IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ARHGEF1 Ensembl ENSG00000076928 Chromosome 19 Start 47079106 End 47103437
Description Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor)(p115-RhoGEF)(p115RhoGEF)(Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 681
     Entrez Gene : 9138
     UCSC : uc002osa.2
     GeneCards : 681
     RefSeq : NM_004706
     CCDS : CCDS12590.1
     Uniprot : Q92888
     Interpro : Q92888
     OMIM : 601855
     GeneTests : ARHGEF1
     CGAP : ARHGEF1
     PMID : 8810315

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38445_at  0.19  1.11e-2  2.55e-2  -0.04  6.98e-1  7.77e-1
 HG_U95  810_at  0.08  3.04e-1  4.08e-1  -0.17  7.18e-2  1.24e-1
 HG_U133A  203055_s_at  -0.26  2.51e-6  6.20e-6  1.35  1.58e-35  2.87e-35
 HG_U133_Plus2  1560445_x_at  -0.16  1.24e-1  1.84e-1  -0.18  1.75e-1  2.22e-1
 HG_U133_Plus2  203055_s_at  0.04  7.16e-1  7.79e-1  0.45  7.72e-4  1.51e-3
 Stanford  21224  0.87  4.42e-3  3.77e-2  0.37  2.73e-1  5.13e-1
 Agilent_HS_21.6K  4207  -0.05  5.01e-1  6.75e-1  -0.09  2.93e-1  4.50e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203055_s_at  -0.09  5.78e-1  9.48e-1  -0.10  3.40e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38445_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 810_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203055_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1560445_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203055_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21224    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4207    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
p115-rhogef oncogene A liposarcoma-derived oncogene (p115-RhoGEF) previously mapped to chromosome 19 and the low-density lipoprotein receptor gene (LDLR) previously mapped to chromosome band 19p13 were evaluated to determine whether they were disrupted by this translocation. 10824997 Human
p115-rhogef liposarcoma A liposarcoma-derived oncogene (p115-RhoGEF) previously mapped to chromosome 19 and the low-density lipoprotein receptor gene (LDLR) previously mapped to chromosome band 19p13 were evaluated to determine whether they were disrupted by this translocation. 10824997 Human
p115-rhogef sarcoma When considered together, these observations suggest that transforming lip sequences represent an alternatively spliced form of p115-RhoGEF that is activated for transformation by C-terminal truncation during transfection, and is not widely involved in sa 18521231 Human
gef1 human prostate carcinoma Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion. 18037957 Human
gef1 tumour These data highlight control of the Rap GEF1-Rap1 molecular switch as a specific requirement for PLCgamma1-mediated tumour cell adhesion. 18037957 Human

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