IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PVR Ensembl ENSG00000073008 Chromosome 19 Start 49839066 End 49858690
Description Poliovirus receptor Precursor (Nectin-like protein 5)(Necl-5)(CD155 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P15151]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9705
     Entrez Gene : 5817
     UCSC : uc002ozm.2
     GeneCards : 9705
     RefSeq : NM_001135768
     CCDS : CCDS12640.1
     Uniprot : P15151
     Interpro : P15151
     OMIM : 173850
     GeneTests : PVR
     CGAP : PVR
     PMID : 2170108

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32698_at  -0.00  9.83e-1  9.89e-1  -0.60  5.77e-2  1.03e-1
 HG_U95  32699_s_at  0.25  2.07e-3  5.95e-3  0.13  1.88e-1  2.76e-1
 HG_U133A  212662_at  -0.05  5.10e-1  5.63e-1  2.08  1.71e-84  7.74e-84
 HG_U133A  214443_at  0.15  5.14e-2  7.13e-2  -1.82  4.12e-37  7.65e-37
 HG_U133A  214444_s_at  0.63  1.16e-7  3.29e-7  -1.36  3.25e-9  4.03e-9
 HG_U133A  216283_s_at  0.21  7.27e-2  9.78e-2  -1.04  2.59e-11  3.31e-11
 HG_U133A  32699_s_at  -0.00  9.89e-1  9.90e-1  4.68  4.95e-126  7.10e-125
 HG_U133_Plus2  1556582_at  0.09  2.61e-1  3.45e-1  0.22  2.08e-2  3.20e-2
 HG_U133_Plus2  212662_at  -0.55  6.68e-7  3.11e-6  -0.90  1.13e-11  6.04e-11
 HG_U133_Plus2  214443_at  0.40  2.68e-2  4.88e-2  0.43  4.61e-2  6.64e-2
 HG_U133_Plus2  214444_s_at  0.22  1.26e-1  1.87e-1  -0.07  6.89e-1  7.35e-1
 HG_U133_Plus2  216283_s_at  0.31  1.39e-1  2.02e-1  -0.42  8.89e-2  1.21e-1
 HG_U133_Plus2  32699_s_at  0.84  3.11e-11  2.63e-10  1.21  4.92e-12  2.76e-11
 Agilent_HS_21.6K  6652  0.01  6.86e-1  8.12e-1  0.01  7.07e-1  8.08e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212662_at  0.15  6.88e-1  9.67e-1  -0.24  1.91e-1  1.00e+0
 HG_U133A  214443_at  0.08  7.96e-1  9.82e-1  0.11  5.78e-1  1.00e+0
 HG_U133A  214444_s_at  0.12  7.89e-1  9.81e-1  -0.12  7.03e-1  1.00e+0
 HG_U133A  216283_s_at  -0.27  5.70e-1  9.45e-1  0.12  6.30e-1  1.00e+0
 HG_U133A  32699_s_at  -0.21  2.66e-1  8.61e-1  -0.14  2.12e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32698_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 32699_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212662_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214443_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214444_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216283_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 32699_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1556582_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212662_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214443_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214444_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216283_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 32699_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6652    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd155 neuroectodermal tumors Its function in adults is as yet unknown, but significantly, CD155 is aberrantly expressed in neuroectodermal tumors. 11983699 Human
cd155 neuroectodermal tumors These data identify the CD155 gene as a transcriptional target of Shh, a finding that has significance for the normal function of CD155 during development and the expression of CD155 in neuroectodermal tumors. 11983699 Human
tage4 colon tumors The Tage4 gene (Tumor-Associated Glycoprotein E4) is a member of the immunoglobulin superfamily overexpressed in rat colon tumors and Min mouse intestinal adenomas. 11255021 Rat
tage4 adenomas The Tage4 gene (Tumor-Associated Glycoprotein E4) is a member of the immunoglobulin superfamily overexpressed in rat colon tumors and Min mouse intestinal adenomas. 11255021 Mouse
cd155 human colorectal carcinoma Overexpression of the CD155 gene in human colorectal carcinoma. 11454801 Human
tage4 tumours BACKGROUND AND AIMS: The Tage4 gene (tumour associated glycoprotein E4) is overexpressed in rat colon tumours and Min mouse intestinal adenomas. 11454801 Rat
tage4 adenomas BACKGROUND AND AIMS: The Tage4 gene (tumour associated glycoprotein E4) is overexpressed in rat colon tumours and Min mouse intestinal adenomas. 11454801 Human
tage4 tumour BACKGROUND AND AIMS: The Tage4 gene (tumour associated glycoprotein E4) is overexpressed in rat colon tumours and Min mouse intestinal adenomas. 11454801 Rat
cd155 human colorectal carcinomas We therefore investigated expression of the CD155 gene in human colorectal carcinomas. 11454801 Human
cd155 adenocarcinomas METHODS: Overall CD155 expression was assessed by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical analysis using tissue specimens from patients with colorectal adenomas and adenocarcinomas. 11454801 Human
cd155 colorectal adenomas METHODS: Overall CD155 expression was assessed by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical analysis using tissue specimens from patients with colorectal adenomas and adenocarcinomas. 11454801 Human
cd155 colorectal cancer RESULTS: mRNA levels of CD155 were increased in six of six colorectal cancer tissues compared with the tumour free colon mucosa. 11454801 Human
cd155 cancer The qualitative RT-PCR assay revealed that relative expression of the different CD155 variant transcripts was similar in the different normal and cancer samples tested, indicating that this overexpression is not associated with a particular mRNA variant g 11454801 Human
cd155 colorectal carcinoma CONCLUSION: We have shown for the first time that the CD155 gene is overexpressed in colorectal carcinoma and that this overexpression begins at an early stage in tumorigenesis and continues to late stages. 11454801 Human
cd155 neoplasms Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. 10841575 Human
poliovirus receptor neoplasms Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. 10841575 Human
cd155 malignant glioma Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. 10841575 Human
poliovirus receptor malignant glioma Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. 10841575 Human
necl-5 metastasis We furthermore show here that enhanced motility and metastasis of V12Ras-NIH3T3 cells are at least partly the result of up-regulated Necl-5. 14871893 Human
tage4 adenomas The corresponding Tage4 gene (tumor-associated glycoprotein E4) is also expressed in rat colon tumors induced by 1,2-dimethylhydrazine and in Min mouse intestinal adenomas. 9538119 Mouse
tage4 colon tumors The corresponding Tage4 gene (tumor-associated glycoprotein E4) is also expressed in rat colon tumors induced by 1,2-dimethylhydrazine and in Min mouse intestinal adenomas. 9538119 Rat
pvr mouse neuroblastoma To determine whether CD44 is involved in poliovirus infection, we analyzed the replication of all three serotypes of poliovirus in human neuroblastoma cells which lack or express CD44 and in mouse neuroblastoma cells which lack Pgp-1, the mouse homolog of 9060634 Mouse
pvr human neuroblastoma To determine whether CD44 is involved in poliovirus infection, we analyzed the replication of all three serotypes of poliovirus in human neuroblastoma cells which lack or express CD44 and in mouse neuroblastoma cells which lack Pgp-1, the mouse homolog of 9060634 Human
pvr human neuroblastoma Furthermore, the binding affinity constants of all three poliovirus serotypes for Pvr are unaffected by the presence or absence of CD44 in the human neuroblastoma cell line. 9060634 Human
cd155 neuroblastoma Poliovirus-induced apoptosis is reduced in cells expressing a mutant CD155 selected during persistent poliovirus infection in neuroblastoma cells. 12477887 Human
tage4 adenomas Here, we analyze expression of the mouse Tage4 gene in Min mouse intestinal adenomas. 8980189 Human
tage4 adenomas Furthermore, Tage4 mRNA was detected in a series of mouse intestinal adenomas by in situ hybridization. 8980189 Mouse
cd155 mouse neuroblastoma In a heterologous coculture system with CD155 expressing mouse neuroblastoma cells, HeLa cell-expressed nectin-3 was recruited to contact sites with CD155 bearing neurites. 12759359 Mouse
tage4 colon carcinoma We examined here whether Tage4, which was originally identified to be a gene overexpressed in colon carcinoma and has a domain structure similar to those of nectins, is involved in cell adhesion and/or migration. 12740392 Human
cd155 glial neoplasms Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. 10841575 Human
cd155 tumor We demonstrated recently that DNAM-1 triggers NK cell-mediated killing of tumor cells upon engagement by its two ligands, poliovirus receptor (PVR; CD155) and Nectin-2 (CD112). 15136589 Human
cd155 tumors Efficacious oncolysis mediated by poliovirus derivatives depends on the presence of CD155 in targeted tumors. 15279713 Human
cd155 malignant glioma To prepare oncolytic polioviruses for clinical application, we have developed a series of assays in high-grade malignant glioma (HGL) to characterize CD155 expression levels and susceptibility to oncolytic poliovirus recombinants. 15279713 Human
cd155 tumors Analysis of 6 HGL cases indicates that CD155 is expressed in these tumors and in primary cell lines derived from these tumors. 15279713 Human
cd155 tumors Upregulation of the molecular target CD155 rendered explant cultures of all studied tumors highly susceptible to a prototype oncolytic poliovirus recombinant. 15279713 Human
cd155 carcinoma Necl-5/Tage4/poliovirus receptor/CD155 has been shown to be the poliovirus receptor and to be up-regulated in rodent and human carcinoma. 15213219 Human
cd155 breast cancer We evaluated CD155 expression in several human breast tumor tissue specimens and cultured breast cancer cell lines. 15269159 Human
cd155 breast tumor We evaluated CD155 expression in several human breast tumor tissue specimens and cultured breast cancer cell lines. 15269159 Human
cd155 breast cancer RESULTS: We observed that breast cancer tissues and cell lines derived thereof express CD155 at levels mediating exquisite sensitivity toward PV-induced oncolysis in the latter. 15269159 Human
cd155 breast cancer An association with the immunoglobulin superfamily molecule CD155 renders breast cancer a likely target for oncolytic PV recombinants. 15269159 Human
cd155 tumor RESULTS: Using this screen, we have identified CD155 (the poliovirus receptor) as a mediator of tumor cell invasion through its role in migration. 15471548 Human
cd155 fibrosarcoma Knockdown of CD155 by FALI or by RNAi resulted in a significant decrease in transwell migration of HT1080 fibrosarcoma cells towards a serum chemoattractant. 15471548 Human
cd155 primary tumors CD155 was found to be highly expressed in multiple cancer cell lines and primary tumors including glioblastoma (GBM). 15471548 Human
cd155 glioblastoma CD155 was found to be highly expressed in multiple cancer cell lines and primary tumors including glioblastoma (GBM). 15471548 Human
cd155 cancer CD155 was found to be highly expressed in multiple cancer cell lines and primary tumors including glioblastoma (GBM). 15471548 Human
cd155 tumor CONCLUSION: These results implicate a role for CD155 in mediating tumor cell invasion and migration and suggest that CD155 may contribute to tumorigenesis. 15471548 Human
cd155 tumor PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. 15607800 Human
cd155 lymphoblastic leukemias Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). 15536144 Human
cd155 carcinoma Necl-5/Tage4/poliovirus receptor/CD155 is the poliovirus receptor and upregulated in rodent and human carcinoma. 15688018 Human
poliovirus receptor glial neoplasms Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. 10841575 Human
poliovirus receptor tumor We demonstrated recently that DNAM-1 triggers NK cell-mediated killing of tumor cells upon engagement by its two ligands, poliovirus receptor (PVR; CD155) and Nectin-2 (CD112). 15136589 Human
poliovirus receptor glioma Poliovirus receptor CD155-targeted oncolysis of glioma. 15279713 Human
poliovirus receptor carcinoma Necl-5/Tage4/poliovirus receptor/CD155 has been shown to be the poliovirus receptor and to be up-regulated in rodent and human carcinoma. 15213219 Human
poliovirus receptor tumor RESULTS: Using this screen, we have identified CD155 (the poliovirus receptor) as a mediator of tumor cell invasion through its role in migration. 15471548 Human
poliovirus receptor lymphoblastic leukemias Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). 15536144 Human
poliovirus receptor myeloid leukemias Analysis of the ligands for triggering NK receptors revealed the consistent expression of Poliovirus receptor (PVR) and Nectin-2 in myeloid leukemias. 15536144 Human
poliovirus receptor carcinoma Necl-5/Tage4/poliovirus receptor/CD155 is the poliovirus receptor and upregulated in rodent and human carcinoma. 15688018 Human
pvr tumors As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. 15034010 Human
pvr tumor We demonstrated recently that DNAM-1 triggers NK cell-mediated killing of tumor cells upon engagement by its two ligands, poliovirus receptor (PVR; CD155) and Nectin-2 (CD112). 15136589 Human
pvr tumor Moreover, monoclonal antibody-mediated masking of either DNAM-1 (on NK cells) or PVR (on neuroblasts) resulted in strong inhibition of tumor cell lysis. 15604290 Human
pvr neuroblastomas Thus, assessment of the PVR surface levels may represent a novel useful criterion to predict the susceptibility/resistance of neuroblastomas to NK-mediated killing. 15604290 Human
pvr tumor PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. 15607800 Human
pvr tumor Importantly, the specific interaction between DNAM-1 (in NK cells) and PVR or Nectin-2 (in target cells) enhanced the NK-mediated lysis of tumor cells that was downregulated by mAb-mediated masking of the receptor or its ligands. 15607800 Human
pvr myeloid leukemias Analysis of the ligands for triggering NK receptors revealed the consistent expression of Poliovirus receptor (PVR) and Nectin-2 in myeloid leukemias. 15536144 Human
pvr lymphoblastic leukemias The expression of PVR and/or Nectin-2 was less frequent in lymphoblastic leukemias. 15536144 Human
tage4 colon tumours BACKGROUND AND AIMS: The Tage4 gene (tumour associated glycoprotein E4) is overexpressed in rat colon tumours and Min mouse intestinal adenomas. 11454801 Rat

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