IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CADM4 Ensembl ENSG00000105767 Chromosome 19 Start 48818362 End 48835831
Description Cell adhesion molecule 4 Precursor (Immunoglobulin superfamily member 4C)(Nectin-like protein 4)(TSLC1-like protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFZ8]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 30825
     Entrez Gene : 199731
     UCSC : uc002oxc.1
     GeneCards : 30825
     RefSeq : NM_145296
     CCDS : CCDS12627.1
     Uniprot : Q8NFZ8
     Interpro : Q8NFZ8
     OMIM : 609744
     GeneTests : CADM4
     CGAP : CADM4
     PMID : 11536053

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39899_at  0.40  3.99e-6  2.27e-5  0.34  7.64e-3  1.83e-2
 HG_U95  39900_at  0.26  1.15e-3  3.57e-3  0.48  5.70e-5  2.41e-4
 HG_U133A  214267_s_at  0.05  5.24e-1  5.77e-1  9.09  1.71e-180  2.25e-178
 HG_U133A  215258_at  0.18  1.14e-1  1.48e-1  1.38  6.91e-25  1.08e-24
 HG_U133A  215259_s_at  0.88  2.61e-6  6.44e-6  2.97  4.10e-50  9.37e-50
 HG_U133A  222293_at  0.67  5.41e-7  1.43e-6  4.91  7.82e-115  8.06e-114
 HG_U133_Plus2  214267_s_at  0.21  1.83e-1  2.57e-1  0.19  2.41e-1  2.95e-1
 HG_U133_Plus2  215258_at  0.82  1.77e-6  7.67e-6  0.54  4.53e-3  7.83e-3
 HG_U133_Plus2  215259_s_at  0.69  2.33e-3  5.58e-3  0.45  9.57e-2  1.29e-1
 HG_U133_Plus2  222293_at  0.17  3.05e-1  3.92e-1  -0.43  2.97e-2  4.44e-2
 HG_U133_Plus2  229335_at  0.59  1.12e-4  3.52e-4  1.04  7.75e-8  2.62e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  214267_s_at  -0.42  7.93e-2  7.44e-1  0.25  1.15e-1  1.00e+0
 HG_U133A  215258_at  0.28  4.71e-1  9.22e-1  0.12  5.62e-1  1.00e+0
 HG_U133A  215259_s_at  -0.12  8.72e-1  9.91e-1  0.42  2.10e-1  1.00e+0
 HG_U133A  222293_at  -0.07  9.01e-1  9.94e-1  0.05  8.83e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39899_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39900_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214267_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215258_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215259_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 222293_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214267_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215258_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215259_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 222293_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229335_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tsll2 tumor Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. 11536053 Human
tsll2 prostate cancer Expression of TSLL1 and TSLL2 was lost or markedly reduced in many human glioma cell lines or some prostate cancer cell lines, suggesting that loss of expression of these genes might be involved in some human cancers. 11536053 Human
tsll2 cancers Expression of TSLL1 and TSLL2 was lost or markedly reduced in many human glioma cell lines or some prostate cancer cell lines, suggesting that loss of expression of these genes might be involved in some human cancers. 11536053 Human
tsll2 glioma Expression of TSLL1 and TSLL2 was lost or markedly reduced in many human glioma cell lines or some prostate cancer cell lines, suggesting that loss of expression of these genes might be involved in some human cancers. 11536053 Human
tsll2 cancers Loss of expression of the TSLL1 or TSLL2 in several cancers suggests that these genes could also act as tumor suppressors. 14659875 Human
tsll2 tumor Loss of expression of the TSLL1 or TSLL2 in several cancers suggests that these genes could also act as tumor suppressors. 14659875 Human
tsll2 cancer Tsll2 was expressed in the brain and several organs including the kidney and liver, whereas loss of Tsll2 expression was detected in some rodent cancer cells derived from these tissues. 14659875 Mouse
tsll2 tumor These data, together with their strong conservation during the vertebrate evolution, suggest that TSLL1and TSLL2 could play an important role in cell-cell interaction as well as in tumor suppression. 14659875 Human
tsll2 prostate cancer The TSLL2 gene is mapped on the chromosomal region 19q13.2, whose loss of heterozygosity has been frequently reported in prostate cancer. 16261159 Human
tsll2 primary prostate cancers TSLL2 protein is lost in nine of nine primary prostate cancers and in a prostate cancer cell, PPC-1. 16261159 Human
tsll2 prostate cancer TSLL2 protein is lost in nine of nine primary prostate cancers and in a prostate cancer cell, PPC-1. 16261159 Human
tsll2 subcutaneous tumor Introduction of TSLL2 into PPC-1 strongly suppresses subcutaneous tumor formation in nude mice. 16261159 Mouse
tsll2 prostate cancer These results suggest that TSLL2 is a new member of the Ig superfamily cell adhesion molecules and is a tumor-suppressor candidate in prostate cancer. 16261159 Human
tsll2 prostate tumor Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. 16261159 Human
tsll2 tumor These results suggest that TSLL2 is a new member of the Ig superfamily cell adhesion molecules and is a tumor-suppressor candidate in prostate cancer. 16261159 Human
igsf4c prostate tumor Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. 16261159 Human

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