IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CEACAM6 Ensembl ENSG00000086548 Chromosome 19 Start 46951341 End 46967953
Description Carcinoembryonic antigen-related cell adhesion molecule 6 Precursor (Normal cross-reacting antigen)(Non-specific crossreacting antigen)(CD66c antigen) [Source:UniProtKB/Swiss-Prot;Acc:P40199]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 1818
     Entrez Gene : 4680
     UCSC : uc002orm.2
     GeneCards : 1818
     RefSeq : NM_002483
     CCDS : CCDS12585.1
     Uniprot : P40199
     Interpro : P40199
     OMIM : 163980
     GeneTests : CEACAM6
     CGAP : CEACAM6

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36105_at  0.47  2.01e-1  2.94e-1  -3.15  1.49e-13  3.49e-12
 HG_U133A  203757_s_at  0.57  4.65e-3  7.67e-3  -3.68  7.35e-87  3.53e-86
 HG_U133A  211657_at  0.40  1.94e-2  2.90e-2  -6.00  3.50e-124  4.80e-123
 HG_U133_Plus2  203757_s_at  0.31  2.48e-1  3.31e-1  -2.80  2.41e-22  4.38e-21
 HG_U133_Plus2  211657_at  0.20  3.64e-1  4.54e-1  -2.34  5.09e-21  7.92e-20
 Stanford  7927  0.40  2.64e-1  4.64e-1  0.11  7.40e-1  8.74e-1
 Stanford  15880  -1.00  2.39e-1  4.37e-1  -3.18  3.02e-5  1.15e-3
 Stanford  17881  0.53  5.15e-2  1.59e-1  0.04  9.14e-1  9.62e-1
 Agilent_HS_21.6K  5767  0.37  1.41e-1  2.98e-1  -0.57  4.09e-2  1.06e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203757_s_at  -1.23  1.28e-1  7.93e-1  -0.78  1.07e-1  1.00e+0
 HG_U133A  211657_at  -0.98  8.90e-2  7.64e-1  -0.43  2.74e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36105_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203757_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211657_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203757_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211657_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7927    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15880    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17881    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5767    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ceacam6 gastric cancer Commonly up-regulated genes in gastric cancer in comparison with normal gastric epithelia included CEACAM6, APOC1 and YF13H12. 15132764 Human
ceacam6 human tumor Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. 11896570 Human
ceacam6 colon carcinomas We have recently demonstrated that the increased cell surface levels of CEA and CEACAM6 in purified human colonocytes from freshly excised, well to poorly differentiated colon carcinomas are inversely correlated with the degree of cellular differentiation 11896570 Human
ceacam6 colorectal carcinomas We report here the direct effects of deregulated overexpression of CEA/CEACAM6, at levels observed in colorectal carcinomas, on the differentiation of two human colonic cell lines, SW-1222 and Caco-2. 11896570 Human
cd66c myeloma CD66a in myeloma cells was considered to be detectable with this mAb, since CD66c and CD66e are not expressed in them. 11948796 Mouse
ceacam6 tumor Frequently overexpressed genes (tumor/normal ratio > 2) were COL1A1 (percentage of cases with overexpression, 78.3%), CDH17 (73.9%), APOC1 (67.4%), COL1A2 (58.7%), YF13H12 (52.2%), CEACAM6 (50.0%), APOE (50.0%), REGIV (47.8%), S100A11 (41.3%), and FUS (41 15059891 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. 15081416 Human
ceacam6 pancreatic adenocarcinoma Using pancreatic adenocarcinoma as a model, we show that crosslinking CEACAM6 induces its cytoplasmic accumulation and that this effect can be utilized to increase the efficacy of antibody-mediated delivery of the ribosomal inhibitory protein saporin. 15081416 Mouse
ceacam6 tumor Given the prevalence of CEACAM6 overexpression among human malignancies, immunological targeting of this tumor antigen may have therapeutic applicability. 15081416 Human
ceacam6 pancreatic adenocarcinoma c-Src-dependent cross-talk between CEACAM6 and alphavbeta3 integrin enhances pancreatic adenocarcinoma cell adhesion to extracellular matrix components. 15047158 Human
ceacam6 pancreatic adenocarcinoma We sought to characterize the effects of CEACAM6 crosslinking on pancreatic adenocarcinoma cellular interaction with the extracellular matrix (ECM) components fibronectin and vitronectin. 15047158 Human
nca cancer Chronic stress may interfere with NCA and low NCA is associated with increased cancer risk. 12115552 Human
ceacam6 colorectal carcinomas Cross-inhibition assays with antigen-coated microtiter plates and immunoradiometric assays were performed in almost all combinations of MAbs, using conventionally purified CEA (domain structure: N-A1B1-A2B2-A3B3-C) from liver metastasis of colorectal carc 12499780 Human
nca colorectal carcinomas Cross-inhibition assays with antigen-coated microtiter plates and immunoradiometric assays were performed in almost all combinations of MAbs, using conventionally purified CEA (domain structure: N-A1B1-A2B2-A3B3-C) from liver metastasis of colorectal carc 12499780 Human
ceacam6 liver metastasis Cross-inhibition assays with antigen-coated microtiter plates and immunoradiometric assays were performed in almost all combinations of MAbs, using conventionally purified CEA (domain structure: N-A1B1-A2B2-A3B3-C) from liver metastasis of colorectal carc 12499780 Human
nca liver metastasis Cross-inhibition assays with antigen-coated microtiter plates and immunoradiometric assays were performed in almost all combinations of MAbs, using conventionally purified CEA (domain structure: N-A1B1-A2B2-A3B3-C) from liver metastasis of colorectal carc 12499780 Human
ceacam6 polyps Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. 10666389 Human
ceacam6 adenomas Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. 10666389 Human
ceacam6 colorectal cancers Four members of the carcinoembryonic antigen (CEA) family, CEA, CEACAM1 (BGP), CEACAM6 (NCA-50/90), and CEACAM7 (CGM2), are coexpressed in normal colorectal epithelia but are deregulated in colorectal cancers, where they could play a role in tumorigenesis 10666389 Human
ceacam6 hyperplastic polyps CEACAM6 revealed a broader expression zone in proliferating cells in hyperplastic polyps and adenomas compared with normal mucosa, whereas CEACAM7 was completely absent. 10666389 Human
ceacam6 adenomas CEACAM6 revealed a broader expression zone in proliferating cells in hyperplastic polyps and adenomas compared with normal mucosa, whereas CEACAM7 was completely absent. 10666389 Human
ceacam6 hyperplastic polyps Down-regulation of CEACAM7 and up-regulation of CEACAM6 expression in hyperplastic polyps and early adenomas represent some of the earliest observable molecular events leading to colorectal tumors. 10666389 Human
ceacam6 adenomas Down-regulation of CEACAM7 and up-regulation of CEACAM6 expression in hyperplastic polyps and early adenomas represent some of the earliest observable molecular events leading to colorectal tumors. 10666389 Human
ceacam6 colorectal tumors Down-regulation of CEACAM7 and up-regulation of CEACAM6 expression in hyperplastic polyps and early adenomas represent some of the earliest observable molecular events leading to colorectal tumors. 10666389 Human
ceacam6 cancers Human carcinoembryonic antigen (CEA), a widely used tumor marker, and CEACAM6 [formerly nonspecific cross-reacting antigen (NCA)] are up-regulated in many types of human cancers, whereas family member CEACAM1 [formerly biliary glycoprotein (BGP)] is usual 10910050 Human
ceacam6 tumor Human carcinoembryonic antigen (CEA), a widely used tumor marker, and CEACAM6 [formerly nonspecific cross-reacting antigen (NCA)] are up-regulated in many types of human cancers, whereas family member CEACAM1 [formerly biliary glycoprotein (BGP)] is usual 10910050 Human
cd66c acute promyelocytic leukemia In vitro exposure of acute promyelocytic leukemia cells to arsenic trioxide (As2O3) induces the solitary expression of CD66c (NCA-50/90), a member of the CEA family. 10674975 Human
nca lung adenocarcinoma Nonspecific cross-reacting antigen (NCA), a constituent of the carcinoembryonic antigen family, was localized ultrastructurally in a human lung adenocarcinoma cell line, PC-9. 2624104 Human
nca cancer Cytoplasmic reactivity for NCA in cancer cells may therefore reflect degradation of plasma membrane-associated NCA and may not necessarily be correlated with increased systhesis of this glycoprotein. 2624104 Human
nca colon adenocarcinomas NCA (nonspecific cross-reacting antigen), a glycoprotein found in normal lung and spleen, is immunologically related to carcinoembryonic antigen (CEA), which is found in over 95% of colon adenocarcinomas. 2830274 Human
nca colon carcinoma The clone was obtained from a lambda gt 10 library made from the colon carcinoma cell line SW 403; the clone contains a 34-amino acid leader sequence, 310 amino acids for the mature protein, and 1.4 kilobases of 3'-untranslated region of the NCA gene 2830274 Human
nca human tumors With these probes, CEA mRNAs with lengths of 3.5 and 3.0 kilobases and an NCA mRNA species of 2.5 kilobases were identified in various human tumors. 3356015 Human
nca human tumor Metabolically-labeled glycoproteins were precipitated from cell lysates of human tumor cell lines and of normal peripheral granulocytes with antibodies specific for NCA, and analyzed by SDS-PAGE. 3128509 Human
nca tumor NCA components synthesized by three tumor cell lines, QGP-1 (pancreas), HLC-1 (lung) and CAOV-2 (ovary) showed slightly different migration patterns on SDS-PAGE, but the molecular weights of their unglycosylated peptides synthesized in the presence of tun 3128509 Human
nca tumor Upon SDS-PAGE, the migration pattern of the unglycosylated NCA peptides from tumor cells was affected by the presence of 2-mercaptoethanol, while that of the peptides of granulocytes was not. 3128509 Human
nca tumor These results suggest that the molecular heterogeneity of NCA observed thus far resulted from diverse glycosylation of the three fundamental molecular forms of unglycosylated peptides: one with a molecular weight of 35K produced by tumor cells and two wit 3128509 Human
nca human colon adenocarcinomas The level of mRNA for carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in human colon adenocarcinomas and normal colon mucosa was analyzed by Northern blot hybridization using as probes 32P-labeled CEA cDNA and synthetic oligodeo 3133333 Human
nca pancreatic adenocarcinoma The position of CEA-cross-reacting antigen, especially of nonspecific cross-reacting antigen (NCA), was also studied in the case of chronic pancreatitis and pancreatic adenocarcinoma. 3389342 Human
nca adenocarcinoma Antibodies to NCA closely mimicked the results obtained with the cross-reacting antibodies both in pancreatitis and adenocarcinoma. 3389342 Human
cd66c human leukemia The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells. 10374883 Human
cd66c acute lymphoblastic leukemia The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells. 10374883 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. 14724575 Human
ceacam6 cancers Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily member overexpressed in a number of human cancers and implicated in anoikis resistance. 14724575 Human
ceacam6 pancreatic adenocarcinoma We tested the effect of CEACAM6 gene silencing on anoikis in pancreatic adenocarcinoma cell lines. 14724575 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 warrants further investigation as a novel therapeutic target for the treatment of pancreatic adenocarcinoma. 14724575 Human
nca carcinomas Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. 9533775 Human
nca carcinomas The transcripts of the CEA, NCA and BGP genes evaluated by reverse transcription-polymerase chain reaction were detectable at various levels in all the gastric adenocarcinoma cell lines tested, while CGM2 mRNA was detectable in the cell lines of poorly di 9533775 Human
nca gastric adenocarcinoma The transcripts of the CEA, NCA and BGP genes evaluated by reverse transcription-polymerase chain reaction were detectable at various levels in all the gastric adenocarcinoma cell lines tested, while CGM2 mRNA was detectable in the cell lines of poorly di 9533775 Human
nca carcinomas The sparse expression of NCA observed in the normal tissues was markedly up-regulated in the carcinomas. 9533775 Human
nca colorectal carcinomas Moreover, NCA appears to be overexpressed at the transcriptional level to a greater extent and more frequently in colorectal carcinomas than CEA. 9654079 Human
cd66c chronic myelogenous leukemia We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c acute myeloid leukemias (aml) We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c t-lineage acute lymphoblastic leukemias We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c non-hodgkin's lymphomas We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c hematologic malignancies We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c acute promyelocytic leukemia In 9 out of 10 cases of acute promyelocytic leukemia, CD66c was totally absent, but antigen expression was easily detectable following in vitro exposure to all-trans retinoic acid. 9714468 Human
nca verruca vulgaris The strongest expression of CEA-related antigens, other than non-specific cross-reacting antigen (NCA) -50/90, was seen in SCC and verruca vulgaris, while no detectable expression was seen in BCC. 9767229 Human
nca colon cancer Cell surface levels of CEA and the CEA family member nonspecific crossreacting antigen (NCA), both overexpressed in colon cancer, were higher in LS-174T than in SW-1222 cells, whereas family member biliary glycoprotein (BGP), downregulated in colon carcin 9028835 Human
nca colon carcinoma Cell surface levels of CEA and the CEA family member nonspecific crossreacting antigen (NCA), both overexpressed in colon cancer, were higher in LS-174T than in SW-1222 cells, whereas family member biliary glycoprotein (BGP), downregulated in colon carcin 9028835 Human
nca hepatocellular carcinomas We have earlier demonstrated that BGP mRNA is expressed in hepatocellular carcinomas (HCCs) and the adjacent non-cancerous regions, neither of which express CEA and NCA mRNA. 9036863 Human
nca colorectal carcinomas BACKGROUND & AIMS: The nonspecific cross-reacting antigen (NCA) is a cell adhesion molecule, and the messenger RNA for NCA is overexpressed in 92% of colorectal carcinomas. 9041239 Human
nca colorectal cancer Nonspecific cross-reacting antigen (NCA), a member of the carcinoembryonic antigen (CEA) family, shows increased expression levels in colorectal cancer tissues. 9085168 Human
nca colon cancer To elucidate the mechanism, we observed the effect of interferon (IFN)-gamma on the expression level of NCA mRNA in colon cancer cell lines by quantitative reverse transcriptase-polymerase chain reaction assay. 9085168 Human
nca colon cancer These findings indicate that IFN-gamma and anti-FnR antibody induce NCA mRNA in cultured colon cancer cell lines, suggesting that inflammatory response and cell-to-extracellular matrix interaction may be related to the increased expression of NCA mRNA in 9085168 Human
nca colorectal cancers These findings indicate that IFN-gamma and anti-FnR antibody induce NCA mRNA in cultured colon cancer cell lines, suggesting that inflammatory response and cell-to-extracellular matrix interaction may be related to the increased expression of NCA mRNA in 9085168 Human
nca tumor CEA mRNA was expressed at an equivalent level in normal epithelia and in tumor cells, whereas NCA transcript levels were upregulated in tumor cells. 9135022 Human
nca tumors Cell-surface NCA showed even greater overexpression (up to 70-told) in dedifferentiated tumors, whereas total-cell biliary glycoprotein showed approximately 2-fold lower levels than was normal in more differentiated tumors and approximately 2-fold higher 9166289 Human
nca tumor We tested the feasibility of FISH to detect tumor cells in CSF by analyzing 22 samples with proven LMM with a probe for chromosome 1 (1q12) to detect NCA in the cells. 9184665 Human
nca carcinomas In contrast, nonspecific cross-reactive antigen (NCA) mRNA is overexpressed in the majority of these carcinomas. 9192807 Human
nca colorectal adenomas Here we investigate the mRNAs of CD66a, CGM2, and NCA in 22 human colorectal adenomas and the respective normal mucosa specimens by Northern blots. 9192807 Human
nca adenomas The tumor:normal ratio of NCA mRNA expression was increased up to 2.4-fold in 11 of 22 adenomas. 9192807 Human
nca human colon carcinoma MIP-101 is a poorly differentiated human colon carcinoma cell line established from ascites that produces minimal amounts of carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, and nonspecific cross-reacting antigen (NCA), a related prote 9196893 Human
nca colorectal carcinomas We investigated a series of 11 colorectal carcinomas by Northern blot and isotopic in situ hybridization (ISH), demonstrating underexpression of CD66a and CGM2 in the majority of the carcinomas as compared with the normal mucosa, whereas NCA was overexpre 9250164 Human
nca carcinomas We investigated a series of 11 colorectal carcinomas by Northern blot and isotopic in situ hybridization (ISH), demonstrating underexpression of CD66a and CGM2 in the majority of the carcinomas as compared with the normal mucosa, whereas NCA was overexpre 9250164 Human
nca breast cancer The 95-kilodalton membrane glycoprotein overexpressed in novel multidrug-resistant breast cancer cells is NCA, the nonspecific cross-reacting antigen of carcinoembryonic antigen. 9407950 Human
nca tumour Since NCA showed cross-reactivity with carcinoembryonic antigen (CEA), animal experiments showed that 99mTc-chNCA Ab was accumulated in the xenografted tumour which expressed CEA, suggesting the preserved immunoreactivity of labelled materials. 8664114 Human
nca cancer Finally, the myogenic differentiation block demonstrated for the ectopic expression of CEA in myoblasts was also observed for NCA but not for BGP, which is consistent with the changes in expression seen in cancer. 8732675 Human
cd66c tumor CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients. 7591230 Human
cd66c colon tumors Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical interest. 7591230 Human
cd66c colon tumor CD66c showed a much higher sensitivity in early colon tumor stages. 7591230 Human
nca myelogenous leukaemias The distribution and localization of NCA and carcinoembryonic antigen CEA in cells of different types of myelogenous leukaemias (acute myelogenous leukaemia - AML; chronic granulocytic leukaemia - CGL; CGL in myeloblastic crisis - CGL-BC) was studied usin 3882113 Human
nca acute myelogenous leukaemia The distribution and localization of NCA and carcinoembryonic antigen CEA in cells of different types of myelogenous leukaemias (acute myelogenous leukaemia - AML; chronic granulocytic leukaemia - CGL; CGL in myeloblastic crisis - CGL-BC) was studied usin 3882113 Human
nca chronic granulocytic leukaemia The distribution and localization of NCA and carcinoembryonic antigen CEA in cells of different types of myelogenous leukaemias (acute myelogenous leukaemia - AML; chronic granulocytic leukaemia - CGL; CGL in myeloblastic crisis - CGL-BC) was studied usin 3882113 Human
nca cervical squamous cell carcinoma The distribution of cervical carcinoma antigens (AgCaCx), CEA, and NCA in different pathologic states of the uterine cervix was studied in cytologic smears by an immunofluorescence method (IF) using specific immune sera against perchloric acid (PCA) extra 3883744 Human
nca cervical carcinoma The distribution of cervical carcinoma antigens (AgCaCx), CEA, and NCA in different pathologic states of the uterine cervix was studied in cytologic smears by an immunofluorescence method (IF) using specific immune sera against perchloric acid (PCA) extra 3883744 Human
nca metaplasias After excluding cross-reactivity with CEA and NCA, the presence of AgCaCx was demonstrated in the majority of cervical carcinomas, severe dysplasias, and only in one-fourth of squamous metaplasias, especially when accompanied by mild or moderate dysplasia 3883744 Human
nca cervical carcinomas After excluding cross-reactivity with CEA and NCA, the presence of AgCaCx was demonstrated in the majority of cervical carcinomas, severe dysplasias, and only in one-fourth of squamous metaplasias, especially when accompanied by mild or moderate dysplasia 3883744 Human
nca human breast carcinomas A retrospective immunocytochemical study was performed on 67 human breast carcinomas to determine whether the epithelial cell-associated antigens, lactoferrin and nonspecific cross-reacting antigen (NCA), could be used as markers in the prognostic assessm 3888366 Human
nca breast cancers A retrospective immunocytochemical study was performed on 67 human breast carcinomas to determine whether the epithelial cell-associated antigens, lactoferrin and nonspecific cross-reacting antigen (NCA), could be used as markers in the prognostic assessm 3888366 Human
nca ductal carcinomas These antigens were observed more often in low-grade ductal carcinomas that had positive estrogen and progestin receptors, but no relationship could be established between lactoferrin or NCA and other prognostic indicators, such as histologic type and gra 3888366 Human
nca tumor These antigens were observed more often in low-grade ductal carcinomas that had positive estrogen and progestin receptors, but no relationship could be established between lactoferrin or NCA and other prognostic indicators, such as histologic type and gra 3888366 Human
nca tumors In perchloric acid extracts of normal lung and colonic tumors, 3 NCA molecules were identified by monoclonal antibodies that cross-reacted with CEA, which itself gave 2 bands in SDS-PAGE. 3839768 Human
nca tumor When tumor markers such as CEA, NCA, CA 19-9 and alpha 1-acid glycoprotein (alpha 1-AG, acute phase reactant) were examined simultaneously, an increase in some of the cyst fluid was observed. 3862578 Human
nca cyst When tumor markers such as CEA, NCA, CA 19-9 and alpha 1-acid glycoprotein (alpha 1-AG, acute phase reactant) were examined simultaneously, an increase in some of the cyst fluid was observed. 3862578 Human
nca tumors Using an antiserum which was able to detect both NCA and CEA, it was found that 16 of 38 tumors (42%) had positive immunostaining reactions. 6197163 Human
nca tumor Of these, 15 were subsequently shown to contain only NCA immunoreactivity, and 1 tumor had both NCA and CEA immunoreactivity. 6197163 Human
nca tumor NCA, but not CEA, immunoreactivity was identified in hyperplastic prostate tissue within tumor specimens and in BPH specimens. 6197163 Human
nca tumors The results of the study identified prostate tumors with different patterns of immunocytochemical markers: 22 of 38 tumors (58%) contained only PSA immunoreactivity; 13 of 38 tumors (34%) contained PSA and NCA immunoreactivity; 2 of 38 tumors (5%) were po 6197163 Human
nca colon carcinoma The three anti-CEA MAb which did not bind any of the crossreacting antigens stained only the colon carcinoma cells; the MAb binding to either one of the two types of NCA gave a similar pattern of reactivity both on colon carcinoma cells and on granulocyte 6724739 Human
nca uterine cancers The immunologic reactivity of glycoprotein antigens extractable from individual, histologically different ovarian and uterine cancers was studied taking into account their relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antige 6204430 Human
nca ovarian mucinous adenocarcinomas A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and 6204430 Human
nca cervical carcinomas A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and 6204430 Human
nca tumour A new monoclonal antibody, that binds to CEA and with low cross-reactivity with NCA, has been raised to an antigen expressed on HT29 colon tumour cells. 6208034 Human
nca malignant breast tumors CEA and NCA in benign and malignant breast tumors. 6388310 Human
nca carcinoma Ninety-three percent of breast carcinomas, 85% of mastopathic lesions not associated with a carcinoma, and 66% of fibroadenomas showed positive reactions with commercial unabsorbed polyclonal anti-CEA serum, which contained antibodies to NCA, whereas incu 6388310 Human
nca carcinomas Ninety-three percent of breast carcinomas, 85% of mastopathic lesions not associated with a carcinoma, and 66% of fibroadenomas showed positive reactions with commercial unabsorbed polyclonal anti-CEA serum, which contained antibodies to NCA, whereas incu 6388310 Human
nca breast carcinomas Ninety-three percent of breast carcinomas, 85% of mastopathic lesions not associated with a carcinoma, and 66% of fibroadenomas showed positive reactions with commercial unabsorbed polyclonal anti-CEA serum, which contained antibodies to NCA, whereas incu 6388310 Human
nca breast cancer Forty-eight percent of breast cancer, 84% of mastopathic lesions, and 50% of the fibroadenomas contained NCA in different quantities. 6388310 Human
nca myeloma Hybridomas were prepared by fusion of mouse spleen cells immunized with purified NCA (non-specific cross-reacting antigen) with cells of myeloma SP2/0. 6402767 Human
nca human lung cancer Antigenic reactivity of 35 perchloric acid (PCA) extracts of different histologic human lung cancer tissues was studied--in comparison with the reactivity of the carcinoembryonic antigen (CEA), the nonspecific cross-reacting antigen (NCA), and alpha-1-ant 6300497 Human
nca lung squamous cell carcinoma Antigenic reactivity of 35 perchloric acid (PCA) extracts of different histologic human lung cancer tissues was studied--in comparison with the reactivity of the carcinoembryonic antigen (CEA), the nonspecific cross-reacting antigen (NCA), and alpha-1-ant 6300497 Human
nca colon carcinoma This reactivity was abolished after absorption of the antiserum with a perchloric acid extract of human lung to remove cross-reacting antibodies against non-specific cross-reacting antigen (NCA); a procedure which did not affect the staining of colon carc 6301969 Human
nca embryonal carcinoma NCA in whole blood was studied in healthy persons and in 8 patients with embryonal carcinoma undergoing chemotherapy, with a myelosuppressive effect. 6687956 Human
nca colon adenocarcinoma NCA was purified from normal human lung (L-NCA) and from liver metastases of colon adenocarcinoma (T-NCA), L-NCA and T-NCA had different carbohydrate compositions, but showed an immunological identity in double immunodiffusion with the use of anti-CEA and 6412074 Human
nca liver metastases NCA was purified from normal human lung (L-NCA) and from liver metastases of colon adenocarcinoma (T-NCA), L-NCA and T-NCA had different carbohydrate compositions, but showed an immunological identity in double immunodiffusion with the use of anti-CEA and 6412074 Human
nca tumor Besides NCA (and CEA in tumor tissue), the presence of a lower molecular weight cross-reacting antigen was observed in lung and tumour. 6412074 Human
nca tumour Besides NCA (and CEA in tumor tissue), the presence of a lower molecular weight cross-reacting antigen was observed in lung and tumour. 6412074 Human
nca carcinomas Immunohistochemical localization of carcinoembryonic antigen (CEA), CEA-S, and nonspecific cross-reacting antigen (NCA) in carcinomas of lung. 6311398 Human
nca bronchogenic carcinomas Antisera to carcinoembryonic antigen (CEA), to a physicochemical subset of CEA, namely CEA-S, and to nonspecific cross-reacting antigen (NCA) were used for the immunohistochemical localization of these antigens in human bronchogenic carcinomas using a tri 6311398 Human
nca tumors CEA, CEA-S, and NCA were all identified in the membrane and/or cytoplasm of neoplastic cells, and a good correlation between the antigens was observed in a majority of tumors. 6311398 Human
nca tumour It is concluded that the positivity of GCM for CEA using commercial rabbit anti-CEA serum is due to the content of non-specific cross-reacting antigen (NCA) and maybe other cross-reacting glycoproteins in this tumour, and not to CEA as claimed in a previo 6314638 Human
nca gastric carcinoma Monoclonal antibodies YK013 and YK024 prepared in the same manner by immunizing with the gastric carcinoma cell line KATO III reacted with antigenic determinants on CEA, but not on NCA or NCA2. 6200030 Human
nca cancer These are: determinants cross-reactint with the normal fecal antigen (NFA) (NFA determinant); determinants cross-reacting antigen (NCA) (NCA determinant); and determinants which appear to be more cancer-specific (cancer determinant). 77849 Human
nca cancer Digestion by pronase E destroyed only the cancer determinant and liberated two antigenic fragments corresponding to the NFA determinant and the NCA determinant, respectively. 77849 Human
nca ovarian cyst Antisera prepared to ZGM and absorbed with saliva, when tested by double immunodiffusion, formed a single precipitation line with saline extracts of colon tumors and did not cross-react with CEA, AFP, normal tissue extracts, ferritin, NCA, NCA-2, CSAp, bl 709528 Human
nca colon tumors Antisera prepared to ZGM and absorbed with saliva, when tested by double immunodiffusion, formed a single precipitation line with saline extracts of colon tumors and did not cross-react with CEA, AFP, normal tissue extracts, ferritin, NCA, NCA-2, CSAp, bl 709528 Human
nca cancer Antibodies directed against NCA were shown in different groups of patients, but high titers (greater than 1/64) were found only in cancer patients. 281546 Human
nca gastric adenocarcinomas In contrast, some of the gastric adenocarcinomas we studied were strained very weakly by absorbed anti-CEA antiserum, although non-absorbed antiserum (or serum absorbed with NCA alone) labelled them strongly. 68014 Human
nca juvenile xanthogranuloma Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
nca xanthoma disseminatum Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
nca reticulohistiocytoma Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
nca reticulohistiocytic granuloma Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
nca xanthoma tuberosum Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
nca esophageal neoplasms Human esophageal neoplasms were studied in comparison to normal, uninvolved, and preneoplastic human esophageal epithelium for the presence of human chorionic gonadotropin (HCG), human placental lactogen (HPL), alpha-fetoprotein (AFP), carcinoembryonic an 2421889 Human
nca cell tumors When stained with an antiserum that was able to detect both CEA and NCA, 27 of 33 squamous cell tumors (82%) and 6 of 6 adenocarcinomas (100%) showed positive immunostaining reactions. 2421889 Human
nca adenocarcinomas When stained with an antiserum that was able to detect both CEA and NCA, 27 of 33 squamous cell tumors (82%) and 6 of 6 adenocarcinomas (100%) showed positive immunostaining reactions. 2421889 Human
nca squamous-cell carcinomas Of these, 8 squamous cell carcinomas and 1 adenocarcinoma were subsequently shown to contain only NCA immunoreactivity, while 19 squamous cell carcinomas and 5 adenocarcinomas contained both NCA and CEA immunoreactivity. 2421889 Human
nca adenocarcinomas Of these, 8 squamous cell carcinomas and 1 adenocarcinoma were subsequently shown to contain only NCA immunoreactivity, while 19 squamous cell carcinomas and 5 adenocarcinomas contained both NCA and CEA immunoreactivity. 2421889 Human
nca adenocarcinoma Of these, 8 squamous cell carcinomas and 1 adenocarcinoma were subsequently shown to contain only NCA immunoreactivity, while 19 squamous cell carcinomas and 5 adenocarcinomas contained both NCA and CEA immunoreactivity. 2421889 Human
nca squamous-cell carcinomas Similarly, both CEA and NCA were more frequently expressed in well-differentiated squamous cell carcinomas, adenosquamous carcinomas, and adenocarcinomas than in less differentiated tumors. 2421889 Human
nca tumors Similarly, both CEA and NCA were more frequently expressed in well-differentiated squamous cell carcinomas, adenosquamous carcinomas, and adenocarcinomas than in less differentiated tumors. 2421889 Human
nca adenosquamous carcinomas Similarly, both CEA and NCA were more frequently expressed in well-differentiated squamous cell carcinomas, adenosquamous carcinomas, and adenocarcinomas than in less differentiated tumors. 2421889 Human
nca adenocarcinomas Similarly, both CEA and NCA were more frequently expressed in well-differentiated squamous cell carcinomas, adenosquamous carcinomas, and adenocarcinomas than in less differentiated tumors. 2421889 Human
nca esophageal cancer Our results suggest that HCG, HPL, AFP, CEA, and NCA are tumor-associated antigens in esophageal cancer. 2421889 Human
nca pulmonary adenocarcinoma To evaluate the usefulness of an immunohistologic approach to the differential diagnosis of mesothelioma and pulmonary adenocarcinoma, the authors studied paraffin-embedded, fixed tissue sections from 50 primary adenocarcinomas of the lung and 28 mesothel 2422942 Human
nca mesothelioma To evaluate the usefulness of an immunohistologic approach to the differential diagnosis of mesothelioma and pulmonary adenocarcinoma, the authors studied paraffin-embedded, fixed tissue sections from 50 primary adenocarcinomas of the lung and 28 mesothel 2422942 Human
nca primary adenocarcinomas To evaluate the usefulness of an immunohistologic approach to the differential diagnosis of mesothelioma and pulmonary adenocarcinoma, the authors studied paraffin-embedded, fixed tissue sections from 50 primary adenocarcinomas of the lung and 28 mesothel 2422942 Human
nca adenocarcinomas When the anti-CEA antiserum was absorbed with NCA, the number of positively reacting adenocarcinomas decreased considerably to 76%; however, after this treatment, none of the mesotheliomas gave positive reactions. 2422942 Human
nca cancer Three extracts (one from lung, two from cancer tissue) and the corresponding NCA samples were negative with Mab 18. 2424986 Human
nca human tumor The production kinetics and immunochemical properties of carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) in various human tumor cell lines were studied. 2426231 Human
nca carcinomas By radioimmunoassay (RIA), five CEA-producing tumor cell lines tested--2 derived from colonic (M7609 and CCK-81), one from pancreatic (QGP-1) and 2 from lung (HLC-1 and KNS-62) carcinomas--were found to produce NCA simultaneously. 2426231 Human
nca tumor By radioimmunoassay (RIA), five CEA-producing tumor cell lines tested--2 derived from colonic (M7609 and CCK-81), one from pancreatic (QGP-1) and 2 from lung (HLC-1 and KNS-62) carcinomas--were found to produce NCA simultaneously. 2426231 Human
nca ovarian adenocarcinomas Comparison of immunological reactivity of glycoprotein antigens extracted from individual cases of mucinous and serous ovarian adenocarcinomas was performed taking into account the immunological relationship with carcinoembryonic antigen (CEA), nonspecifi 3017557 Human
nca serous adenocarcinomas It was established that: 1) ovarian mucinous and serous adenocarcinomas are immunologically different and possess various tumor-associated antigens, 2) ovarian mucinous adenocarcinomas contain considerable amounts of CEA and NCA, whereas serous type neopl 3017557 Human
nca neoplasms It was established that: 1) ovarian mucinous and serous adenocarcinomas are immunologically different and possess various tumor-associated antigens, 2) ovarian mucinous adenocarcinomas contain considerable amounts of CEA and NCA, whereas serous type neopl 3017557 Human
nca ovarian mucinous adenocarcinomas It was established that: 1) ovarian mucinous and serous adenocarcinomas are immunologically different and possess various tumor-associated antigens, 2) ovarian mucinous adenocarcinomas contain considerable amounts of CEA and NCA, whereas serous type neopl 3017557 Human
nca tumors It was established that: 1) ovarian mucinous and serous adenocarcinomas are immunologically different and possess various tumor-associated antigens, 2) ovarian mucinous adenocarcinomas contain considerable amounts of CEA and NCA, whereas serous type neopl 3017557 Human
nca esophageal neoplasms The unlabeled antibody peroxidase-antiperoxidase technique was used to examine esophageal neoplasms for the tumor markers beta-human chorionic gonadotropin, human placental lactogen (HPL), alpha-fetoprotein, carcinoembryonic antigen (CEA), and nonspecific 2428482 Human
nca tumor The unlabeled antibody peroxidase-antiperoxidase technique was used to examine esophageal neoplasms for the tumor markers beta-human chorionic gonadotropin, human placental lactogen (HPL), alpha-fetoprotein, carcinoembryonic antigen (CEA), and nonspecific 2428482 Human
nca primary tumors NCA and CEA were detected in six of seven primary tumors and in all tumor xenografts. 2428482 Human
nca tumor NCA and CEA were detected in six of seven primary tumors and in all tumor xenografts. 2428482 Human
nca primary neoplasms Five of seven primary neoplasms and six of seven tumor xenografts were found to contain both NCA and CEA, while one tumor and its xenografts displayed only NCA immunoreactivity. 2428482 Human
nca tumor Five of seven primary neoplasms and six of seven tumor xenografts were found to contain both NCA and CEA, while one tumor and its xenografts displayed only NCA immunoreactivity. 2428482 Human
nca medullary carcinoma Carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) were studied immunohistochemically in formalin-fixed, paraffin-embedded tissues of 73 cases of medullary carcinoma of the thyroid (MTC) using 2 polyclonal antibodies (CEA antisera 2371832 Human
nca tumor The NCA immunoreactivity was located in the tumor cell cytoplasm as globular aggregates, which were also labeled for CEA. 2371832 Human
nca epithelial tumors The authors conclude that CEA immunostaining may assist in identifying the histogenesis of epithelial tumors in several morphologic categories; that differential reactivities of the CEA monoclonal antibody panel exceed those of the polyclonal antibody; an 1695478 Human
nca human promyelocytic leukemia The expression of a nonspecific cross-reacting antigen (NCA) species on the cell surface of the human promyelocytic leukemia cell line HL-60 was investigated via binding of 125I-labeled carcinoembryonic antigen (CEA) and NCA-specific monoclonal antibodies 2174725 Human
nca adenomas Expression of mRNAs of carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) genes in colorectal carcinomas and adenomas was investigated by in situ hybridization (ISH) with specific biotinylated probes. 2125040 Human
nca colorectal carcinomas Expression of mRNAs of carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) genes in colorectal carcinomas and adenomas was investigated by in situ hybridization (ISH) with specific biotinylated probes. 2125040 Human
nca carcinomas Hybridization was clearly detected throughout the cytoplasm of 7 out of 15 adenomas and 13 out of 15 carcinomas with the CEA cDNA probe, and in 6 out of 15 adenomas and 10 out of 15 carcinomas with the NCA cDNA probe. 2125040 Human
nca adenomas Hybridization was clearly detected throughout the cytoplasm of 7 out of 15 adenomas and 13 out of 15 carcinomas with the CEA cDNA probe, and in 6 out of 15 adenomas and 10 out of 15 carcinomas with the NCA cDNA probe. 2125040 Human
nca carcinomas The intensity of signal appeared to be stronger in carcinomas than that in adenomas, and the CEA and NCA mRNAs were expressed together in most of the positive tissue specimens. 2125040 Human
nca adenomas The intensity of signal appeared to be stronger in carcinomas than that in adenomas, and the CEA and NCA mRNAs were expressed together in most of the positive tissue specimens. 2125040 Human
nca carcinoma On the other hand, noninvaded tissues adjacent to the carcinoma did not show any signal except for 4 cases faintly stained with the NCA probe. 2125040 Human
nca carcinoma This finding was partly confirmed by Northern blot analysis which indicated that the specific bands for the CEA and NCA mRNAs were more intense in RNAs from carcinoma tissues than in those from adjacent noninvaded tissues. 2125040 Human
nca myelocytic leukemias It was observed that the blood myeloid cells in 78.8% of the patients with different types of myelocytic leukemias and all granulocytes of 15 normal donors showed similar expression of the NCA species studied. 2920218 Human
nca tumor The expression of carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) on tumor cell fractions was also checked. 2705745 Human
nca ovarian neoplasms Neither CEA nor NCA were constant and characteristic markers for serous ovarian neoplasms. 2705745 Human
nca urinary bladder carcinoma These findings indicate that positive reactions seen with conventional CEA antibodies (P-CEA and NCA-aCEA) are possibly related to NCA and that urinary bladder carcinoma may contain relatively more NCA than true CEA. 2751258 Human
ceacam6 resectable colorectal cancer Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. 14512395 Human
ceacam6 colorectal cancers (crc) PURPOSE: CEACAM6, CEACAM1, and human carcinoembryonic antigen (CEA) are coexpressed in normal colorectal epithelia, but show deregulated expression in colorectal cancers (CRC). 14512395 Human
ceacam6 adenomas Upregulation of CEACAM6 expression in hyperplastic polyps and early adenomas represents one of the earliest observable molecular events leading to colorectal tumors. 14512395 Human
ceacam6 hyperplastic polyps Upregulation of CEACAM6 expression in hyperplastic polyps and early adenomas represents one of the earliest observable molecular events leading to colorectal tumors. 14512395 Human
ceacam6 colorectal tumors Upregulation of CEACAM6 expression in hyperplastic polyps and early adenomas represents one of the earliest observable molecular events leading to colorectal tumors. 14512395 Human
ceacam6 tumor Multivariate Cox analysis including sex, age, tumor site, stage, differentiation grade, treatment, and nodal status as covariates showed that CEACAM6 overexpression independently predicted poor OS (HR, 1.86; P =.0100) and DFS (HR, 2.00; P =.0028), whereas 14512395 Human
nca breast carcinomas We studied the immunoreactivity by immunohistology of two carcinoembryonic antigens (CEA) with specific and two CEA antibodies with nonspecific cross-reacting antigen (NCA) cross reactivity (CEA/NCA) in 180 primary breast carcinomas. 2790676 Human
nca breast cancer This large study with a long follow-up period for patients has shown that CEA and CEA/NCA immunocytochemistry have no relation to prognosis in breast cancer. 2790676 Human
nca breast cancer An extensive review of the literature that confirms these findings should end the controversy over the place of CEA and CEA/NCA immunocytochemistry in breast cancer. 2790676 Human
nca metastases DNA ploidy, histological grade, and immunoreactivity for carcino-embryonic antigen (CEA), carcino-embryonic antigen with normal cross-reacting antigen (CEA/NCA), and to NCRC-11 were assessed in primary breast carcinomas and metastases from the ovary and a 2553906 Human
nca breast carcinomas DNA ploidy, histological grade, and immunoreactivity for carcino-embryonic antigen (CEA), carcino-embryonic antigen with normal cross-reacting antigen (CEA/NCA), and to NCRC-11 were assessed in primary breast carcinomas and metastases from the ovary and a 2553906 Human
nca metastases Changes in these variables between primary tumours and their metastases were found in 44 per cent of cases for DNA ploidy, 44 per cent of cases for histological grade, 17 per cent of cases for immunoreactivity to NCRC-11, 28 per cent of cases for CEA, and 2553906 Human
nca primary tumours Changes in these variables between primary tumours and their metastases were found in 44 per cent of cases for DNA ploidy, 44 per cent of cases for histological grade, 17 per cent of cases for immunoreactivity to NCRC-11, 28 per cent of cases for CEA, and 2553906 Human
nca pulmonary neoplasms The frequency and pattern of NCA expression in human pulmonary neoplasms was found to correlate with the known distribution of CEA: and was often present in the non-small-cell carcinomas. 2480629 Human
nca non-small-cell carcinomas The frequency and pattern of NCA expression in human pulmonary neoplasms was found to correlate with the known distribution of CEA: and was often present in the non-small-cell carcinomas. 2480629 Human
nca non-small-cell carcinoma In addition, the expression of CEA relative to NCA was evaluated in a select group of non-small-cell carcinoma cases using several anti-CEA MAbs, to directly compare the expression of CEA to NCA. 2480629 Human
nca tumors In general, the NCA reaction pattern is more intense and expressed on more cells within the tumors than that of CEA expression. 2480629 Human
nca breast cancer NCA 50/90 measurements were elevated in 7 of 25 patients with active breast cancer whose CEA and CA 15-3 values were below cutoff, and NCA 50/90 values do not correlate with CEA in breast cancer. 8118811 Human
nca chronic lymphocytic leukemia Serum from leukemia patients showed an overall sensitivity of 43%, but 71% (10 of 14) sera from patients with chronic myelogenous leukemia were positive compared to, for example, chronic lymphocytic leukemia where 0 of 7 sera had NCA 50/90 values above th 8118811 Human
nca chronic myelogenous leukemia Serum from leukemia patients showed an overall sensitivity of 43%, but 71% (10 of 14) sera from patients with chronic myelogenous leukemia were positive compared to, for example, chronic lymphocytic leukemia where 0 of 7 sera had NCA 50/90 values above th 8118811 Human
nca leukemia Serum from leukemia patients showed an overall sensitivity of 43%, but 71% (10 of 14) sera from patients with chronic myelogenous leukemia were positive compared to, for example, chronic lymphocytic leukemia where 0 of 7 sera had NCA 50/90 values above th 8118811 Human
nca cancers These studies suggest that NCA 50/90 may have clinical utility in the management of patients with a variety of cancers. 8118811 Human
nca gastrointestinal carcinomas Both chimeric Fab fragments exhibited strong immunohistochemical reactivity with various gastrointestinal carcinomas and no reactivity with CEA-related antigens, such as NCA (nonspecific cross-reacting antigen) or BGPI (biliary glycoprotein I). 8188529 Human
nca colon adenocarcinoma The precise localization of carcinoembryonic antigen (CEA) and non-specific cross-reacting 50-kDa antigen (NCA 50) in normal colon mucosa and colon adenocarcinoma was investigated by using an indirect immunoperoxidase electron microscopic technique with s 8205554 Human
nca tumor Some of the neoplastic cells contained CEA in so-called "intracellular lumina." In contrast to normal colon epithelial cells most tumor cells synthesized NCA 50 actively. 8205554 Human
nca lung cancer Nonspecific crossreacting antigen (NCA) is a major member of the carcinoembryonic antigen (CEA)-related gene family expressed in lung cancer. 7678982 Human
nca tumour Recently isolated CEA and NCA cDNA clones enabled us to analyse CEA and NCA expression of in vivo tumour specimens and tumour cell lines at mRNA levels. 7678982 Human
nca lung cancer Of 21 lung cancer tissue specimens, nine expressed both NCA and CEA and five expressed only NCA. 7678982 Human
nca tumour Of 16 tumour cell lines, two expressed only NCA and one expressed both NCA and CEA, although its level of CEA mRNA was weaker than that of NCA mRNA. 7678982 Human
nca lung cancer These findings suggest that NCA is a major member of the CEA-related gene family expressed in lung cancer. 7678982 Human
nca pancreatic adenocarcinoma To analyse the molecular nature of these glycoproteins further, a lambda gt11 expression library has been constructed from the GER pancreatic adenocarcinoma cell line and screened with an NCA sequence-specific oligonucleotide probe. 8460091 Human
nca tumors The results indicate that a majority of breast and lung tumors express CEA, and nearly all breast and lung tumors express NCA. 8386136 Mouse
nca tumors Fairly homogeneous expression of CEA and NCA was seen in the majority of both breast and lung tumors. 8386136 Mouse
nca human gastric cancer The regulation by interferon-gamma (IFN-gamma) of the expression of seven distinct human tumor-associated antigens [M 110,000, carcinoembryonic antigen (CEA), nonspecific crossreacting antigen (NCA), CA19-9, 17-1A, TAG-72, and D612] was studied in eight h 8504201 Human
nca gastric carcinoma Constitutive CEA and NCA expression was detected on the surface of five of the eight gastric carcinoma cell lines. 8504201 Human
nca tumors The assay system, referred to as New EIA, showed very homogeneous reactivity with purified CEA preparations from different tumors and could discriminate CEA from four CEA-related normal antigens tested; nonspecific cross-reacting antigen (NCA), NCA-2, nor 7686200 Human
nca gastrointestinal cancer Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation. 8318403 Human
nca colorectal cancers We examined the mRNA expression of CEA and NCA in 26 gastric and 14 colorectal cancers together with adjacent morphologically normal mucosae. 8318403 Human
nca colorectal cancers The expression of NCA, on the other hand, was more cancer-specific and was significantly up-regulated in both gastric and colorectal cancers compared with the corresponding normal mucosae. 8318403 Human
nca poorly differentiated cancers Further analysis revealed significant up-regulation of NCA in well and moderately differentiated gastric cancers over poorly differentiated cancers, suggesting that NCA might have roles in differentiation. 8318403 Human
nca gastric cancers Further analysis revealed significant up-regulation of NCA in well and moderately differentiated gastric cancers over poorly differentiated cancers, suggesting that NCA might have roles in differentiation. 8318403 Human
nca an adenocarcinoma CEA and NCA transcripts were, however, present in an adenocarcinoma located in the nasal sinuses. 7690349 Human
nca ovarian mucinous adenocarcinomas In ovarian mucinous adenocarcinomas, we always found co-expression of CEA and NCA transcripts, and occasionally BGP mRNA. 7690349 Human
nca cervical carcinomas CEA, NCA and BGP transcripts were present in endometrial carcinomas of the uterus and cervical carcinomas, whereas uterine leiomyomas were completely negative. 7690349 Human
nca endometrial carcinomas CEA, NCA and BGP transcripts were present in endometrial carcinomas of the uterus and cervical carcinomas, whereas uterine leiomyomas were completely negative. 7690349 Human
nca tumor Finally, Ab3 did not detect NCA, a major CEA-related glycoprotein in Western blots, either in a purified form or in a crude tumor extract, indicating a high specificity of the anti-anti-idiotypic response. 1592535 Human
nca tumor This may be due to CEA expression by tumor cells, or crossreactivity of the polyclonal antibody with substances such as nonspecific crossreacting antigen (NCA) that share antigenic sites with CEA. 1495947 Human
nca lung cancers Carcinoembryonic antigen (CEA), a tumor marker for lung cancers of small cell (SCLC) and non-small cell (NSCLC) types, belongs in a multigene family which includes non-specific cross-reacting antigen (NCA) and biliary glycoprotein 1 (BGP). 1330929 Human
nca tumor Carcinoembryonic antigen (CEA), a tumor marker for lung cancers of small cell (SCLC) and non-small cell (NSCLC) types, belongs in a multigene family which includes non-specific cross-reacting antigen (NCA) and biliary glycoprotein 1 (BGP). 1330929 Human
nca lung cancers Thus, NCA constitutes most of the "CEA-like" immunoreactivity previously described in lung cancers. 1330929 Human
nca colon carcinoma CEA and NCA expressed by colon carcinoma cells affect their interaction with and lysability by activated lymphocytes. 1431336 Human
nca tumor The tumor cells with high susceptibility to LAK (LoVo/Dx, HT29) expressed higher amounts of the adhesion molecules ICAMl, LFA3 and NCA/CEA than cells with low LAK sensitivity (LoVo/H). 1431336 Human
nca colonic carcinomas CEA and NCA levels in peripheral and tumour venous blood of patients with gastric and colonic carcinomas estimated by RIA and EIA methods. 1995360 Human
nca tumour CEA and NCA levels in peripheral and tumour venous blood of patients with gastric and colonic carcinomas estimated by RIA and EIA methods. 1995360 Human
nca tumour Carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) levels in draining tumour blood were compared with concentrations of these antigens in peripheral blood of patients with gastric and colonic malignancies. 1995360 Human
nca neoplasms NCA determination had no significance in clinical monitoring of studied neoplasms. 1995360 Human
nca tumor More adhesion molecules ICAM-1, LFA-3 and NCA were expressed on LoVo/Dx than on LoVo/H, while no significant amounts of CEA were detectable on the cell surface or in culture supernatant of either tumor subline. 1706327 Human
nca tumor These data indicate that sensitivity of chemoresistant tumor cells to cytotoxic effectors depends on the level of expression of adhesion molecules, including NCA, and is related to differentiation stage. 1706327 Human
nca chronic myelocytic leukemias (cml) In chronic and acute phase of chronic myelocytic leukemias (CML) the number of NCA containing cells increased and the amount of PNA-binding cells decreased as more mature granulocytic fractions were isolated on Ficoll--Uropoline density gradient. 2011210 Human
nca tumor To clarify the molecular structures of nonspecific cross-reacting antigens (NCAs), a family of glycoproteins antigenically related to carcinoembryonic antigen (CEA), in human granulocytes, we have screened a cDNA library of human leukocytes using a cDNA p 2050678 Human
nca colon carcinoma In 2 other colon carcinoma cell lines, SW1222 and T84, which are differentiated in culture to varying degrees, little if any changes were seen in CEA and NCA mRNA and protein levels in pre- versus postconfluent cultures. 1905198 Human
nca adenomas CEA mRNA was detected together with NCA mRNA in nine cultured cell lines, with the exception of the lung carcinoma A549 cell line, and in 19 colon tissue specimens, including carcinomas, adjacent noninvaded tissues and adenomas. 2067130 Human
nca carcinomas CEA mRNA was detected together with NCA mRNA in nine cultured cell lines, with the exception of the lung carcinoma A549 cell line, and in 19 colon tissue specimens, including carcinomas, adjacent noninvaded tissues and adenomas. 2067130 Human
nca lung carcinoma CEA mRNA was detected together with NCA mRNA in nine cultured cell lines, with the exception of the lung carcinoma A549 cell line, and in 19 colon tissue specimens, including carcinomas, adjacent noninvaded tissues and adenomas. 2067130 Human
nca adenomas When we compared the intensity of the hybridization signal for CEA or NCA mRNA among adenomas, carcinomas and adjacent noninvaded tissues, NCA mRNA rather than CEA mRNA was highly expressed in carcinomas compared to adjacent nonivaded tissues. 2067130 Human
nca carcinomas When we compared the intensity of the hybridization signal for CEA or NCA mRNA among adenomas, carcinomas and adjacent noninvaded tissues, NCA mRNA rather than CEA mRNA was highly expressed in carcinomas compared to adjacent nonivaded tissues. 2067130 Human
nca colon carcinoma When, however, the relation between the intensities of hybridization signals for CEA and NCA mRNAs were evaluated in five colon carcinoma cell lines and 19 colon tissue specimens, a statistically significant correlation was observed (gamma = 0.462, P less 2067130 Human
nca colon carcinoma These data suggest that NCA may be more useful as a tumor marker for colon carcinoma than CEA at the level of mRNA, and that transcriptions of the CEA and NCA genes might be regulated by some common mechanisms in malignant and nonmalignant tissues of the 2067130 Human
nca tumor These data suggest that NCA may be more useful as a tumor marker for colon carcinoma than CEA at the level of mRNA, and that transcriptions of the CEA and NCA genes might be regulated by some common mechanisms in malignant and nonmalignant tissues of the 2067130 Human
nca gastric carcinoma A high percentage of Hs 746T (i.e., greater than 85%) and GaCa (approximately 75%) gastric carcinoma cells expressed the Mr 110,000 antigen after IFN-gamma treatment; yet, neither cell type expressed CEA or NCA as measured by the binding of the anti-CEA M 1913687 Human
nca tubulovillous adenoma The NCA mRNA was detectable in 87% of the CRCs examined, with 92% of these expressing the NCA mRNA at higher levels than the tubulovillous adenoma and the specimen from Crohn's colitis, whereas CEA was easily detected. 1962152 Human
nca crohn's colitis The NCA mRNA was detectable in 87% of the CRCs examined, with 92% of these expressing the NCA mRNA at higher levels than the tubulovillous adenoma and the specimen from Crohn's colitis, whereas CEA was easily detected. 1962152 Human
nca colon carcinoma Our findings demonstrate that NCA mRNA is more consistently overexpressed in colon carcinoma relative to distant mucosa than CEA mRNA. 1962152 Human
nca colon carcinoma Three Carcinoembryonic Antigen (CEA) gene family members: CEA, Non-specific cross-reactive antigen 50/90 (NCA) and biliary glycoprotein (BGP) were expressed in the colon carcinoma cell lines LS174T and HT29. 1815506 Human
nca tumor A clone, NCA-W272, was found to code a protein similar to NCA of tumor cells. 2306228 Human
nca tumor Similarity of the amino acid sequence of each domain to that of the tumor NCA was 72, 92, 76 and 79%, respectively. 2306228 Human
nca tumor Thus the clone NCA-W272 was indicated to encode a new species of NCA distinct from the tumor NCA. 2306228 Human
nca tumor Complementary DNA clones coding for both carcinoembryonic antigen (CEA), a well characterized colonic tumor marker, and nonspecific cross-reacting antigen (NCA), a related antigen, were expressed in Chinese hamster ovary (CHO) cells and L-cells (mouse fib 2317824 Human
nca chronic myeloid leukemia Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia. 2332039 Human
nca tumor In various tumor tissues, CEA and NCA were colocalized and expression increased sufficiently to be detected in paraffin sections. 2187320 Human
nca adenocarcinomas Adenocarcinomas of the stomach and colon and cystadenocarcinoma of the pancreas, as well as neuroendocrine carcinomas of the lung and thyroid, showed a CEA predominance over NCA. 2187320 Human
nca cystadenocarcinoma of the pancreas Adenocarcinomas of the stomach and colon and cystadenocarcinoma of the pancreas, as well as neuroendocrine carcinomas of the lung and thyroid, showed a CEA predominance over NCA. 2187320 Human
nca neuroendocrine carcinomas Adenocarcinomas of the stomach and colon and cystadenocarcinoma of the pancreas, as well as neuroendocrine carcinomas of the lung and thyroid, showed a CEA predominance over NCA. 2187320 Human
nca cholangiocarcinoma In ductal adenocarcinomas of the pancreas and breast and in cholangiocarcinoma, NCA reactivity was greater than CEA. 2187320 Human
nca ductal adenocarcinomas In ductal adenocarcinomas of the pancreas and breast and in cholangiocarcinoma, NCA reactivity was greater than CEA. 2187320 Human
nca tumors Hence the relative ratio of CEA/NCA expression in tumors was dependent on the tissue of origin and histologic type. 2187320 Human
nca cancer The cytoplasmic granular staining of NCA in cancer cells was a noteworthy difference from the plasma membrane-associated localization of CEA. 2187320 Human
nca colonic carcinoma Two glycoforms of NCA were purified from a single liver metastasis of a colonic carcinoma and characterized with respect to their primary sequence and position of glycosylation sites. 2341397 Human
nca liver metastasis Two glycoforms of NCA were purified from a single liver metastasis of a colonic carcinoma and characterized with respect to their primary sequence and position of glycosylation sites. 2341397 Human
nca adenocarcinoma To characterize the CEA and NCA promoters, we carried out transient transfection assays with promoter-indicator gene constructs in the CEA-producing adenocarcinoma cell line SW403, as well as in nonproducing HeLa cells. 2342461 Human
nca chronic myelocytic leukemia Clinical evaluation of NCA in patients with chronic myelocytic leukemia. 6949877 Human
nca blast crisis In blast crisis low values with a mean of 109 micrograms NCA/l was found. 6949877 Human
nca metastatic colorectal carcinoma Immunochemical studies confirmed that CEA and NCA produced by the QGP-1 cells had properties identical to those of authentic CEA derived from metastatic colorectal carcinoma and to those of NCA from normal lungs, respectively. 6810002 Human
nca chronic myeloid leukaemia An investigation of factors influencing serum NCA (non-specific cross-reacting antigen) level in patients with chronic myeloid leukaemia. 6756460 Human
nca cancer The results obtained by immunodiffusion analyses of antigenic determinants indicate that CEA and NFA-2 can be divided into four antigenic moieties: the first one is distinctive for CEA (cancer determinant) or NFA-2 (NFA-2-distinctive determinant); the sec 6160910 Human
nca lung cancer Eighty-two per cent of tumour sections from 105 patients with lung cancer showed positive immunocytochemical localization of an anti-carcinoembryonic antigen (CEA) immunoglobulin free of antibody to normal cross-reacting antigen (NCA). 7023523 Human
nca tumour Eighty-two per cent of tumour sections from 105 patients with lung cancer showed positive immunocytochemical localization of an anti-carcinoembryonic antigen (CEA) immunoglobulin free of antibody to normal cross-reacting antigen (NCA). 7023523 Human
nca acute myeloid leukemias Non-specific cross-reacting antigen (NCA) was assayed radioimmunologically in normal sera and sera obtained from patients with chronic and acute myeloid leukemias. 6930335 Human
nca chronic myeloid leukemia In patients with chronic myeloid leukemia NCA serum concentration was significantly increased, and a study with regard to the stage of the disease (acute phase, blastic crisis, remission) was made. 6930335 Human
nca colon carcinoma According to the double immunodiffusion method, this antigen is partially identical to purified CEA of colon carcinoma, and is completely identical to nonspecific crossreacting antigen (NCA). 86182 Human
nca neuroblastoma This antigen is, therefore, referred to not as the CEA as described by Gold, but as NCA in neuroblastoma tissue. 86182 Human
nca neuroblastoma The elevation of plasma CEA activity in patients with neuroblastoma may be due to the release of NCA from tumor cells, or to the destruction tissues by metastasis, of normal which are rich in NCA, or to a combination of both. 86182 Human
nca tumor The elevation of plasma CEA activity in patients with neuroblastoma may be due to the release of NCA from tumor cells, or to the destruction tissues by metastasis, of normal which are rich in NCA, or to a combination of both. 86182 Human
nca metastasis The elevation of plasma CEA activity in patients with neuroblastoma may be due to the release of NCA from tumor cells, or to the destruction tissues by metastasis, of normal which are rich in NCA, or to a combination of both. 86182 Human
nca medullary carcinomas CEA and non-specific cross-reacting antigen (NCA) in medullary carcinomas of the thyroid. 89098 Human
nca medullary carcinoma An immunohistological study of five cases of medullary carcinoma of the thyroid was undertaken with monospecific antisera against CEA and NCA. 89098 Human
nca tumors NCA was found in the same tumors and in the same localizations. 89098 Human
carcinoembryonic antigen-related cell adhesion molecule 6 cancers Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily member overexpressed in a number of human cancers and implicated in anoikis resistance. 14724575 Human
carcinoembryonic antigen-related cell adhesion molecule 6 pancreatic adenocarcinoma A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. 15173012 Human
carcinoembryonic antigen-related cell adhesion molecule 6 cancers Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers. 15208677 Human
carcinoembryonic antigen-related cell adhesion molecule 6 human gastrointestinal cancer SUMMARY BACKGROUND DATA: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is widely overexpressed in human gastrointestinal cancer. 15383794 Human
carcinoembryonic antigen-related cell adhesion molecule 6 cancers The immunoglobulin superfamily member carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers. 15316565 Human
carcinoembryonic antigen-related cell adhesion molecule 6 tumors In contrast, genes underexpressed in tumors included genes involved in apoptosis (B-cell CLL/lymphoma 6, secretory leukocyte protease inhibitor, and calpastatin), cell structure (keratin 7 and carcinoembryonic antigen-related cell adhesion molecule 6), an 15297395 Human
carcinoembryonic antigen-related cell adhesion molecule 6 b-cell cll In contrast, genes underexpressed in tumors included genes involved in apoptosis (B-cell CLL/lymphoma 6, secretory leukocyte protease inhibitor, and calpastatin), cell structure (keratin 7 and carcinoembryonic antigen-related cell adhesion molecule 6), an 15297395 Human
carcinoembryonic antigen-related cell adhesion molecule 6 lymphoma In contrast, genes underexpressed in tumors included genes involved in apoptosis (B-cell CLL/lymphoma 6, secretory leukocyte protease inhibitor, and calpastatin), cell structure (keratin 7 and carcinoembryonic antigen-related cell adhesion molecule 6), an 15297395 Human
carcinoembryonic antigen-related cell adhesion molecule 6 pancreatic adenocarcinoma SUMMARY BACKGROUND DATA: Previously, we have demonstrated carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) to be an oncoprotein that plays an important role in the biology of pancreatic adenocarcinoma. 15729073 Human
cd66c solid tumors In sera of most patients suffering from solid tumors, sensitivities for CD66c are comparable to or lower than those for CEA. 7591230 Human
cd66c t-cell non-hodgkin's lymphomas We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c t-all We analyzed by flow cytometry cell surface expression of CD66c on bone marrow cells from 4 healthy subjects and on bone marrow or peripheral blood cells from 127 patients with newly diagnosed hematologic malignancies: 70 de novo acute myeloid leukemias (A 9714468 Human
cd66c aml As for de novo AML, slight expression of CD66c was found on 6/25 (24%) AML-M4 and only occasionally in other subgroups. 9714468 Human
cd66c apl Of interest, in all APL samples (but not in AML) every tested dose of As2O3 determined a dramatic upregulation of CD66c display; intermediate concentration (0.5 microM) of As2O3 increased the median percentage of CD66c+ cells from 5% in control cultures ( 10674975 Human
cd66c aml Of interest, in all APL samples (but not in AML) every tested dose of As2O3 determined a dramatic upregulation of CD66c display; intermediate concentration (0.5 microM) of As2O3 increased the median percentage of CD66c+ cells from 5% in control cultures ( 10674975 Human
cd66c apl The induction of solitary expression of CD66c is a new finding which demonstrates As2O3 capability of generating phenotypic changes absolutely restricted to APL cells Moreover, these results provide experimental basis for considering the involvement of th 10674975 Human
cd66c childhood lymphoblastic leukemia Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens. 15826304 Human
ceacam6 hyperplastic Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. 10666389 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells. 15047698 Human
ceacam6 metastasis CEACAM6 is a glycosylphosphatidylinositol-linked cell surface protein of importance in the anchorage-independent survival and metastasis of pancreatic adenocarcinoma cells. 15047698 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 is a glycosylphosphatidylinositol-linked cell surface protein of importance in the anchorage-independent survival and metastasis of pancreatic adenocarcinoma cells. 15047698 Human
ceacam6 pancreatic ductal adenocarcinoma We examined the effects of antibody-mediated cross-linking of CEACAM6 on intracellular signaling events and anchorage-independent survival of the CEACAM6-overexpressing pancreatic ductal adenocarcinoma cell line, BxPC3. 15047698 Human
ceacam6 pancreatic adenocarcinoma Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. 15208677 Human
ceacam6 cancers Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers. 15208677 Human
ceacam6 pancreatic adenocarcinoma We have recently reported that suppression of CEACAM6 expression impairs pancreatic adenocarcinoma progression in vivo. 15208677 Human
ceacam6 pancreatic adenocarcinoma In order to characterize the mechanisms through which CEACAM6 influences the malignant phenotype, CEACAM6-overexpressing Capan2 pancreatic adenocarcinoma cells were established by stable transfection. 15208677 Human
ceacam6 tumor We determined the effect of CEACAM6 overexpression on cellular invasiveness towards insulin-like growth factor I (IGF-I), a peptide of critical importance in pancreatic cancer malignant cellular behavior and tumor progression. 15208677 Human
ceacam6 pancreatic cancer We determined the effect of CEACAM6 overexpression on cellular invasiveness towards insulin-like growth factor I (IGF-I), a peptide of critical importance in pancreatic cancer malignant cellular behavior and tumor progression. 15208677 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 is an important determinant of pancreatic adenocarcinoma malignant cellular behavior and, together with its downstream targets, warrants further investigation as a therapeutic target in this disease. 15208677 Human
ceacam6 human gastrointestinal cancer SUMMARY BACKGROUND DATA: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is widely overexpressed in human gastrointestinal cancer. 15383794 Human
ceacam6 metastasis Overexpression of CEACAM6 promotes cell survival under anchorage independent conditions, a characteristic associated with tumorigenesis and metastasis. 15383794 Human
ceacam6 tumor Tumor growth, CEACAM6 expression, cellular proliferation (Ki-67 immunohistochemistry), apoptosis, angiogenesis (CD34 immunohistochemistry), and survival were compared for mice administered either systemic CEACAM6-specific or control single-base mismatch s 15383794 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness. 15316565 Human
ceacam6 cancers The immunoglobulin superfamily member carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers. 15316565 Human
ceacam6 pancreatic adenocarcinoma We sought to define the role of CEACAM6 in pancreatic adenocarcinoma cellular invasiveness. 15316565 Human
ceacam6 pancreatic adenocarcinoma Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner. 15316565 Human
ceacam6 leukemias This novel mouse will ensure better assessment than previously utilized models for the preclinical testing of CEA-targeted therapies and perhaps allow the testing of CEACAM6, which is overexpressed in many solid tumors and leukemias, as a therapeutic targ 15194045 Human
ceacam6 solid tumors This novel mouse will ensure better assessment than previously utilized models for the preclinical testing of CEA-targeted therapies and perhaps allow the testing of CEACAM6, which is overexpressed in many solid tumors and leukemias, as a therapeutic targ 15194045 Human
ceacam6 panin CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions. 15729073 Human
ceacam6 pancreatic adenocarcinoma CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions. 15729073 Human
ceacam6 pancreatic adenocarcinoma OBJECTIVE: The purpose of this study was to test the hypothesis that CEACAM6 expression is an indicator of adverse pathologic features and clinical outcome in pancreatic adenocarcinoma. 15729073 Human
ceacam6 pancreatic adenocarcinoma SUMMARY BACKGROUND DATA: Previously, we have demonstrated carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) to be an oncoprotein that plays an important role in the biology of pancreatic adenocarcinoma. 15729073 Human
ceacam6 metastasis Suppression of CEACAM6 expression reduces tumorigenesis and metastasis in vivo. 15729073 Human
ceacam6 pancreatic adenocarcinoma RESULTS: Tumoral CEACAM6 expression was detected in 82 (92%) pancreatic adenocarcinoma specimens. 15729073 Human
ceacam6 panin CEACAM6 expression was more prevalent in high-grade than in low-grade PanIN lesions (P = 0.0002). 15729073 Human
ceacam6 lymph-node metastases Negative tumoral CEACAM6 expression was associated with absence of lymph node metastases (P = 0.012), lower disease stage (P = 0.008), and longer postoperative survival (P = 0.047). 15729073 Human
ceacam6 pancreatic adenocarcinoma CONCLUSIONS: CEACAM6 is a novel biomarker for pancreatic adenocarcinoma. 15729073 Human
ceacam6 pancreatic cancer CEACAM6 warrants further evaluation as both a prognostic factor and a therapeutic target in pancreatic cancer. 15729073 Human
nca carcinomas of lung Immunohistochemical localization of carcinoembryonic antigen (CEA), CEA-S, and nonspecific cross-reacting antigen (NCA) in carcinomas of lung. 6311398 Human
nca primary tumors The unlabeled antibody peroxidase-antiperoxidase technique was used to examine human malignant prostatic tissue (primary tumors) for the presence of prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), 6197163 Human
nca bph NCA, but not CEA, immunoreactivity was identified in hyperplastic prostate tissue within tumor specimens and in BPH specimens. 6197163 Human
nca hyperplastic NCA, but not CEA, immunoreactivity was identified in hyperplastic prostate tissue within tumor specimens and in BPH specimens. 6197163 Human
nca prostate tumors The results of the study identified prostate tumors with different patterns of immunocytochemical markers: 22 of 38 tumors (58%) contained only PSA immunoreactivity; 13 of 38 tumors (34%) contained PSA and NCA immunoreactivity; 2 of 38 tumors (5%) were po 6197163 Human
nca xanthoma disseminatum [Xanthoma disseminatum--differentiation from histiocytosis X with immunohistochemical demonstration of S100 protein, lysozyme and NCA] 6381818 Human
nca colon tumour A new monoclonal antibody, that binds to CEA and with low cross-reactivity with NCA, has been raised to an antigen expressed on HT29 colon tumour cells. 6208034 Human
nca aml The distribution and localization of NCA and carcinoembryonic antigen CEA in cells of different types of myelogenous leukaemias (acute myelogenous leukaemia - AML; chronic granulocytic leukaemia - CGL; CGL in myeloblastic crisis - CGL-BC) was studied usin 3882113 Human
nca aml It was established that: (a) AML blasts without maturation (MO type) and monoblasts did not synthesize NCA; (b) individual blasts of AML with features of maturation (M1, M2 types) and some myeloblasts of CGL-BC exhibited a limited ability to express cytop 3882113 Human
nca colonic tumors In perchloric acid extracts of normal lung and colonic tumors, 3 NCA molecules were identified by monoclonal antibodies that cross-reacted with CEA, which itself gave 2 bands in SDS-PAGE. 3839768 Human
nca squamous cell tumors When stained with an antiserum that was able to detect both CEA and NCA, 27 of 33 squamous cell tumors (82%) and 6 of 6 adenocarcinomas (100%) showed positive immunostaining reactions. 2421889 Human
nca mesotheliomas of the pleura To evaluate the usefulness of an immunohistologic approach to the differential diagnosis of mesothelioma and pulmonary adenocarcinoma, the authors studied paraffin-embedded, fixed tissue sections from 50 primary adenocarcinomas of the lung and 28 mesothel 2422942 Human
nca mesotheliomas When the anti-CEA antiserum was absorbed with NCA, the number of positively reacting adenocarcinomas decreased considerably to 76%; however, after this treatment, none of the mesotheliomas gave positive reactions. 2422942 Human
nca malignant tumors CEA, or a CEA-like antigen that is not nonspecific cross-reacting antigen (NCA), was demonstrated in the majority of aggressive or malignant tumors showing squamous differentiation, including cases of ameloblastoma, odontogenic carcinoma, and squamous car 2462204 Human
nca colonic tumor Complementary DNA clones coding for both carcinoembryonic antigen (CEA), a well characterized colonic tumor marker, and nonspecific cross-reacting antigen (NCA), a related antigen, were expressed in Chinese hamster ovary (CHO) cells and L-cells (mouse fib 2317824 Human
nca adenocarcinomas of the stomach Adenocarcinomas of the stomach and colon and cystadenocarcinoma of the pancreas, as well as neuroendocrine carcinomas of the lung and thyroid, showed a CEA predominance over NCA. 2187320 Human
nca ductal adenocarcinomas of the pancreas In ductal adenocarcinomas of the pancreas and breast and in cholangiocarcinoma, NCA reactivity was greater than CEA. 2187320 Human
nca medullary carcinoma of the thyroid Carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) were studied immunohistochemically in formalin-fixed, paraffin-embedded tissues of 73 cases of medullary carcinoma of the thyroid (MTC) using 2 polyclonal antibodies (CEA antisera 2371832 Human
nca human pancreatic cancer [Boron neutron capture therapy using 10B entrapped anti-CEA immunoliposome] A new murine monoclonal antibody (2C-8) was prepared by immunizing mice ip with CEA producing human pancreatic cancer cell line, AsPC-1.SDS-PAGE and Western blot analysis showed t 2519218 Human
nca nsclc Carcinoembryonic antigen (CEA), a tumor marker for lung cancers of small cell (SCLC) and non-small cell (NSCLC) types, belongs in a multigene family which includes non-specific cross-reacting antigen (NCA) and biliary glycoprotein 1 (BGP). 1330929 Human
nca tumor Consequently, it was considered that CEA was present in the normal urothelium and that destruction and regeneration of these cells due to tumor or inflammation might release CEA, not NCA, into the urine. 1434262 Human
nca lung tumors The results indicate that a majority of breast and lung tumors express CEA, and nearly all breast and lung tumors express NCA. 8386136 Human
nca lung tumors Fairly homogeneous expression of CEA and NCA was seen in the majority of both breast and lung tumors. 8386136 Human
nca childhood all The expression of CEA subgroup members in childhood ALL cells might have prognostic impacts, as an inverse correlation exists between NCA expression on leukemic blasts and the risk factor white blood count at diagnosis. 7808000 Human
nca bcc The strongest expression of CEA-related antigens, other than non-specific cross-reacting antigen (NCA) -50/90, was seen in SCC and verruca vulgaris, while no detectable expression was seen in BCC. 9767229 Human
nca medullary carcinomas of the thyroid CEA and non-specific cross-reacting antigen (NCA) in medullary carcinomas of the thyroid. 89098 Human
nca medullary carcinoma of the thyroid An immunohistological study of five cases of medullary carcinoma of the thyroid was undertaken with monospecific antisera against CEA and NCA. 89098 Human
non-specific cross reacting antigen xanthoma tuberosum Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
non-specific cross reacting antigen juvenile xanthogranuloma Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
non-specific cross reacting antigen reticulohistiocytic granuloma Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
non-specific cross reacting antigen xanthoma disseminatum Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
non-specific cross reacting antigen reticulohistiocytoma Immunohistochemical examinations were performed using five kinds of histiocytic markers [S100 protein, lysozyme, non-specific cross reacting antigen with carcinoembryonic antigen (NCA), alpha 1-antichymotrypsin (alpha 1-ACT) and alpha 1-antitrypsin (alpha 2826848 Human
non-specific cross reacting antigen tumours To determine whether variations in the expression of tumour related antigen can predict the origin of tumours, the immunoreactivity of a series of adenocarcinomas from a wide range of sites was studied with a panel of monoclonal antibodies with specificit 3192728 Human
non-specific cross reacting antigen tumour To determine whether variations in the expression of tumour related antigen can predict the origin of tumours, the immunoreactivity of a series of adenocarcinomas from a wide range of sites was studied with a panel of monoclonal antibodies with specificit 3192728 Human
non-specific cross reacting antigen adenocarcinomas To determine whether variations in the expression of tumour related antigen can predict the origin of tumours, the immunoreactivity of a series of adenocarcinomas from a wide range of sites was studied with a panel of monoclonal antibodies with specificit 3192728 Human
the nca cdna carcinomas Hybridization was clearly detected throughout the cytoplasm of 7 out of 15 adenomas and 13 out of 15 carcinomas with the CEA cDNA probe, and in 6 out of 15 adenomas and 10 out of 15 carcinomas with the NCA cDNA probe. 2125040 Human
the nca cdna adenomas Hybridization was clearly detected throughout the cytoplasm of 7 out of 15 adenomas and 13 out of 15 carcinomas with the CEA cDNA probe, and in 6 out of 15 adenomas and 10 out of 15 carcinomas with the NCA cDNA probe. 2125040 Human
the nca gene colon carcinoma The clone was obtained from a lambda gt 10 library made from the colon carcinoma cell line SW 403; the clone contains a 34-amino acid leader sequence, 310 amino acids for the mature protein, and 1.4 kilobases of 3'-untranslated region of the NCA gene 2830274 Human
the nca mrna tubulovillous adenoma The NCA mRNA was detectable in 87% of the CRCs examined, with 92% of these expressing the NCA mRNA at higher levels than the tubulovillous adenoma and the specimen from Crohn's colitis, whereas CEA was easily detected. 1962152 Human

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