IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DMPK Ensembl ENSG00000104936 Chromosome 19 Start 50964818 End 50977655
Description Myotonin-protein kinase (EC 2.7.11.1)(Myotonic dystrophy protein kinase)(MDPK)(DMPK)(DM-kinase)(DMK)(MT-PK) [Source:UniProtKB/Swiss-Prot;Acc:Q09013]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2933
     Entrez Gene : 1760
     UCSC : uc002pdf.1
     GeneCards : 2933
     RefSeq : NM_001081560
     CCDS : CCDS12674.1
     Uniprot : Q09013
     Interpro : Q09013
     OMIM : 605377
     GeneTests : DMPK
     CGAP : DMPK
     PMID : 1546325

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
3 1.33 225 2 1.03 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16678 AD c.1631C>T p.T544M Substitution - Missense Homozygous 19:50966464-5096646418948947
17733 AD c.1680G>A p.Q560Q Substitution - coding silent Heterozygous 19:50966126-5096612618948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37996_s_at  -0.03  7.48e-1  8.16e-1  0.29  5.26e-2  9.55e-2
 HG_U133A  217066_s_at  0.38  4.89e-3  8.04e-3  4.53  3.62e-94  2.10e-93
 HG_U133A  37996_s_at  -0.15  2.19e-2  3.24e-2  -3.41  1.54e-99  1.03e-98
 HG_U133_Plus2  217066_s_at  -0.43  1.32e-2  2.62e-2  -0.53  7.31e-3  1.22e-2
 HG_U133_Plus2  37996_s_at  0.32  1.46e-2  2.85e-2  0.77  2.84e-5  6.85e-5
 Agilent_HS_21.6K  14163  0.08  1.09e-1  2.50e-1  0.08  9.52e-2  2.00e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  217066_s_at  -0.30  4.62e-1  9.19e-1  0.22  4.01e-1  1.00e+0
 HG_U133A  37996_s_at  0.10  6.57e-1  9.61e-1  0.13  2.37e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37996_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217066_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 37996_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217066_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 37996_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14163    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
myotonic dystrophy protein kinase tumors Elongation of (CTG)n repeats in myotonic dystrophy protein kinase gene in tumors associated with myotonic dystrophy patients. 10454725 Human
dmpk tumors Length of (CTG)n triplet repeats in myotonic dystrophy protein kinase gene (DMPK) was estimated in tumors, normal tissues of the same organs, muscles, and leukocytes from three myotonic dystrophy (DM) patients and a non-DM patient. 10454725 Human
myotonic dystrophy protein kinase tumors Length of (CTG)n triplet repeats in myotonic dystrophy protein kinase gene (DMPK) was estimated in tumors, normal tissues of the same organs, muscles, and leukocytes from three myotonic dystrophy (DM) patients and a non-DM patient. 10454725 Human
dm-1 tumour In 4 out of 78 (5%) paired tumour-normal DNA samples we found evidence of somatic microsatellite instability at DM-1: a novel allele of a different size was seen in the tumour DNA which was not present in the normal DNA sample. 8645585 Human
dmi pd OBJECTIVE: To compare the efficacy of clomipramine hydrochloride (CMI), a serotonin reuptake inhibitor with the noradrenergic tricyclic antidepressant agent, and desipramine hydrochloride (DMI) for patients with panic disorder (PD). 10208287 NA
dmi pd METHOD: Following a 2-week, single-blind placebo washout phase, 17 PD outpatients completed a 16-week, double-blind, crossover comparison of CMI and DMI. 10208287 NA
dmi apl OBJECTIVES: To present the first reported cases of DMI in association with positive antiphospholipid (aPL) antibody titers and to discuss the etiologic and pathogenic significance of the association between type 1 diabetes and aPL antibodies. 11182027 NA
dmi apl METHODS: Descriptive case reports of 2 patients with DMI and positive aPL antibodies and a review of the relevant literature. 11182027 NA

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