IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GRLF1 Ensembl ENSG00000160007 Chromosome 19 Start 52113773 End 52199404
Description Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1)(GRF-1)(Rho GAP p190A)(p190-A) [Source:UniProtKB/Swiss-Prot;Acc:Q9NRY4]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4591
     Entrez Gene : 2909
     UCSC : uc010ekv.2
     GeneCards : 4591
     RefSeq : NM_004491
     CCDS : CCDS46127.1
     Uniprot : Q9NRY4
     Interpro : Q9NRY4
     OMIM : 605277
     GeneTests : GRLF1
     CGAP : GRLF1
     PMID : 1894621

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34724_at  -0.52  1.72e-3  5.06e-3  -0.13  3.24e-1  4.29e-1
 HG_U95  34725_at  0.42  5.67e-4  1.91e-3  0.41  1.28e-2  2.87e-2
 HG_U133A  202044_at  0.87  3.62e-10  1.31e-9  4.87  2.38e-120  2.92e-119
 HG_U133A  202045_s_at  -0.21  2.76e-4  5.42e-4  0.98  4.18e-18  5.91e-18
 HG_U133A  202046_s_at  0.24  9.92e-4  1.81e-3  2.09  3.22e-47  7.01e-47
 HG_U133_Plus2  202044_at  -0.13  4.46e-1  5.35e-1  -0.40  5.92e-2  8.35e-2
 HG_U133_Plus2  202045_s_at  -0.06  5.71e-1  6.53e-1  0.52  3.89e-7  1.21e-6
 HG_U133_Plus2  202046_s_at  1.04  2.25e-13  2.50e-12  1.53  7.61e-14  5.21e-13
 HG_U133_Plus2  229394_s_at  -0.52  1.23e-8  7.44e-8  -0.33  1.14e-3  2.18e-3
 HG_U133_Plus2  229397_s_at  -1.03  4.65e-9  2.96e-8  -0.61  1.54e-4  3.36e-4
 HG_U133_Plus2  239456_at  0.24  1.49e-1  2.15e-1  -0.34  8.27e-2  1.13e-1
 Stanford  4723  -0.68  7.08e-4  1.16e-2  -0.15  5.76e-1  7.71e-1
 Agilent_HS_21.6K  3695  0.01  8.88e-1  9.38e-1  0.04  3.70e-1  5.30e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202044_at  -0.09  8.61e-1  9.89e-1  0.09  7.60e-1  1.00e+0
 HG_U133A  202045_s_at  -0.13  5.18e-1  9.34e-1  0.04  7.40e-1  1.00e+0
 HG_U133A  202046_s_at  0.17  5.37e-1  9.35e-1  -0.07  7.17e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34724_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 34725_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202044_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202045_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202046_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202044_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202045_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202046_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229394_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229397_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239456_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4723    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3695    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
p190-a human tumor p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. 11054565 Human
p190-a tumor We have previously demonstrated, using rat p190-A cDNA, that full-length p190-A is a tumor suppressor, reversing v-Ha-Ras-induced malignancy of NIH 3T3 cells through both the N-terminal GTPase (residues 1-251) and the C-terminal Rho GAP (residues 1168-144 11054565 Rat
p190-a glioblastoma Moreover, at least 40% glioblastoma/astrocytoma cases with breakpoints in this region were previously reported to show loss of the chromosomal region encompassing p190-A, suggesting the possibility that loss or mutations of this gene might be in part resp 11054565 Human
p190-a tumors Moreover, at least 40% glioblastoma/astrocytoma cases with breakpoints in this region were previously reported to show loss of the chromosomal region encompassing p190-A, suggesting the possibility that loss or mutations of this gene might be in part resp 11054565 Human
p190-a astrocytoma Moreover, at least 40% glioblastoma/astrocytoma cases with breakpoints in this region were previously reported to show loss of the chromosomal region encompassing p190-A, suggesting the possibility that loss or mutations of this gene might be in part resp 11054565 Human
p190rhogap neuroblastoma Phosphorylation by Arg also promotes p190RhoGAP's association with p120RasGAP and stimulates p190RhoGAP's ability to induce neuritogenesis in neuroblastoma cells. 15084284 Mouse
p190-a gliomas p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. 11054565 Human
p190-a malignancy We have previously demonstrated, using rat p190-A cDNA, that full-length p190-A is a tumor suppressor, reversing v-Ha-Ras-induced malignancy of NIH 3T3 cells through both the N-terminal GTPase (residues 1-251) and the C-terminal Rho GAP (residues 1168-144 11054565 Rat
p190rhogap gliomas p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. p190RhoGAP and Rho are key regulators of oligodendrocyte differentiation. 12600941 Mouse
p190rhogap oligodendrogliomas The gene encoding p190RhoGAP is located at 19q13.3 of the human chromosome, a locus that is deleted in 50%-80% of oligodendrogliomas. 12600941 Human
p190rhogap gliomas Independent experiments revealed that the retroviral vector insertion site in 3 of 50 PDGF-induced gliomas was within the p190RhoGAP gene. 12600941 Human

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