IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ERF Ensembl ENSG00000105722 Chromosome 19 Start 47443564 End 47451093
Description ETS domain-containing transcription factor ERF (Ets2 repressor factor)(PE-2) [Source:UniProtKB/Swiss-Prot;Acc:P50548]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3444
     Entrez Gene : 2077
     UCSC : uc002ote.3
     GeneCards : 3444
     RefSeq : NM_006494
     CCDS : CCDS12600.1
     Uniprot : P50548
     Interpro : P50548
     OMIM : 611888
     GeneTests : ERF
     CGAP : ERF
     PMID : 7588608

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1242_at  -0.18  1.59e-1  2.42e-1  0.40  1.70e-2  3.65e-2
 HG_U95  38996_at  -0.11  1.85e-1  2.75e-1  0.28  5.89e-3  1.46e-2
 HG_U133A  203643_at  0.40  1.43e-5  3.28e-5  -3.47  5.60e-66  1.69e-65
 HG_U133_Plus2  203643_at  0.18  1.06e-1  1.61e-1  1.05  9.21e-12  5.00e-11
 HG_U133_Plus2  230368_at  0.03  8.51e-1  8.89e-1  0.56  6.93e-3  1.16e-2
 Stanford  650  1.09  3.50e-3  3.28e-2  1.20  1.61e-2  9.59e-2
 Stanford  22939  0.24  5.32e-1  7.06e-1  0.99  1.90e-2  1.07e-1
 Agilent_HS_21.6K  5010  0.01  6.78e-1  8.07e-1  0.03  2.60e-1  4.13e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203643_at  0.08  8.26e-1  9.84e-1  -0.09  7.00e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1242_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38996_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203643_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203643_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230368_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 650    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22939    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5010    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
erf ewing's sarcoma Suppression of the Ewing's sarcoma phenotype by FLI1/ERF repressor hybrids. 10975680 Human
erf breast carcinoma The expression pattern of one novel gene, DEME -6, correlated with expression of ER and ERF -1/ AP -2gamma in a panel of breast carcinoma cell lines. 9461476 Human
erf pituitary tumor We demonstrate here that the ETS-2 repressor factor (ERF) is expressed in pituitary tumor cells and that overexpression of recombinant ERF inhibits prolactin promoter activity, but not the closely related growth hormone promoter. 9822660 Human
erf pituitary tumor The potential role of ERF in the inhibitory response of the prolactin promoter to dopamine was examined using pituitary tumor cells stably expressing dopamine D2 receptors. 9822660 Human
pe-2 leukemias Using mouse-human somatic hybrids and FISH analysis, the PE-2 gene is localized to human chromosome 19q13.2, a region involved in translocations and deletions in leukemias and several solid tumors, suggesting that this novel ETS factor may play a role in 9192842 Human
erf embryonal carcinoma Here we show that the cellular protein Ets-2 Repressor Factor (ERF) physically interacts with the MIEP and represses MIEP activity in undifferentiated non-permissive T2 embryonal carcinoma cells. 12533699 Human
pe-2 solid tumors Using mouse-human somatic hybrids and FISH analysis, the PE-2 gene is localized to human chromosome 19q13.2, a region involved in translocations and deletions in leukemias and several solid tumors, suggesting that this novel ETS factor may play a role in 9192842 Human
pe-2 carcinogenesis Using mouse-human somatic hybrids and FISH analysis, the PE-2 gene is localized to human chromosome 19q13.2, a region involved in translocations and deletions in leukemias and several solid tumors, suggesting that this novel ETS factor may play a role in 9192842 Human
erf tumorigenesis ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. 7588608 Human
erf oncogene Furthermore, ERF can suppress the ets-dependent transforming activity of the gag-myb-ets fusion oncogene of ME26 virus. 7588608 Human
erf tumorigenesis Specifically ADAM-10 produces the same growth-inhibitory products from Substance P (i.e., SP (1-7)) that Neprilysin does, so that loss of ADAM-10 expression actually results in loss of production of growth inhibitory peptides from Substance P. Similarly, 16583263 Mouse

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