IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GIP Ensembl ENSG00000159224 Chromosome 17 Start 44390917 End 44400954
Description Gastric inhibitory polypeptide Precursor (GIP)(Glucose-dependent insulinotropic polypeptide) [Source:UniProtKB/Swiss-Prot;Acc:P09681]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4270
     Entrez Gene : 2695
     UCSC : uc002iol.1
     GeneCards : 4270
     RefSeq : NM_004123
     CCDS : CCDS11542.1
     Uniprot : P09681
     Interpro : P09681
     OMIM : 137240
     GeneTests : GIP
     CGAP : GIP
     PMID : 2739653

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  611_at  0.12  4.19e-1  5.26e-1  0.21  3.59e-1  4.65e-1
 HG_U133A  207899_at  0.10  2.98e-1  3.50e-1  1.87  7.48e-41  1.47e-40
 HG_U133_Plus2  207899_at  0.49  3.71e-3  8.44e-3  0.58  1.27e-3  2.40e-3
 Agilent_HS_21.6K  7182  0.05  1.91e-1  3.63e-1  0.05  1.30e-1  2.52e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207899_at  -0.24  4.62e-1  9.19e-1  -0.27  2.06e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 611_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207899_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207899_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7182    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
gip tumor Incubation of adenomatous cells prepared from this tumor with GIP resulted in increased cortisol secretion. 12099397 Human
gip tumor A steroidogenic secretory pattern, indicating the concomitant release of adrenal androgens and cortisol, was also observed in vitro from tumor cells cultured in the presence of GIP. 11158012 Human
gastric inhibitory polypeptide macronodular adrenal hyperplasia Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome has been described in patients with either unilateral adenoma or bilateral macronodular adrenal hyperplasia; this syndrome results from the large adrenal overexpression of the GIP rece 11004721 Human
gastric inhibitory polypeptide adenoma Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome has been described in patients with either unilateral adenoma or bilateral macronodular adrenal hyperplasia; this syndrome results from the large adrenal overexpression of the GIP rece 11004721 Human
gip adenoma Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome has been described in patients with either unilateral adenoma or bilateral macronodular adrenal hyperplasia; this syndrome results from the large adrenal overexpression of the GIP rece 11004721 Human
gastric inhibitory polypeptide macronodular adrenal hyperplasia Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome has been reported to occur either in unilateral adrenal adenoma or in bilateral macronodular adrenal hyperplasia. 10443649 Human
gastric inhibitory polypeptide adrenal adenoma Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome has been reported to occur either in unilateral adrenal adenoma or in bilateral macronodular adrenal hyperplasia. 10443649 Human
gip tumor In this patient we were able to confirm a paradoxical stimulation of cortisol secretion by GIP in vivo as well as in vitro on dispersed tumor adrenal cells obtained at surgery. 10523036 Human
gip tumor In addition to GIP, in vitro stimulation of these cultured tumor adrenal cells with leptin, the secreted product of the adipocyte, induced cortisol secretion. 10523036 Human
gip tumor Cortisol secretion by isolated tumor cells was stimulated by GIP and ACTH, but not by the gut hormone glucagon-like peptide-1 (GLP-1). 9888586 Human
gip tumor In quiescent tumor cells, GIP and ACTH stimulated [3H]-thymidine incorporation and p42-p44 MAP kinase activity. 9888586 Human
gip adrenal adenoma Cortisol production by cultured adrenal adenoma cells from the patient was stimulated by GIP and ACTH. 8784063 Human
gastric inhibitory polypeptide tumors A cell line derived from intestinal tumors of transgenic mice (STC-1) was subcloned to produce a stable line with approximately 30% immunoreactive gastric inhibitory polypeptide (irGIP)-containing cells (STC 6-14). 7653549 Mouse
gip human gastric cancer Gastric inhibitory peptide (GIP), pancreatic glucagon and vasoactive intestinal peptide (VIP) are cAMP-inducing hormones in the human gastric cancer cell line HGT-1. 6329177 Human
gastric inhibitory polypeptide beta-cell tumors High affinity binding sites have been found in membrane preparations from hamster beta-cell tumors by using radiolabeled gastric inhibitory polypeptide (125I-GIP). 6383787 Human
gip pancreatic tumor Specific binding sites for GIP have been characterized in a insulin-secreting pancreatic tumor cell line, In 111. 6091638 Human
gip beta-cell tumors The purification was monitored by a recently developed radioreceptor assay, specific for GIP, using membrane preparations from hamster beta-cell tumors. 6391923 Human
gip insulinoma Glucose-induced GIP levels in patients with insulinoma. 6099816 Human
gip insulinoma Our data show that the insulinotropic effect of GIP is almost abolished in insulinoma patients. 6099816 Human
gip prolactinoma Enteroglucagon and GIP after oral glucose in patients with prolactinoma and acromegaly. 6342859 Human
gip prolactinoma Prolactinoma patients had higher GIP levels than those with active acromegaly and both showed a failure of suppression of pancreatic glucagon. 6342859 Human
gip human insulinoma The GIP binding sites of human insulinoma were coupled to adenylate cyclase stimulation. 2822518 Human
gip rat insulinoma Differential insulin responses to oral and intravenous glucose in the transplantable rat insulinoma--a role for GIP. 3006156 Human
gip tumour In view of the different effects of oral and intravenous glucose on insulin secretion in the RIN, implicating an involvement of incretin factors from the gut, the response of the tumour to GIP was investigated. 3006156 Human
gip tumour We conclude that (a) the transplantable rat insulinoma is responsive to GIP, and (b) that whilst the tumour B-cell has lost its insulin responsiveness to hyperglycaemia produced by intraperitoneal or intravenous glucose, it retains its ability to respond 3006156 Human
gip rat insulinoma We conclude that (a) the transplantable rat insulinoma is responsive to GIP, and (b) that whilst the tumour B-cell has lost its insulin responsiveness to hyperglycaemia produced by intraperitoneal or intravenous glucose, it retains its ability to respond 3006156 Rat
gastric inhibitory polypeptide cell hyperplasia Immunoreactive gastric inhibitory polypeptide and K cell hyperplasia in obese hyperglycaemic (ob/ob) mice fed high fat and high carbohydrate cafeteria diets. 3526784 Mouse
gip tumor The experimental data: (1) support the enterogastrone activity of GIP, via adenylate cyclase activation and somatostatin release by gastric D cells; (2) demonstrate that HGT-1 cells originating from a human fundic tumor are sensitive to the glucagon-like 3018690 Human
gip hamster insulinoma The effect of bovine GIP 1-42 and several of its fragments in competing with the binding of 125I-GIP to beta-cell plasma membranes from transplantable hamster insulinoma, and in stimulating insulin release from the isolated perfused rat pancreas, was inve 3018705 Cow
gip epithelial ovarian tumors RESULTS: Comparison of the extent of LOH among 25 epithelial ovarian tumors showing allele loss at one or more loci on 17q, the smallest overlapping region of allelic deletion is between D17S579 and GIP, with a genetic distance of approximate 2 cM. 8640474 Human
gastric inhibitory polypeptide gastric cancer The HGT-1 gastric cancer cell line was used to determine the actions of protein kinase C on the stimulation of adenylate cyclase by the human histamine H2 receptor, and the receptors for gastric inhibitory polypeptide and truncated glucagon like peptide 1 8393830 Human
gastric inhibitory polypeptide insulinoma Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells. 8396943 Rat
gip insulinoma Binding studies with 125I-labelled GIP and 125I-labelled GLP-1(7-36)amide were performed in RINm5F insulinoma cells to investigate receptor specificity and to compare both receptors directly. 8396943 Rat
gastric inhibitory polypeptide insulinoma Interrelationships among insulin, glucagon, and gastric inhibitory polypeptide in insulinoma. 6243728 Human
gastric inhibitory polypeptide insulinoma The interrelationships of serum insulin, glucagon, and gastric inhibitory polypeptide were examined in 13 patients with insulinoma during fed and fasted states. 6243728 Human
gip islet cell hyperplasia Diffuse pancreatic islet cell hyperplasia was present and, although GIP was unmeasureable in the pancreas of normal subjects, it was at least 83 ng/g wet weight in this patient. 375726 Human
gastric inhibitory polypeptide intestinal tumors A cell line derived from intestinal tumors of transgenic mice (STC-1) was subcloned to produce a stable line with approximately 30% immunoreactive gastric inhibitory polypeptide (irGIP)-containing cells (STC 6-14). 7653549 Mouse
gastric inhibitory polypeptide insulinoma [A case of insulinoma studied on secretion of gastric inhibitory polypeptide (author's transl)] 6282503 Human
gip crohn's disease In contrast, patients with Crohn's disease had normal gastrin levels but had increased fasting and postprandial levels of GIP and motilin and, in addition, of enteroglucagon, compared with controls. 6374867 Human
gip crohn's disease Increased mucosal concentrations of all peptides except vasoactive intestinal polypeptide (VIP) were found in coeliac disease and selective increases of VIP found in Crohn's disease, motilin in the irritable bowel syndrome and gastrin and GIP in panc 6145662 Human
gip hyperplastic However, cultures taken from all four ACTH-dependent and the one food-dependent hyperplastic adrenals studied were also responsive to GIP (EC50 for cAMP, 1.3 x 10(-9) M in Cushing's disease and 4.1 x 10(-10) M in food-dependent disease). 15705925 Human
gip adenoma Multiple endocrine adenoma from another viewpoint] The 24 endocrine pancreatic tumors and 14 carcinoids were examined immunohistochemically for cholecystokinin, insulin, gastrin, GIP, glucagon, sercretin, VIP, motilin, neurotensin, pancreatic polypeptide 6105939 Human
gip tumour The tumour produced both VIP and GIP. 179772 Human
gip tumor Hyperresponses of CCK, NT and GIP were observed before surgery in patients with tumor of the pancreatic head. 1944186 Human
gip endocrine pancreatic tumors Multiple endocrine adenoma from another viewpoint] The 24 endocrine pancreatic tumors and 14 carcinoids were examined immunohistochemically for cholecystokinin, insulin, gastrin, GIP, glucagon, sercretin, VIP, motilin, neurotensin, pancreatic polypeptide 6105939 Human
gip periampullary cancer To elucidate the role of gastric inhibitory polypeptide (GIP) in the alteration of insulin secretion following pancreatoduodenal resection, in which the main sources of GIP are removed, plasma levels of GIP were measured for 180 minutes after oral glucose 6367676 Human
gip aldosterone-producing adenomas In contrast, adrenal cells from normal adults and fetuses or patients with cortisol-producting or aldosterone-producing adenomas responded to corticotropin but not to GIP. CONCLUSIONS. 1325608 Human
gip adrenal hyperplasia Nodular adrenal hyperplasia and Cushing's syndrome may be food-dependent as a result of abnormal responsiveness of adrenal cells to physiologic secretion of GIP. 1325608 Human
gip adrenal hyperplasia CONCLUSIONS. The development of aberrant adrenal sensitivity to GIP can result in food-dependent adrenal hyperplasia and therefore in Cushing's syndrome. 1325609 Human
gip insulinoma To characterize the domains required for interaction of the peptide ligands with their specific receptors, we performed displacement studies with various synthetic GLP-1/GIP hybrid peptides on RINm5F insulinoma cells. 8795084 Rat
gip adenomas GIP-dependent Cushing's syndrome has been described in patients with either unilateral adenomas or bilateral macronodular adrenal hyperplasia; this syndrome results from the adrenal overexpression of the GIP receptor, which was found to be without an 11353892 Human
gip hyperplasia Daily injection of (Pro3)GIP reduced pancreatic insulin content (1.3-fold; P < 0.05) and partially corrected the obesity-related islet hypertrophy and beta-cell hyperplasia of ob/ob mice. 16046312 Mouse
gip adrenal hyperplasia New entities have recently emerged as bilateral adrenal hyperplasia not dependent from ACTH; their etiopathogenies are heterogeneous with illicit expressions at the adrenal level of functional receptors to various ligands: GIP, catecholamines, lutropin... 11244801 Human
gip macronodular adrenal hyperplasia GIP-dependent Cushing's syndrome has been described in patients with either unilateral adenomas or bilateral macronodular adrenal hyperplasia; this syndrome results from the adrenal overexpression of the GIP receptor, which was found to be without an 11353892 Human
gastric inhibitory polypeptide macronodular adrenal hyperplasia Adrenocorticotrophin-independent macronodular adrenal hyperplasia in a patient with lysine vasopressin responsiveness but insensitivity to gastric inhibitory polypeptide. 9497882 Human
gastric inhibitory polypeptide acth-independent macronodular adrenal hyperplasia All six patients with bilateral ACTH-independent macronodular adrenal hyperplasia were found to have one or two abnormal adrenal receptors, including those for gastric inhibitory polypeptide, vasopressin (V1-vasopressin), beta-adrenergic agonists, LH/huma 11061496 Human
gip hamster insulinoma The existence of functional GIP receptors in human insulinoma substantiates our recent reports demonstrating the presence of GIP binding sites in transplantable hamster insulinoma and indicates that GIP could exert a direct control of the beta-cell functi 2822518 Human
gip human insulinoma The existence of functional GIP receptors in human insulinoma substantiates our recent reports demonstrating the presence of GIP binding sites in transplantable hamster insulinoma and indicates that GIP could exert a direct control of the beta-cell functi 2822518 Human
gip pancreatic tumour [VIP and GIP-producing pancreatic tumour: relationship to the Verner-Morrison syndrome] A 59-year-old man had explosive watery diarrhoea, tendency towards collapse, flushes and aphonia. 179772 Human
gastric inhibitory polypeptide adrenocortical tumors The elucidation of gastric inhibitory polypeptide-dependent Cushing's syndrome suggested that ectopic expression or increased responsiveness of other adrenal hormone receptors may underlie ACTH-independent macronodular adrenal hyperplasia (AIMAH) or 9253310 Human
gastric inhibitory polypeptide acth-independent macronodular adrenal hyperplasia (aimah) The elucidation of gastric inhibitory polypeptide-dependent Cushing's syndrome suggested that ectopic expression or increased responsiveness of other adrenal hormone receptors may underlie ACTH-independent macronodular adrenal hyperplasia (AIMAH) or 9253310 Human
gastric inhibitory polypeptide tumorigenesis Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. 9745416 Human
gastric inhibitory polypeptide adrenal adenoma Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. 9745416 Human
gip macronodular adrenal hyperplasia In macronodular adrenal hyperplasia, we have identified, in addition to GIP-dependent Cushing's syndrome, other patients in whom cortisol production was regulated abnormally by vasopressin, ss-adrenergic receptor agonists, hCG/LH, or serotonin 5HT-4 11004721 Human
gip macronodular adrenal hyperplasia In 6 cases of macronodular adrenal hyperplasia, we have identified, in addition to 2 cases of GIP-dependent Cushing's syndrome, 4 other patients in whom cortisol production was regulated abnormally either by vasopressin, B-adrenergic receptor agonist 11353892 Human
gip adrenal adenoma We present the first case of food- and GIP-dependent adrenal adenoma in an adolescent. 12099397 Human
gip acth-independent macronodular adrenal hyperplasia In GIP-dependent Cushing syndrome, the most frequent subtype of ACTH-independent macronodular adrenal hyperplasia associated with the presence of aberrant adrenocortical hormone receptors described so far, octreotide administration before each meal showed 15783246 Human
gip cortisol-secreting adenomas Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-depend 16087722 Human
gip macronodular hyperplasias Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-depend 16087722 Human
gip adrenal adenomas Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-depend 16087722 Human
gip adenomas DESIGN AND METHODS: RNA was extracted from adrenal tissues from nine patients with GIP-dependent CS [seven ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH), two adenomas], two control whole adult adrenals, two fasciculata cell-enriched 16402925 Human
gip macronodular adrenal hyperplasia DESIGN AND METHODS: RNA was extracted from adrenal tissues from nine patients with GIP-dependent CS [seven ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH), two adenomas], two control whole adult adrenals, two fasciculata cell-enriched 16402925 Human
gip adrenal hyperplasias Whole genome expression profiling of glucose-dependent insulinotropic peptide (GIP)- and adrenocorticotropin-dependent adrenal hyperplasias reveals novel targets for the study of GIP-dependent Cushing's syndrome. 16772347 Human
gip acth-independent macronodular adrenal hyperplasia Chronic adrenal stimulation by ACTH in Cushing's disease or GIP in GIP-dependent ACTH-independent macronodular adrenal hyperplasia both lead to the induction of genes implicated in adrenal proliferation and steroidogenesis. 16772347 Human
gip adenoma METHODS: We used the Affymetrix U133 plus 2.0 microarray oligochips to compare the whole genome expression profile of adrenal tissues from five cases of GIP-dependent bilateral ACTH-independent macronodular adrenal hyperplasia with CS, one case of GIP-dep 16772347 Human
gip hyperplasias METHODS: We used the Affymetrix U133 plus 2.0 microarray oligochips to compare the whole genome expression profile of adrenal tissues from five cases of GIP-dependent bilateral ACTH-independent macronodular adrenal hyperplasia with CS, one case of GIP-dep 16772347 Human
gip acth-independent macronodular adrenal hyperplasia METHODS: We used the Affymetrix U133 plus 2.0 microarray oligochips to compare the whole genome expression profile of adrenal tissues from five cases of GIP-dependent bilateral ACTH-independent macronodular adrenal hyperplasia with CS, one case of GIP-dep 16772347 Human
gip hyperplasia We also isolated 94 probe sets potentially linked to the formation of GIP-dependent nodules adjacent to the diffuse hyperplasia. 16772347 Human
gastric inhibitory polypeptide adrenal hyperplasia Asynchronous development of bilateral nodular adrenal hyperplasia in gastric inhibitory polypeptide-dependent cushing's syndrome. 10443649 Human
gastric inhibitory polypeptide macronodular adrenal hyperplasia In vivo and in vitro screening for illegitimate receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome: identification of two cases of gonadotropin/gastric inhibitory polypeptide-dependent hypercortis 15585558 Human
gip acth-independent macronodular adrenal hyperplasia GIP-dependent Cushing's syndrome has been described in patients with unilateral adenomas or bilateral ACTH-independent macronodular adrenal hyperplasia (AIMAH) and results from the adrenal overexpression of non-mutated GIP receptor. 9888584 Human

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