IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SP2 Ensembl ENSG00000167182 Chromosome 17 Start 43328515 End 43361320
Description Transcription factor Sp2 [Source:UniProtKB/Swiss-Prot;Acc:Q02086]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11207
     Entrez Gene : 6668
     UCSC : uc002imk.2
     GeneCards : 11207
     RefSeq : NM_003110
     CCDS : CCDS11521.2
     Uniprot : Q02086
     Interpro : Q02086
     OMIM : 601801
     GeneTests : SP2
     CGAP : SP2
     PMID : 1341900

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37212_at  -0.21  9.90e-3  2.32e-2  -0.26  1.06e-3  3.25e-3
 HG_U133A  204367_at  -0.34  4.69e-10  1.68e-9  -0.07  4.58e-1  4.69e-1
 HG_U133A  211736_at  -0.64  4.12e-4  7.92e-4  0.81  6.29e-7  7.46e-7
 HG_U133_Plus2  204367_at  -0.02  7.56e-1  8.12e-1  0.17  4.80e-2  6.89e-2
 HG_U133_Plus2  211736_at  0.33  1.13e-1  1.70e-1  0.72  2.64e-3  4.75e-3
 HG_U133_Plus2  237795_s_at  0.53  1.03e-2  2.10e-2  1.16  7.53e-6  1.96e-5
 Stanford  6878  -0.20  5.21e-1  6.98e-1  -0.34  3.28e-1  5.68e-1
 Agilent_HS_21.6K  1426  0.04  2.38e-1  4.20e-1  0.03  5.07e-1  6.54e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204367_at  0.41  4.57e-2  7.08e-1  0.04  7.58e-1  1.00e+0
 HG_U133A  211736_at  0.05  9.33e-1  9.96e-1  -0.16  7.54e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37212_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204367_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211736_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204367_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211736_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 237795_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6878    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1426    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
sp2 breast cancer CA 549 and SP2: new tumor markers in breast cancer. 2283484 Human
sp2 tumor CA 549 and SP2: new tumor markers in breast cancer. 2283484 Human
sp2 prostate cancer Here, we report that down-regulation of CEACAM1 expression in prostate cancer cells occurs primarily at the transcriptional level and is mediated by Sp2, a member of the Sp family of transcription factors. 15126343 Human
sp2 human prostate cancer In human prostate cancer specimens, Sp2 expression is high in prostate cancer cells but low in normal prostate epithelial cells and is inversely correlated with CEACAM1 expression. 15126343 Human
sp2 prostate cancer In human prostate cancer specimens, Sp2 expression is high in prostate cancer cells but low in normal prostate epithelial cells and is inversely correlated with CEACAM1 expression. 15126343 Human
sp2 prostate cancer Our studies show that transcriptional repression by Sp2 represents one mechanism by which CEACAM1 tumor suppressor gene is down-regulated in prostate cancer. 15126343 Human

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