IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PVRL2 Ensembl ENSG00000130202 Chromosome 19 Start 50041233 End 50084325
Description Poliovirus receptor-related protein 2 Precursor (Herpes virus entry mediator B)(HveB)(Nectin-2)(CD112 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q92692]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9707
     Entrez Gene : 5819
     UCSC : uc002ozw.1
     GeneCards : 9707
     RefSeq : NM_001042724
     CCDS : CCDS12645.1
     Uniprot : Q92692
     Interpro : Q92692
     OMIM : 600798
     GeneTests : PVRL2
     CGAP : PVRL2
     PMID : 7622062

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32156_at  0.06  4.70e-1  5.75e-1  -0.36  5.22e-4  1.74e-3
 HG_U133A  203149_at  0.08  1.36e-1  1.73e-1  -4.00  2.92e-92  1.61e-91
 HG_U133_Plus2  203149_at  0.15  6.22e-2  1.02e-1  0.05  6.24e-1  6.76e-1
 HG_U133_Plus2  225418_at  0.35  1.45e-4  4.46e-4  -0.17  4.05e-2  5.89e-2
 HG_U133_Plus2  232078_at  0.73  3.28e-4  9.43e-4  0.34  1.47e-1  1.90e-1
 HG_U133_Plus2  232079_s_at  0.62  1.78e-5  6.51e-5  0.32  2.33e-2  3.55e-2
 HG_U133_Plus2  243187_at  -0.04  8.23e-1  8.67e-1  0.04  8.02e-1  8.35e-1
 Stanford  20972  0.31  3.80e-1  5.79e-1  0.58  1.06e-1  2.84e-1
 Agilent_HS_21.6K  11592  -0.05  5.06e-1  6.80e-1  -0.20  8.04e-3  3.01e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203149_at  -0.24  2.25e-1  8.44e-1  0.05  7.22e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32156_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203149_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203149_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225418_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232078_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232079_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243187_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20972    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11592    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hveb melanoma The human herpesvirus entry (Hve) receptors (HveA, HveB, and HveC) and a control plasmid were transfected into B78H1 murine melanoma cells. 11237672 Human
cd112 tumor We demonstrated recently that DNAM-1 triggers NK cell-mediated killing of tumor cells upon engagement by its two ligands, poliovirus receptor (PVR; CD155) and Nectin-2 (CD112). 15136589 Human

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