IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FOSB Ensembl ENSG00000125740 Chromosome 19 Start 50663093 End 50670254
Description Protein fosB (G0/G1 switch regulatory protein 3) [Source:UniProtKB/Swiss-Prot;Acc:P53539]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3797
     Entrez Gene : 2354
     UCSC : uc002pbx.3
     GeneCards : 3797
     RefSeq : NM_001114171
     CCDS : CCDS12664.1
     Uniprot : P53539
     Interpro : P53539
     OMIM : 164772
     GeneTests : FOSB
     CGAP : FOSB
     PMID : 1301997

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36669_at  -1.10  3.39e-6  1.96e-5  -1.53  8.68e-6  4.45e-5
 HG_U133A  202768_at  -3.77  5.53e-35  1.16e-33  -2.40  7.66e-26  1.21e-25
 HG_U133_Plus2  202768_at  -3.49  3.76e-25  1.52e-23  -3.78  2.65e-23  5.43e-22
 Stanford  6870  -0.53  2.16e-1  4.10e-1  -1.65  1.98e-3  2.24e-2
 Agilent_HS_21.6K  21065  -0.02  3.37e-1  5.25e-1  -0.03  2.08e-1  3.54e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202768_at  0.81  4.95e-1  9.27e-1  -0.26  6.82e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36669_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202768_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202768_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6870    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21065    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
fosb colon carcinoma BACKGROUND: The colon mitosis inhibiting peptide pyroglutamyl-histidyl-glycine (pEHG) increases the expression of c-fos, fosB and egr-1 genes in the colon carcinoma cell line HT-29. 15160998 Human
fosb human colon tumors By contrast, the fos family member fra-1 was up-regulated in the human colon tumors, suggesting a compensatory mechanism for the reduction in fos and fosB expression. 11751871 Human
fosb tumour The constitutive expression of JunB was diminished in the undifferentiated, more aggressive tumour phenotype compared with the well-differentiated, less aggressive keratinocytes, whereas the expression of other AP-1 family members (c-jun, junD, c-fos, fra 11267971 Human
fosb endometrial carcinomas METHODS: We performed Western blot experiments with specific antibodies for each of the AP-1 proteins (c-jun, junB, junD, c-fos, fosB, fra-1, fra-2) with 41 endometrial carcinomas. 11570575 Human
fosb breast cancer Therefore, we studied protein expression of 6 cell cycle-regulatory proteins (Rb, p16, p21, p27, cyclin D1, and cyclin E) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP-1 fami 10918184 Human
fosb breast tumors In the present study, the expression of members of the AP-1 family of transcription factors in breast tumors (n = 53) was investigated by Western blot with antibodies specific for each of the AP-1 family members (c-jun, junB, junD and c-fos, fosB, fra1 an 10502734 Human
fosb tumor Pretreatment with the four preventive agents commonly inhibited TNF-alpha mRNA expression and TNF-alpha release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c-jun, junB, c-fos, and fosB) was 8706012 Human
fosb hepatoma In mouse hepatoma Hepa-1 cells, which have Ah receptor (AHR) and Ah receptor nuclear translocator (ARNT) proteins, inclusion of TRE, SRE, and the AhRE motifs from c-jun and junD, but not CRE or the AhREs from c-fos, fosB, and junB, causes a large TCDD-dep 8917696 Human
fosb human neuroblastoma Exposure of human neuroblastoma SH-SY5Y cells to ethanol for 2-4 days caused a dose-dependent increase in c-jun and junD mRNA levels, whereas mRNAs for c-fos, fosB and junB were not detectable in control or ethanol-treated cells. 8930987 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.