IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene APOE Ensembl ENSG00000130203 Chromosome 19 Start 50100879 End 50104489
Description Apolipoprotein E Precursor (Apo-E) [Source:UniProtKB/Swiss-Prot;Acc:P02649]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 613
     Entrez Gene : 348
     UCSC : uc002pab.2
     GeneCards : 613
     RefSeq : NM_000041
     CCDS : CCDS12647.1
     Uniprot : P02649
     Interpro : P02649
     OMIM : 107741
     GeneTests : APOE
     CGAP : APOE
     PMID : 10662539

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  608_at  0.58  8.17e-3  1.96e-2  -0.22  4.75e-1  5.79e-1
 HG_U133A  203381_s_at  0.56  1.13e-4  2.33e-4  -1.59  3.53e-28  5.78e-28
 HG_U133A  203382_s_at  0.09  4.24e-1  4.80e-1  -2.34  1.70e-60  4.63e-60
 HG_U133A  212884_x_at  0.29  8.92e-3  1.41e-2  0.22  6.80e-2  7.21e-2
 HG_U133_Plus2  203381_s_at  0.04  7.98e-1  8.46e-1  -0.20  3.56e-1  4.17e-1
 HG_U133_Plus2  203382_s_at  0.02  8.97e-1  9.24e-1  -0.14  5.34e-1  5.92e-1
 HG_U133_Plus2  212884_x_at  0.12  3.59e-1  4.49e-1  0.15  3.37e-1  3.98e-1
 Stanford  3654  0.30  3.05e-1  5.08e-1  0.03  9.53e-1  9.80e-1
 Stanford  18942  -1.10  7.32e-3  5.26e-2  -0.31  5.11e-1  7.24e-1
 Agilent_HS_21.6K  18695  -0.22  1.07e-1  2.47e-1  -0.35  5.94e-3  2.35e-2

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203381_s_at  1.10  3.86e-2  7.08e-1  -0.59  1.17e-1  1.00e+0
 HG_U133A  203382_s_at  0.79  4.87e-2  7.08e-1  -0.33  3.17e-1  1.00e+0
 HG_U133A  212884_x_at  0.69  4.89e-2  7.08e-1  -0.19  4.66e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 608_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203381_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203382_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212884_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203381_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203382_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212884_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3654    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18942    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18695    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
apoe astrocytoma Here, we demonstrate that, starting around day 2 of growth arrest, both apoD and apoE mRNA levels increase between 1.5- and 27-fold in other cell types, including mouse primary fibroblasts and fibroblast-like and human astrocytoma cell lines. 11711530 Human
apoe familial adenomatous polyposis Our studies on candidate genes of eye diseases in the Chinese population in Hong Kong include MYOC and TISR for primary open angle glaucoma, RHO and RP1 for retinitis pigmentosa, ABCA4 and APOE for age-related macular degeneration, RB1 for retinoblastoma, 11857735 Human
apoe retinoblastoma Our studies on candidate genes of eye diseases in the Chinese population in Hong Kong include MYOC and TISR for primary open angle glaucoma, RHO and RP1 for retinitis pigmentosa, ABCA4 and APOE for age-related macular degeneration, RB1 for retinoblastoma, 11857735 Human
apolipoprotein e neointimal hyperplasia Both apolipoprotein E and immune deficiency exacerbate neointimal hyperplasia after vascular injury in mice. 11884289 Mouse
apoe tumor Frequently overexpressed genes (tumor/normal ratio > 2) were COL1A1 (percentage of cases with overexpression, 78.3%), CDH17 (73.9%), APOC1 (67.4%), COL1A2 (58.7%), YF13H12 (52.2%), CEACAM6 (50.0%), APOE (50.0%), REGIV (47.8%), S100A11 (41.3%), and FUS (41 15059891 Human
apoe lymph-node metastasis Among these genes, mRNA expression levels of CDH17 and APOE were associated with depth of tumor invasion (P = 0.0060 and P = 0.0139, respectively), and those of FUS and APOE were associated with degree of lymph node metastasis (P = 0.0416 and P = 0.0006, 15059891 Human
apoe tumor Among these genes, mRNA expression levels of CDH17 and APOE were associated with depth of tumor invasion (P = 0.0060 and P = 0.0139, respectively), and those of FUS and APOE were associated with degree of lymph node metastasis (P = 0.0416 and P = 0.0006, 15059891 Human
apoe mouse neuroblastoma We confirm the finding: in mouse neuroblastoma cells truncated apoE fragments lacking the carboxyterminus induce structures that have the appearance of neurofibrillary tangles. 11997703 Mouse
apoe astrocytoma The inverse relationship between apoE monomer concentration and CSF lipoprotein delivery was duplicated in SK-N-BE(2)C cells, but not human astrocytoma cells, using artificial lipid particles and purified human apoE. 12214015 Human
apolipoprotein e colorectal adenomas Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men. 11166913 Human
apolipoprotein e colorectal adenomas We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. 11166913 Human
apolipoprotein e human hepatoma Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2. 11223871 NA
apoe human hepatoma We used the human hepatoma cell line KYN-2 to better delineate the characteristics of apoE secretion and to validate it with respect to the classical human hepatoma cell line HepG2. 11223871 NA
apoe astrocytoma The response of KYN-2 cells to both cytokines and cholesterol differs from that found in astrocytoma cells, suggesting that blood variations of apoE concentrations in AD may not reflect the dysregulations taking place in the brain. 11223871 NA
apoe glioblastoma Cotransfection of Zic1 and Zic2 expression vector and different APOE promoter-luciferase reporter constructs in U87 glioblastoma cell line showed that the three binding sites partially contributed to the trans-stimulation of the luciferase reporter. 11038359 Human
apoe tumour In addition, tumour cells of various origins overexpress the low density lipoprotein (LDL) receptor that recognises apolipoprotein E (apoE) on small triglyceride-rich particles and apoB-100 on LDL. 11311995 NA
apolipoprotein e tumour In addition, tumour cells of various origins overexpress the low density lipoprotein (LDL) receptor that recognises apolipoprotein E (apoE) on small triglyceride-rich particles and apoB-100 on LDL. 11311995 NA
apolipoprotein e polycystic-ovary syndrome Apolipoprotein E alleles in women with polycystic ovary syndrome. 11334897 Human
apoe polycystic-ovary syndrome OBJECTIVE: To investigate the frequency of apoE alleles among women with polycystic ovary syndrome. 11334897 Human
apoe polycystic-ovary syndrome CONCLUSION(S): The observed profiles of allele and genotype frequencies confirm the equilibrium state between apoE polymorphism and polycystic ovary syndrome and suggest that apoE does not play a major role in the development of hyperlipidemia in the grou 11334897 Human
apoe tumours Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype. 11489139 Human
apoe tumours The distribution of ApoE genotypes was similar among those tumours that contained tau-associated neuropathology and those that did not. 11489139 Human
apoe tumours GVD, tau-positive NFT and NPT, and argentophilic bodies occur more often in ganglion cell tumours from patients over 30-yrs-old, but do not appear to be associated with a specific ApoE genotype. 11489139 Human
apoe basal-cell carcinoma OBJECTIVES: To determine whether the apoE epsilon4 allele is associated with increased risk of PCA and whether apoE and apoA-I are present in PCA and common secondary cutaneous amyloidosis (SCA) (i.e. basal cell carcinoma, Bowen's disease and seborrh 11531831 Human
apolipoprotein e tumors Whereas the latter group of tumors expressed some proapoptotic genes, tumors with high FAS levels overexpressed, among other genes, its transcriptional regulator, steroid regulator binding protein, and apolipoprotein E. 12939396 Human
apolipoprotein e astrocytoma Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1. 11693580 Human
apolipoprotein e prostate cancer The apolipoprotein E epsilon4 allele is no risk factor for prostate cancer in the Norwegian population. 11720484 Human
apolipoprotein e breast cancer Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk. 10642431 Human
apoe breast cancer In this case-control study we examined whether apoE genotype affected the association between serum lipids and breast cancer risk. 10642431 Human
apoe neointimal hyperplasia In addition, overexpression of the apoE gene also reduces neointimal hyperplasia in mice after endothelial denudation. 15161645 Mouse
apoe neointimal hyperplasia The vascular accumulation of apoE after endothelial denudation, and its association with alpha-actin-depleted smooth muscle cells, suggest that apoE inhibition of injury-induced neointimal hyperplasia is not due to the inhibition of injury-induced smooth 15161645 Human
apolipoprotein e astrocytoma Effects of pro-inflammatory cytokines on apolipoprotein E secretion by a human astrocytoma cell line (CCF-STTG1). 10686578 Human
apolipoprotein e central nervous system tumors Apolipoprotein E polymorphism and central nervous system tumors: correlation with cell proliferation indices and clinical outcome. 10774944 Human
apoe tumor AIMS: This study was designed to determine whether the polymorphism of apolipoprotein E (apoE), one of the key regulatory proteins in cholesterol metabolism, is related to varying susceptibility to central nervous system (CNS) neoplasms, and to evaluate a 10774944 Human
apolipoprotein e tumor AIMS: This study was designed to determine whether the polymorphism of apolipoprotein E (apoE), one of the key regulatory proteins in cholesterol metabolism, is related to varying susceptibility to central nervous system (CNS) neoplasms, and to evaluate a 10774944 Human
apoe tumors There was a non-significant trend for apoE epsilon2 allele carriers to have high-grade tumors and apoE epsilon4 allele carriers to have low-grade tumors. 10774944 Human
apoe low-grade tumors There was a non-significant trend for apoE epsilon2 allele carriers to have high-grade tumors and apoE epsilon4 allele carriers to have low-grade tumors. 10774944 Human
apoe neoplasms CONCLUSIONS: These preliminary findings suggest that possession of apoE epsilon4 allele may correspond to a more favorable clinical course in terms of more advanced age of disease presentation, and longer duration of follow-up and survival in patients wit 10774944 Human
apolipoprotein e human neuroblastoma Effect of apolipoprotein E on cell viability in a human neuroblastoma cell line: influence of oxidation and lipid-association. 10806314 Human
apoe human neuroblastoma We evaluated the effects of apoE oxidation and lipid-association on the viability of human neuroblastoma IMR32 cells. 10806314 Human
apolipoprotein e xanthoma Apolipoprotein E accelerates the efflux of cholesterol from macrophages: mechanism of xanthoma formation in apolipoprotein E deficiency. 10870678 Human
apolipoprotein e xanthoma Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice. 11030760 Human
apoe xanthoma Intramuscular plasmid injection in apoE(-/-) mice, which develop spontaneous atherosclerotic plaque and xanthoma resulted in expression and secretion of apoE. 11030760 Human
apoe astrocytoma Lack of apoE secretion was found in three astrocytoma cell lines, human T98G, rat C6, and GA-1 [Kano-Tanaka et al. 11056397 Human
apolipoprotein e prostate cancer Apolipoprotein E phenotype, cholesterol and breast and prostate cancer. 11076992 Human
apoe human teratocarcinoma The presence of apoE was investigated in undifferentiated human teratocarcinoma NT2/D1 (NT2) cells and during their differentiation into postmitotic hNT neurons induced by retinoic acid (RA) treatment. 11085906 Human
apoe ovarian cancer Interestingly, both apolipoprotein E (ApoE) and ApoJ, two proteins involved in lipid homeostasis, are among the genes highly up-regulated in ovarian cancer. 11103784 Human
apolipoprotein e ovarian cancer Interestingly, both apolipoprotein E (ApoE) and ApoJ, two proteins involved in lipid homeostasis, are among the genes highly up-regulated in ovarian cancer. 11103784 Human
apolipoprotein e breast carcinoma Apolipoprotein E polymorphism and breast carcinoma: correlation with cell proliferation indices and clinical outcome. 11110053 Human
apoe carcinoma of the colon There is preliminary evidence that polymorphism of apolipoprotein E (apoE, protein; APOE, gene), one of the key regulatory proteins in cholesterol metabolism, influences the pathobiology of carcinoma of the colon, prostate and breast and also primary tumo 11110053 Human
apolipoprotein e carcinoma of the colon There is preliminary evidence that polymorphism of apolipoprotein E (apoE, protein; APOE, gene), one of the key regulatory proteins in cholesterol metabolism, influences the pathobiology of carcinoma of the colon, prostate and breast and also primary tumo 11110053 Human
apoe carcinoma of the breast This study was designed to determine whether APOE polymorphism is related to variation in the rate of tumour cell proliferation and clinical outcome in carcinoma of the breast. 11110053 Human
apoe tumour This study was designed to determine whether APOE polymorphism is related to variation in the rate of tumour cell proliferation and clinical outcome in carcinoma of the breast. 11110053 Human
apoe carcinoma of the breast Although there is evidence to suggest that APOE epsilon4 may predispose to the development of carcinoma of the breast our data do not support the hypothesis that APOE genotype influences the rate of tumour cell proliferation or the clinical course. 11110053 Human
apoe tumour Although there is evidence to suggest that APOE epsilon4 may predispose to the development of carcinoma of the breast our data do not support the hypothesis that APOE genotype influences the rate of tumour cell proliferation or the clinical course. 11110053 Human
apolipoprotein e neointimal hyperplasia Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice. 11106557 Mouse
apoe neointimal hyperplasia The human apoE3 transgenic mice in FVB/N genetic background were then used to verify a direct effect of apoE in protection against neointimal hyperplasia in response to mechanically induced vascular injury. 11106557 Mouse
apolipoprotein e cancer Association between apolipoprotein E genotypes and cancer risk in patients with acquired immunodeficiency syndrome. 11129992 Human
apoe cancers Our study thus indicates that apoE genotype affects the development of cancers among AIDS patients. 11129992 Human
apolipoprotein e human hepatoma Part I. A stimulant of apolipoprotein E secretion in human hepatoma G2 cells. 11217804 Human
apolipoprotein e human hepatoma Analogs of N-4909 (1), which had a stimulating activity for apolipoprotein E (apo E) secretion in Human hepatoma Hep G2 cells, were prepared and their activities examined. 11217804 Human
apoe astrocytoma We report here that small molecule ligands that activate either liver X receptors (LXR) or retinoid X receptor (RXR) lead to a dramatic increase in apoE mRNA and protein expression as well as secretion of apoE in a human astrocytoma cell line (CCF-STTG1 c 14720212 Human
apoe human hepatoma To evaluate current models concerning apoE's role in remnant lipoprotein clearance by the liver, we performed a detailed and quantitative pulse-chase analysis of apoE secretion, subcellular distribution, and proteolytic degradation by the human hepat 9869648 Human
apoe lewis lung carcinoma We tested this hypothesis by evaluating the growth of Lewis lung carcinoma in three different murine models of hypercholesterolemia: Pluronic treated mice, apolipoprotein E (ApoE) deficient mice, and low density lipoprotein receptor (LDL-R) deficient mice 10049716 Human
apolipoprotein e lewis lung carcinoma We tested this hypothesis by evaluating the growth of Lewis lung carcinoma in three different murine models of hypercholesterolemia: Pluronic treated mice, apolipoprotein E (ApoE) deficient mice, and low density lipoprotein receptor (LDL-R) deficient mice 10049716 Human
apoe tumor Accumulation of chylomicrons, very low density lipoproteins (VLDL), and cholesterol-enriched remnants in the Pluronic treated mice and ApoE deficient mice did not inhibit tumor growth, even though mice in all three models were equally hypercholesterolemic 10049716 Mouse
apoe tumors We conclude that LAD-loaded apoE liposomes constitute a stable drug-carrier complex that is well suited for LDL receptor-mediated selective drug delivery to tumors. 10086980 Human
apoe xanthoma Phenotypes of SHL mice, however, were distinct from those of Apoetm1Unc (hereafter Apoe-/-) mice, whose Apoe gene was disrupted by homologous recombination; hypercholesterolemia and xanthoma were more severe in SHL mice than in Apoe-/- mice, while atheros 10087291 Mouse
apoe human neuroblastoma By in situ hybridization, we show the ability of human neuroblastoma SY 5Y cells to synthesize apolipoprotein E (apoE) mRNA. 10327190 Human
apolipoprotein e human neuroblastoma By in situ hybridization, we show the ability of human neuroblastoma SY 5Y cells to synthesize apolipoprotein E (apoE) mRNA. 10327190 Human
apolipoprotein e breast cancer Apolipoprotein E and the risk of breast cancer in African-American and non-Hispanic white women. 15138359 Human
apolipoprotein e neoplasms Immunohistochemical localization of apolipoprotein E in human glial neoplasms. 3392206 Human
apolipoprotein e intracranial neoplasms Immunocytochemical analyses revealed the presence and distribution of apolipoprotein E (apo E) in normal human brain tissue as well as in 77 human intracranial neoplasms. 3392206 Human
apolipoprotein e schwannoma Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. 3100319 Human
apolipoprotein e neurofibrosarcoma Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. 3100319 Human
apolipoprotein e neurofibromatosis Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. 3100319 Human
apolipoprotein e schwannoma Apolipoprotein E is expressed in neurofibrosarcoma and Schwannoma cell cultures derived from two patients with different types of neurofibromatosis, but not in six cell cultures derived from the benign neurofibromatosis neurofibromas. 3100319 Human
apolipoprotein e neurofibrosarcoma Apolipoprotein E is expressed in neurofibrosarcoma and Schwannoma cell cultures derived from two patients with different types of neurofibromatosis, but not in six cell cultures derived from the benign neurofibromatosis neurofibromas. 3100319 Human
apolipoprotein e neurofibromatosis Apolipoprotein E is expressed in neurofibrosarcoma and Schwannoma cell cultures derived from two patients with different types of neurofibromatosis, but not in six cell cultures derived from the benign neurofibromatosis neurofibromas. 3100319 Human
apolipoprotein e malignant astrocytoma In addition, a cell culture derived from a nonneurofibromatosis human malignant astrocytoma showed apolipoprotein E expression. 3100319 Human
apolipoprotein e schwannoma Although all cells in either the neurofibrosarcoma or Schwannoma cultures appeared morphologically similar (suggesting homogeneity), apolipoprotein E was immunochemically detected in the perinuclear region of only half of the cells. 3100319 Human
apolipoprotein e neurofibrosarcoma Although all cells in either the neurofibrosarcoma or Schwannoma cultures appeared morphologically similar (suggesting homogeneity), apolipoprotein E was immunochemically detected in the perinuclear region of only half of the cells. 3100319 Human
apolipoprotein e neurofibroma Thus, production of apolipoprotein E in neurofibromatosis-associated neurofibroma tumors may be a marker for a specific subclass of transformed cells. 3100319 Human
apolipoprotein e tumors Thus, production of apolipoprotein E in neurofibromatosis-associated neurofibroma tumors may be a marker for a specific subclass of transformed cells. 3100319 Human
apolipoprotein e embryonal carcinoma Expression of the murine apolipoprotein E gene is coupled to the differentiated state of F9 embryonal carcinoma cells. 3468509 Mouse
apoe embryonal carcinoma Apolipoprotein E (apoE) expression was studied in F9 embryonal carcinoma cells that differentiate in response to retinoic acid into cells resembling either parietal endoderm or visceral endoderm of the parietal or visceral yolk sac. 3468509 Mouse
apolipoprotein e embryonal carcinoma Apolipoprotein E (apoE) expression was studied in F9 embryonal carcinoma cells that differentiate in response to retinoic acid into cells resembling either parietal endoderm or visceral endoderm of the parietal or visceral yolk sac. 3468509 Mouse
apolipoprotein e human hepatoma First total synthesis of N-4909 and its diastereomer; a stimulant of apolipoprotein E secretion in human hepatoma Hep G2 cells. 10344569 Human
apolipoprotein e human hepatoma The R configuration of 3-hydroxy-13-methyltetradecanoic acid was found to be important for stimulating the activity of apolipoprotein E secretion in human hepatoma Hep G2 cells. 10344569 Human
apolipoprotein e cancer Other links between meat, cooking methods, metabolic genotypes and risk for cancer might include enhanced activation of polycyclic aromatic hydrocarbons and N-nitroso compounds by variant genotypes of CYP1A1 and CYP2E1, respectively, and modulation by mea 10443949 Human
apoe human hepatoma Functional effects of the polymorphisms, assayed by transient transfection and electrophoretic mobility shift assays in a human hepatoma cell line, showed that polymorphisms at sites -491 and -219 of the APOE promoter produce variations in the transcripti 9468288 Human
apoe tumor The greater efficacy of PDT in the ApoE deficient mice was associated with more rapid clearance of drug from the blood, greater accumulation of sensitizer in tumor tissue, and substantially greater drug binding to the very low density lipoprotein/low dens 9579539 Mouse
apoe tumor LAD-loaded emulsions and liposomes provided with recombinant apoE will be tested in the near future for their ability to deliver LAD to tumor tissue in vivo via the LDL receptor. 9587947 Human
apolipoprotein e human hepatoma The effect of cytokines on apolipoprotein E (apo E) production and secretion was investigated in a human hepatoma cell line HepG2. 9617572 Human
apolipoprotein e pituitary adenomas Basement membrane proteins, apolipoprotein E and glycosaminoglycans in pituitary adenomas and their correlation to amyloid. 9692822 Human
apolipoprotein e adenomas The aim of the study was to confirm earlier reports of the association of amyloid deposits in growth hormone (GH)-producing adenomas of the pituitary and the presence of glycosaminoglycans, basement membrane proteins and apolipoprotein E (apo E). 9692822 Human
apolipoprotein e human neuroblastoma Apolipoprotein E and Tau phosphorylation in human neuroblastoma cells. 9697924 Human
apoe cancer The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy. 12923801 Human
apoe breast cancer PURPOSE: The primary purpose of this study was to compare the neuropsychological performance of long-term survivors of breast cancer and lymphoma treated with standard dose chemotherapy who carried the epsilon 4 allele of the Apolipoprotein E (APOE) gene 12923801 NA
apolipoprotein e breast cancer PURPOSE: The primary purpose of this study was to compare the neuropsychological performance of long-term survivors of breast cancer and lymphoma treated with standard dose chemotherapy who carried the epsilon 4 allele of the Apolipoprotein E (APOE) gene 12923801 NA
apoe prostate cancer Possible relationship of the apolipoprotein E (ApoE) epsilon4 allele to prostate cancer. 9823988 Human
apolipoprotein e prostate cancer Possible relationship of the apolipoprotein E (ApoE) epsilon4 allele to prostate cancer. 9823988 Human
apoe tumours We conclude that apoE liposomes enable LDL receptor-mediated specific delivery of antineoplastic (pro)drugs to tumours, and, therefore, constitute an attractive novel option for anti-tumour chemotherapy. 9862571 Human
apolipoprotein e glioblastoma Involvement of apolipoprotein E in glioblastoma: immunohistochemistry and clinical outcome. 14561921 Human
apoe tumour We hypothesised that apolipoprotein E (apoE) influences brain tumours by delivery of lipids to tumour cells and by analogy with other brain insults. 14561921 Human
apolipoprotein e tumour We hypothesised that apolipoprotein E (apoE) influences brain tumours by delivery of lipids to tumour cells and by analogy with other brain insults. 14561921 Human
apoe brain tumour APOE gene analysis was performed for 126 glioblastomas, the commonest primary brain tumour. 14561921 Human
apoe tumour However, there was apoE immunoreactivity of tumour cells, macrophages in areas of necrosis and astrocytes nearby. 14561921 Human
apoe tumour The immunohistochemistry findings support the hypothesis that apoE is involved in the delivery of lipids to tumour cells and in the recycling of lipids by macrophages in necrotic areas, raising the possibility that apoE-mediated lipid transport may repres 14561921 Human
apoe monocytic leukemia Human monocytic leukemia cells, THP-1, and human monocyte-derived macrophages were exposed to various forms of oxidatively modified LDL for determination of their effect on apoE mRNA and protein levels. 9186915 Human
apoe b16 melanoma In vitro studies using B16 melanoma cells showed that the liposomes bound exclusively to the LDLr via their apoE moiety (90,000 liposomes/cell), with a 14-fold higher affinity (Kd = 0.77 +/- 0.09 nM) than LDL itself. 9281607 Human
apoe xanthomas Brains from 42 additional animals, fed only conventional chow, were examined; 3 of 15 aged (15- to 23-month-old) apoE knockout mice developed small choroidal xanthomas. 9358763 Mouse
apoe human neuroblastoma ApoE synthesis in human neuroblastoma cells. 9440124 Human
apoe hepatoma McArdle rat hepatoma cells (McA-RH7777), which secrete VLDL- and HDL-like particles, were stably transfected with these cDNAs, and the cDNAs for human apoE and human apoA-I. 8626391 Rat
apolipoprotein e carcinoma Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E phenotype? 8964404 Human
apolipoprotein e adenoma Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E phenotype? 8964404 NA
apolipoprotein e colorectal adenoma METHODS: Apolipoprotein E phenotype was determined in 135 patients with colorectal adenoma, 122 patients with colorectal carcinoma, and 199 randomly selected control subjects. 8964404 NA
apolipoprotein e colorectal carcinoma METHODS: Apolipoprotein E phenotype was determined in 135 patients with colorectal adenoma, 122 patients with colorectal carcinoma, and 199 randomly selected control subjects. 8964404 NA
apolipoprotein e carcinoma RESULTS: The frequency of the epsilon 4 allele of apolipoprotein E was low (0.075 and 0.073) in patients with proximal adenoma and those with carcinoma, respectively, compared with the control subjects (0.181) (P < 0.05). 8964404 Human
apolipoprotein e adenoma RESULTS: The frequency of the epsilon 4 allele of apolipoprotein E was low (0.075 and 0.073) in patients with proximal adenoma and those with carcinoma, respectively, compared with the control subjects (0.181) (P < 0.05). 8964404 Human
apolipoprotein e carcinoma CONCLUSIONS: The data suggest that the epsilon 4 allele of apolipoprotein E provides protection from the development of adenoma and carcinoma of the proximal colon. 8964404 Human
apolipoprotein e adenoma CONCLUSIONS: The data suggest that the epsilon 4 allele of apolipoprotein E provides protection from the development of adenoma and carcinoma of the proximal colon. 8964404 Human
apolipoprotein e colon cancer Apolipoprotein E polymorphism: another player in the genetics of colon cancer susceptibility? 8964432 Human
apoe xanthomas Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increased plasma residence time, or that their apolipoprotein E (apoE) content was abnormally elevated. 8725150 Human
apolipoprotein e xanthomas Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increased plasma residence time, or that their apolipoprotein E (apoE) content was abnormally elevated. 8725150 Human
apolipoprotein e localized prostate cancers Apolipoprotein E expression in localized prostate cancers. 12632068 Human
apoe prostatic intraepithelial neoplasias Prostatic intraepithelial neoplasias (PINs) adjacent to clinically manifested cancer were positive whereas more distant PINs were negative for ApoE. 12632068 Human
apoe human prostate cancers ApoE may represent a marker of more aggressive cells in human prostate cancers. 12632068 Human
apolipoprotein e astrocytoma Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells. 8922411 Human
apolipoprotein e human hepatoma Stimulation of apolipoprotein E secretion in human hepatoma Hep G2 cells by a cyclic acylpeptide, N-4909. 8931734 Human
apolipoprotein e xanthoma Apolipoprotein E deficiency leads to familial dysbetalipoproteinemia characterized by increases in serum lipid levels, atherosclerosis, and cutaneous xanthoma. 7829881 Human
apolipoprotein e xanthoma In the present study, we determined whether transgenic mice deficient in apolipoprotein E develop cutaneous xanthoma and the effect of dietary fat intake on these lesions. 7829881 Human
apoe hepatoma In addition to HepG2, we studied rat hepatoma McA-RH7777 cells for production of endogenous rat apoE and transfected human apoE3. 7749873 Rat
apoe hepatoma In both hepatoma cell lines stimulation of lipogenesis and production of large apoB-containing lipoproteins by serum resulted in increased apoE association with these particles and in decreased apoE association with HDL without affecting the total apoE ou 7749873 NA
apoe hepatoma These data suggest that the redistribution of apoE from HDL to apoB-containing lipoproteins upon activated lipogenesis in hepatoma cells occurs intracellularly and is not attributable to a decrease in HDL production. 7749873 NA
apoe metaplasia Finally, we observed widespread calcified cartilaginous metaplasia within spontaneous atherosclerotic lesions in mice targeted for a null mutation in the apoE gene, suggesting that cartilaginous metaplasia is a potential pathway for artery wall calcificat 7489252 Mouse
apolipoprotein e monocytic leukemia Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. 3855620 Human
apolipoprotein e acute monocytic leukemia A human cell line established from a patient of an acute monocytic leukemia (THP-1) retained an ability to synthesize and secrete plasma apolipoprotein E like protein. 3855620 Human
apolipoprotein e human hepatoma The human hepatoma cell line, Hep G2, has been used to compare the metabolism by isolated liver cells of purified isoforms of human apolipoprotein E (apo E). 6089844 Human
apoe hepatoma Effect of apoE on triglyceride emulsion interaction with hepatocyte and hepatoma G2 cells. 3625037 NA
apoe hepatoma Heparin inhibited the apoE stimulation in both hepatocytes and hepatoma monolayers. 3625037 NA
apolipoprotein e cancer Apolipoprotein E isoforms, serum cholesterol, and cancer. 2869248 Human
apolipoprotein e hepatoma As a positive control, apolipoprotein E doubled the uptake of labeled liposomes by hepatoma cells, compared to apolipoprotein-free controls, and this increase could be blocked by the addition of excess unlabeled low density lipoprotein. 2492020 NA
apolipoprotein e hepatoma Degradation of labeled liposomes by hepatoma cells was increased 6-fold by the addition of apolipoprotein E. 2492020 NA
apolipoprotein e malignant astrocytoma Immunohistochemistry of human malignant astrocytoma cells xenografted to rat brain: apolipoprotein E. 2710299 Human
apoe malignant astrocytoma Fresh human malignant astrocytoma cells (Grade 3 and 4) contained APOE and GFAP. 2710299 Human
apolipoprotein e breast cancer The apolipoprotein E epsilon 4 allele is not a risk factor for Turkish breast cancer patients. 14499704 Human
apoe glioma We established neural (HS683 human glioma) and non-neural (Chinese hamster ovary) cell culture systems that constitutively secrete both ApoE and Abeta at concentrations like those in human cerebrospinal fluid. betaAPP metabolites, generated in the presenc 9174001 Human
apoe xanthomas We observed two patients with hypercholesterolaemia and tendon xanthomas associated with apolipoprotein (apoE-7) E-7, a rare variant of the apoE isoforms. 8308480 Human
apoe hepatoma Cell culture media from hepatoma cells or mouse peritoneal macrophages, both of which contain apoE of cellular origin, also promoted efflux of [3H]cholesterol from fibroblasts into a gamma-migrating fraction. 8127890 Mouse
apolipoprotein e tumor Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation. 8200910 Human
apoe tumor Recombinant human apolipoprotein E3 (apoE), purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor cells in a dose- and time-dependent manner. 8200910 Human
apolipoprotein e3 tumor Recombinant human apolipoprotein E3 (apoE), purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor cells in a dose- and time-dependent manner. 8200910 Human
apoe melanoma ApoE also inhibited growth of bovine corneal endothelial cells, human melanoma cells, and human breast carcinoma cells. 8200910 Human
apoe human breast carcinoma ApoE also inhibited growth of bovine corneal endothelial cells, human melanoma cells, and human breast carcinoma cells. 8200910 Human
apoe tumor The present results demonstrate that apoE is a potent inhibitor of proliferation of several cell types and suggest that apoE may be effective in modulating angiogenesis, tumor cell growth, and metastasis. 8200910 Human
apoe metastasis The present results demonstrate that apoE is a potent inhibitor of proliferation of several cell types and suggest that apoE may be effective in modulating angiogenesis, tumor cell growth, and metastasis. 8200910 Human
apolipoprotein-e heavy chain deposition disease Although 100% of amyloid specimens (7 amyloid A, 15 immunoglobulin light chain, and 1 transthyretin) had amyloid P component and 100% had apolipoprotein-E (2 amyloid A, 10 immunoglobulin light chain, and 1 transthyretin) co-localized with the primary amyl 8080036 Human
apolipoprotein-e light chain deposition disease Although 100% of amyloid specimens (7 amyloid A, 15 immunoglobulin light chain, and 1 transthyretin) had amyloid P component and 100% had apolipoprotein-E (2 amyloid A, 10 immunoglobulin light chain, and 1 transthyretin) co-localized with the primary amyl 8080036 Human
apolipoprotein e-3 kaposi's sarcoma Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli, was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS-KS). 7525844 Human
apoe tumor A murine Leydig tumor cell line (I-10 cells) also demonstrated apoE immunoreactivity, suggesting that at least one source of interstitial apoE is the Leydig cell. 8439620 Mouse
apoe hepatoma We transfected the rat hepatoma cell line McA-RH7777 with apoE Leiden or normal human apoE3, and studied their secretion and media distribution. 8468528 Rat
apolipoprotein e colorectal cancer Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis. 12529167 Human
apoe tumours Likewise, the proportion of male patients with more advanced tumours (Dukes' C&D) was significantly increased among those with the ApoE epsilon 2/epsilon 3 genotype (OR = 4.16; 95% confidence interval 1.36-12.75). 12529167 Human
apoe human hepatoma 1. Hormonal regulation of apolipoprotein E (apoE) gene expression by insulin and thyroid hormone was studied in a human hepatoma cell line, HepG2. 8349006 NA
apolipoprotein e human hepatoma 1. Hormonal regulation of apolipoprotein E (apoE) gene expression by insulin and thyroid hormone was studied in a human hepatoma cell line, HepG2. 8349006 NA
apolipoprotein e meningiomas Samples of normal brain, two meningiomas, one medulloblastoma and seven astrocytomas were analyzed along with two glioma lines to determine the genic expression of apolipoprotein E, which in addition to its major function in lipid metabolism has been post 1608541 Human
apolipoprotein e glioma Samples of normal brain, two meningiomas, one medulloblastoma and seven astrocytomas were analyzed along with two glioma lines to determine the genic expression of apolipoprotein E, which in addition to its major function in lipid metabolism has been post 1608541 Human
apolipoprotein e glioma Messenger ribonucleic acid encoding apolipoprotein E was found to be expressed in significant amounts in all of the brain tumor specimens and in the normal brain, but in only one of the two glioma lines. 1608541 Human
apolipoprotein e astrocytoma Secretion of apolipoprotein E by an astrocytoma cell line. 1404494 NA
apoe astrocytoma As there are few data concerning the regulation of apoE gene expression in extrahepatic tissues, we employed a human astrocytoma cell line (CCF-STTG1) as a model to study apoE production in astrocytes. 1404494 NA
apoe astrocytoma Insulin (5 micrograms/ml) caused a 45-55% reduction in the amount of apoE secreted by the astrocytoma cells. 1404494 NA
apoe astrocytoma ApoE was secreted from the astrocytoma cells associated with particles of plasma VLDL to IDL and HDL size. 1404494 NA
apolipoprotein e human hepatoma The effect of 25-hydroxycholesterol on the regulation of apolipoprotein E mRNA levels and secretion in the human hepatoma HepG2. 1329783 Human
apolipoprotein e choriocarcinoma Synthesis and secretion of apolipoprotein E by human placenta and choriocarcinoma cell lines. 1666673 Human
apoe glasgow comas Univariate and multivariate analysis revealed no significant relationship in patients with the APOE-epsilon4 allele with regard to age, admission Glasgow Comas Scale score, contusion volume, type of neurosurgical management, and outcome. 12593615 Human
apoe secondary amyloidosis Studies have identified apolipoprotein E (apoE) ubiquitously in biochemically distinct amyloid deposits including amyloid A protein (AA) in secondary amyloidosis and amyloid beta protein (A beta) amyloid in Alzheimer's disease (AD). 9325076 Human
apoe secondary amyloidosis To determine if apoE is essential for and apoA-1 may be a factor in AA-amyloidogenesis we investigated induction of secondary amyloidosis in mutant C57BL/6J mice that lack either apoE or apoA-1. 9325076 Mouse
apoe necrosis Nevertheless, different studies on apoE immunoreactivity reported the presence of apoE in neurons of Alzheimer, control, and necrosis pontisubicular brains. 9440124 Human
apoe cns neoplasms CONCLUSIONS: These preliminary findings suggest that possession of apoE epsilon4 allele may correspond to a more favorable clinical course in terms of more advanced age of disease presentation, and longer duration of follow-up and survival in patients wit 10774944 Human
apoe necrosis APOE epsilon 2 has now been found to be associated with some of these vascular abnormalities, specifically a "double-barrel" appearance and fibrinoid necrosis. 10818505 Human
apoe primary tumours There is preliminary evidence that polymorphism of apolipoprotein E (apoE, protein; APOE, gene), one of the key regulatory proteins in cholesterol metabolism, influences the pathobiology of carcinoma of the colon, prostate and breast and also primary tumo 11110053 Human
apoe necrosis This experiment examined the effect of endogenous murine apoE on selective neuronal necrosis resulting from a transient forebrain ischemia insult. 10229753 Mouse
apoe necrosis Fibrinoid necrosis alone was associated with the APOE epsilon2 allele (p < 0.04) and we suggest that over-representation of APOE epsilon2 in CAAH may result from its association with fibrinoid necrosis. 10411341 Human
apoe cell tumours Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype. 11489139 Human
apoe cell tumours GVD, tau-positive NFT and NPT, and argentophilic bodies occur more often in ganglion cell tumours from patients over 30-yrs-old, but do not appear to be associated with a specific ApoE genotype. 11489139 Human
apoe bowen's disease OBJECTIVES: To determine whether the apoE epsilon4 allele is associated with increased risk of PCA and whether apoE and apoA-I are present in PCA and common secondary cutaneous amyloidosis (SCA) (i.e. basal cell carcinoma, Bowen's disease and seborrh 11531831 Human
apoe brain tumours We hypothesised that apolipoprotein E (apoE) influences brain tumours by delivery of lipids to tumour cells and by analogy with other brain insults. 14561921 Human
apoe glioblastomas APOE gene analysis was performed for 126 glioblastomas, the commonest primary brain tumour. 14561921 Human
apoe primary brain tumour APOE gene analysis was performed for 126 glioblastomas, the commonest primary brain tumour. 14561921 Human
apoe brain tumours The immunohistochemistry findings support the hypothesis that apoE is involved in the delivery of lipids to tumour cells and in the recycling of lipids by macrophages in necrotic areas, raising the possibility that apoE-mediated lipid transport may repres 14561921 Human
apoe liposarcoma Synthesis and secretion of apoC-I and apoE during maturation of human SW872 liposarcoma cells. 15514255 Human
apoe liposarcoma The aim of the present study, therefore, was to investigate the effect of different tissue culture conditions on the synthesis and secretion of apoC-I and apoE in human SW872 liposarcoma cells. 15514255 Human
apoe hyperplasia Using the mouse carotid artery flow cessation model, we show that there are differences in vessel remodeling in ADAMTS-1 transgenic/apoE-deficient mice compared with apoE deficiency alone, particularly a significant increase in intimal hyperplasia. 15539621 Mouse
apoe ovarian cancer Apolipoprotein E (ApoE) has been recently identified as a potential tumor-associated marker in ovarian cancer by serial analysis of gene expression. 15665311 Human
apoe ovarian cancer In this study, apoE expression was frequently detected in ovarian serous carcinomas, the most common and lethal type of ovarian cancer. 15665311 Human
apoe ovarian serous carcinomas In this study, apoE expression was frequently detected in ovarian serous carcinomas, the most common and lethal type of ovarian cancer. 15665311 Human
apoe ovarian cancer Inhibition of apoE expression using an apoE-specific siRNA led to G(2) cell cycle arrest and apoptosis in an apoE-expressing ovarian cancer cell line, OVCAR3, but not in apoE-negative cell lines. 15665311 Human
apoe ovarian cancer This study suggests a new role of apoE in cancer as apoE expression is important for the proliferation and survival in apoE-expressing ovarian cancer cells. 15665311 Human
apoe cancer This study suggests a new role of apoE in cancer as apoE expression is important for the proliferation and survival in apoE-expressing ovarian cancer cells. 15665311 Human
apoe cancer Statistically significant associations were noted between SNPs in beta-catenin and APOE and a positive family history of cancer (beta-catenin: p=0.034, APOE: p=0.033); tumor location and a DCC SNP (p=0.038) and the P53 R72P mutation and survival (p=0.0336 15523694 Human
apoe cancer In Ashkenazi patients, ERCC2 and MTHFR genes' SNPs were associated with age at diagnosis (ERCC2: p=0.025, MTHFR: p=0.0005); a P53 polymorphism, APOE and Rb SNPs with a family history of cancer (P53 p=0.034;APOE p=0.04, Rb p= 0.022); DCC SNP with tumo 15523694 Human
apoe cancer Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer's disease and cancer. 15830139 Human
apoe breast cancer We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. 15830139 Human
apoe breast cancer We found risk for breast cancer was associated with the APOE genotype (xi(2) = 8.652, p = 0.013). 15830139 Human
apoe breast cancer No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. 15830139 Human
apoe tumor No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. 15830139 Human
apoe breast cancer These results suggest that the APOE epsilon4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status. 15830139 Human
apoe astrocytoma In this report, we study the transcriptional activity of different APOE proximal promoter regions and their binding to nuclear proteins from human neural (astrocytoma and neuroblastoma) and peripheral (hepatoma and lymphoma) cell lines. 15931082 NA
apoe hepatoma In this report, we study the transcriptional activity of different APOE proximal promoter regions and their binding to nuclear proteins from human neural (astrocytoma and neuroblastoma) and peripheral (hepatoma and lymphoma) cell lines. 15931082 NA
apoe rectal cancer Associations between apoE genotype and colon and rectal cancer. 15817610 Human
apoe colorectal cancer Given the potential role of bile acids in colorectal cancer etiology, it is reasonable that colorectal cancer risk might be modified by apoE genotype. 15817610 Human
apoe colon cancer The absence of an e3 apoE allele significantly increased the risk of colon cancer (OR=1.37 95% CI 1.00-1.87), particularly among those diagnosed when older than 64 years (OR=1.88 95% CI 1.17-3.04; P interaction between age and apoE genotype equal to 0.05) 15817610 Human
apoe colorectal cancer A significant three-way interaction was detected for family history of colorectal cancer, age at diagnosis and apoE genotype (P = 0.05), in those diagnosed when older, not having an e3 allele and having a significantly increased risk of colon cancer with 15817610 Human
apoe colon cancer A significant three-way interaction was detected for family history of colorectal cancer, age at diagnosis and apoE genotype (P = 0.05), in those diagnosed when older, not having an e3 allele and having a significantly increased risk of colon cancer with 15817610 Human
apoe rectal cancer We did not detect any significant associations between apoE genotype and rectal cancer, survival after diagnosis with colorectal cancer, stage of disease at diagnosis or type of tumor mutation. 15817610 Human
apoe tumor We did not detect any significant associations between apoE genotype and rectal cancer, survival after diagnosis with colorectal cancer, stage of disease at diagnosis or type of tumor mutation. 15817610 Human
apoe colorectal cancer We did not detect any significant associations between apoE genotype and rectal cancer, survival after diagnosis with colorectal cancer, stage of disease at diagnosis or type of tumor mutation. 15817610 Human
apoe colon cancer These findings suggest those apoE genotypes that do not include the e3 allele, the same genotypes that are associated with increased risk of coronary heart disease, may influence development of colon cancer among those who are older at diagnosis. 15817610 Human
apoe neointimal hyperplasia This investigation explored the relationship between medial apoE recruitment and iNOS activation in protection against neointimal hyperplasia. 16061951 Human
apoe neointimal hyperplasia In contrast, overexpression of apoE in FVB/N mice activated iNOS expression in the injured vessels, resulting in protection against neointimal hyperplasia. 16061951 Mouse
apoe hyperplasia Moreover, both apoE and iNOS are necessary for the suppression of cell proliferation, and apoE recruitment without iNOS expression resulted in medial hyperplasia without cell migration to the intima. 16061951 Mouse
apoprotein liver cancer The binding of epidermal growth factor, asialoorosomucoid, and apoprotein E-rich lipoproteins to isolated hepatocytes was investigated at various time intervals during the step-by-step development of liver cancer in rats. 3038301 Human
apoprotein human hepatoma Regulation of apoprotein synthesis and secretion in the human hepatoma Hep G2. 2843542 Human
apoprotein human hepatoma To begin to identify the determinants of apoprotein synthesis and distribution among lipoprotein classes, we have examined the effects of chylomicron remnants which deliver triglyceride and cholesterol, and beta very low density lipoprotein (beta VLDL), w 2843542 Human
apoprotein xanthoma Xanthoma striatum palmare as an early sign of familial type III hyperlipoproteinemia with an apoprotein E genotype epsilon2/epsilon2. 12780724 Human
apolipoprotein e cancer Apolipoprotein E isoforms, serum cholesterol, and cancer. 15075136 Human
apolipoprotein e glial neoplasms Immunohistochemical localization of apolipoprotein E in human glial neoplasms. 3392206 Human
apolipoprotein e hyperplasia Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. 16061951 Mouse
apolipoprotein e prostatic cancer Hyper HDL cholesterolemias, excluding the patients with prostatic cancer who had undergone estrogen-treatment, showed elevated levels of apolipoprotein E in alpha 2-area on electrophoresis. 2262973 Human
apolipoprotein e secondary amyloidosis Studies have identified apolipoprotein E (apoE) ubiquitously in biochemically distinct amyloid deposits including amyloid A protein (AA) in secondary amyloidosis and amyloid beta protein (A beta) amyloid in Alzheimer's disease (AD). 9325076 Human
apolipoprotein e ovarian cancer Apolipoprotein e is required for cell proliferation and survival in ovarian cancer. 15665311 Human
apolipoprotein e ovarian cancer Apolipoprotein E (ApoE) has been recently identified as a potential tumor-associated marker in ovarian cancer by serial analysis of gene expression. 15665311 Human
apolipoprotein e ovarian neoplasms [Apolipoprotein E immunoreactivities in normal human ovary and ovarian neoplasms] An immunohistochemical study on localization of apoE in normal human ovary and various ovarian neoplasms was performed using polyclonal anti-human apoE antibody. 9492541 Human
apolipoprotein e myelofibrosis On the other hand, transgenic mice (Tg) overexpressing TPO using a liver-specific apolipoprotein E (Apo-E) promoter did not exhibit myelofibrosis or osteosclerosis. 15927672 Human
apolipoprotein e malignancy Alterations of lipoproteins occur in chronic inflammation and in malignancy with possible de novo synthesis of apolipoprotein E by tumor cells. 1517695 NA
apolipoprotein e mammary tumors Mammary tumors expressed apolipoprotein E mRNA. 8481894 Mouse
apolipoprotein e medulloblastoma Samples of normal brain, two meningiomas, one medulloblastoma and seven astrocytomas were analyzed along with two glioma lines to determine the genic expression of apolipoprotein E, which in addition to its major function in lipid metabolism has been post 1608541 Human
apolipoprotein e xanthomas Presence of palmar xanthomas in myotonic dystrophy identifies different patterns of linkage disequilibrium between the apolipoprotein E and myotonic dystrophy protein kinase loci. 15775763 Human
apoe tumourbearing We examined in B16 tumour-bearing mice the tumour-localizing properties of apoE liposomes and the disposition of an incorporated lipophilic derivative of daunorubicin (LAD). 9862571 Human
apoe tumourbearing The distribution patterns of LAD-loaded apoE liposomes and native LDL in the tumour-bearing mice were very similar, which supports the role of the LDL receptor in the disposition of the prodrug-loaded particles. 9862571 Mouse
apolipoprotein-e astrocytomas Although the role of apolipoprotein-E in the brain and in brain tumor growth remains undefined, it is clear that this gene is expressed in substantial amounts in a variety of brain tumors and is not specific for astrocytomas. 1608541 Human
apolipoprotein-e brain tumors Although the role of apolipoprotein-E in the brain and in brain tumor growth remains undefined, it is clear that this gene is expressed in substantial amounts in a variety of brain tumors and is not specific for astrocytomas. 1608541 Human
apolipoprotein-e brain tumor Although the role of apolipoprotein-E in the brain and in brain tumor growth remains undefined, it is clear that this gene is expressed in substantial amounts in a variety of brain tumors and is not specific for astrocytomas. 1608541 Human
apolipoprotein-e necrosis Transient expression of apolipoprotein-E in neonates with pontosubicular neuron necrosis. 8928616 Human
apolipoprotein-e necrosis An apolipoprotein-E (Apo-E) immunohistochemical study was performed on neonates with pontosubicular neuron necrosis (PSN), aged 38-42 weeks of gestation, and compared to findings for age-matched neonates without PSN. 8928616 Human
apolipoprotein e neoplasia This study was designed to determine whether the polymorphism of apolipoprotein E, one of the key regulatory proteins in cholesterol metabolism, is associated with proximal or distal colonic neoplasia. 8964404 Human
apolipoprotein e bladder tumor An interaction between apolipoprotein E and TERE1 with a possible association with bladder tumor formation. 15782423 Human
apolipoprotein e brain tumor Messenger ribonucleic acid encoding apolipoprotein E was found to be expressed in significant amounts in all of the brain tumor specimens and in the normal brain, but in only one of the two glioma lines. 1608541 Human
apolipoprotein e brain tumors Gene expression of apolipoprotein E in human brain tumors. 1608541 Human
apolipoprotein e brain tumours We hypothesised that apolipoprotein E (apoE) influences brain tumours by delivery of lipids to tumour cells and by analogy with other brain insults. 14561921 Human
apolipoprotein e breast cancer Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. 15830139 Human
apolipoprotein e brain cancer The identified proteins alpha1-antichymotrypsin and apolipoprotein E have been described in relation to Alzheimer's disease and brain cancer. 17274072 Human
apolipoprotein e xanthelasma The different types of serum lipoproteins, including apolipoprotein E phenotypes, were measured in 50 patients with xanthelasma. 3401027 Human
apolipoprotein e breast cancer Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese. 16752225 Human
apolipoprotein e breast cancer To display the association between the apolipoprotein E (APOE) genotypes and breast cancer patients, a cross sectional study including 291 patients and 148 controls was performed. 16752225 NA
apoe ovarian neoplasms [Apolipoprotein E immunoreactivities in normal human ovary and ovarian neoplasms] An immunohistochemical study on localization of apoE in normal human ovary and various ovarian neoplasms was performed using polyclonal anti-human apoE antibody. 9492541 Human
apoe tumours The present results show that an immunohistochemical study for apoE may be helpful for the diagnosis of steroid producing tumours. 9492541 Human
apoe adrenal tumor Vimentin-dependent utilization of LDL-cholesterol in human adrenal tumor cells is not associated with the level of expression of apoE, sterol carrier protein-2, or caveolin. 10428980 Human
apoe adrenal tumor These studies demonstrate that the difference in the capacity of these adrenal tumor cells that contain or lack vimentin filaments to esterify low density lipoprotein-cholesterol is not obviously associated with the level of expression or distribution of 10428980 Human
apoe basal cell carcinoma OBJECTIVES: To determine whether the apoE epsilon4 allele is associated with increased risk of PCA and whether apoE and apoA-I are present in PCA and common secondary cutaneous amyloidosis (SCA) (i.e. basal cell carcinoma, Bowen's disease and seborrh 11531831 Human
apoe transitional cell carcinoma (tcc) We found that there was ubiquitous expression of the apoE transcript in normal bladder and in various grades and stages of transitional cell carcinoma (TCC) of the bladder. 15782423 Human
apoe cancer In this study, we tested if apoE 133-162 also has anti-tumor activity against several cancer cell lines. 15796184 Human
apoe cancer RESULTS: The apoE 133-162 peptide had cytotoxic activity against all tested human cancer cell lines in a dose-dependent manner. 15796184 Human
apoe breast cancer To display the association between the apolipoprotein E (APOE) genotypes and breast cancer patients, a cross sectional study including 291 patients and 148 controls was performed. 16752225 NA
apoe breast cancer The APOE genotypes were measured in all participants, and the pathological diagnosis, estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER-2) among breast cancer patients were collected. 16752225 NA
apoe breast cancer The results showed the APOE allele frequency in breast cancer patients was 11.7% epsilon2 carriers, 74.6% epsilon3 carriers and 13.7% epsilon4 carriers, and there was no significant difference when they were compared with those of the control group (15.5% 16752225 Human
apoe breast cancer Among breast cancer patients, there was no significant association between the APOE genotypes and menopausal status, pathological diagnosis, estrogen receptor, progesterone receptor, and HER-2. 16752225 Human
apoe breast cancer Our findings demonstrated that the APOE genotypes were not associated with breast cancer patients, and epsilon2 allele tended to induce breast cancer on the left site among those patients in pre-menopause. 16752225 Human
apolipoprotein e primary tumours There is preliminary evidence that polymorphism of apolipoprotein E (apoE, protein; APOE, gene), one of the key regulatory proteins in cholesterol metabolism, influences the pathobiology of carcinoma of the colon, prostate and breast and also primary tumo 11110053 Human
apolipoprotein e astrocytomas Samples of normal brain, two meningiomas, one medulloblastoma and seven astrocytomas were analyzed along with two glioma lines to determine the genic expression of apolipoprotein E, which in addition to its major function in lipid metabolism has been post 1608541 Human
apolipoprotein e adenoma The intimate spatial relationship between BMC as well as apolipoprotein E and amyloid fibrils may indicate morphological evidence of a particular arrangement of amyloid components in GH-secreting adenoma amyloid and a pathophysiological link. 15304839 Human
apolipoprotein e adenomas Basement Membrane Proteins and Apolipoprotein E in Growth Hormone Secreting Adenomas and their Correlation to Amyloid: An Immunoelectron Microscopic Study. 15304839 Human
apolipoprotein e adenomas of the pituitary The aim of the study was to confirm earlier reports of the association of amyloid deposits in growth hormone (GH)-producing adenomas of the pituitary and the presence of glycosaminoglycans, basement membrane proteins and apolipoprotein E (apo E). 9692822 Human
apolipoprotein e pituitary adenomas Having previously demonstrated the association of basement membrane components (BMC), as well as apolipoprotein E and amyloid in growth hormone (GH)-producing pituitary adenomas, the aim of this study was to further analyze this relationship at the ultras 15304839 Human
apolipoprotein e xanthelasma Lipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma. 7485205 Human
apolipoprotein e primary localized cutaneous amyloidosis Apolipoprotein E is present in primary localized cutaneous amyloidosis. 9740234 Human
apolipoprotein e polycystic ovary syndrome Apolipoprotein E alleles in women with polycystic ovary syndrome. 11334897 Human
apolipoprotein e sporadic colorectal cancer METHODS: The frequency of polymorphisms involving N-acetyltransferase 1 (NAT1), NAT2, cytochrome P450 1A1 (CYP1A1), CYP2D6, CYP2E1, glutathione S-transferase M1 (GSTM1), GSTT1 and apolipoprotein E were compared in 219 white adults with sporadic colorectal 11422615 Human
apoe primary localized cutaneous amyloidosis In this study, we investigated whether apoE is associated with amyloid deposits of primary localized cutaneous amyloidosis using immunohistochemistry, immunogold electron microscopy, and immunoblotting. 9740234 Human
apoe primary localized cutaneous amyloidosis These results indicate that apoE is a component of primary localized cutaneous amyloidosis, and that it might play an important role in primary localized cutaneous amyloidosis. 9740234 Human
apoe polycystic ovary syndrome OBJECTIVE: To investigate the frequency of apoE alleles among women with polycystic ovary syndrome. 11334897 Human
apoe polycystic ovary syndrome CONCLUSION(S): The observed profiles of allele and genotype frequencies confirm the equilibrium state between apoE polymorphism and polycystic ovary syndrome and suggest that apoE does not play a major role in the development of hyperlipidemia in the grou 11334897 Human
apoe seborrhoeic keratosis OBJECTIVES: To determine whether the apoE epsilon4 allele is associated with increased risk of PCA and whether apoE and apoA-I are present in PCA and common secondary cutaneous amyloidosis (SCA) (i.e. basal cell carcinoma, Bowen's disease and seborrh 11531831 Human
apoe clinically manifested cancer Prostatic intraepithelial neoplasias (PINs) adjacent to clinically manifested cancer were positive whereas more distant PINs were negative for ApoE. 12632068 Human
apoe lymph node metastasis Among these genes, mRNA expression levels of CDH17 and APOE were associated with depth of tumor invasion (P = 0.0060 and P = 0.0139, respectively), and those of FUS and APOE were associated with degree of lymph node metastasis (P = 0.0416 and P = 0.0006, 15059891 Human
apolipoprotein e3 colorectal adenomas Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5%) (p=0.012). 16501668 Human
apolipoprotein e hcc Variations in protein accumulation were confirmed for two selected proteins (apolipoprotein E, chloride intracellular channel 1) by Western blotting in ten additional cases of HCC developing in patients with viral hepatitis C. 16097030 Human
apolipoprotein e pancreatic cancer In an independent series of serum samples from 20 patients with pancreatic cancer and 14 controls, increased levels of apolipoprotein E, alpha-1-antichymotrypsin, and inter-alpha-trypsin inhibitor were found to be associated with pancreatic cancer. 16212428 Human
apolipoprotein e human hepatocellular carcinoma Protein level of apolipoprotein E increased in human hepatocellular carcinoma. 16465366 Human
apolipoprotein e colorectal adenomas Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. 16501668 Human
apolipoprotein e arteriovenous malformations Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformations. 16639317 Human
apoe human hepatoma Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. 16195596 Human
apoe human pancreatic cancer In addition, overexpression of several proteins not described previously to be elevated in human pancreatic cancer (CD9, perlecan, SDF4, apoE, and fibronectin receptor) was confirmed by immunohistochemical labeling using pancreatic cancer tissue microarra 16215274 Human
apoe pancreatic cancer In addition, overexpression of several proteins not described previously to be elevated in human pancreatic cancer (CD9, perlecan, SDF4, apoE, and fibronectin receptor) was confirmed by immunohistochemical labeling using pancreatic cancer tissue microarra 16215274 Human
apoe tumor Proteomic study of tumor tissues from HCC patients, focusing on apolipoprotein (apo) of apoA1, apoB100 and apoE, was performed by immunoblotting. 16465366 Human
apoe tumor Although the significant changes of apoA1 or apoB100 could not be shown statistically, the immunoblotting showed the increase in protein level of apoE in the tumor tissues of 88% of patients without increase of apoE gene expression and serum level. 16465366 Human
apoe colorectal adenomas OBJECTIVE: To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas. 16501668 Human
apoe colorectal adenomas CONCLUSION: The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes. 16501668 Human
apoe astrocytoma Moreover, 24(S)-hydroxycholesterol primes astrocytoma, but not neuroblastoma cells, to mediate cholesterol efflux to apoE. 16524875 Human
apoe xanthomas Since he was 25 years old, the patient had sometimes noticed xanthomas on his knees and eyelids, and for that reason we made a diagnosis of apoE deficiency associated with type III hyperlipidemia. 16548231 Human
apoe astrocytoma Moreover, sitosterol upregulated apoE mRNA and protein levels in astrocytoma, but not in neuroblastoma cells, to a higher extend than cholesterol. 16677856 NA
apolipoprotein e xanthelasma Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients. 16503883 Human
apolipoprotein e tuberous xanthomas Tuberous xanthomas associated with olanzapine therapy and hypertriglyceridemia in the setting of a rare apolipoprotein e mutation. 16690468 Human
apolipoprotein e tuberous xanthomas Objective: To describe a patient with tuberous xanthomas and high levels of cholesterol and triglycerides, who was found to have type III hyperlipoproteinemia (HLP) and a rare apolipoprotein E (apoE) mutation. 16690468 NA
apoe tuberous xanthomas Objective: To describe a patient with tuberous xanthomas and high levels of cholesterol and triglycerides, who was found to have type III hyperlipoproteinemia (HLP) and a rare apolipoprotein E (apoE) mutation. 16690468 NA
apolipoprotein e astrocytoma The human malignant astrocytoma cells in the host brain were immunocytochemically double-labeled for the presence of PHAL, which is used as a marker for graft derived cells, and either glial fibrillary acidic protein (GFAP), a specific marker for astrocyt 2710299 Human
apolipoprotein e malignant astrocytoma The human malignant astrocytoma cells in the host brain were immunocytochemically double-labeled for the presence of PHAL, which is used as a marker for graft derived cells, and either glial fibrillary acidic protein (GFAP), a specific marker for astrocyt 2710299 Human
apolipoprotein e neurofibromatosis Thus, production of apolipoprotein E in neurofibromatosis-associated neurofibroma tumors may be a marker for a specific subclass of transformed cells. 3100319 Human
apolipoprotein e neoplasms The expression of apolipoprotein E in glial cell neoplasms is possibly related to an alteration in their lipid metabolism. 3100319 Human
apolipoprotein e kaposi's sarcoma Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice. 7525844 Mouse
apolipoprotein e leukemia Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells. 8371577 Human
apolipoprotein e tumor Alterations of lipoproteins occur in chronic inflammation and in malignancy with possible de novo synthesis of apolipoprotein E by tumor cells. 1517695 NA
apoe astrocytoma The human malignant astrocytoma cells in the host brain were immunocytochemically double-labeled for the presence of PHAL, which is used as a marker for graft derived cells, and either glial fibrillary acidic protein (GFAP), a specific marker for astrocyt 2710299 Human
apoe malignant astrocytoma The human malignant astrocytoma cells in the host brain were immunocytochemically double-labeled for the presence of PHAL, which is used as a marker for graft derived cells, and either glial fibrillary acidic protein (GFAP), a specific marker for astrocyt 2710299 Human
apoe malignant astrocytoma APOE was a consistent marker for the migrating human malignant astrocytoma cells, but not an exclusive marker of the xenografted cells, since host rat reactive astrocytes also expressed APOE. 2710299 Human
apoe hepatoma Heparin wash of hepatocytes or hepatoma cells incubated with apoE-[14C]triolein emulsions at 4 degrees C resulted in a considerable loss in radiolabeled cell lipid. 3625037 NA
apoe hepatoma Hepatocytes had lower affinity but similar apoE-emulsion binding capacity compared to hepatoma cells. 3625037 NA
apoe kaposi's sarcoma Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice. 7525844 Mouse
apoe secondary amyloidosis It is assumed that competitive interactions in the HSA-SAP-apoE system may be involved in the development of secondary amyloidosis. 8063017 Human
apoe hepatoma To determine the impact of enhanced apolipoprotein (apo) E secretion on the mechanism of remnant lipoprotein uptake, rat hepatoma cells (McA-RH7777) were stably transfected with normal human apoE3 or receptor binding-defective apoE-Leiden. 8300609 Human
apoe bile duct carcinoma [Rapid alteration in serum lipoprotein profile after bile drainage in a patient with acute bile duct obstruction: contribution of cholestasis to cholesteryl ester-dominant ApoE-rich HDL accumulation] Remarkably increased cholesteryl ester-dominant apoE-ri 8361035 Human
apoe leukemia ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. 8371577 Human
apoe hepatoma Rat hepatoma cells (Fu5AH) were studied as a model for the net delivery of apoE-free high-density lipoprotein (HDL) cholesterol to a cell. 1990016 Human
apoe hepatoma Metabolism of apoE-free high density lipoproteins in rat hepatoma cells: evidence for a retroendocytic pathway. 2324643 Rat
apoe hepatoma The cellular metabolism of apoE-free HDL (HDL) was studied in rat hepatoma cells (FU5AH). 2324643 Rat
apolipoprotein e neoplasms AIMS: This study was designed to determine whether the polymorphism of apolipoprotein E (apoE), one of the key regulatory proteins in cholesterol metabolism, is related to varying susceptibility to central nervous system (CNS) neoplasms, and to evaluate a 10774944 Human
apolipoprotein e neuroblastoma Effect of apolipoprotein AII on the interaction of apolipoprotein E with beta-amyloid: some apo(E-AII) complexes inhibit the internalization of beta-amyloid in cultures of neuroblastoma cells. 11070505 Human
apolipoprotein e neuroblastoma Recently, we showed expression of apolipoprotein E (apoE) in human neuronal-type cells such as neuroblastoma SK N SH-SY 5Y cells. 11085906 Human
apolipoprotein e neuroblastoma The toxic effects of beta-amyloid (A beta) (1-42), apolipoprotein E (apoE) isoforms, and apoE/A beta complexes were studied in human SH-SY5Y neuroblastoma cells and fibroblasts using MTT reduction. 11209921 NA
apolipoprotein e neuroblastoma Apolipoprotein E externally added to neuroblastoma cells in culture stimulates [35S]sulfate incorporation on cell and extracellular matrix glycosaminoglycans (sGAG). 11278162 Human
apolipoprotein e neuroblastoma Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. 11290387 NA
apolipoprotein e neuroblastoma We investigated the effects of different apolipoprotein E (apoE) isoforms, Abeta (1-42), and apoE/Abeta complexes on PKC-alpha translocation and APP processing in human SH-SY5Y neuroblastoma cells and fibroblasts. 11290387 NA
apolipoprotein e neuroblastoma Isoform-specific effect of apolipoprotein E on endocytosis of beta-amyloid in cultures of neuroblastoma cells. 11848621 NA
apolipoprotein e neuroblastoma Internalization of beta-amyloid causes downregulation of apolipoprotein E mRNA expression in neuroblastoma cells. 12661900 Human
apolipoprotein e lymphoma PURPOSE: The primary purpose of this study was to compare the neuropsychological performance of long-term survivors of breast cancer and lymphoma treated with standard dose chemotherapy who carried the epsilon 4 allele of the Apolipoprotein E (APOE) gene 12923801 Human
apoe neoplasms AIMS: This study was designed to determine whether the polymorphism of apolipoprotein E (apoE), one of the key regulatory proteins in cholesterol metabolism, is related to varying susceptibility to central nervous system (CNS) neoplasms, and to evaluate a 10774944 Human
apoe neuroblastoma This was pursued by cell culture and immunoblot experiments utilizing neuroblastoma N2a cells in which the effects of distinct apoE isoforms on the levels of intracellular APP and of secreted APPs were determined. 10961428 Human
apoe xanthoma Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice. 11030760 Human
apoe neuroblastoma Recently, we showed expression of apolipoprotein E (apoE) in human neuronal-type cells such as neuroblastoma SK N SH-SY 5Y cells. 11085906 Human
apoe neointimal hyperplasia The potential cytostatic function of apolipoprotein (apo) E in vivo was explored by measuring neointimal hyperplasia in response to vascular injury in apoE-deficient and apoE-overexpressing transgenic mice. 11106557 Human
apoe neuroblastoma Beta-VLDL protects against A beta(1-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells. 11209921 NA
apoe neuroblastoma The toxic effects of beta-amyloid (A beta) (1-42), apolipoprotein E (apoE) isoforms, and apoE/A beta complexes were studied in human SH-SY5Y neuroblastoma cells and fibroblasts using MTT reduction. 11209921 NA
apoe neuroblastoma Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. 11290387 NA
apoe neuroblastoma We investigated the effects of different apolipoprotein E (apoE) isoforms, Abeta (1-42), and apoE/Abeta complexes on PKC-alpha translocation and APP processing in human SH-SY5Y neuroblastoma cells and fibroblasts. 11290387 NA
apoe neuroblastoma Using flow cytometric analysis, we investigated the isoform-specific effects of apoE on the endocytosis of Abeta in cultured neuroblastoma cells. 11848621 NA
apoe hyperplasia Glomerular lesions in apoE-/- mice were characterized by macrophage accumulation, commonly with foam cell appearance, deposition of extracellular matrix, glomerular hyperplasia, and at times prominent mesangiolysis associated with capillary microaneurysms 12177238 Mouse
apoe neuroblastoma ApoE expression was also estimated on immunoblot on protein extracts from autopsied brains and a cultured neuroblastoma cell line of human origin (GOTO) subjected to an oxidative stress induced by exposure to hydrogen peroxide (0.2 mmol/L). 12649507 Human
apoe neuroblastoma Immunoblot demonstrated an increase in expression of ApoE in brain extracts from ischemic lesion, and this increase was also pronounced in the cultured neuroblastoma cell line after the stress. 12649507 Human
apoe lymphoma PURPOSE: The primary purpose of this study was to compare the neuropsychological performance of long-term survivors of breast cancer and lymphoma treated with standard dose chemotherapy who carried the epsilon 4 allele of the Apolipoprotein E (APOE) gene 12923801 Human
apoe hyperplasia In addition, treatment with shosaikoto suppressed intimal hyperplasia in apoE-deficient mice fed a cholesterol-enriched diet for nine weeks. 12937613 Mouse
apoe neuroblastoma We investigated the effects of two key AD molecules, namely apoE (E3 and E4 isoforms) and beta-amyloid (Abeta) 1-42 on GSK-3beta and its major upstream regulators, intracellular calcium and protein kinases C and B (PKC and PKB) in human SH-SY5Y neuroblast 14622095 Human
apoe hyperplasia Histological results depict hyperplasia in ApoE-/- hearts without atherosclerosis of the coronaries. 15734885 Mouse
apoe cancer We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. 15830139 Human
apoe necrosis We found that intrathecal delivery of an apoE-mimetic peptide caused a significant reduction in post-ischemic brain necrosis, as reflected by decreased reduction in ipsilateral brain weight 7 days following hypoxic-ischemic injury. 15896489 Human
apoe lymphoma In this report, we study the transcriptional activity of different APOE proximal promoter regions and their binding to nuclear proteins from human neural (astrocytoma and neuroblastoma) and peripheral (hepatoma and lymphoma) cell lines. 15931082 Human
apoe neuroblastoma In this report, we study the transcriptional activity of different APOE proximal promoter regions and their binding to nuclear proteins from human neural (astrocytoma and neuroblastoma) and peripheral (hepatoma and lymphoma) cell lines. 15931082 NA
apoe neuroblastoma Overexpression of ApoE in neuroblastoma cells (Neuro2a) leads to the generation of an intracellular 13 kDa carboxy-terminal fragment of ApoE comparable to fragments seen in brains of AD patients. 16011742 Human
apoe necrosis Livers from FXR-/- and FXR-/- ApoE-/- mice exhibited marked lipid accumulation, focal necrosis (accompanied by increased levels of plasma aspartate aminotransferase), and increased inflammatory gene expression. 16186601 Mouse
apoe neuroblastoma We examined the effects of apoE isoforms on the processing of amyloid precursor protein (APP) and on Abeta production in rat neuroblastoma B103 cells stably transfected with human wild-type APP695 (B103-APP). 16344478 Human
apoe hcc Proteomic study of tumor tissues from HCC patients, focusing on apolipoprotein (apo) of apoA1, apoB100 and apoE, was performed by immunoblotting. 16465366 Human
apoe hcc Moreover, immunoblot analysis on two-dimensional electrophoresis showed a strong possibility that sialylated forms of apoE also were increased in tumorous tissues of HCC. 16465366 Human
apoe hcc ApoE level in tumorous tissues is frequently elevated and may be a good histological marker for HCC. 16465366 Human
apoe xanthelasma Patients with xanthelasma demonstrated slight differentiations in the apoE polymorphism and metabolism of lipoproteins that require further clarifications. 16503883 Human
apoe neuroblastoma Moreover, 24(S)-hydroxycholesterol primes astrocytoma, but not neuroblastoma cells, to mediate cholesterol efflux to apoE. 16524875 Human
apoe astrocytoma Furthermore, apoE-mediated cholesterol efflux from astrocytoma cells may be controlled by the ATP binding cassette transporters ABCA1 and ABCG1, since their expression was also up-regulated by both compounds. 16524875 Human
apoe hyperplasia Ligation of the carotid artery in apoE-deficient mice for 4 weeks induced marked intimal hyperplasia, which is a lipid- and collagen-rich lesion that contains a number of macrophages, T lymphocytes, and smooth muscle cells. 16574894 Mouse
apoe neuroblastoma Moreover, sitosterol upregulated apoE mRNA and protein levels in astrocytoma, but not in neuroblastoma cells, to a higher extend than cholesterol. 16677856 NA
apoe gliomas Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. 17146289 Human
apoe oligodendrogliomas GFAP, YKL-40, and ApoE reliably distinguished grade II-III oligodendrogliomas from grade II-IV astrocytomas (p < 0.0001, p = 0.002, and p < 0.0001, respectively). 17146289 Human
apoe grade ii astrocytomas GFAP, YKL-40, and ApoE reliably distinguished grade II-III oligodendrogliomas from grade II-IV astrocytomas (p < 0.0001, p = 0.002, and p < 0.0001, respectively). 17146289 Human
apoe tumor In addition to GFAP, therefore, YKL-40, ApoE, ASCL1, and NKX2-2 represent promising tumor cell markers to distinguish oligodendrogliomas from astrocytomas. 17146289 Human
apoe oligodendrogliomas In addition to GFAP, therefore, YKL-40, ApoE, ASCL1, and NKX2-2 represent promising tumor cell markers to distinguish oligodendrogliomas from astrocytomas. 17146289 Human
apoe astrocytomas In addition to GFAP, therefore, YKL-40, ApoE, ASCL1, and NKX2-2 represent promising tumor cell markers to distinguish oligodendrogliomas from astrocytomas. 17146289 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.