IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PSG1 Ensembl ENSG00000221878 Chromosome 19 Start 48049852 End 48075711
Description Pregnancy-specific beta-1-glycoprotein 1 Precursor (PSBG-1)(Pregnancy-specific beta-1 glycoprotein C/D)(PS-beta-C/D)(Fetal liver non-specific cross-reactive antigen 1/2)(FL-NCA-1/2)(PSG95)(CD66 antigen-like family member F)(CD66f antigen)(CD66 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P11464]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 9524
     Entrez Gene : 5676
     GeneCards : 9524
     RefSeq : NM_002783
     CCDS : CCDS46092.1
     Uniprot : Q13046
     Interpro : Q13046
     OMIM : 176396
     GeneTests : PSG7
     CGAP : PSG7

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40858_at  0.21  6.00e-2  1.07e-1  0.31  5.87e-2  1.05e-1
 HG_U133A  208257_x_at  0.52  9.71e-6  2.26e-5  4.75  3.02e-136  6.11e-135
 HG_U133A  210195_s_at  0.13  5.21e-2  7.21e-2  -1.34  9.89e-27  1.58e-26
 HG_U133A  210196_s_at  0.06  7.37e-1  7.74e-1  5.65  5.84e-105  4.53e-104
 HG_U133_Plus2  208257_x_at  0.47  5.10e-3  1.12e-2  0.11  4.89e-1  5.49e-1
 HG_U133_Plus2  210195_s_at  0.58  3.89e-7  1.88e-6  0.82  6.10e-11  3.00e-10
 HG_U133_Plus2  210196_s_at  0.49  2.02e-2  3.82e-2  0.78  5.90e-4  1.18e-3
 Stanford  9833  -0.38  3.53e-1  5.54e-1  -0.85  1.53e-2  9.25e-2
 Stanford  17091  -0.81  1.17e-1  2.76e-1  -1.87  2.05e-3  2.28e-2
 Agilent_HS_21.6K  16849  0.02  4.46e-1  6.28e-1  0.02  4.05e-1  5.64e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208257_x_at  0.03  9.39e-1  9.97e-1  0.03  8.55e-1  1.00e+0
 HG_U133A  210195_s_at  0.17  4.56e-1  9.16e-1  -0.14  3.04e-1  1.00e+0
 HG_U133A  210196_s_at  -0.22  7.16e-1  9.71e-1  -0.14  6.92e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40858_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208257_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210195_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210196_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208257_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210195_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210196_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9833    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17091    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16849    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
sp1 complete moles Serum PAPP-A and SP1 were high in complete moles. 10221724 Human
sp1 ductal carcinoma A tumor marker, a pregnancy-specific glycoprotein (Schwangerschaftsprotein 1; SP1), and carcinoma characteristics compatible with ductal carcinoma of the breast were seen in KT cells by electron microscopic observation. 3147274 Human
sp-1 squamous-cell carcinoma (sqcc) Squamous cell carcinoma (SQCC) showed positive staining with hCG in 21% of cases, hPL in 28%, and SP-1 in 64%. 7590693 Human
sp-1 large-cell carcinoma (lcc) Large cell carcinoma (LCC) showed positive staining with hCG in 93% of cases, hPL in 56%, and SP-1 in 93%. 7590693 Human
sp1 myeloma In a study of 90 myeloma patients, the SP1 value correlated (p less than 0.001) with the concentration of beta 2-microglobulin in serum, a value which had been corrected for possible renal dysfunction, but not with the concentration of the monoclonal comp 3096609 Human
sp1 myeloma SP1 was detected by direct immunofluorescence in myeloma cells of bone-marrow smears from six of 10 patients with myelomatosis. 3096609 Human
sp1 myeloma These six patients had serum SP1 values greater than 1 microgram/L, whereas the four patients with fluorescence-negative myeloma cells had SP1 values less than 1 microgram/L. 3096609 Human
sp1 acute myeloblastic leukemia In 29% of 950 consecutive patients' sera, SP1 concentrations exceeded 1 microgram/L--in sarcoma (six of six), in malignant hemopathies (101/127, 80%) such as myeloma (20/26, 92%) and acute myeloblastic leukemia (23/27, 90%), and in various other type 3871671 Human
sp1 myeloma In 29% of 950 consecutive patients' sera, SP1 concentrations exceeded 1 microgram/L--in sarcoma (six of six), in malignant hemopathies (101/127, 80%) such as myeloma (20/26, 92%) and acute myeloblastic leukemia (23/27, 90%), and in various other type 3871671 Human
sp1 epithelioma In 29% of 950 consecutive patients' sera, SP1 concentrations exceeded 1 microgram/L--in sarcoma (six of six), in malignant hemopathies (101/127, 80%) such as myeloma (20/26, 92%) and acute myeloblastic leukemia (23/27, 90%), and in various other type 3871671 Human
sp1 crohn's ileitis The concentration of SP1 was also frequently increased in patients with Crohn's ileitis (28/43, 65%) but not in patients with other inflammatory disorders. 3871671 Human
sp1 multiple myeloma Sera from 51 patients with multiple myeloma, 48 patients with monoclonal gammopathy of undetermined significance (MGUS), and 10 patients with Waldenstrom's macroglobulinemia (78 men and 31 women) were analyzed by radioimmunoassay for four placental p 3934736 Human
sp1 waldenstrom's macroglobulinemia Sera from 51 patients with multiple myeloma, 48 patients with monoclonal gammopathy of undetermined significance (MGUS), and 10 patients with Waldenstrom's macroglobulinemia (78 men and 31 women) were analyzed by radioimmunoassay for four placental p 3934736 Human
sp1 mgus Sera from 51 patients with multiple myeloma, 48 patients with monoclonal gammopathy of undetermined significance (MGUS), and 10 patients with Waldenstrom's macroglobulinemia (78 men and 31 women) were analyzed by radioimmunoassay for four placental p 3934736 Human
sp1 monoclonal gammopathy of undetermined significance Sera from 51 patients with multiple myeloma, 48 patients with monoclonal gammopathy of undetermined significance (MGUS), and 10 patients with Waldenstrom's macroglobulinemia (78 men and 31 women) were analyzed by radioimmunoassay for four placental p 3934736 Human
sp1 endodermal sinus tumor Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. alpha-Fetoprotein (alpha FP) and four placental proteins, human chorionic gonadotropin (hCG), human placental lactogen (hpL), pregna 6203815 Human
sp-1 axillary lymph node metastases SP-1 positivity in tumors of infiltrating duct morphology less than 3 cm in diameter, correlated highly (P less than 0.01) with the presence of axillary lymph node metastases. 6380703 Human
sp-1 lobular carcinoma The presence of SP-1 in normal breast epithelium and fibrocystic disease and the low rate of positivity in lobular carcinoma casts doubt on the usefulness of SP-1 as a tumor marker. 6380703 Human
sp1 extragonadal germ cell tumors Using an immunoperoxidase technique, a series of 13 extragonadal germ cell tumors were screened for the presence of 7 different antigens: human chorionic gonadotropin, beta-subunit (beta-hCG), pregnancy-specific beta 1-glycoprotein (SP1), human placental 6100361 Human
sp1 teratoma Teratomas were negative for all antigens, except for CEA and SP1 in duct-lining cells of sweat glands in one teratoma. 6100361 Human
sp1 teratomas Teratomas were negative for all antigens, except for CEA and SP1 in duct-lining cells of sweat glands in one teratoma. 6100361 Human
sp1 testicular germ-cell tumors Evaluation of five tumor markers (AFP, CEA, hCG, hPL and SP1) in monitoring therapy and follow-up of patients with testicular germ cell tumors. 6185897 Human
sp1 seminoma 61 patients with seminoma and 113 with nonseminomatous germ cell tumors of the testis were treated according to the histology, stage of disease, and serum levels of tumor markers (CEA, AFP, hCG, hPL and SP1). 6185897 Human
sp1 myeloma Hybrid cell lines secreting monoclonal antibodies against pregnancy-specific beta 1-glycoprotein (SP1) were produced by fusion of a mouse myeloma cell line with spleen cells from BALB/c mice immunized with purified placental SP1. 6343499 Human
sp1 uterine cervical cancer The production of early and term placental alkaline phosphatase (ALP), human chorionic gonadotropin beta-subunit (beta-hCG) and pregnancy-specific beta 1-glycoprotein (SP1) was confirmed in the newly established uterine cervical cancer call line SKG-IIIa. 6604031 Human
sp1 squamous cell carcinoma of the lung Concomitant presence of pregnancy-specific beta-I-glycoprotein (SP1) and human chorionic gonadotropin (HCG) in a squamous cell carcinoma of the lung. 6604237 Human
spi testicular neoplasms Testicular neoplasms incorporating trophoblastic tumour can contain HCG, SPI and PP5 and have a bad prognosis. 6676077 Human
spi malignant teratoma intermediate In sections from 89 malignant teratoma intermediate tumours of pathological stage P1 syncytial giant cells containing HCG were observed in 66 per cent, PP5 in 47 per cent and SPI in 46 per cent. 6676077 Human
sp1 malignant mesothelioma The results of our study indicate that especially CEA, but also SP1 are valuable markers in the diagnosis of malignant mesothelioma. 2442887 Human
sp1 myeloid leukemia Treatment of the myeloid leukemia cell line ML-2 with tetraphorbol acetate (TPA) strongly induced SP1 in the membrane and cytoplasm as revealed by immunofluorescence and polyacrylamide gel electrophoresis (PAGE) of immunoprecipitates from lysates of surfa 3311199 Human
sp1 ovarian carcinoma Significance of CEA, AFP, SP1 and HCG as tumor markers in ovarian carcinoma. 2447510 Human
sp1 ovarian cancer The significance of CEA, AFP, HCG and SP1 determinations in 85 patients with ovarian cancer were analyzed from the point of view of evaluation of the clinical status of the patients. 2447510 Human
sp1 choriocarcinoma Serum levels of human chorionic gonadotropin (hCG), specific pregnancy protein (SP1), and hPL were measured in 675 samples from women with uneventful pregnancy, and serially from the time of presentation in 125 patients with hydatidiform mole (HM), 43 wit 3002918 Human
sp1 invasive mole Serum levels of human chorionic gonadotropin (hCG), specific pregnancy protein (SP1), and hPL were measured in 675 samples from women with uneventful pregnancy, and serially from the time of presentation in 125 patients with hydatidiform mole (HM), 43 wit 3002918 Human
sp1 nonseminomatous germ-cell tumors In order to examine the relative usefulness of measurements of oncoplacental proteins as tumor markers in patients with nonseminomatous germ cell tumors, the authors measured alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), pregnancy-specific 2420442 Human
sp1 nonseminomatous germ-cell tumors These results indicate that measurements of SP1, hPL, and CAP do not provide additional useful information over that obtained from measurements of hCG and AFP in patients with nonseminomatous germ cell tumors. 2420442 Human
sp-1 pulmonary metastases After the last isolated peak of SP-1 the pulmonary metastases disappeared. 1699189 Human
sp1 mesothelioma One of the two adenocarcinomas negative for CEA was positive for TAG-72, Leu-M1, and SC, and the only B72.3-positive mesothelioma was negative for CEA, Leu-M1, SC, CA19-9, and SP1. 2648877 Human
sp1 mesothelioma These findings indicate that greater sensitivity in differentiating mesothelioma and adenocarcinoma can be achieved by immunostaining for both CEA and one or more of the markers TAG-72 (B72.3), Leu-M1, SC (these three have the highest sensitivity and spec 2648877 Human
sp-1 transitional cell carcinoma In one case, HPL and SP-1 could be found in areas of well-differentiated transitional cell carcinoma. 2655871 Human
sp-1 cyst Keratin filaments could be demonstrated in the cyst lining and papillae covering cells by means of PAP-technique; AFP and SP-1 were lacking. 2473043 Human
sp1 invasive mole Serum SP1 (pregnancy specific beta 1 glycoprotein), hPL (human placental lactogen) and beta-hCG (beta-human chorionic gonadotropin) in patients with choriocarcinoma, invasive mole, and hydati-diform mole were determined by radioimmunoassay (RIA), and comp 1723674 Human
sp1 basal-cell carcinoma Possibilities for application of radioimmunological analysis of CEA, AFP, SP1 and ferritin in patients with basal cell carcinoma of the eyelids. 1726640 Human
sp 1 invasive mole Serum human chorionic gonadotrophin (hCG), pregnancy-specific beta 1-glycoprotein (SP 1) and placental proteins 5 (PP5) levels have been measured by radioimmunoassay in 20 patients (116 samples) with hydatidiform mole, one patient (nine samples) with inva 6277363 Human
sp1 metaplasia Tissue sections taken from areas of carcinoma, areas of intestinal metaplasia in stomachs bearing carcinoma are areas of intestinal metaplasia in stomachs showing atrophic gastritis only were examined for eight markers: a tumour-derived colon-specific ant 6178591 Human
sp1 invasive mole Serum SP1 and hCG beta-subunit (hCG beta) levels in choriocarcinoma, invasive mole, and hydatidiform mole--clinical significance of SP1/hCG beta ratio. 6178652 Human
sp1 trophoblastic tumors The beta-subunit of human chorionic gonadotrophin (hCG) and pregnancy-specific beta 1-glycoprotein (SP1) were measured simultaneously by specific radioimmunoassays in 473 serum samples from 43 patients with trophoblastic tumors. 6291007 Human
sp1 ovarian adenocarcinomas Immunohistochemical detection of pregnancy-specific protein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11 and PP12) in ovarian adenocarcinomas. 6755403 Human
sp1 serous cystadenocarcinoma By using an immunoglobulin-enzyme bridge method, pregnancy-specific beta 1-glycoprotein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11, PP12) were investigated in 15 cases of mucinous cystadenocarcinoma and 20 cases of serous cystadenocarcin 6755403 Human
sp1 mucinous cystadenocarcinoma By using an immunoglobulin-enzyme bridge method, pregnancy-specific beta 1-glycoprotein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11, PP12) were investigated in 15 cases of mucinous cystadenocarcinoma and 20 cases of serous cystadenocarcin 6755403 Human
sp1 gestational trophoblastic tumors Measurement of circulating levels of SP1 and PP5, but not hCG, provides a distinction between benign and malignant gestational trophoblastic tumors. 6971058 Human
sp1 testicular germ-cell tumors Value of five tumor markers (AFP, CEA, hCG, hPL and SP1) in diagnosis and staging of testicular germ cell tumors. 6165945 Human
sp1 testicular germ-cell tumors Serum levels of AFP, CEA, hCG, hPL and SP1 were measured by specific radioimmunoassays in 111 patients with testicular germ cell tumors. 6165945 Human
sp1 mature teratomas Seminomas, mature teratomas and "pure type" embryonal carcinomas, as well as the latter two types of tumor with seminomatous admixture, do not produce markers unless in advanced stages when they may do so (small amounts of hCP, hPL and SP1). 6165945 Human
sp1 teratomas Tumors composed of yolk-sac elements alone or mixed with embryonal carcinoma produce AFP: of syncytiotrophoblastic elements - hCG, hPL or SP1; and teratomas with differentiated structures - CEA. 6165945 Human
sp1 glioma The normal brain-derived and glioma cells were found to contain SP1 when studied by radioimmunoassay and by the triple-bridge immunoperoxidase technique. 7018548 Human
sp1 breast tumors Sensitive radioimmunoassays for the placental proteins PP5 and SP1 were used to investigate possible ectopic synthesis of these proteins by breast tumors. 6975467 Human
sp1 cystic disease PP5 and SP1 were found to be present in the majority of homogenates of malignant and benign breast lesions; the highest concentrations of SP1 were found in malignant tumors, whereas with PP5, especially high levels were found in cases of simple cystic dis 6975467 Human
sp1 colorectal carcinoma The serum levels of human alpha-fetoprotein, AFP, choriogonadotropin, hCG, placental lactogen, hPL, and pregnancy-specific beta 1-glycoprotein, SP1, are of no clinical significance in colorectal carcinoma. 6173222 Human
sp1 embryonal carcinoma of the testis Cellular localization of AFP, hCG and its free subunits, and SP1 in embryonal carcinoma of the testis and ovary. 6174958 Human
sp-1 testicular cancer Is SP-1 a marker for testicular cancer? 6153825 Human
sp1 teratomas SP1 was elevated at 11-440 ng/ml in 3 of 6 men with choriocarcinomas, in 5 of 17 men with teratomas or "teratocarcinomas" (embryonal carcinomas and teratomas), and in 5 of 50 men with embryonal carcinomas; the highest value in 143 patients with 286116 Human
sp1 testicular choriocarcinoma In the 1 patient examined, testicular choriocarcinoma SP1 had immunochemical and gel chromatographic properties similar to those of highly purified SP1 of placental origin. 286116 Human
sp1 trophoblastic tumours Serum-PP12 levels would seem to be of less value in monitoring patients with trophoblastic tumours than other tumour-markers (hCG, and SP1). 6318674 Human
sp1 genital neoplasms [Pregnancy-specific beta 1-glycoprotein (SP1) in the serum of women with malignant genital neoplasms] 6607863 Human
sp1 malignant breast tumours Pregnancy-specific beta 1-glycoprotein (SP1) in serum and tissue from patients with benign and malignant breast tumours. 6609709 Human
sp1 seminomas 38 pure and 11 mixed seminomas were studied with the peroxidase-anti-peroxidase method for the presence of chorionic gonadotropin (beta-HCG) and pregnancy-specific beta 1-glycoprotein (SP1). 3887714 Human
sp1 seminomas The 5 pure seminomas with positive tumor markers appear to have no worse prognosis than pure seminomas without HCG or SP1 production. 3887714 Human
sp1 gestational trophoblastic diseases Gestational trophoblastic diseases: the ratio of choriogonadotropin to specific pregnancy protein, hCG/SP1, provides useful diagnostic and prognostic evidence. 3002918 Human
sp1 sweat gland tumors Using immunoperoxidase methods, normal sweat glands, 44 benign and 4 malignant sweat gland tumors were tested for the presence of carcinoembryonic antigen (CEA), pregnancy-specific-B1-glycoprotein (SP1) and actin (ACT). 3525625 Human
sp1 benign tumors Among benign tumors, 74% were positive for CEA and 44% for SP1. 3525625 Human
sp1 sweat gland tumors The potential value of CEA, SP1 and ACT in the diagnosis of sweat gland tumors is discussed. 3525625 Human
sp1 mesotheliomas In order to investigate the value of immunohistochemistry for the separation of the two entities formalin fixed and paraffin embedded blocks of 47 mesotheliomas and 22 adenocarcinomas were investigated with the PAP technique and commercially available ant 2442887 Human
sp1 mesotheliomas SP1 was positive in 13/22 (59%) of the adenocarcinomas, whereas only 3/47 (6%) mesotheliomas were positive for this marker. 2442887 Human
sp1 ductal carcinoma of the breast A tumor marker, a pregnancy-specific glycoprotein (Schwangerschaftsprotein 1; SP1), and carcinoma characteristics compatible with ductal carcinoma of the breast were seen in KT cells by electron microscopic observation. 3147274 Human
sp1 mesotheliomas Twenty-one adenocarcinomas (91.3%) reacted for CEA, 14 (60.9%) for Leu-M1, 14 (60.9%) for SC, nine (39.1%) for CA19-9, and eight (34.8%) for SP1; no mesotheliomas stained for any of these markers. 2648877 Human
sp1 hyperplastic We conclude that SP1 biosynthesis is regulated at transcriptional level during placental development and a similar mechanism would occur in hydatiform mole which is a hyperplastic trophoblast tumor. 2528957 Human
sp1 invasive moles The expression of hPL and SP1 in the metastatic tumors of invasive moles was weaker than the expression at in the primary tumors, but the secretory capacity of hCG in metastatic choriocarcinomas was stronger than that in the primary neoplasms. 7712876 Human
sp1 lung tumours CEA and SP1 expressions in lung tumours were found in a majority of carcinomas-86% and 79% respectively. 9337537 Human
sp1 nsclc Tumour marker expression was compared with the serum levels of CEA, SP1 and betahCG in 57 patients (pts) with NSCLC and four pts with SCLC. 9511851 Human
sp1 nsclc Positive immunostaining of CEA and SP1 was observed in 87% NSCLC, and betahCG was found in 24% NSCLC. 9511851 Human
sp1 germ cell tumors of the testis Schwangerschafts (pregnancy) protein No. 1 (SP1), a recently identified beta1-glycoprotein that occurs during pregnancy, was assayed in the sera of 97 men with germ cell tumors of the testis. 286116 Human
sp1 seminomas None of 24 sera from men with seminomas and none of 5 sera from men with orchitis had elevated SP1. 286116 Human
sp1 gynecologic neoplasms [CEA, SP1 and HCG in serum and tissue homogenates of patients with gynecologic neoplasms] 485550 Human
sp1 germ cell tumors of the testis The various histologic components of 39 germ cell tumors of the testis were studied with indirect labeled immunoperoxidase technique for the presence of the following tumor-associated antigens: alpha-fetoprotein (AFP), alpha 1-antitrypsin (A1AT), chorioni 7195154 Human
sp1 testicular germ cell tumors Value of five tumor markers (AFP, CEA, hCG, hPL and SP1) in diagnosis and staging of testicular germ cell tumors. 6165945 Human
sp1 testicular germ cell tumors Serum levels of AFP, CEA, hCG, hPL and SP1 were measured by specific radioimmunoassays in 111 patients with testicular germ cell tumors. 6165945 Human
sp1 seminomas Seminomas, mature teratomas and "pure type" embryonal carcinomas, as well as the latter two types of tumor with seminomatous admixture, do not produce markers unless in advanced stages when they may do so (small amounts of hCP, hPL and SP1). 6165945 Human
sp1 trophoblastic tumor [Pregnancy and placental proteins (SP1, HCG, PP5, alpha 2-PAG) in trophoblastic tumor diseases] 6275329 Human
sp1 mucinous cystadenocarcinomas In mucinous cystadenocarcinomas, SP1, was present in 53.3% of cases, PP5 in 80.0%, PP10 in 20.0%, PP11 in 66.7% and PP12 in 46.7%. 6755403 Human
sp1 serous cystadenocarcinomas In serous cystadenocarcinomas, SP1 was present in 35.0% of cases, PP5 in 76.2%, PP10 in 9.5%, PP11 in 57.1% and PP12 in 23.8%. 6755403 Human
sp1 testicular germ cell tumors Evaluation of five tumor markers (AFP, CEA, hCG, hPL and SP1) in monitoring therapy and follow-up of patients with testicular germ cell tumors. 6185897 Human
sp1 gestational trophoblastic disease Schwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic disease. 6188478 Human
sp1 gestational trophoblastic disease The beta subunit of human chorionic gonadotrophin (beta-hCG) and Schwangerschaftsprotein 1 (SP1) were measured by radioimmunoassay in the serum and cerebrospinal fluid (CSF) of 46 postmolar and postpartum patients who developed gestational trophoblastic d 6188478 Human
sp1 bronchial carcinoma The concentrations of pregnancy protein 1 (SP1), placental-specific tissue protein 10 (PP10), placental-specific tissue protein 12 (PP12) and alpha1-Fetoprotein (AFP) were analyzed in serum samples of 83 patients with bronchial carcinoma at stages II-IV P 16033079 Human
sp1 tumoral diseases [Pregnancy-specific beta-1 glycoprotein (SP1) as a marker for tumors with or without trophoblastic character] The pregnancy specific beta-1-glycoprotein (SP1) was measured by radioimmunoassay in 854 persons (control group 103, non-tumoral diseases 212, ge 6100801 Human
sp-1 stage ii breast carcinoma The primary tumors and metastases from 30 patients with stage II breast carcinoma treated with low- or standard-dose combination chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil) were studied by the immunoperoxidase technique for pregnancy-ass 2579017 Human
sp-1 testicular tumors [Enzyme immunoassay for pregnancy-specific beta 1-glycoprotein (SP-1) in patients with testicular tumors] The use of a two-side-binding-enzyme-immunoassay for pregnancy-specific beta 1-glycoprotein (SP-1) in tumours of the testicles is described. 2994322 Human
sp-1 intracranial tumours Histologically verified intracranial tumours, mainly germ cell tumours of the pineal and suprasellar regions, were studied immunohistochemically using anti-serum of alpha fetoprotein (AFP), human chorionic gonadotropin (HCG), carcinoembryonic antigen (CEA 2441574 Human
sp-1 endodermal sinus tumours Endodermal sinus tumours were positive for AFP, choriocarcinomas for HCG and SP-1, and embryonal carcinomas for AFP, HCG and SP-1. 2441574 Human
spi trophoblastic tumour Testicular neoplasms incorporating trophoblastic tumour can contain HCG, SPI and PP5 and have a bad prognosis. 6676077 Human
sp-1 ovarian cysts In all 24 patients with tubal pregnancy SP-1 levels estimated by enzyme immunoassay Enzygnost were higher than 5 ng/ml, whereas SP-1 levels in 7 cases with benign ovarian cysts were less than 2 ng/ml. 6972332 Human
sp1 hydatidiform mole Serum levels of human chorionic gonadotropin (hCG), specific pregnancy protein (SP1), and hPL were measured in 675 samples from women with uneventful pregnancy, and serially from the time of presentation in 125 patients with hydatidiform mole (HM), 43 wit 3002918 Human
sp1 hydatidiform mole An increase in the hCG/SP1 ratio seemed to be a characteristic sign of malignant change when compared with this ratio in normal pregnancy and hydatidiform mole. 3002918 Human
sp1 benign tumors [Pregnancy protein-1 in the serum of patients with diseases of the breast] Pregnancy-specific beta 1-glycoprotein (SP1) was assayed by enzyme immunoassay in serum from 32 patients with breast diseases (11 mastopathies, 6 benign tumors and 15 breast cancer 3035827 Human
sp1 sarcoma Very low levels of SP1 or SP1-like activity were found in only 2 out of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma, and sarcoma, in 2 out of 11 sera from patients with infectious diseases, and in none out of 15 sera 317495 Human
sp1 malignant ovarian tumors [Protein studies in cystic and peritoneal fluids of ovarian tumors with special reference to CEA] The levels of total protein, Ig, AFP, beta-HCG, CEA, SC, SP1 and alpha 2-PAG were measured in cystic and peritoneal effusions obtained from 70 females with b 3376613 Human
sp1 ovarian tumors [Protein studies in cystic and peritoneal fluids of ovarian tumors with special reference to CEA] The levels of total protein, Ig, AFP, beta-HCG, CEA, SC, SP1 and alpha 2-PAG were measured in cystic and peritoneal effusions obtained from 70 females with b 3376613 Human
sp1 sarcoma In 29% of 950 consecutive patients' sera, SP1 concentrations exceeded 1 microgram/L--in sarcoma (six of six), in malignant hemopathies (101/127, 80%) such as myeloma (20/26, 92%) and acute myeloblastic leukemia (23/27, 90%), and in various other type 3871671 Human
sp1 trophoblastic neoplasms SP1 is a good marker for trophoblastic neoplasms and shows a correlation with HCG-beta. 6100801 Human
sp1 endodermal sinus tumor of the ovary Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. alpha-Fetoprotein (alpha FP) and four placental proteins, human chorionic gonadotropin (hCG), human placental lactogen (hpL), pregna 6203815 Human
sp1 ovarian germ cell tumor Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. alpha-Fetoprotein (alpha FP) and four placental proteins, human chorionic gonadotropin (hCG), human placental lactogen (hpL), pregna 6203815 Human
sp1 bronchial carcinoma [Tumor markers (alpha 2-macroglobulin, secretory immunoglobulin A, pregnancy-associated alpha 2-glycoprotein) in the serum of patients with bronchial carcinoma] Concentration of alpha 2-macroglobulin (AMG), pregnancy associated-alpha 2-glycoprotein (alpha 6208875 Human
sp1 germinoma Among the 18 cases of germinoma, except 3 out of 18 were CEA positive, otherwise, all were CEA, beta-HCG, SP1, AFP and GFAP negative. 8403104 Human
sp1 adenomas SP1 was found neither in noncancer colon mucosa nor in transitional mucosa and adenomas. 1290826 Human
sp1 colon cancer The results allow considering SP1 the tumor marker suitable for immunohistochemical diagnosis of colon cancer. 1290826 Human
sp1 metaplasia The expression of SP1 was revealed in focus of intestinal metaplasia, dysplasia as well as in cover epithelial cells. 1720986 Human
sp1 invasive mole SP1/beta-hCG ratios were less than 1.5 in 4/43 (9.3%) cases of hydatidiform mole and 17/19 (89.5%) cases of invasive mole and choriocarcinoma. 1723674 Human
sp1 basal cell carcinoma Possibilities for application of radioimmunological analysis of CEA, AFP, SP1 and ferritin in patients with basal cell carcinoma of the eyelids. 1726640 Human
sp1 bronchial carcinoma [Levels of tumor markers (orosomucoid, pregnancy-associated alpha 2-glycoprotein, pregnancy protein-1, placental specific-tissue protein 10, placental specific-tissue protein 12, alpha 1-fetoprotein) in the serum of patients with bronchial carcinoma] Conc 2421681 Human
sp1 endometrial cancer The combined stainings, i.e. either for TPA and SP1 or for TPA and PAPP-A, are efficient immunohistochemical screening methods to use in diagnosing endometrial cancer in the biopsied specimens (p less than 0.05). 2445880 Human
sp1 invasive mole The SP1/beta-hCG ratio was less than 1.5 in 4/36(11.1%) of the cases of hydatidiform mole, 13/16 (81.2%) of the cases of invasive mole and choriocarcinoma. 2476204 Human
sp-1 germ cell testicular cancer We measured the serum levels of the pregnancy-associated protein SP-1 by radioimmunoassay in 91 patients with a diagnosis of germ cell testicular cancer. 6153825 Human
sp-1 germ cell testicular cancer SP-1 is a clinically useful marker in germ cell testicular cancer. 6153825 Human
sp-1 infiltrating duct carcinomas However, these findings suggest that immunopositivity for SP-1 in small infiltrating duct carcinomas may be an indicator of poor prognosis. 6380703 Human
sp-1 metastatic gestational trophoblastic diseases Elevated sera levels of SP-1 induced by chemotherapy in patients with metastatic gestational trophoblastic diseases. 1699189 Human
sp-1 metastatic gestational trophoblastic disease (mgtd) In 2 patients with metastatic gestational trophoblastic disease (MGTD) SP-1 peaks were found during chemotherapy. 1699189 Human
sp1 nonseminomatous germ cell tumors In order to examine the relative usefulness of measurements of oncoplacental proteins as tumor markers in patients with nonseminomatous germ cell tumors, the authors measured alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), pregnancy-specific 2420442 Human
sp1 tumoral diseases SP1 rarely is higher than 5 ng/ml in non-tumoral diseases and non-germinal tumors, while it is higher than 5 ng/ml in germinal tumors. 6100801 Human
sp-1 lung carcinomas The authors studied the expression of trophoblastic cell markers in lung carcinomas cells by immunoperoxidase staining using antibodies against three trophoblastic glycoproteins (human chorionic gonadotropin [hCG]; human placental lactogen [hPL]; pregnanc 7590693 Human
sp-1 squamous cell carcinoma Squamous cell carcinoma (SQCC) showed positive staining with hCG in 21% of cases, hPL in 28%, and SP-1 in 64%. 7590693 Human
sp-1 large cell carcinoma (lcc) Large cell carcinoma (LCC) showed positive staining with hCG in 93% of cases, hPL in 56%, and SP-1 in 93%. 7590693 Human
sp1 mesothelioma A positive immunostaining with CEA, Leu-M1, SP1, B72-3 supports the diagnosis of pleural metastatic adenocarcinoma versus mesothelioma. 7703564 Human
sp1 metastatic adenocarcinoma A positive immunostaining with CEA, Leu-M1, SP1, B72-3 supports the diagnosis of pleural metastatic adenocarcinoma versus mesothelioma. 7703564 Human
sp1 invasive moles The results indicated that the expression of hCG in invasive moles was weaker than that in choriocarcinoma, but the expression of hPL and SP1 was stronger than those in choriocarcinoma. 7712876 Human
sp1 metastatic tumors The expression of hPL and SP1 in the metastatic tumors of invasive moles was weaker than the expression at in the primary tumors, but the secretory capacity of hCG in metastatic choriocarcinomas was stronger than that in the primary neoplasms. 7712876 Human
sp1 trophoblastic neoplasms We believe that the detection of hCG, hPL and SP1, in malignant trophoblastic neoplasms was of value for establishing tumor diagnosis and typing and for judgement on prognosis. 7712876 Human
sp1 sclc Tumour marker expression was compared with the serum levels of CEA, SP1 and betahCG in 57 patients (pts) with NSCLC and four pts with SCLC. 9511851 Human
sp1 sclc In the SCLC group positive staining showed in 29% of tumours, SP1 in 51% and betahCG in 18%. 9511851 Human
sp-1 adenocarcinoma Adenocarcinoma showed positive staining with hCG in 60% of cases, hPL in 10%, and SP-1 in 80%. 7590693 Human
sp-1 tcc Beta HCG, human placental lactogen (HPL), pregnancy specific beta-1 glycoprotein (SP-1) and placental alkaline phosphatase were determined immunohistochemically in paraffin-embedded TCC of urinary bladder. 10909500 Human
sp1 benign tumors There were significant differences between the SP1-serum concentrations of patient group (mastopathies, benign tumors, breast cancer) and the control group (p less than 0.001). 3035827 Human
sp1 benign tumors The SP1-values of the groups with mastopathies, benign tumors and breast cancer did not differ significantly. 3035827 Human
sp1 benign tumor Elevated SP1-concentrations were found in 4 of 11 patients with mastopathy, in 3 of 6 patients with benign tumor and in 10 of 15 patients with breast cancer versus 1 of 24 blood donors. 3035827 Human
sp1 tumor antigens Specific tumor antigens were identified using the immunohistochemical (P.A.P.) technique to detect carcinoembryonic antigen (CEA), human placental lactogen (HPL), alphafetoprotein (AFP), colon-specific antigen (CSA), pregnancy-specific beta lipoprotein 1 6164469 Human
sp1 tumour specific antigen Tissue sections taken from areas of carcinoma, areas of intestinal metaplasia in stomachs bearing carcinoma are areas of intestinal metaplasia in stomachs showing atrophic gastritis only were examined for eight markers: a tumour-derived colon-specific ant 6178591 Human
sp1 tumor-associated antigens The various histologic components of 39 germ cell tumors of the testis were studied with indirect labeled immunoperoxidase technique for the presence of the following tumor-associated antigens: alpha-fetoprotein (AFP), alpha 1-antitrypsin (A1AT), chorioni 7195154 Human
sp1 metastatic adenocarcinoma Analysis of its immunohistochemical aspects] To evaluate the usefulness of immunohistochemistry in the diagnostic distinction between pleural mesothelioma and metastatic adenocarcinoma to the pleura, the authors studied formalin-fixed paraffin-embedded ti 2328062 Human
sp1 pleural mesothelioma Analysis of its immunohistochemical aspects] To evaluate the usefulness of immunohistochemistry in the diagnostic distinction between pleural mesothelioma and metastatic adenocarcinoma to the pleura, the authors studied formalin-fixed paraffin-embedded ti 2328062 Human
sp1 pleural mesotheliomas Analysis of its immunohistochemical aspects] To evaluate the usefulness of immunohistochemistry in the diagnostic distinction between pleural mesothelioma and metastatic adenocarcinoma to the pleura, the authors studied formalin-fixed paraffin-embedded ti 2328062 Human
sp1 mesotheliomas S100 protein, SP1-beta and Leu M1 were also absent in mesotheliomas but present only in less than half of the adenocarcinomas. 2328062 Human

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