IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HOXB3 Ensembl ENSG00000120093 Chromosome 17 Start 43981232 End 44006809
Description Homeobox protein Hox-B3 (Hox-2G)(Hox-2.7) [Source:UniProtKB/Swiss-Prot;Acc:P14651]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5114
     Entrez Gene : 3213
     UCSC : uc002ino.2
     GeneCards : 5114
     RefSeq : NM_002146
     CCDS : CCDS11528.1
     Uniprot : P14651
     Interpro : P14651
     OMIM : 142966
     GeneTests : HOXB3
     CGAP : HOXB3
     PMID : 1973146

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33620_at  0.36  3.89e-2  7.47e-2  0.27  2.59e-1  3.59e-1
 HG_U133A  208414_s_at  0.01  8.96e-1  9.12e-1  3.72  5.31e-110  4.76e-109
 HG_U133_Plus2  208414_s_at  0.59  3.96e-4  1.12e-3  0.87  2.35e-5  5.72e-5
 HG_U133_Plus2  228904_at  0.35  9.02e-3  1.87e-2  0.61  1.27e-8  4.71e-8
 HG_U133_Plus2  241958_at  0.18  2.75e-1  3.61e-1  0.58  1.65e-3  3.06e-3
 Agilent_HS_21.6K  12845  0.11  1.82e-1  3.51e-1  0.12  1.24e-1  2.43e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208414_s_at  0.12  7.49e-1  9.74e-1  -0.06  8.29e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33620_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208414_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208414_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228904_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241958_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12845    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hoxb3 leukemias In addition, we show that the HOXA9 and HOXB3 genes play key roles in establishing all the main characteristics of the leukemias, while MEIS1 functions only to accelerate the onset of the leukemic transformation. 11113197 Human
hoxb3 leukemia Notably, NUP98-HOXA10 and NUP98-HOXB3 but not NUP98-HOXB4 induced leukemia in a murine transplant model, which is consistent with the reported leukemogenic potential ability of HOXA10 and HOXB3 but not HOXB4. 14966272 Human
hox-2 embryonal carcinoma (ec) We have studied the expression of four human homeobox genes representative of four different clusters (i.e., HOX-1, HOX-2, HOX-3 and HOX-5) in the embryonal carcinoma (EC) cell line NT2/D1. 2576519 Human
hox 2 embryonal carcinoma (ec) We have studied the expression of nine homeobox genes from Hox 1, Hox 2, Hox 3 and Hox 5 clusters in human embryonal carcinoma (EC) cell lines analyzed as both stem cells and after exposure to the differentiation-inducing agents retinoic acid (RA), hexame 2898410 Human
hoxb3 embryonal carcinoma Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. 9556594 Human
hoxb3 embryonal carcinoma In this report, we show that a 1821-base pair (bp) upstream DNA fragment of the Otx2 gene is positively regulated by co-transfection with expression vectors for the human HOXB1, HOXB2, and HOXB3 proteins in an embryonal carcinoma cell line (NT2/D1) and th 9556594 Human
hox2 embryonal carcinoma Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. 1975088 Human
hox2 embryonal carcinoma At both high and low retinoic acid concentrations, HOX2 genes are sequentially activated in embryonal carcinoma cells in the 3' to 5' direction. 1975088 Human
hox2 acute non-lymphocytic leukemia Six contiguous genes of the HOX2 locus, highly expressed in acute non-lymphocytic leukemia, are switched off in chronic myelogenous leukemia, suggesting that down-regulation of HOX2 genes might be required for cell maturation of the myeloid lineages. 7678830 Human
hox2 chronic myelogenous leukemia Six contiguous genes of the HOX2 locus, highly expressed in acute non-lymphocytic leukemia, are switched off in chronic myelogenous leukemia, suggesting that down-regulation of HOX2 genes might be required for cell maturation of the myeloid lineages. 7678830 Human
hox-2 acute lymphoid leukemia Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. 1351762 Human
hox-2 acute lymphoid leukemia (all) We have analyzed, in normal adult blood cell subpopulations, acute lymphoid leukemia (ALL) cells lines, and primary blasts, the RNA expression of all HOX-2 cluster genes (5'-2.5, 2.4, 2.3, 2.2, 2.1, 2.6, 2.7, 2.8, 2.9, 3') and nine genes in the 1351762 Human
hox-2 leukemia In B- and T-ALL cell lines, HOX-2 genes are expressed according to different patterns: (1) widespread transcription (seven of nine genes, including 2.3 and 2.6) in the Peer line bearing the TCR gamma/delta; (2) expression of 2.5, 2.2, and 2.6 in the SEZ 6 1351762 Human
hox-2 renal carcinoma Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies. 1379214 Human
hox-2 cancer Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies. 1379214 Human
hox2 embryonal carcinoma The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines. 1360433 Human
hox2 human neuroblastoma The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines. 1360433 Human
hox2 glioblastoma The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines. 1360433 Human
hox2 neuroblastoma The two uninduced neuroblastoma cell lines show a similar pattern of expression for a number of HOX2 genes although the levels of expression are different for individual cell lines. 1360433 Human
hox2 embryonal carcinoma The embryonal carcinoma cell line F9 expresses low levels of several HOX2 genes which is restricted to the 5' region of the HOX2 cluster. 1360433 Human
hox2 glioblastoma The glioblastoma cell line, 251-MG expresses almost all of the genes of the HOX2 locus. 1360433 Human
hox-2 teratocarcinoma Furthermore, in the continuous presence of RA F9 teratocarcinoma cells show a differential ability to maintain Hox-2 expression depending upon whether the cells follow a visceral or parietal endoderm pathway. 1682879 Human
hox-2 t-all In B- and T-ALL cell lines, HOX-2 genes are expressed according to different patterns: (1) widespread transcription (seven of nine genes, including 2.3 and 2.6) in the Peer line bearing the TCR gamma/delta; (2) expression of 2.5, 2.2, and 2.6 in the SEZ 6 1351762 Human
hox-2 t-all Our data are compatible with the hypothesis that selected HOX-2 genes play a role in the IL-2/IL-1 beta-induced activation and/or proliferation of normal NK lymphocytes and possibly in the oncogenetic process of some T- and B-ALL. 1351762 Human
hoxb3 aml In this report, we demonstrate that HOXB3, which is highly divergent from HOXA9, also genetically interacts with MEIS1, but not with PBX1, in generating AML. 11113197 Human

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