IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CD177 Ensembl ENSG00000204936 Chromosome 19 Start 48549665 End 48559320
Description CD177_HUMAN Isoform 3 of Q8N6Q3 - Homo sapiens (Human) [Source:UniprotKB/SpliceVariant;Acc:Q8N6Q3-3]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 30072
     Entrez Gene : 57126
     UCSC : uc002owi.2
     GeneCards : 30072
     RefSeq : NM_020406
     Uniprot : Q8N6Q3
     Interpro : Q8N6Q3
     OMIM : 162860
     GeneTests : CD177
     CGAP : CD177
     PMID : 10753836

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  219669_at  0.31  5.24e-3  8.58e-3  0.87  1.31e-20  1.91e-20
 HG_U133_Plus2  219669_at  0.28  1.57e-1  2.26e-1  0.89  1.60e-5  3.98e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  219669_at  -0.09  8.32e-1  9.86e-1  0.18  4.75e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 219669_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 219669_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
polycythemia rubra vera-1 polycythemia vera The gene encoding neutrophil alloantigen NB1, CD177, is highly homologous to a gene overexpressed in polycythemia vera neutrophils, polycythemia rubra vera-1 (PRV-1). 11846455 Human
prv-1 polycythemia vera The gene encoding neutrophil alloantigen NB1, CD177, is highly homologous to a gene overexpressed in polycythemia vera neutrophils, polycythemia rubra vera-1 (PRV-1). 11846455 Human
nb1 polycythemia vera The gene encoding neutrophil alloantigen NB1, CD177, is highly homologous to a gene overexpressed in polycythemia vera neutrophils, polycythemia rubra vera-1 (PRV-1). 11846455 Human
cd177 polycythemia vera The gene encoding neutrophil alloantigen NB1, CD177, is highly homologous to a gene overexpressed in polycythemia vera neutrophils, polycythemia rubra vera-1 (PRV-1). 11846455 Human
cell surface receptor polycythemia rubra vera Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. 12239154 Human
prv-1 polycythemia rubra vera Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. 12239154 Human
prv-1 polycythemia vera The cDNA for polycythemia rubra vera 1 (PRV-1), a novel hematopoietic receptor, was recently cloned by virtue of its overexpression in patients with polycythemia vera. 12239154 Human
polycythemia rubra vera 1 polycythemia vera The cDNA for polycythemia rubra vera 1 (PRV-1), a novel hematopoietic receptor, was recently cloned by virtue of its overexpression in patients with polycythemia vera. 12239154 Human
prv1 polycythemia vera We have determined the intron-exon structure of the PRV1 gene and show that the locus is structurally intact in patients with polycythemia vera. 12239154 Human
prv-1 polycythemia vera Flow cytometry of bone marrow and peripheral blood of both healthy donors and patients with polycythemia vera showed that PRV-1 protein is expressed on myeloid cells of the granulocytic lineage. 12239154 Human
prv-1 polycythemia vera However, unlike the significant difference in PRV-1 expression observed on the mRNA level, the amount of PRV-1 protein on the cell surface is not consistently elevated in patients with polycythemia vera compared with healthy controls. 12239154 Human
prv-1 polycythemia vera Therefore, quantification of PRV-1 surface expression cannot be used for the diagnosis of polycythemia vera. 12239154 Human
polycythemia rubra vera-1 essential thrombocythemia Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia. 12377969 Human
polycythemia rubra vera-1 essential thrombocythemia (et) PURPOSE: To examine the utility of polycythemia rubra vera-1 (PRV-1)-specific reverse transcriptase polymerase chain reaction (RT-PCR) to discriminate essential thrombocythemia (ET) and polycythemia vera (PV) from secondary thrombocytosis (ST) or secondar 12377969 Human
polycythemia rubra vera-1 polycythemia vera PURPOSE: To examine the utility of polycythemia rubra vera-1 (PRV-1)-specific reverse transcriptase polymerase chain reaction (RT-PCR) to discriminate essential thrombocythemia (ET) and polycythemia vera (PV) from secondary thrombocytosis (ST) or secondar 12377969 Human
prv-1 chronic myelogenous leukemia (cml) PATIENTS AND METHODS: We analyzed the expression of PRV-1 in granulocytes isolated from 37 patients with ET, 37 patients with PV, 25 patients with ST, 10 patients with SE, 25 patients with secondary leukocytosis (SL), five patients with chronic myelogenou 12377969 Human
prv-1 myelodysplastic syndrome PATIENTS AND METHODS: We analyzed the expression of PRV-1 in granulocytes isolated from 37 patients with ET, 37 patients with PV, 25 patients with ST, 10 patients with SE, 25 patients with secondary leukocytosis (SL), five patients with chronic myelogenou 12377969 Human
prv-1 chronic idiopathic myelofibrosis PATIENTS AND METHODS: We analyzed the expression of PRV-1 in granulocytes isolated from 37 patients with ET, 37 patients with PV, 25 patients with ST, 10 patients with SE, 25 patients with secondary leukocytosis (SL), five patients with chronic myelogenou 12377969 Human
polycythemia rubra vera-1 polycythemia vera Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decr 12430925 Human
prv-1 polycythemia vera Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decr 12430925 Human
prv-1 essential thrombocythemia Endogenous erythroid and megakaryocytic circulating progenitors, HUMARA clonality assay, and PRV-1 expression are useful tools for diagnosis of polycythemia vera and essential thrombocythemia. 14998917 Human
prv-1 polycythemia vera Endogenous erythroid and megakaryocytic circulating progenitors, HUMARA clonality assay, and PRV-1 expression are useful tools for diagnosis of polycythemia vera and essential thrombocythemia. 14998917 Human
prv-1 essential thrombocythemia Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients. 14998918 Human
prv-1 polycythemia vera Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients. 14998918 Human
nb1 chronic myeloid leukaemia Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor. 11380420 Human
prv-1 essential thrombocythemia PRV-1 mRNA expression discriminates two types of essential thrombocythemia. 15034760 Human
polycythemia rubra vera-1 polycythemia vera We have recently described the overexpression of a hematopoietic receptor, PRV-1 (polycythemia rubra vera-1), in patients with polycythemia vera (PV). 15034760 Human
prv-1 polycythemia vera We have recently described the overexpression of a hematopoietic receptor, PRV-1 (polycythemia rubra vera-1), in patients with polycythemia vera (PV). 15034760 Human
prv-1 polycythemia rubra vera Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. 10753836 Human
prv-1 chronic myelogenous leukemia Moreover, PRV-1 is not expressed in mononuclear cells from patients with chronic myelogenous leukemia (n = 4) or acute myelogenous leukemia (n = 5) or in granulocytes from patients with essential thrombocythemia (n = 4) or secondary erythrocytosis (n = 4) 10753836 Human
prv-1 acute myelogenous leukemia Moreover, PRV-1 is not expressed in mononuclear cells from patients with chronic myelogenous leukemia (n = 4) or acute myelogenous leukemia (n = 5) or in granulocytes from patients with essential thrombocythemia (n = 4) or secondary erythrocytosis (n = 4) 10753836 Human
prv-1 essential thrombocythemia Moreover, PRV-1 is not expressed in mononuclear cells from patients with chronic myelogenous leukemia (n = 4) or acute myelogenous leukemia (n = 5) or in granulocytes from patients with essential thrombocythemia (n = 4) or secondary erythrocytosis (n = 4) 10753836 Human
prv-1 polycythemia rubra vera PRV-1 is a gene that is over-expressed in neutrophils from patients with polycythemia rubra vera. 14692971 Human
prv-1 polycythemia rubra vera The function of the CD177 is not known, but the CD177 gene is highly homologous to a gene overexpressed in neutrophils from patients with polycythemia rubra vera called PRV-1. 11788931 Human
cd177 polycythemia rubra vera The function of the CD177 is not known, but the CD177 gene is highly homologous to a gene overexpressed in neutrophils from patients with polycythemia rubra vera called PRV-1. 11788931 Human
nb1 chronic myelogenous leukaemia A monoclonal antibody (MoAb) specific for NB1 (1B5) and flow cytometry was used to assess the frequency and characteristics of the NB1-positive cells found in umbilical cord blood (n = 11), children (n = 37), healthy adults (n = 46) and patients with chro 9675788 Human
prv-1 polycythemia vera Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis. 12893745 Human
prv-1 polycythaemia vera To determine the expression level of PRV-1 in the bone marrow, we analysed PRV-1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. 14617008 Human
prv-1 chronic myeloproliferative disorders To determine the expression level of PRV-1 in the bone marrow, we analysed PRV-1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. 14617008 Human
prv-1 polycythaemia vera We concluded that, rather than an upregulation of the PRV-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in pe 14617008 Human
prv-1 polycythaemia vera Polycythaemia rubra vera-1 (PRV-1) positivity, i.e. PRV-1 mRNA overexpression, is known to be present in the vast majority of patients with polycythaemia vera and also in some patients with ET. 14617016 Human
prv-1 polycythemia vera Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis. 12591276 Human
nb1 chronic granulocytic leukaemia The granulocytes of 23 patients with chronic granulocytic leukaemia were examined in the indirect immunofluorescence test and some also in the microleucoagglutination test, with specific alloantisera against the NA1, NA2, NB1 and ND1 antigens and a specif 93490 Human
prv-1 polycythemia rubra vera PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera. 12901344 Human
prv-1 polycythemia vera Increased expression of PRV-1 (polycythemia ruba vera) in granulocytes may assist in discriminating between polycythemia vera and at least some cases of ET. 12901346 Human
prv-1 polycythemia vera We observed concordance between EECs and PRV-1 in MPD patients across all diagnostic subclasses, but our results indicate that EECs remain the most reliable auxiliary test for polycythemia vera (PV). 12730106 Human
prv-1 polycythemia vera Quantitative real-time polymerase chain reaction shows that treatment with interferon reduces the initially upregulated PRV-1 expression in polycythemia vera patients. 12651277 Human
prv-1 chronic myeloproliferative disorders Neutrophil PRV-1 expression across the chronic myeloproliferative disorders and in secondary or spurious polycythemia. 14701686 Human
prv-1 polycythemia vera Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). 14701686 Human
polycythemia rubra vera-1 polycythemia vera Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). 14701686 Human
prv-1 mds PATIENTS AND METHODS: We analyzed the expression of PRV-1 in granulocytes isolated from 37 patients with ET, 37 patients with PV, 25 patients with ST, 10 patients with SE, 25 patients with secondary leukocytosis (SL), five patients with chronic myelogenou 12377969 Human
prv-1 mds RESULTS: PRV-1 was not expressed in granulocytes isolated from normal individuals or from patients with ST, SE, CML, IM, MDS, and inflammatory/infectious SL. 12377969 Human

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