IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CEACAM8 Ensembl ENSG00000124469 Chromosome 19 Start 47776236 End 47790906
Description Carcinoembryonic antigen-related cell adhesion molecule 8 Precursor (Carcinoembryonic antigen CGM6)(Non-specific cross-reacting antigen NCA-95)(CD67 antigen)(CD66b antigen) [Source:UniProtKB/Swiss-Prot;Acc:P31997]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1820
     Entrez Gene : 1088
     UCSC : uc002oud.2
     GeneCards : 1820
     RefSeq : NM_001816
     CCDS : CCDS12610.1
     Uniprot : P31997
     Interpro : P31997
     GeneTests : CEACAM8
     CGAP : CEACAM8
     PMID : 2208113

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33530_at  -0.03  8.90e-1  9.22e-1  -0.26  4.10e-1  5.15e-1
 HG_U133A  206676_at  -0.36  6.66e-2  9.02e-2  -0.52  3.04e-3  3.35e-3
 HG_U133_Plus2  206676_at  -0.80  2.40e-3  5.72e-3  -1.61  3.18e-8  1.13e-7
 Agilent_HS_21.6K  20423  0.16  3.48e-2  1.13e-1  0.05  4.38e-1  5.95e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206676_at  0.55  4.21e-1  9.09e-1  0.16  6.43e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33530_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206676_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206676_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20423    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd66b human leukemia It was also found to be a potent inducer of differentiation in human leukemia derived HL-60 cells through the examination of differentiation markers, as assessed by the reduction of nitroblue-tetrazolium, the increase in esterase activities and phagocytic 12214860 Human
cd66b myeloid leukemia Consistent with the hypothesis, the HIV-1 protease inhibitors enhanced the ability of ATRA to inhibit growth and induce differentiation of HL-60 and NB4 myeloid leukemia cells, as measured by expression of CD11b and CD66b cell surface antigens, as well as 11071654 Human
cd66b leukemia In addition, forced expression of C/EBPepsilon in the U937 myelomonoblastic leukemia cells mimicked terminal granulocytic differentiation, including morphologic changes, increased CD11b/CD66b expression, and induction of secondary granule protein expressi 10330422 Human
nca-95 colorectal carcinoma Chimeric mouse-human antigranulocyte monoclonal antibody (ch MAb) against non-specific cross-reacting antigen (NCA-95) was labeled with 99mTc (using a direct method) and 125I (using the chloramine T method), and its binding to human granulocytes and LS-18 9862166 Human
nca-95 multifocal eosinophilic granuloma MATERIALS: The authors present the first case of multifocal eosinophilic granuloma that was imaged by Tc-99m monoclonal antibody BW250/183 recognizing NCA-95 antigen on granulocytes. 9363388 Human
cd66b acute promyelocytic leukaemia (apl) We have investigated the expression of CD16/Fc(tau)R-III and CD66b GPI linked molecules at the surface of blast cells from five acute promyelocytic leukaemia (APL) patients before and after in vitro stimulation with all-trans retinoic acid (ATRA). 8639434 Human
cd66b tumor CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients. 7591230 Human
cd66b kidney carcinomas Sensitivities over 40% have been determined for CD66b in sera of patients with uterine and kidney carcinomas. 7591230 Human
cd66b malignant tumors The simultaneous determination of CEA and CD66b/c can increase the sensitivities for malignant tumors but high sensitivities of CD66b/c for benign diseases limit their usefulness as tumor markers. 7591230 Human
cd66b tumor The simultaneous determination of CEA and CD66b/c can increase the sensitivities for malignant tumors but high sensitivities of CD66b/c for benign diseases limit their usefulness as tumor markers. 7591230 Human
cd66b carcinomas CD66b may be interesting as a marker for kidney and corpus carcinomas, for which good markers are not yet available. 7591230 Human
nca-95 colon carcinoma Out of six MAb which all bound CEA purified from colon carcinoma, three did not react with these two crossreacting antigens, one bound only NCA-95, one reacted only with NCA-55 and one reacted with both NCA-55 and NCA-95. 6724739 Human
nca 95 carcinoma in situ Immunocytochemical staining with monoclonal antibodies (MAb) against carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen 95 (NCA 95) were used to help in discriminating carcinoma in situ from papillary duct hyperplasia. 2819857 Human
nca 95 hyperplasia Immunocytochemical staining with monoclonal antibodies (MAb) against carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen 95 (NCA 95) were used to help in discriminating carcinoma in situ from papillary duct hyperplasia. 2819857 Human
nca 95 pancreatic ductal adenocarcinoma The epitope recognized by MAb 250 (present on CEA and NCA 95) was expressed in all but one pancreatic ductal adenocarcinoma and ampullary carcinoma (42/43). 3004013 Human
nca 95 carcinoma The epitope recognized by MAb 250 (present on CEA and NCA 95) was expressed in all but one pancreatic ductal adenocarcinoma and ampullary carcinoma (42/43). 3004013 Human
nca 95 carcinomas The findings suggest that paraffin-embedded tissues of pancreatic duct type carcinomas, in contrast to nonduct type tumours and normal ducts, are distinguished by the presence of a CEA and NCA 95 related epitope. 3004013 Human
nca 95 tumours The findings suggest that paraffin-embedded tissues of pancreatic duct type carcinomas, in contrast to nonduct type tumours and normal ducts, are distinguished by the presence of a CEA and NCA 95 related epitope. 3004013 Human
cgm6 chronic myeloid leukemia CGM6 transcripts were only found thus far in leukocytes of chronic myeloid leukemia patients, in normal bone marrow, and in marginal amounts in normal granulocytes. 2208113 Human
nca-95 metastases Granulopoietic bone-marrow was scintigraphically imaged in 15 patients with carcinoma of the breast and known skeletal metastases, 10 patients with malignant lymphomas, and 15 controls without suspected malignant disease, with a technetium-99m labelled mu 2563458 Human
nca-95 malignant lymphomas Granulopoietic bone-marrow was scintigraphically imaged in 15 patients with carcinoma of the breast and known skeletal metastases, 10 patients with malignant lymphomas, and 15 controls without suspected malignant disease, with a technetium-99m labelled mu 2563458 Human
nca-95 carcinoma of the breast Granulopoietic bone-marrow was scintigraphically imaged in 15 patients with carcinoma of the breast and known skeletal metastases, 10 patients with malignant lymphomas, and 15 controls without suspected malignant disease, with a technetium-99m labelled mu 2563458 Human
nca-95 childhood acute lymphoblastic leukemias In the present study, we analyzed 62 childhood acute lymphoblastic leukemias (ALLs) and seven surface immunoglobulin positive (sig+) B-cell lines for the expression of the CEA family members CEA, NCA-50/90, NCA-95, NCA-160, CGM1 and CGM7. 7808000 Human
cgm6 tumors No transcripts were found from CGM1, CGM6, CGM7 or from PSG genes in any of the tumors tested. 7690349 Human
cd66b apl Exposure of APL as well as non-APL samples to any concentration of As2O3 did not affect the expression of beta2 integrins (CD11a and CD11b), CD45 isoforms (RA, RB and R0), CD44/H-CAM, CD33 and the CEA-related antigen family members CD66ade and CD66b, thus 10674975 Human
cd66b human leukemia This compound was also found to be a potent inducer of differentiation in human leukemia derived HL-60 cells through the examination of differentiation markers, as assessed by nitroblue tetrazolium reduction test, esterase activity assay, phagocytic activ 15467202 Human
nca-95 tumor [Kinetics and immunocytochemical staining of 99mTc-labeled monoclonal anti-CEA antibodies against granulocytes following intravenous administration] Until now the clinical identification of the affinity of monoclonal 99mTc-anti-CEA antibodies (MAK BW 250/ 1690879 Human
nca-95 ovarian tumors The PCR data were compared with immunohistochemical investigations of ovarian tumors at the protein level using CEA (26/3/13)-, NCA-50/90 (9A6FR) and NCA-95 (80H3)-specific monoclonal antibodies. 7690349 Human
nca 95 ampullary carcinoma The epitope recognized by MAb 250 (present on CEA and NCA 95) was expressed in all but one pancreatic ductal adenocarcinoma and ampullary carcinoma (42/43). 3004013 Human
nca 95 tumor They contribute not only in tumor diagnostic where monoclonal antibodies against tumorous antigens (TAG 72, CEA) are used but also in the sphere of inflammation diagnostic with the use of monoclonal antibody BW 250/183 which is bound onto non-specific cro 10103164 Human

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