IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTGIR Ensembl ENSG00000160013 Chromosome 19 Start 51815566 End 51820194
Description Prostacyclin receptor (Prostanoid IP receptor)(PGI receptor)(Prostaglandin I2 receptor) [Source:UniProtKB/Swiss-Prot;Acc:P43119]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9602
     Entrez Gene : 5739
     UCSC : uc002pex.2
     GeneCards : 9602
     RefSeq : NM_000960
     CCDS : CCDS12686.1
     Uniprot : P43119
     Interpro : P43119
     OMIM : 600022
     GeneTests : PTGIR
     CGAP : PTGIR
     PMID : 7759114

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  758_at  -0.97  2.66e-14  7.48e-13  -1.20  2.14e-16  8.89e-15
 HG_U133A  206187_at  -1.64  8.43e-33  1.58e-31  -2.23  1.12e-26  1.80e-26
 HG_U133_Plus2  1555620_a_at  -0.00  9.82e-1  9.87e-1  -0.45  8.29e-3  1.37e-2
 HG_U133_Plus2  206187_at  -1.32  8.95e-20  2.05e-18  -1.44  1.10e-15  9.36e-15
 Agilent_HS_21.6K  16176  -0.02  5.35e-1  7.02e-1  -0.03  2.83e-1  4.39e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206187_at  0.85  6.04e-2  7.24e-1  0.10  7.67e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 758_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206187_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1555620_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206187_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16176    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
prostacyclin receptor tumor In tumor cell lines expressing a functional prostacyclin receptor, stimulated tumor cell migration is inhibited and changes of differentiation status are obvious. 8825130 Human
prostacyclin receptor mastocytoma Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells. 1701557 Human
prostacyclin receptor mastocytoma These results indicate that a specific prostacyclin receptor is coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mastocytoma cells. 1701557 Human
prostacyclin receptor human erythroleukemia Induction of prostacyclin receptor expression in human erythroleukemia cells. 2477277 Human
prostacyclin receptor megakaryocytic leukaemia A functional cDNA for the human prostacyclin receptor was isolated from a cDNA library of CMK cells, a human megakaryocytic leukaemia cell line. 7514139 Human
prostanoid ip receptor mouse neuroblastoma NG108-15 mouse neuroblastoma x rat glioma cells were treated with the prostanoid IP receptor agonist iloprost (1 microM) and the time course of changes in the levels of prostanoid IP receptors, adenylyl cyclase activity, and the alpha-subunit of the stimu 7525317 Human
prostanoid ip receptor rat glioma NG108-15 mouse neuroblastoma x rat glioma cells were treated with the prostanoid IP receptor agonist iloprost (1 microM) and the time course of changes in the levels of prostanoid IP receptors, adenylyl cyclase activity, and the alpha-subunit of the stimu 7525317 Human
prostacyclin receptor mastocytoma Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells. 1370818 Human
prostacyclin receptor mastocytoma These results suggest that the prostacyclin receptor differentially regulates two distinct Ca2+ mobilizing systems via cAMP in mastocytoma cells. 1708239 Human
prostacyclin receptor mastocytoma TEI-9063, a stable and highly specific prostacyclin analogue for the prostacyclin receptor in mastocytoma P-815 cells. 1723528 Human
prostacyclin receptor tumor cell migration In tumor cell lines expressing a functional prostacyclin receptor, stimulated tumor cell migration is inhibited and changes of differentiation status are obvious. 8825130 Human
prostacyclin receptor tumor Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: A model with prostanoid-related cachexia. 15704139 Human
prostacyclin receptor tumor Tumor growth, with and without provision of a classical cyclo-oxygenase inhibitor (indomethacin), was related to tumor content of COX-1/COX-2 protein as well as to EP1-EP4 and prostacyclin receptor expression. 16142306 Human

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