IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HOXB13 Ensembl ENSG00000159184 Chromosome 17 Start 44157132 End 44161110
Description Homeobox protein Hox-B13 [Source:UniProtKB/Swiss-Prot;Acc:Q92826]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5112
     Entrez Gene : 10481
     UCSC : uc002ioa.2
     GeneCards : 5112
     RefSeq : NM_006361
     CCDS : CCDS11536.1
     Uniprot : Q92826
     Interpro : Q92826
     OMIM : 604607
     GeneTests : HOXB13
     CGAP : HOXB13
     PMID : 8756292

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40327_at  0.23  1.15e-1  1.85e-1  0.31  8.84e-2  1.48e-1
 HG_U133A  209844_at  0.08  3.73e-1  4.28e-1  6.07  8.52e-165  5.40e-163
 HG_U133_Plus2  209844_at  0.52  9.44e-4  2.46e-3  0.72  5.54e-6  1.47e-5
 HG_U133_Plus2  230105_at  0.54  3.72e-4  1.06e-3  0.72  2.99e-5  7.18e-5
 Stanford  2816  0.59  3.75e-1  5.74e-1  0.72  2.39e-1  4.73e-1
 Stanford  8212  0.38  3.17e-1  5.19e-1  -0.06  9.14e-1  9.62e-1
 Agilent_HS_21.6K  11289  0.13  6.08e-3  3.16e-2  0.13  1.84e-3  8.95e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209844_at  0.09  6.12e-1  9.54e-1  0.14  5.12e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40327_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209844_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209844_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230105_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2816    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8212    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11289    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hoxb13 primary breast cancer Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. 15193263 Human
hoxb-13 advanced prostate cancer The identification of hoxb-13 as an androgen-independent gene expressed in adult mouse prostate epithelial cells provides a new potential target for developing therapeutics to treat advanced prostate cancer. 10517879 Human
hoxb13 kaposis sarcoma Expression in hyperproliferative skin conditions remained cytoplasmic with the exception of epidermis associated with Kaposi's sarcoma, which showed strong HOXB13 expression that was partially localized to the nucleus. 12761847 Human
hoxb13 prostate cancer HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. 15126340 Human
hoxb13 prostate cancer Expression of HOXB13 was forced in HOXB13-negative PC3 prostate cancer cells using a liposome-mediated gene transfer approach. 15126340 Human

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