IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC1A5 Ensembl ENSG00000105281 Chromosome 19 Start 51969982 End 51983691
Description Neutral amino acid transporter B(0) (ATB(0))(Sodium-dependent neutral amino acid transporter type 2)(RD114/simian type D retrovirus receptor)(Baboon M7 virus receptor)(Solute carrier family 1 member 5) [Source:UniProtKB/Swiss-Prot;Acc:Q15758]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10943
     Entrez Gene : 6510
     UCSC : uc002pfs.2
     GeneCards : 10943
     RefSeq : NM_001145144
     CCDS : CCDS12692.1
     Uniprot : Q15758
     Interpro : Q15758
     OMIM : 109190
     GeneTests : SLC1A5
     CGAP : SLC1A5
     PMID : 8702519

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41778_at  0.60  1.29e-11  2.28e-10  1.10  5.83e-14  1.49e-12
 HG_U133A  208916_at  0.70  5.64e-19  4.11e-18  1.12  6.06e-27  9.74e-27
 HG_U133_Plus2  208916_at  0.24  7.35e-3  1.55e-2  1.08  2.13e-16  1.96e-15
 Stanford  3829  0.05  8.68e-1  9.28e-1  0.84  3.39e-2  1.30e-1
 Agilent_HS_21.6K  15639  0.02  6.27e-1  7.73e-1  0.07  2.38e-2  7.04e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208916_at  -0.03  9.03e-1  9.94e-1  -0.09  6.08e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41778_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208916_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208916_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3829    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15639    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
asct2 placental choriocarcinoma Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. 12175968 Human
asct2 human hepatoma Amino acid inhibition, kinetic, Northern blotting, RT-PCR, and restriction enzyme analyses collectively identified the transporter responsible in six human hepatoma cell lines as amino acid transporter B(0) (ATB(0)), the human ortholog of rodent ASCT2. 12381519 Human
asct2 hepatoma Thus enhanced glutamine uptake in rat hepatoma cells is mediated by the expression of a novel ASCT/B0 transporter isoform rather than by increased expression of the ASCT2 mRNA found in normal rat liver. 12171599 Human
asct2 colorectal adenocarcinoma Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma. 12529963 Human
asct2 colorectal adenocarcinomas (crc) Our aim was to determine whether the neutral amino acid transporter ASCT2 is expressed in colorectal adenocarcinomas (CRC), and whether its expression is of biological significance. 12529963 Human
asct2 cancer ASCT2 immunoreactivity was present in 1-25% of the cancer cells in 24% of the cases, 26-50% of the cells in 13%, and in > 50% of the cells in 22% of the cases. 12529963 Human
asct2 glioblastoma We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transporters: ASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astro 15094455 Human
asct2 malignant gliomas We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transporters: ASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astro 15094455 Human
asct2 anaplastic astrocytoma We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transporters: ASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astro 15094455 Human
asct2 brain metastases We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transporters: ASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astro 15094455 Human
asct2 human hepatoma Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells. 14563674 Human
asct2 malignant tumors The neutral amino acid transporter ASCT2 has been associated with increased metabolism in malignant tumors. 12926082 Human
asct2 cancer High-level expression of ASCT2 was significantly higher in normal tissues (49%) as compared to BPH (25.8%) or cancer (25.3%) (p < 0.001). 12926082 Human
asct 2 tumor ASCT 2 seems to be involved in tumor progression. 12926082 Human
asct2 c6 glioma Glutamine transport in C6 glioma cells shows ASCT2 system characteristics. 12742097 Rat
asct2 bph ASCT2 was localized in the cytoplasm of epithelial cells of normal prostate, BPH and PCa. 12926082 Human
asct2 bph High-level expression of ASCT2 was significantly higher in normal tissues (49%) as compared to BPH (25.8%) or cancer (25.3%) (p < 0.001). 12926082 Human
asct2 cancer Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime? 15916903 Human
asct2 cancers Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the "tumor metabolome". 15916903 Human

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