IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HOXB5 Ensembl ENSG00000120075 Chromosome 17 Start 44023619 End 44026127
Description Homeobox protein Hox-B5 (Hox-2A)(HHO.C10)(HU-1) [Source:UniProtKB/Swiss-Prot;Acc:P09067]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5116
     Entrez Gene : 3215
     UCSC : uc002inr.2
     GeneCards : 5116
     RefSeq : NM_002147
     CCDS : CCDS11530.1
     Uniprot : P09067
     Interpro : P09067
     OMIM : 142960
     GeneTests : HOXB5
     CGAP : HOXB5
     PMID : 1973146

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34251_at  -0.66  2.00e-3  5.79e-3  -0.64  2.18e-3  6.13e-3
 HG_U133A  205600_x_at  -0.44  1.21e-12  5.43e-12  -1.14  1.74e-29  2.91e-29
 HG_U133A  205601_s_at  -0.33  1.25e-6  3.18e-6  -0.43  3.02e-5  3.48e-5
 HG_U133_Plus2  205600_x_at  0.09  4.76e-1  5.64e-1  0.35  1.33e-3  2.50e-3
 HG_U133_Plus2  205601_s_at  -0.08  3.83e-1  4.74e-1  -0.02  8.20e-1  8.50e-1
 Stanford  18931  0.87  5.69e-2  1.70e-1  0.17  5.61e-1  7.59e-1
 Agilent_HS_21.6K  17704  0.03  3.56e-1  5.44e-1  0.04  2.23e-1  3.71e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205600_x_at  -0.08  7.25e-1  9.72e-1  -0.08  4.14e-1  1.00e+0
 HG_U133A  205601_s_at  -0.07  7.95e-1  9.82e-1  -0.04  7.92e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34251_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205600_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205601_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205600_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205601_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18931    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17704    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hox-2 embryonal carcinoma (ec) We have studied the expression of four human homeobox genes representative of four different clusters (i.e., HOX-1, HOX-2, HOX-3 and HOX-5) in the embryonal carcinoma (EC) cell line NT2/D1. 2576519 NA
hox 2 embryonal carcinoma (ec) We have studied the expression of nine homeobox genes from Hox 1, Hox 2, Hox 3 and Hox 5 clusters in human embryonal carcinoma (EC) cell lines analyzed as both stem cells and after exposure to the differentiation-inducing agents retinoic acid (RA), hexame 2898410 NA
hoxb5 tumors Spinal ependymomas were characterized by high-expression levels of HOXB5, PLA2G, and CDKN2A and tumors in young patients (< or =16 years of age) by high-expression levels of LDHB and STAM. 14578171 Human
hoxb5 human neuroblastoma We cloned a full-length HoxB5 cDNA from the human neuroblastoma cell line, SHSY5Y, and used it to raise specific antibodies against a divergent domain of its protein. 8930688 Human
hu1 human teratocarcinoma We found that a human teratocarcinoma cell line expresses high levels of Hu1 homeo-box-containing mRNA only after differentiation of the cells following treatment with retinoic acid. 4075393 Human
hox2 embryonal carcinoma Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. 1975088 Human
hox2 embryonal carcinoma At both high and low retinoic acid concentrations, HOX2 genes are sequentially activated in embryonal carcinoma cells in the 3' to 5' direction. 1975088 Human
hox2 acute non-lymphocytic leukemia Six contiguous genes of the HOX2 locus, highly expressed in acute non-lymphocytic leukemia, are switched off in chronic myelogenous leukemia, suggesting that down-regulation of HOX2 genes might be required for cell maturation of the myeloid lineages. 7678830 Human
hox2 chronic myelogenous leukemia Six contiguous genes of the HOX2 locus, highly expressed in acute non-lymphocytic leukemia, are switched off in chronic myelogenous leukemia, suggesting that down-regulation of HOX2 genes might be required for cell maturation of the myeloid lineages. 7678830 Human
hox-2 acute lymphoid leukemia Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. 1351762 Human
hox-2 acute lymphoid leukemia (all) We have analyzed, in normal adult blood cell subpopulations, acute lymphoid leukemia (ALL) cells lines, and primary blasts, the RNA expression of all HOX-2 cluster genes (5'-2.5, 2.4, 2.3, 2.2, 2.1, 2.6, 2.7, 2.8, 2.9, 3') and nine genes in the 1351762 NA
hox-2 leukemia In B- and T-ALL cell lines, HOX-2 genes are expressed according to different patterns: (1) widespread transcription (seven of nine genes, including 2.3 and 2.6) in the Peer line bearing the TCR gamma/delta; (2) expression of 2.5, 2.2, and 2.6 in the SEZ 6 1351762 Human
hox-2 renal carcinoma Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies. 1379214 Human
hox-2a renal carcinoma Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies. 1379214 Human
hox-2 cancer Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies. 1379214 Human
hox-2a cancer Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies. 1379214 Human
hox2 embryonal carcinoma The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines. 1360433 Human
hox2 human neuroblastoma The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines. 1360433 Human
hox2 glioblastoma The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines. 1360433 Human
hox2 neuroblastoma The two uninduced neuroblastoma cell lines show a similar pattern of expression for a number of HOX2 genes although the levels of expression are different for individual cell lines. 1360433 Human
hox2 embryonal carcinoma The embryonal carcinoma cell line F9 expresses low levels of several HOX2 genes which is restricted to the 5' region of the HOX2 cluster. 1360433 Human
hox2 glioblastoma The glioblastoma cell line, 251-MG expresses almost all of the genes of the HOX2 locus. 1360433 Human
hox-2 teratocarcinoma Furthermore, in the continuous presence of RA F9 teratocarcinoma cells show a differential ability to maintain Hox-2 expression depending upon whether the cells follow a visceral or parietal endoderm pathway. 1682879 Human
hox-2 t-all In B- and T-ALL cell lines, HOX-2 genes are expressed according to different patterns: (1) widespread transcription (seven of nine genes, including 2.3 and 2.6) in the Peer line bearing the TCR gamma/delta; (2) expression of 2.5, 2.2, and 2.6 in the SEZ 6 1351762 Human
hox-2 t-all Our data are compatible with the hypothesis that selected HOX-2 genes play a role in the IL-2/IL-1 beta-induced activation and/or proliferation of normal NK lymphocytes and possibly in the oncogenetic process of some T- and B-ALL. 1351762 Human
hoxb5 ependymomas Spinal ependymomas were characterized by high-expression levels of HOXB5, PLA2G, and CDKN2A and tumors in young patients (< or =16 years of age) by high-expression levels of LDHB and STAM. 14578171 Human

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