IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PPP5C Ensembl ENSG00000011485 Chromosome 19 Start 51542134 End 51585949
Description Serine/threonine-protein phosphatase 5 (PP5)(EC 3.1.3.16)(Protein phosphatase T)(PP-T)(PPT) [Source:UniProtKB/Swiss-Prot;Acc:P53041]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9322
     Entrez Gene : 5536
     UCSC : uc002pem.2
     GeneCards : 9322
     RefSeq : NM_006247
     CCDS : CCDS12684.1
     Uniprot : P53041
     Interpro : P53041
     OMIM : 600658
     GeneTests : PPP5C
     CGAP : PPP5C
     PMID : 8666404

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  391_at  0.16  4.17e-2  7.93e-2  0.08  3.58e-1  4.64e-1
 HG_U95  392_g_at  0.15  7.87e-2  1.35e-1  0.26  4.07e-3  1.05e-2
 HG_U133A  201979_s_at  0.72  1.30e-16  7.92e-16  5.29  7.46e-109  6.46e-108
 HG_U133A  215705_at  -0.14  5.16e-2  7.15e-2  -0.85  1.21e-14  1.63e-14
 HG_U133_Plus2  201979_s_at  0.65  1.00e-5  3.83e-5  1.13  1.16e-11  6.22e-11
 HG_U133_Plus2  215705_at  0.50  2.07e-3  5.00e-3  0.82  5.36e-6  1.43e-5
 Stanford  19163  0.65  2.64e-2  1.20e-1  0.44  1.03e-1  2.77e-1
 Agilent_HS_21.6K  10473  -0.11  1.81e-2  7.10e-2  -0.12  2.70e-2  7.75e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201979_s_at  0.24  3.76e-1  8.96e-1  0.02  8.91e-1  1.00e+0
 HG_U133A  215705_at  -0.22  2.62e-1  8.61e-1  0.15  4.11e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 391_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 392_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201979_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215705_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201979_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215705_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19163    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10473    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pp5 tumor Bacterially expressed PP5 is inhibited by several tumor promoters but not by the anticancer drug fostriecin. 11240142 Human
pp5 human breast carcinoma Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively. 11331294 Human
pp5 human breast carcinoma Here we show that the expression of PP5, an evolutionarily conserved Ser/Thr phosphatase that functions as an inhibitor of glucocorticoid- and p53-induced signaling cascades leading to growth suppression, is responsive to 17beta-estradiol (E(2)) in ER-pos 11331294 Human
pp5 malignant ascites The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver. 11029491 Rat
pp5 cancers Thus, aberrant PP5 expression may have an additive effect on the development of human cancers by promoting cell proliferation via the inhibition of a GR-induced antiproliferative signaling cascade, and facilitating neoplastic transformation via the inhibi 10413457 Human
pp5 tumor In addition, since the inhibition of PP5 gene expression has marked antiproliferative activity and the overexpression of p21(WAF1/Cip1) blocks the growth of tumor cells, these studies suggest that compounds that inhibit of PP5 gene expression may be usefu 9575175 Human
pp5 cancers In addition, since the inhibition of PP5 gene expression has marked antiproliferative activity and the overexpression of p21(WAF1/Cip1) blocks the growth of tumor cells, these studies suggest that compounds that inhibit of PP5 gene expression may be usefu 9575175 Human
pp5 hepatomas The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver. 11029491 Rat
pp5 tumor Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice. 15374638 Mouse
pp5 tumor In estrogen-responsive cells, PP5 expression is stimulated by 17 beta-estradiol, and in a variety of p53 wild-type tumor cells the suppression of PP5 expression with ISIS 15534 inhibits growth. 15374638 Human
pp5 tumor To further explore the relationship between PP5 and the development of human cancer, here we tested the effect of elevated PP5 expression on tumor growth using a mouse xenograph model and a stable MCF-7 cell line in which the expression of wild-type PP5 w 15374638 Human
pp5 cancer To further explore the relationship between PP5 and the development of human cancer, here we tested the effect of elevated PP5 expression on tumor growth using a mouse xenograph model and a stable MCF-7 cell line in which the expression of wild-type PP5 w 15374638 Human
pp5 tumors In the xenograph model a modest two fold increase in PP5 protein levels significantly enhanced the growth rate of estrogen-dependent tumors, suggesting PP5 plays a positive role in tumor development. 15374638 Mouse
pp5 tumor In the xenograph model a modest two fold increase in PP5 protein levels significantly enhanced the growth rate of estrogen-dependent tumors, suggesting PP5 plays a positive role in tumor development. 15374638 Mouse
pp5 breast cancer In ERalpha-positive breast cancer MCF7 cells, estrogen- and epidermal growth factor-dependent phosphorylation of ERalpha on serine residue 118, a major phosphorylation site of the receptor, was reduced by expressing PP5 but enhanced by PP5 antisense oligo 14764652 Human

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