IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LIPE Ensembl ENSG00000079435 Chromosome 19 Start 47597499 End 47623418
Description Hormone-sensitive lipase (HSL)(EC 3.1.1.79) [Source:UniProtKB/Swiss-Prot;Acc:Q05469]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6621
     Entrez Gene : 3991
     UCSC : uc002otr.2
     GeneCards : 6621
     RefSeq : NM_005357
     CCDS : CCDS12607.1
     Uniprot : Q05469
     Interpro : Q05469
     OMIM : 151750
     GeneTests : LIPE
     CGAP : LIPE
     PMID : 8506334

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38320_s_at  0.51  1.41e-7  1.12e-6  0.66  1.35e-6  8.22e-6
 HG_U95  38321_r_at  -0.09  1.62e-1  2.46e-1  -0.23  1.59e-2  3.44e-2
 HG_U133A  208186_s_at  -0.17  1.39e-1  1.77e-1  -0.13  3.42e-1  3.52e-1
 HG_U133A  213855_s_at  0.13  1.42e-1  1.80e-1  0.81  2.41e-17  3.37e-17
 HG_U133_Plus2  208186_s_at  0.22  1.50e-1  2.17e-1  0.04  8.52e-1  8.78e-1
 HG_U133_Plus2  213855_s_at  0.21  1.92e-1  2.67e-1  0.74  4.40e-5  1.03e-4
 Stanford  4809  -0.45  1.34e-1  3.02e-1  -0.05  8.55e-1  9.34e-1
 Stanford  16720  0.59  3.81e-2  1.39e-1  0.64  5.79e-2  1.89e-1
 Agilent_HS_21.6K  1338  -0.17  3.93e-3  2.25e-2  -0.15  7.52e-3  2.86e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208186_s_at  -0.32  4.94e-1  9.26e-1  -0.11  6.53e-1  1.00e+0
 HG_U133A  213855_s_at  -0.39  2.04e-1  8.32e-1  0.07  7.04e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38320_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38321_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208186_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213855_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208186_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213855_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4809    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16720    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1338    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hormone-sensitive lipase cancer Subsequent partial hydrolysis by hormone-sensitive lipase could provide 'free' cholesterol that is available for the synthesis of cellular membranes during proliferation of cancer cells. 10880355 Human
hormone-sensitive lipase tumor The present study examined the expression of hormone-sensitive lipase (HSL) and the scavenger receptors CLA-1/SR-BI and CD36 in normal human testis and in nontumor and tumor testicular disorders by immunohistochemistry and Western blotting analysis. 14745722 Human
hsl tumor The present study examined the expression of hormone-sensitive lipase (HSL) and the scavenger receptors CLA-1/SR-BI and CD36 in normal human testis and in nontumor and tumor testicular disorders by immunohistochemistry and Western blotting analysis. 14745722 Human
hsl spermatocytic seminoma In seminoma and spermatocytic seminoma, neoplastic cells labeled to HSL but failed to stain with antilipid receptors; in the seminiferous tubules at the periphery of the tumour, Charcot-Böttcher crystalloids of Sertoli cells were strongly positive to CLA 14745722 Human
hsl seminoma In seminoma and spermatocytic seminoma, neoplastic cells labeled to HSL but failed to stain with antilipid receptors; in the seminiferous tubules at the periphery of the tumour, Charcot-Böttcher crystalloids of Sertoli cells were strongly positive to CLA 14745722 Human
hsl tumour In seminoma and spermatocytic seminoma, neoplastic cells labeled to HSL but failed to stain with antilipid receptors; in the seminiferous tubules at the periphery of the tumour, Charcot-Böttcher crystalloids of Sertoli cells were strongly positive to CLA 14745722 Human
hsl immature teratoma Testes with mature teratoma showed a weak reaction to CD36 and SR-BI in some cells of enteric-type glands, and immature teratoma were exclusively immunolabeled with HSL. 14745722 Human
hsl mature teratoma Testes with mature teratoma showed a weak reaction to CD36 and SR-BI in some cells of enteric-type glands, and immature teratoma were exclusively immunolabeled with HSL. 14745722 Human
hormone-sensitive lipase human hepatoma Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase. 10393105 Human
hormone-sensitive lipase cancer Since previous studies have indicated that cancer patients exhibit a 2.5-fold enhancement in hormone-sensitive lipase (HSL) versus normal controls, as a potential mechanism for elevated lipolysis, the ability of ascites-derived factors to induce HSl was e 8557225 Human
hsl cancer Since previous studies have indicated that cancer patients exhibit a 2.5-fold enhancement in hormone-sensitive lipase (HSL) versus normal controls, as a potential mechanism for elevated lipolysis, the ability of ascites-derived factors to induce HSl was e 8557225 Human
hormone-sensitive lipase human colon adenocarcinoma Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29. 7695773 Human
hormone-sensitive lipase human colon adenocarcinoma Hormone-sensitive lipase expression was studied in the human colon adenocarcinoma cell line, HT29. 7695773 Human
hormone-sensitive lipase lipomas Lipoprotein lipase and hormone-sensitive lipase activities in human subcutaneous lipomas: comparison with normal subcutaneous adipose tissue. 1261213 Human
hormone-sensitive lipase lipomas 1. Lipoprotein lipase activity and hormone-sensitive lipase activity were investigated in subcutaneous lipomas removed from two patients and compared with the enzyme activities in subcutaneous adipose tissue from two normal subjects. 1261213 Human
hormone-sensitive lipase lipomas 3. Hormone-sensitive lipase activity was demonstrated in lipomas under basal conditions of assay as well as in the presence of adrenaline plus theophylline. 1261213 Human
hormone-sensitive lipase cancer Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. 8422428 Human
hormone-sensitive lipase cancer However, there was a significant two-fold increase in the relative level of mRNA for hormone-sensitive lipase (HSL) in adipose tissue of cancer patients compared with control patients. 8422428 Human
hsl cancer However, there was a significant two-fold increase in the relative level of mRNA for hormone-sensitive lipase (HSL) in adipose tissue of cancer patients compared with control patients. 8422428 Human
hormone-sensitive lipase cancer The results suggest that at least one of the mechanisms for depletion of lipid from adipose tissue in cancer patients operates at the level of increased expression of mRNA of the lipolytic regulatory enzyme, hormone-sensitive lipase. 8422428 Human
hsl intratubular germ cell neoplasia Seminiferous tubules with intratubular germ cell neoplasia exhibited intense immunolabeling to the 3 lipid receptors in the surface of neoplastic cells and to HSL in the nucleus. 14745722 Human
hsl cancer Levels of mRNA for HSL are elevated twofold in adipose tissue of cancer patients, while there are no changes in lipoprotein lipase (LPL), involved in extraction of fatty acids from plasma lipoproteins for storage. 15168125 Human
hormone-sensitive lipase hepatoma The level of adipose tissue lipoprotein lipase was decreased by hepatoma implantation and LPS injection, while the hormone-sensitive lipase activity was increased by the same treatments. 14745166 Human

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