IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CKM Ensembl ENSG00000104879 Chromosome 19 Start 50501512 End 50517974
Description Creatine kinase M-type (EC 2.7.3.2)(Creatine kinase M chain)(M-CK) [Source:UniProtKB/Swiss-Prot;Acc:P06732]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 1994
     Entrez Gene : 1158
     UCSC : uc002pbd.2
     GeneCards : 1994
     RefSeq : NM_001824
     CCDS : CCDS12659.1
     Uniprot : P06732
     Interpro : P06732
     OMIM : 123310
     GeneTests : CKM
     CGAP : CKM

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32486_at  0.15  3.01e-1  4.05e-1  -0.11  5.97e-1  6.89e-1
 HG_U133A  204810_s_at  0.26  5.20e-2  7.20e-2  2.78  9.19e-96  5.54e-95
 HG_U133_Plus2  204810_s_at  1.08  1.55e-7  7.97e-7  0.72  1.49e-5  3.72e-5
 Agilent_HS_21.6K  4885  -0.07  4.30e-1  6.14e-1  -0.05  5.68e-1  7.04e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204810_s_at  -0.24  6.70e-1  9.64e-1  -0.03  8.38e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32486_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204810_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204810_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4885    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
m-ck tumours It is concluded that in most tumours there is a decrease in the expression of type B- and type M-CK subunits, whereas in lung carcinoid the expression of type B-CK activity increases. 9303358 Human
ckmm osteogenic sarcoma Both PTH and PGE2 stimulated the brain type isoenzyme of CK (CKBB), although the osteogenic sarcoma cell clones contain a significant proportion of the muscle type of CK (CKMM). 3937588 Human
ckm liver carcinoma CKm activities in the gastric carcinoma group were higher than those in other groups, particularly in comparison to the liver carcinoma group. 6723059 Human
ckm gastric carcinoma CKm activities in the gastric carcinoma group were higher than those in other groups, particularly in comparison to the liver carcinoma group. 6723059 Human
ckm malignancy CKm was also present in sera from patients with malignancy of the lung, the mammary gland etc. 6723059 Human
ckm malignancy In the CKm positive group, about 85% had metastatic and/or infiltrating malignancy, and about 90% were undergoing chemotherapy. 6723059 Human
ckm metastatic tumors CKm may be a marker of some biological factors leading to and/or resulting from a poor prognosis and not simply of primary or metastatic tumors. 6723059 Human
ckm cancer [Simultaneous presence of isoenzymes CK-BB and CKm of serum creatine kinase in small-cell bronchopulmonary cancer. 3024533 Human
m-ck carcinoid It is concluded that in most tumours there is a decrease in the expression of type B- and type M-CK subunits, whereas in lung carcinoid the expression of type B-CK activity increases. 9303358 Human
creatine kinase m chain tumor The levels of adenylate kinase 1, beta-enolase, creatine kinase M chain, hemoglobin beta chain and prohibitin were statistically increased whereas the level of a creatine kinase fragment, which is undocumented, was decreased in the tumor of vaccinated mic 15717328 Mouse
ckmm necrosis Studies have now shown that CK-MM isoform patterns provide a unique means of assessing the time of onset of necrosis and a monitor of the duration of enzyme release from the site of injury. 2686906 Human
ckmm liver metastasis An atypical creatine kinase (CK) isoenzyme migrating cathodically to CK-MM in the electrophoresis was observed as response to the embolization of the right hepatic artery in two patients with liver metastasis. 2985864 Human
ckmm tumor Three creatine kinase isozymes (CK-BB, CK-MB and CK-MM) were estimated by immunoassay in tumor tissues and in sera of patients with various lung carcinomas. 3034455 Human
ckmm lung carcinomas Three creatine kinase isozymes (CK-BB, CK-MB and CK-MM) were estimated by immunoassay in tumor tissues and in sera of patients with various lung carcinomas. 3034455 Human
ckmm carcinoma CK-MM and CK-MB were not increased in any types of carcinoma. 3034455 Human
ckmm lung carcinoma Serum CK-BB was increased in all types of lung carcinoma examined, while serum CK-MM and CK-MB were within normal limits in all patients. 3034455 Human
ckmm tumor The atypical CK-MM band, also reported by others, might be an insensitive and nonspecific tumor marker. 6640897 Human
ckmm necrosis In the halothane-sensitive pigs skeletal muscle necrosis besides the myocardial lesions contributed to the high levels of CK-MM activity in serum. 6883187 others
ckmm leiomyoma The CK isoenzyme composition of leiomyoma tissue is predominantly CK-BB and similar to adjacent myometrium tissue, while the leiomyosarcoma revealed a lesser quantity of CK-BB, but a greater quantity of CK-MM. 7449081 Human
ckmm leiomyosarcoma The CK isoenzyme composition of leiomyoma tissue is predominantly CK-BB and similar to adjacent myometrium tissue, while the leiomyosarcoma revealed a lesser quantity of CK-BB, but a greater quantity of CK-MM. 7449081 Human
ckmm stomach cancer A rare isozyme of serum creatine kinase (CK) migrating cathodic to CK-MM on electrophoresis was found in a 30-year-old male with stomach cancer complicated by disseminated intravascular coagulation leading to massive upper gastrointestinal bleeding and ma 7449149 Human
ckmm rhabdomyosarcoma This agent increased CK-MM and/or CK-MB fractions, and decreased CK-BB isoenzyme in rhabdomyosarcoma cell lines. 7792206 Human
ckmm rhabdomyosarcomas Our findings suggest that CK-MM, CK-MB and CK-BB isoenzymes are good markers of the degree of differentiation in rhabdomyosarcomas and could be used as specific markers of prognostic and diagnostic value. 7792206 Human
ckmm carcinogenesis No significant difference in the serum and HBPT CK-MM, CK-MB and CK-BB activity, in DMBA-induced carcinogenesis, could be established. 1753351 Human
ckmm fibromatosis Gingival fibroblasts from normal subjects (A), and from patients with periodontitis (B) or fibromatosis (C), exhibited CK-MM (muscle form) as a predominant isoenzyme and CK-BB (brain form) as a minor fraction. 1973720 Human
ckmm cell hyperplasia The IEF spectra offered useful information on cell hyperplasia, augmented cell membrane permeability, cell destruction and release time of CK-MM in the circulation from the cells for diagnosis, progress observation and prognosis, especially in the cases o 2193938 Human
ckmm malignant tumor CK-MM is useful in skeletal muscle diseases, such as muscle dystrophy, CK-MB in acute myocardial infarction (AMI), and CK-BB in brain damage and malignant tumor of the gastro-intestinal tract. 11797380 Human
ckmm necrosis [Clinical significance of the change of serum CK-MM in electrical injured patients] OBJECTIVE: To evaluate the diagnostic value of the changes in serum CK and its isozymes in the muscular infection and necrosis in electrical injured patients. 12467535 Human
ckmm necrosis CONCLUSION: CK-MM could be employed as the index for the infection and necrosis of the muscle in electrical injured patients due to its high specificity and sensitivity. 12467535 Human

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