IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MARK4 Ensembl ENSG00000007047 Chromosome 19 Start 50446390 End 50500381
Description MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)(MAP/microtubule affinity-regulating kinase-like 1) [Source:UniProtKB/Swiss-Prot;Acc:Q96L34]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 13538
     Entrez Gene : 57787
     UCSC : uc002pba.1
     GeneCards : 13538
     RefSeq : NM_031417
     CCDS : CCDS12658.1
     Uniprot : Q96L34
     Interpro : Q96L34
     OMIM : 606495
     GeneTests : MARK4
     CGAP : MARK4
     PMID : 11326310

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221560_at  0.13  2.21e-1  2.68e-1  2.12  6.80e-48  1.50e-47
 HG_U133A  55065_at  0.01  7.97e-1  8.27e-1  -0.92  8.72e-36  1.59e-35
 HG_U133_Plus2  221560_at  0.20  2.03e-1  2.80e-1  0.72  7.83e-4  1.53e-3
 HG_U133_Plus2  55065_at  0.41  4.45e-7  2.12e-6  0.77  1.72e-10  8.01e-10
 Agilent_HS_21.6K  21541  -0.04  1.00e-1  2.36e-1  -0.05  6.51e-2  1.50e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221560_at  0.39  3.45e-1  8.87e-1  0.54  6.05e-2  1.00e+0
 HG_U133A  55065_at  0.11  7.44e-1  9.74e-1  0.10  5.35e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 221560_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 55065_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221560_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 55065_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21541    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mark4 neuroblastoma In differentiated neuroblastoma cells, MARK4 is localized prominently at the tips of neurite-like processes. 14594945 Human
mark4 glioblastoma The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. 12735302 Human
mark4 primary glioblastoma Following our previous studies on structural 19q chromosome rearrangements in gliomas, we have undertaken a detailed FISH analysis of the breakpoints and identified a 19q13.2 intrachromosomal amplification of the MAP/microtubule affinity-regulating kinase 12735302 Human
mark4 glioblastoma Perturbation of expression using antisense oligonucleotides against MARK4 in glioblastoma cell lines, consistently induced a decreased proliferation of tumor cells. 12735302 Human
mark4 tumor Perturbation of expression using antisense oligonucleotides against MARK4 in glioblastoma cell lines, consistently induced a decreased proliferation of tumor cells. 12735302 Human
mark4 gliomas The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. 12735302 Human
mark4 gliomas Following our previous studies on structural 19q chromosome rearrangements in gliomas, we have undertaken a detailed FISH analysis of the breakpoints and identified a 19q13.2 intrachromosomal amplification of the MAP/microtubule affinity-regulating kinase 12735302 Human
mark4 gliomas Taken together, these data show that MARK4, which is normally expressed in neural progenitors, is re-expressed in gliomas and may become a key target of intrachromosomal amplification upon 19q rearrangements. 12735302 Human

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