IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CEACAM3 Ensembl ENSG00000170956 Chromosome 19 Start 46992374 End 47007431
Description Carcinoembryonic antigen-related cell adhesion molecule 3 Precursor (Carcinoembryonic antigen CGM1)(CD66d antigen) [Source:UniProtKB/Swiss-Prot;Acc:P40198]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 1815
     Entrez Gene : 1084
     UCSC : uc002orn.1
     GeneCards : 1815
     RefSeq : NM_001815
     CCDS : CCDS12586.2
     Uniprot : P40198
     Interpro : P40198
     OMIM : 609142
     GeneTests : CEACAM3
     CGAP : CEACAM3

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32468_f_at  0.42  3.99e-3  1.06e-2  0.27  1.79e-1  2.66e-1
 HG_U95  32469_at  0.02  9.29e-1  9.48e-1  -0.45  2.02e-1  2.92e-1
 HG_U133A  208052_x_at  -0.26  1.80e-7  5.01e-7  0.05  4.49e-1  4.60e-1
 HG_U133A  210789_x_at  -0.30  3.35e-4  6.51e-4  -2.65  5.88e-57  1.51e-56
 HG_U133A  217209_at  0.62  4.56e-7  1.22e-6  1.10  3.00e-18  4.24e-18
 HG_U133_Plus2  208052_x_at  0.22  7.19e-2  1.15e-1  0.72  8.40e-8  2.83e-7
 HG_U133_Plus2  210789_x_at  -0.34  1.54e-2  3.00e-2  -0.39  1.71e-2  2.68e-2
 HG_U133_Plus2  217209_at  0.36  3.72e-2  6.50e-2  -0.07  7.21e-1  7.64e-1
 Agilent_HS_21.6K  15199  -0.21  3.07e-1  4.95e-1  -0.65  6.02e-4  3.57e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208052_x_at  -0.07  7.35e-1  9.74e-1  0.02  8.77e-1  1.00e+0
 HG_U133A  210789_x_at  0.46  8.50e-2  7.57e-1  0.19  2.62e-1  1.00e+0
 HG_U133A  217209_at  0.01  9.87e-1  9.99e-1  -0.19  4.64e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32468_f_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 32469_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208052_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210789_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217209_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208052_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210789_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217209_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15199    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd66d tumour CD66D was suggested to be a tumour suppressor gene. 12472567 Human
cgm1 childhood acute lymphoblastic leukemias In the present study, we analyzed 62 childhood acute lymphoblastic leukemias (ALLs) and seven surface immunoglobulin positive (sig+) B-cell lines for the expression of the CEA family members CEA, NCA-50/90, NCA-95, NCA-160, CGM1 and CGM7. 7808000 Human
cgm1 tumors CGM1a mRNA, the predominant CGM1 transcript, was found in the granulocytic lineage, but not in monocytes, lymphocytes nor in a number of tumors derived from all three germ layers. 8508798 Human
cgm1 tumors No transcripts were found from CGM1, CGM6, CGM7 or from PSG genes in any of the tumors tested. 7690349 Human
cea childhood acute lymphoblastic leukemias In the present study, we analyzed 62 childhood acute lymphoblastic leukemias (ALLs) and seven surface immunoglobulin positive (sig+) B-cell lines for the expression of the CEA family members CEA, NCA-50/90, NCA-95, NCA-160, CGM1 and CGM7. 7808000 Human
cea childhood all The expression of CEA subgroup members in childhood ALL cells might have prognostic impacts, as an inverse correlation exists between NCA expression on leukemic blasts and the risk factor white blood count at diagnosis. 7808000 Human
cea tumor RESULTS: The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human 16504122 Human
cea apl Exposure of APL as well as non-APL samples to any concentration of As2O3 did not affect the expression of beta2 integrins (CD11a and CD11b), CD45 isoforms (RA, RB and R0), CD44/H-CAM, CD33 and the CEA-related antigen family members CD66ade and CD66b, thus 10674975 Human

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