IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NOVA2 Ensembl ENSG00000104967 Chromosome 19 Start 51134631 End 51168497
Description RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2)(Astrocytic NOVA1-like RNA-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNW9]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7887
     Entrez Gene : 4858
     UCSC : uc002pdv.2
     GeneCards : 7887
     RefSeq : NM_002516
     CCDS : CCDS12679.1
     Uniprot : Q9UNW9
     Interpro : Q9UNW9
     OMIM : 601991
     GeneTests : NOVA2
     CGAP : NOVA2
     PMID : 9344654

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39667_at  0.15  7.43e-2  1.29e-1  -0.29  2.18e-2  4.51e-2
 HG_U133A  206476_s_at  0.29  2.29e-2  3.38e-2  5.06  4.09e-118  4.65e-117
 HG_U133A  206477_s_at  -0.07  5.03e-1  5.56e-1  -1.79  5.40e-23  8.19e-23
 HG_U133_Plus2  206476_s_at  -0.20  3.23e-1  4.12e-1  -0.18  4.51e-1  5.12e-1
 HG_U133_Plus2  206477_s_at  -0.18  9.44e-2  1.46e-1  -0.54  8.70e-5  1.96e-4
 Stanford  8483  -0.94  1.31e-2  7.66e-2  -0.68  3.18e-2  1.24e-1
 Agilent_HS_21.6K  19927  -0.39  4.46e-5  6.12e-4  -0.45  2.17e-4  1.53e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206476_s_at  -1.23  8.81e-3  6.80e-1  -0.14  6.12e-1  1.00e+0
 HG_U133A  206477_s_at  -0.51  3.21e-1  8.82e-1  0.36  2.54e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39667_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206476_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206477_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206476_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206477_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8483    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19927    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nova-2 paraneoplastic opsoclonus-myoclonus ataxia (poma) In patients suffering from paraneoplastic opsoclonus myoclonus ataxia (POMA), Nova-1 and Nova-2 proteins are present as auto-antigens. 11784037 Human
nova-2 cancer Indicative of intriguing differences in the regulatory mechanisms for excitatory and inhibitory synaptic plasticity, LTP of sIPSC but not EPSC was abolished in mice lacking Nova-2, a neuronal-specific RNA binding protein that is an autoimmune target in pa 16213216 Mouse
nova-2 paraneoplastic opsoclonus-myoclonus ataxia (poma) BACKGROUND: Nova-1 and Nova-2 are related neuronal proteins that were initially cloned using antisera obtained from patients with the autoimmune neurological disease paraneoplastic opsoclonus-myoclonus ataxia (POMA). 10368286 Human
nova-2 paraneoplastic opsoclonus myoclonus ataxia (poma) In patients suffering from paraneoplastic opsoclonus myoclonus ataxia (POMA), Nova-1 and Nova-2 proteins are present as auto-antigens. 11784037 Human
nova-2 paraneoplastic opsoclonus myoclonus ataxia (poma) Indicative of intriguing differences in the regulatory mechanisms for excitatory and inhibitory synaptic plasticity, LTP of sIPSC but not EPSC was abolished in mice lacking Nova-2, a neuronal-specific RNA binding protein that is an autoimmune target in pa 16213216 Mouse

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