IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GSK3A Ensembl ENSG00000105723 Chromosome 19 Start 47426182 End 47438591
Description Glycogen synthase kinase-3 alpha (GSK-3 alpha)(EC 2.7.11.26) [Source:UniProtKB/Swiss-Prot;Acc:P49840]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4616
     Entrez Gene : 2931
     UCSC : uc002otb.1
     GeneCards : 4616
     RefSeq : NM_019884
     CCDS : CCDS12599.1
     Uniprot : P49840
     Interpro : P49840
     OMIM : 606784
     GeneTests : GSK3A
     CGAP : GSK3A
     PMID : 9809441

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.44 225 1 0.51 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16724 AD c.1199A>G p.H400R Substitution - Missense Heterozygous 19:47428574-4742857418948947
16724 AD c.688C>T p.R230C Substitution - Missense Heterozygous 19:47430649-4743064918948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  632_at  0.40  8.72e-7  5.81e-6  0.43  4.07e-5  1.78e-4
 HG_U133A  202210_x_at  -0.19  8.50e-2  1.13e-1  3.44  2.21e-90  1.17e-89
 HG_U133A  632_at  0.03  5.32e-1  5.84e-1  -3.12  2.76e-35  4.97e-35
 HG_U133_Plus2  202210_x_at  -0.13  3.67e-1  4.57e-1  0.16  2.99e-1  3.58e-1
 HG_U133_Plus2  632_at  0.59  1.13e-7  5.94e-7  1.30  4.48e-18  5.00e-17
 Agilent_HS_21.6K  5670  -0.05  2.16e-1  3.93e-1  -0.02  5.38e-1  6.80e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202210_x_at  -0.34  4.19e-1  9.08e-1  0.27  2.45e-1  1.00e+0
 HG_U133A  632_at  -0.12  4.28e-1  9.11e-1  0.10  3.56e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 632_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202210_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 632_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202210_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 632_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5670    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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