IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RPS19 Ensembl ENSG00000105372 Chromosome 19 Start 47055828 End 47067322
Description 40S ribosomal protein S19 [Source:UniProtKB/Swiss-Prot;Acc:P39019]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10402
     Entrez Gene : 6223
     UCSC : uc002ort.2
     GeneCards : 10402
     RefSeq : NM_001022
     CCDS : CCDS12588.1
     Uniprot : P39019
     Interpro : P39019
     OMIM : 603474
     GeneTests : RPS19
     CGAP : RPS19
     PMID : 9582194

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31330_at  0.30  6.35e-5  2.72e-4  0.42  8.97e-6  4.58e-5
 HG_U133A  202649_x_at  0.27  6.85e-9  2.20e-8  -3.66  6.06e-109  5.26e-108
 HG_U133A  213414_s_at  0.23  7.75e-8  2.23e-7  -5.40  1.59e-152  5.89e-151
 HG_U133_Plus2  202649_x_at  0.16  5.67e-4  1.55e-3  0.27  6.44e-7  1.94e-6
 HG_U133_Plus2  213414_s_at  0.08  9.78e-2  1.50e-1  0.18  6.10e-4  1.21e-3
 HG_U133_Plus2  242451_x_at  1.06  6.39e-20  1.49e-18  1.47  2.30e-22  4.19e-21
 Stanford  1872  0.65  7.02e-2  1.96e-1  0.11  7.98e-1  9.06e-1
 Stanford  9684  0.50  6.42e-2  1.84e-1  0.96  9.49e-3  6.64e-2
 Stanford  11185  0.58  5.73e-2  1.70e-1  0.92  1.71e-2  1.00e-1
 Stanford  11196  0.76  2.62e-2  1.20e-1  1.17  5.67e-3  4.65e-2
 Stanford  12547  0.42  1.12e-1  2.67e-1  0.80  3.87e-2  1.43e-1
 Stanford  22533  0.58  7.74e-2  2.09e-1  0.93  2.25e-2  1.16e-1
 Agilent_HS_21.6K  21360  0.05  5.66e-1  7.27e-1  0.19  1.92e-2  5.96e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202649_x_at  -0.04  8.11e-1  9.83e-1  0.11  3.37e-1  1.00e+0
 HG_U133A  213414_s_at  0.07  6.67e-1  9.63e-1  0.06  5.32e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31330_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202649_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213414_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202649_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213414_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242451_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1872    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9684    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11185    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11196    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12547    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22533    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21360    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ribosomal protein s19 diamond blackfan anemia Mutations in ribosomal protein S19 gene and diamond blackfan anemia: wide variations in phenotypic expression. 10590074 Human
ribosomal protein s19 diamond blackfan anemia Approximately 25% of cases of Diamond Blackfan anemia, a severe hypoplastic anemia, are linked to heterozygous mutations in the gene encoding ribosomal protein S19 that result in haploinsufficiency for this protein. 16159874 Human
ribosomal protein s19 diamond blackfan anemia The 20 genes with at least a 3-fold change, annotated with known phenotypic associations in the current gene databank (phenotype association, fold change) were aspartoacylase (Canavan disease, 9.96), growth hormone receptor (Laron dwarfism, idiopathic sho 16121806 Human
ribosomal protein s19 diamond blackfan anemia Approximately 25% of Diamond Blackfan anemia cases are associated with mutations in the gene encoding ribosomal protein S19. 16239073 Human
rps19 aplasia Diamond-Blackfan anemia (DBA) is a rare congenital red-cell aplasia characterized by anemia, bone-marrow erythroblastopenia, and congenital anomalies and is associated with heterozygous mutations in the ribosomal protein (RP) S19 gene (RPS19) in approxima 17186470 Human
rps19 diamond blackfan anemia Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis. 16159874 Human
rps19 diamond blackfan anemia When introduced in yeast Rps19, amino acid substitutions found in Diamond Blackfan anemia patients induce defects in the processing of the pre-rRNA similar to those observed in cells under-expressing Rps19. 16159874 others
rps19 diamond blackfan anemia These results uncover a pivotal role of Rps19 in the assembly and maturation of the pre-40 S particles and demonstrate for the first time the effect of Diamond Blackfan anemia-associated mutations on the function of Rps19, strongly connecting the patholog 16159874 others
dba tumors Two tumors which had positive reactions to the lower nephron markers such as SBA, PNA, and/or DBA were considered to be of lower nephron origin and displayed poor prognosis. 3630706 Human
rps19 red cell aplasia Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein S19 (RPS19) gene. 15771965 Human
rps19 hematopoietic cell proliferation These findings show that RPS19 plays an important role in the regulation of hematopoietic cell proliferation and erythroid differentiation. 15771965 Human
rps19 red cell aplasia Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein S19 (RPS19) gene. 15626736 Human
ribosomal protein s19 red cell aplasia Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein S19 (RPS19) gene. 15626736 Human
ribosomal protein s19 red cell aplasia Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein S19 (RPS19) gene. 15771965 Human
ribosomal protein s19 head and neck squamous cell carcinoma BACKGROUND: The differential display method showed altered expression of ribosomal protein S19 gene in human head and neck squamous cell carcinoma (HNSCC) cell lines. 15330156 Human
rps19 osteogenic sarcomas The role of mutations in RPS19 in erythropoiesis or developmental defects in DBA patients is not obvious, and the increased frequency of osteogenic sarcomas suggests that at least that subset of patients may have a mutant tumor suppressor gene (such as p5 12430621 Human
ribosomal protein s19 congenital pure red cell aplasia Ribosomal protein S19 (RPS19) is currently the only gene associated with Diamond-Blackfan anemia (DBA), a rare congenital pure red cell aplasia characterized by normochromic macrocytic anemia, reticulocytopenia, and normocellular bone marrow with a select 16531079 Human
rps19 congenital pure red cell aplasia Ribosomal protein S19 (RPS19) is currently the only gene associated with Diamond-Blackfan anemia (DBA), a rare congenital pure red cell aplasia characterized by normochromic macrocytic anemia, reticulocytopenia, and normocellular bone marrow with a select 16531079 Human
rps19 diamond blackfan anemia RPS19 and JAK2 genes are not silenced by DNA methylation in diamond blackfan anemia. 17356406 Human
ribosomal protein s19 hnscc BACKGROUND: The differential display method showed altered expression of ribosomal protein S19 gene in human head and neck squamous cell carcinoma (HNSCC) cell lines. 15330156 Human

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