IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LYPD3 Ensembl ENSG00000124466 Chromosome 19 Start 48656786 End 48661671
Description Ly6/PLAUR domain-containing protein 3 Precursor (GPI-anchored metastasis-associated protein C4.4A homolog)(Matrigel-induced gene C4 protein)(MIG-C4) [Source:UniProtKB/Swiss-Prot;Acc:O95274]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 24880
     Entrez Gene : 27076
     UCSC : uc002owl.1
     GeneCards : 24880
     RefSeq : NM_014400
     CCDS : CCDS12620.1
     Uniprot : O95274
     Interpro : O95274
     OMIM : 609484
     GeneTests : LYPD3
     CGAP : LYPD3
     PMID : 11179665

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 44/108(42%) IHCKaplanMeier survival(P=0.012) 17706320 Lung Cancer. 2007 Nov;58(2):260-6.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41641_at  0.89  1.40e-7  1.11e-6  2.54  2.12e-14  5.93e-13
 HG_U133A  204952_at  0.64  2.42e-4  4.78e-4  -1.21  1.37e-10  1.73e-10
 HG_U133_Plus2  204952_at  1.48  1.56e-7  8.03e-7  4.42  1.52e-27  5.19e-26

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204952_at  0.13  7.72e-1  9.77e-1  0.01  9.68e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41641_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204952_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204952_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
c4.4a tumors Yet, tumors derived from the latter tissues frequently contained C4.4A mRNA. 11179665 Human
c4.4a malignant melanoma As demonstrated for malignant melanoma, C4.4A mRNA expression correlated with tumor progression. 11179665 Human
c4.4a tumor As demonstrated for malignant melanoma, C4.4A mRNA expression correlated with tumor progression. 11179665 Human
c4.4a metastases While nevi were negative and only a minority of primary malignant melanoma expressed C4.4A, all metastases were C4.4A-positive. 11179665 Human
c4.4a primary malignant melanoma While nevi were negative and only a minority of primary malignant melanoma expressed C4.4A, all metastases were C4.4A-positive. 11179665 Human
c4.4a tumor Taking into account the high degree of homology between rat and human C4.4A, the conformity of the expression profiles and the association of rat C4.4A with tumor progression, human C4.4A might well become a prognostic marker and possibly a target of ther 11179665 Human
c4.4a melanoma Upregulation of C4.4A expression during progression of melanoma. 11180013 Human
c4.4a tumor After intrafootpad and intravenous application of C4.4A transfected and mock-transfected tumor cells, an increased number of lung nodules was detected with the former, whereby the individual metastatic nodules amalgamated without any encapsulation of the 9788443 Human
c4.4a tumor Furthermore, C4.4A is involved in adhesion to laminin and, although transfection of a non-metastasizing tumor line with the molecule was not sufficient, constitutively C4.4A-positive tumor cells penetrated through matrigel. 9788443 Human
c4.4a metastasis In view of the observed influence of C4.4A on metastasis formation and matrix penetration it is tempting to speculate that this newly described metastasis-associated molecule may exert functional activity similar to the uPAR, i.e. via activation of matrix 9788443 Human
c4.4a metastasis hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. hAG-2 and hAG-3 are recently discovered human homologues of th 12592373 Human
c4.4a tumours hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. hAG-2 and hAG-3 are recently discovered human homologues of th 12592373 Human
c4.4a metastasis Yeast two-hybrid cloning identified metastasis-associated GPI-anchored C4.4a protein and extracellular alpha-dystroglycan (DAG-1) as binding partners for both hAG-2 and hAG-3, which if replicated in clinical oncology would demonstrate a potential role in 12592373 Human
c4.4a tumour Yeast two-hybrid cloning identified metastasis-associated GPI-anchored C4.4a protein and extracellular alpha-dystroglycan (DAG-1) as binding partners for both hAG-2 and hAG-3, which if replicated in clinical oncology would demonstrate a potential role in 12592373 Human
c4.4a breast tumours hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. hAG-2 and hAG-3 are recently discovered human homologues of th 12592373 Human
c4.4a hyperplasia Phorbol-ester-induced hyperplasia of mouse skin is also accompanied by a significant induction of C4.4A expression in the multilayered, suprabasal keratinocytes. 15012588 Mouse
c4.4a tumor ELISA screening of several components of the extracellular matrix revealed selective binding of rrC4.4A to LN1 and LN5 and that transfection of the BSp73AS tumor line with C4.4A cDNA (BSp73AS-1B1) promoted LN1 and LN5 binding. 15729693 Rat
c4.4a tumor C4.4A also associates with galectin-3 in nontransformed tissues and tumor lines. 15729693 Rat
c4.4a metastasis Our findings that LN1 and LN5 are C4.4A ligands, that galectin-3 associates with C4.4A and that C4.4A ligand binding confers a migratory phenotype are well in line with the supposed metastasis association. 15729693 Rat

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