IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PPP1R13L Ensembl ENSG00000104881 Chromosome 19 Start 50574741 End 50600136
Description RelA-associated inhibitor (Inhibitor of ASPP protein)(Protein iASPP)(PPP1R13B-like protein)(NFkB-interacting protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q8WUF5]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 18838
     Entrez Gene : 10848
     UCSC : uc002pbn.2
     GeneCards : 18838
     RefSeq : NM_001142502
     CCDS : CCDS33050.1
     Uniprot : Q8WUF5
     Interpro : Q8WUF5
     OMIM : 607463
     GeneTests : PPP1R13L
     CGAP : PPP1R13L
     PMID : 10336463

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218849_s_at  -0.21  1.66e-3  2.93e-3  -1.47  1.10e-26  1.77e-26
 HG_U133_Plus2  218849_s_at  0.57  5.37e-5  1.79e-4  1.39  1.90e-14  1.40e-13

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  218849_s_at  -0.06  7.53e-1  9.75e-1  0.09  5.32e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 218849_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 218849_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rai basal-cell carcinoma In this paper, we present evidence that alleles of several polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes RAI and XPD, are associated with occurrence of basal cell carcinoma in Caucasian Americans. 12433725 Human
rai post-menopausal breast cancer A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2-3 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55. 12771034 Human
rai breast cancer The likely explanation for our results is a common recessive genetic variant located in or near the gene RAI, which, when homozygous, conveys an increased risk of breast cancer. 12771034 Human
iaspp acute leukemias The expression of iASPP in acute leukemias. 15607367 Human
iaspp human breast carcinomas Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and its expression is upregulated in human breast carcinomas expressing wild-type p53. 15607367 Human
rai bcc Specifically, persons that are homozygous for the haplotype RAI intron 1(A) RAI exon 6(A) appear at increased risk for BCC. 12117772 Human
rai basal-cell carcinoma Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. 15936590 Human
rai testicular cancer Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer. 15885892 Human
rai testicular cancer We found that neither polymorphisms in several DNA repair genes nor alleles of several polymorphisms in the chromosomal of region 19q13.2-3, encompassing the genes ASE, ERCC1, RAI and XPD, were associated with risk of testicular cancer in Danish patients. 15885892 Human
rai other cancers This is in contrast to other cancers, where we reported strong associations between polymorphisms in ERCC1, ASE and RAI and occurrence of basal cell carcinoma, breast cancer and lung. 15885892 Human
rai breast cancer This is in contrast to other cancers, where we reported strong associations between polymorphisms in ERCC1, ASE and RAI and occurrence of basal cell carcinoma, breast cancer and lung. 15885892 Human
rai basal-cell carcinoma This is in contrast to other cancers, where we reported strong associations between polymorphisms in ERCC1, ASE and RAI and occurrence of basal cell carcinoma, breast cancer and lung. 15885892 Human
iaspp gene aml The expression level of iASPP gene and its overexpression in M3 and M4EO were significantly lower than in other subtypes of AML. 15607367 Human
ppp1r13l multiple myeloma We have studied the effect on time to treatment failure (TTF) and overall survival (OS) of polymorphism in the DNA repair genes ERCC1, ERCC2 and XRCC3, and in the apoptotic genes PPP1R13L and CD3EAP in 348 patients with multiple myeloma undergoing autolog 17131345 Human
iaspp human breast carcinomas Increased expression of iASPP also confers resistance to ultraviolet radiation and to cisplatin-induced apoptosis. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53 and normal levels of ASPP. 12524540 Human
iaspp tumors Inhibition of iASPP could provide an important new strategy for treating tumors expressing wild-type p53. 12524540 Human
iaspp acute leukemia (al) To examine the role of iASPP in acute leukemia (AL), we analyzed iASPP mRNA expression in AL by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). 15607367 Human
rai basal cell carcinoma In this paper, we present evidence that alleles of several polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes RAI and XPD, are associated with occurrence of basal cell carcinoma in Caucasian Americans. 12433725 Human
rai basal cell carcinoma This is in contrast to other cancers, where we reported strong associations between polymorphisms in ERCC1, ASE and RAI and occurrence of basal cell carcinoma, breast cancer and lung. 15885892 Human
rai basal cell carcinoma Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. 15936590 Human
rai carcinomas Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas. 16914027 Human
rai colorectal adenomas Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas. 16914027 Human
rai adenomas METHODS: We have examined mRNA expression of two DNA repair genes, ERCC1 and OGG1 as well as the putative apoptosis controlling gene RAI, in normal tissues and lesions from 36 cases with adenomas (mild/moderat n = 21 and severe n = 15, dysplasia) and 9 wi 16914027 Human
rai carcinomas METHODS: We have examined mRNA expression of two DNA repair genes, ERCC1 and OGG1 as well as the putative apoptosis controlling gene RAI, in normal tissues and lesions from 36 cases with adenomas (mild/moderat n = 21 and severe n = 15, dysplasia) and 9 wi 16914027 Human
rai adenomas The levels of ERCC1, OGG1 and RAI expressions when comparing lesions, did not differ between adenomas and CRC cases, P = 0.836, P = 0.341 and P = 0.909, respectively. 16914027 Human
rai adenomas When comparing expression levels in normal tissue, the levels for OGG1 and RAI from CRC cases were significantly lower compared to the cases with adenomas, P = 0.012 and P = 0.011, respectively. 16914027 Human
rai lung cancer ERCC1, XPD and RAI mRNA levels in lymphocytes are not associated with lung cancer risk in a prospective study of Danes. 16054657 Human
rai lung cancer In this nested case-cohort study, which to our knowledge, is the first prospective study of DNA-repair gene mRNA levels as predictors of lung cancer, we have investigated the occurrence of lung cancer in relation to the mRNA level of the two DNA-repair ge 16054657 Human
rai adenomas Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. 16817948 Human
rai colorectal carcinomas Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. 16817948 Human
rai adenomas METHODS: We used a case-control study design (156 carcinomas, 981 adenomas and 399 controls) to test the association between polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes ERCC1, ASE-1 and RAI, and risk of colorectal adenomas an 16817948 Human
rai carcinomas METHODS: We used a case-control study design (156 carcinomas, 981 adenomas and 399 controls) to test the association between polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes ERCC1, ASE-1 and RAI, and risk of colorectal adenomas an 16817948 Human
rai colorectal adenomas METHODS: We used a case-control study design (156 carcinomas, 981 adenomas and 399 controls) to test the association between polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes ERCC1, ASE-1 and RAI, and risk of colorectal adenomas an 16817948 Human
rai adenomas The RAI polymorphism showed a trend towards risk reduction for both adenomas (OR of 0.70, 95% CI 0.49-1.01) and carcinomas (OR of 0.49, 95% CI 0.21-1.13) among women, although not significant. 16817948 Human
rai carcinomas The RAI polymorphism showed a trend towards risk reduction for both adenomas (OR of 0.70, 95% CI 0.49-1.01) and carcinomas (OR of 0.49, 95% CI 0.21-1.13) among women, although not significant. 16817948 Human
iaspp gene leukemogenesis The results of the present study suggest that iASPP gene overexpression may play an important role in the leukemogenesis and/or disease progression of AL. 15607367 Human
iaspp oncoprotein iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. 12524540 Human
iaspp oncoprotein Moreover, iASPP is an oncoprotein that cooperates with Ras, E1A and E7, but not mutant p53, to transform cells in vitro. 12524540 Human
rai lung cancer Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study. 16690207 Human
rai lung cancer Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. 16690207 Human
iaspp non-small cell lung cancer To evaluate the effect of genetic variations on chemotherapy and/or radiotherapy, we genotyped four single nucleotide polymorphisms (SNPs) in ATM (A60G), ERCC1 (Asn118Asn), APE1 (Asn148Glu), and iASPP (A67T), and examined their associations with treatment 17222938 Human
iaspp nsclc To evaluate the effect of genetic variations on chemotherapy and/or radiotherapy, we genotyped four single nucleotide polymorphisms (SNPs) in ATM (A60G), ERCC1 (Asn118Asn), APE1 (Asn148Glu), and iASPP (A67T), and examined their associations with treatment 17222938 Human
iaspp nsclc CONCLUSION: We found that SNPs in ERCC1 and iASPP were associated with response to chemotherapy or combined chemotherapy and radiotherapy in NSCLC patients. 17222938 Human
rai cancer Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons. 17570360 Human
ppp1r13l cancer METHODS AND RESULTS: Studying one marker at a time, we found a region spanning the gene RAI (alias PPP1R13L or iASPP) and the 5' portion of XPD to be associated with this cancer. 18588689 Human
iaspp tumors In tumors bearing wild-type p53, expression of Pin1 and iASPP are inversely correlated, supporting the clinical relevance of these interactions. 17906639 Human
iaspp cancer METHODS AND RESULTS: Studying one marker at a time, we found a region spanning the gene RAI (alias PPP1R13L or iASPP) and the 5' portion of XPD to be associated with this cancer. 18588689 Human
iaspp cancer iASPP inhibition: increased options in targeting the p53 family for cancer therapy. 18593889 Human
rai colorectal cancer A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study. 18289367 Human
rai breast cancer The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer. 18289367 Human
rai lung cancer The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer. 18289367 Human
rai colorectal cancer CONCLUSION: Our results suggest that the ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn polymorphisms and the previously identified haplotype are not associated with risk of colorectal cancer. 18289367 Human
rai breast cancer Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP. 18588689 Human
rai cancer METHODS AND RESULTS: Studying one marker at a time, we found a region spanning the gene RAI (alias PPP1R13L or iASPP) and the 5' portion of XPD to be associated with this cancer. 18588689 Human
rai cancers The haplotypes with strongest association with cancers were located in the gene RAI and just 3' to the gene. 18588689 Human
rai breast cancer We tested an additional 44 of these for association with disease and found a new tandem repeat marker, called RAI-3'd1, located downstream of the transcribed region of RAI, which was more strongly associated with breast cancer than any other marker w 18588689 Human
rai cancer CONCLUSION: We expect the marker RAI-3'd1 to be (part of) the cause for the association of the chromosome 19q13.3 region's association with cancer. 18588689 Human
rela-associated inhibitor tumor Molecular docking analysis of the protein-protein interaction between RelA-associated inhibitor and tumor suppressor protein p53 and its inhibitory effect on p53 action. 18201273 Human
iaspp acute leukemia To examine the role of iASPP in acute leukemia (AL), we analyzed iASPP mRNA expression in AL by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). 15607367 Human

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