreased expression of CD61 on megakaryocytes and of CD31 on vessels and hemopoietic cells. 9042664 Human
cd61 cml In conclusion, CML samples at diagnosis showed increased fibrosis and decreased CD31 and CD61 expression compared to controls. 9042664 Human
cd61 cml MATERIAL AND METHODS: Mononuclear cells of 17 patients with CML in BC were immunophenotyped employing a panel of 18 monoclonal antibodies: CD5, CD10, CD14, CD22, and anti-HLA-DR used in all patients; CD2, CD15, CD19, CD34, and CD41 in 13 to 16 patients; a 9229753 Human
cd61 cml For this reason, a retrospective clinicopathological study was performed on 83 patients with CML including 209 sequential bone marrow biopsies (intervals ranging between 6 and 143 months) and immunohistological staining of CD34(+) cells (QBEND10), megakar 11798509 Human
cd61 erythroleukemia K562 erythroleukemia cells and IEC6 rat cells were examined using confocal microscopy and antibodies raised against DMT-1 (Nramp-2, DCT-1), transferrin receptor (CD71), beta(3) integrin (CD61), mobilferrin (calreticulin), and Hephaestin. 11891802 Human
cd61 acute leukemias [LAT (linker for activation of T cells): a useful marker for megakaryocyte evaluation on bone marrow biopsies] Detection of atypical megakaryocytes in bone marrow biopsies, especially in cases of myelodysplastic syndromes (MDS), chronic myeloproliferative 12540999 Human
cd61 chronic myeloproliferative disorders [LAT (linker for activation of T cells): a useful marker for megakaryocyte evaluation on bone marrow biopsies] Detection of atypical megakaryocytes in bone marrow biopsies, especially in cases of myelodysplastic syndromes (MDS), chronic myeloproliferative 12540999 Human
cd61 cmpd [LAT (linker for activation of T cells): a useful marker for megakaryocyte evaluation on bone marrow biopsies] Detection of atypical megakaryocytes in bone marrow biopsies, especially in cases of myelodysplastic syndromes (MDS), chronic myeloproliferative 12540999 Human
cd61 mds [LAT (linker for activation of T cells): a useful marker for megakaryocyte evaluation on bone marrow biopsies] Detection of atypical megakaryocytes in bone marrow biopsies, especially in cases of myelodysplastic syndromes (MDS), chronic myeloproliferative 12540999 Human
cd61 myelodysplastic syndromes [LAT (linker for activation of T cells): a useful marker for megakaryocyte evaluation on bone marrow biopsies] Detection of atypical megakaryocytes in bone marrow biopsies, especially in cases of myelodysplastic syndromes (MDS), chronic myeloproliferative 12540999 Human
cd61 necrosis [The relationship between the peripheral blood of CD61, CD63, PAC-1 and the transplant kidney function] OBJECTIVES: To explore the relationships between the peripheral blood levels of CD61, CD63, PAC-1 and the incidence of acute rejection and tubular necr 14728824 Human
cd61 necrosis RESULTS: The peripheral blood levels of CD61, CD63 and PAC-1 significantly increased (P < 0.05) in the patients with acute rejection, in comparison with those with normal grafts function and those with acute tubular necrosis. 14728824 Human
cd61 necrosis CONCLUSIONS: The patients with acute rejection have significantly high peripheral blood levels of CD61, CD63 and PAC-1 before transplantation, however, these values in patients with acute tubular necrosis are not high, this suggesting that acute rejection 14728824 Human
cd61 cml Therefore an immunohistochemical (CD61) and fluorescence in-situ hybridization (FISH) study was performed on sequential BM biopsies in 5 patients with CML receiving STI571 without any pretreatment. 15370216 Human
cd 61 mds However, on CD 61 staining the number of megakaryocytes per hpf increased in cases of MDS. 16121636 Human
cd 61 mds Micromegakaryocytes were seen in scanty numbers in the normals but increased in MDS cases and increased significantly on CD 61 immunostaining. 16121636 Human
cd 61 mds The mean area, perimeter and diameter of megakaryocytes decreased significantly on immunostaining with CD 61, indicating the increased numbers of micromegakaryocytes in MDS. 16121636 Human
cd61 metastasis The expressions of CD44, E-cadherin, HER2/neu, H-Ras and VEGF-C in the high metastasis group were higher than those in the low metastasis group shown by the cDNA micro array experiment but the expressions of nm23A, nm23-E4, p16ink4a, CD61 were lower. 16556412 Human
gp3a prostatic cancer (pc) [Prognostic implications of GP3a glucoprotein gene PLA1/PLA2 allele in prostatic cancer: pilot results of the study] We studied the role of integrins, primarily, the role of allele distribution of GP3a gene in development of prostatic cancer (PC) and asse 16158739 Human
gpiiia leukemia Extramedullary tumor as presentation of leukemia: establishment of a new human GPIIb- and GPIIIa-positive leukemia cell line. 8167181 Human
gpiiia tumor Extramedullary tumor as presentation of leukemia: establishment of a new human GPIIb- and GPIIIa-positive leukemia cell line. 8167181 Human
gpiiia leukemia KH184 cells, human GPIIb- and GPIIIa-positive leukemia cells, which lack response to TPA-induced differentiation, provide a new and unique model for the characterization of factors that are implicated in the terminal differentiation of megakaryocytes, and 8167181 Human
gpiiia sarcoma KH184 cells, human GPIIb- and GPIIIa-positive leukemia cells, which lack response to TPA-induced differentiation, provide a new and unique model for the characterization of factors that are implicated in the terminal differentiation of megakaryocytes, and 8167181 Human
cd61 chronic myeloid leukemia Morphological findings based on elaborate techniques were in keeping with the assumption that in chronic myeloid leukemia (1) the number of CD61-positive megakaryocytes, and in particular their precursors were the parameters most closely associated with m 9086437 Human
cd61 myelofibrosis Morphological findings based on elaborate techniques were in keeping with the assumption that in chronic myeloid leukemia (1) the number of CD61-positive megakaryocytes, and in particular their precursors were the parameters most closely associated with m 9086437 Human
cd61 tumor Morphological findings based on elaborate techniques were in keeping with the assumption that in chronic myeloid leukemia (1) the number of CD61-positive megakaryocytes, and in particular their precursors were the parameters most closely associated with m 9086437 Human
cd61 cml A total of 311 CD61-positive megakaryocytes, including precursors and atypical microforms, were evaluated in pre-treatment specimens derived from 11 patients with Ph1+ CML. 9354890 Human
cd61 hyperplasia In comparison with a control group megakaryocytes (CD61-Y2/51) revealed not only a significant hyperplasia, but remarkably irregular shapes of cells and nuclei, together with a disturbance of the nuclear-cytoplasmic ratio. 1724814 Human
cd61 erythroleukemia K562 erythroleukemia cells and IEC6 rat cells were examined using confocal microscopy and antibodies raised against DMT-1 (Nramp-2, DCT-1), transferrin receptor (CD71), beta(3) integrin (CD61), mobilferrin (calreticulin), and Hephaestin. 11891802 Human
cd61 aml CD61-positive cells in suspension cultures increased with PEG-rHuMGDF alone in 20/25 RA + RAS, 11/14 RAEB + RAEBt and 29/33 AML cases. 10792278 Human
cd61 juvenile hemangioma Thirty-three cases of KH were reviewed and immunostained for alpha-smooth muscle actin, various endothelial markers (CD31, CD34, vWf, FLI1), a platelet marker (CD61), and the juvenile hemangioma-associated markers GLUT-1 and Lewis Y antigen (LeY). 15105642 Human
cd 61 mds STUDY DESIGN: Comparative image morphometry using hematoxylin-eosin-stained and CD 61-stained trephine biopsies was carried out on 40 cases of MDS and 10 normal subjects to analyze the megakaryocytes objectively. 16121636 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.