IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PRKD2 Ensembl ENSG00000105287 Chromosome 19 Start 51869414 End 51912224
Description Serine/threonine-protein kinase D2 (EC 2.7.11.13)(nPKC-D2) [Source:UniProtKB/Swiss-Prot;Acc:Q9BZL6]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17293
     Entrez Gene : 25865
     UCSC : uc002pfj.2
     GeneCards : 17293
     RefSeq : NM_001079880
     CCDS : CCDS12689.1
     Uniprot : Q9BZL6
     Interpro : Q9BZL6
     OMIM : 607074
     GeneTests : PRKD2
     CGAP : PRKD2
     PMID : 11042152

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38269_at  0.05  4.36e-1  5.42e-1  0.19  6.03e-2  1.07e-1
 HG_U133A  209282_at  -0.03  6.69e-1  7.11e-1  -1.62  7.84e-54  1.90e-53
 HG_U133A  38269_at  -0.24  5.35e-7  1.42e-6  -6.75  2.35e-187  4.44e-185
 HG_U133_Plus2  209282_at  -0.08  2.34e-1  3.15e-1  0.21  1.02e-2  1.66e-2
 HG_U133_Plus2  241669_x_at  -0.09  7.18e-1  7.81e-1  1.34  1.36e-14  1.02e-13
 HG_U133_Plus2  38269_at  -0.00  9.76e-1  9.83e-1  0.32  4.02e-3  7.02e-3
 Agilent_HS_21.6K  16773  -0.21  1.00e-13  1.55e-11  -0.19  1.98e-7  3.93e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209282_at  0.47  1.29e-2  6.83e-1  0.04  7.97e-1  1.00e+0
 HG_U133A  38269_at  0.24  1.59e-1  8.13e-1  0.06  6.42e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38269_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209282_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 38269_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209282_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241669_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 38269_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16773    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pkd2 human gastric cancer PKD2 can be activated by phorbol esters both in vivo and in vitro but also by gastrin via the cholecystokinin/CCK(B) receptor in human gastric cancer cells stably transfected with the CCK(B)/gastrin receptor (AGS-B cells). 12058027 Human
pkd2 chronic myeloid leukemia PKD2 was found to be the major isoform of the PKD family expressed in chronic myeloid leukemia cells and is tyrosine phosphorylated by Bcr-Abl in its pleckstrin homology domain. 15604256 Human
pkd2 myeloid leukemia Targeting PKD2 tyrosine phosphorylation, not its kinase activity, could be a novel therapeutic approach for the treatment of Bcr-Abl(+) myeloid leukemia. 15604256 Human
pkd2 cancer Gastrin triggers nuclear accumulation of PKD2 in living AGS-B cancer cells. 15975900 Human
protein kinase d2 human myeloid leukemia Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. 15604256 Human

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