IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene BBC3 Ensembl ENSG00000105327 Chromosome 19 Start 52415924 End 52427699
Description Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis)(JFY-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9BXH1]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17868
     Entrez Gene : 27113
     UCSC : uc010xyl.1
     GeneCards : 17868
     RefSeq : NM_001127240
     CCDS : CCDS12697.1
     Uniprot : Q9BXH1
     Interpro : Q9BXH1
     OMIM : 605854
     GeneTests : BBC3
     CGAP : BBC3
     PMID : 11463392

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1700_at  0.35  2.10e-3  6.02e-3  0.34  2.18e-2  4.52e-2
 HG_U133A  211692_s_at  -0.03  7.58e-1  7.92e-1  -3.68  4.64e-67  1.43e-66
 HG_U133_Plus2  211692_s_at  0.41  6.02e-4  1.64e-3  0.53  1.92e-4  4.11e-4
 Stanford  1425  0.30  3.59e-1  5.59e-1  0.27  3.93e-1  6.29e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  211692_s_at  -0.81  5.84e-2  7.19e-1  -0.21  3.91e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1700_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211692_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211692_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1425    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
bbc3 tumor Additionally, bbc3 mRNA was induced by p53-independent apoptotic stimuli, including dexamethasone treatment of thymocytes, and serum deprivation of tumor cells. 11572983 Human
bbc3 tumor Insulin-like growth factor-1 and epidermal growth factor, growth factors with broad anti-apoptotic activity, were each sufficient to suppress Bbc3 expression in serum-starved tumor cells. 11572983 Human
bbc3 neuroblastoma Overexpression of Bbc3/PUMA was sufficient to trigger apoptosis in SH-SY5Y neuroblastoma cells, and human cells deficient in Bbc3/PUMA showed dramatically reduced apoptosis in response to ER stress. 12913114 Human
the puma gene lung cancers The PUMA gene was mapped to chromosomal arm 19q, a region frequently deleted in head/neck and lung cancers. 12963126 Human
the puma gene primary tumors We then sequenced the entire coding region of the PUMA gene in all the 30 primary tumors and in 10 head/neck cancer cell lines. 12963126 Human
the puma gene neck cancer We then sequenced the entire coding region of the PUMA gene in all the 30 primary tumors and in 10 head/neck cancer cell lines. 12963126 Human
puma cancer Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. 16983338 Human
puma human colon cancer Further characterization of the transcriptional response to Epoxo in HCT116 human colon cancer cells demonstrated that PUMA induction was p53-dependent; with deficiency in either p53 or PUMA significantly protected HCT116 cells against Epoxo-induced apopt 16983338 Human
puma cancer Our data suggest that p53 activation and the transcriptional induction of its target gene PUMA play an important role in the sensitivity of cancer cells to apoptosis induced by proteasome inhibition, and imply that antineoplastic therapies with PIs might 16983338 Human
puma cancers Our data suggest that p53 activation and the transcriptional induction of its target gene PUMA play an important role in the sensitivity of cancer cells to apoptosis induced by proteasome inhibition, and imply that antineoplastic therapies with PIs might 16983338 Human
puma gastric cancer METHODS: A recombinant adenovirus that carries a lethal gene (p53 up-regulated modulator of apoptosis [PUMA]) under the control of a beta-catenin/Tcf-responsive promoter (AdTOP-PUMA) was used selectively to target gastric cancer cells (AGS) that posses an 17149756 Human
puma melanoma E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. 17263886 Human
puma melanoma We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis in melanoma cells. 17263886 Human
puma colon cancer Moreover, a 2.2-fold induction of the PUMA promoter was also noted in the HCT116 PUMA+/+ colon cancer cell line after Ad-E2F-1 infection. 17263886 Human
puma cancer E2F-1-induced cancer cell apoptosis was accompanied by Bax translocation from the cytosol to mitochondria and the induction of caspase-9 activity, suggesting that E2F-1-induced apoptosis is mediated by PUMA through the cytochrome C/Apaf-1-dependent pathwa 17263886 Human
puma melanoma CONCLUSION: Our studies strongly demonstrated that E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. 17263886 Human
puma gastric carcinomas Immunohistochemical analysis of pro-apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas. 17267315 NA
puma human gastric carcinomas AIM: The aim of this study was to explore whether alteration of PUMA protein expression is a characteristic of human gastric carcinomas. 17267315 NA
puma gastric adenocarcinomas PATIENTS AND METHODS: We analysed expression of PUMA protein in 60 gastric adenocarcinomas by immunohistochemistry. 17267315 NA
puma gastric carcinomas RESULTS: PUMA protein expression was detected in 44 cases (73%) of the 60 gastric carcinomas, whereas it was not detected in normal gastric mucosal epithelial cells. 17267315 Human
puma gastric carcinomas The mutational analysis revealed no PUMA mutation in the gastric carcinomas. 17267315 Human
puma tumor As a result, the balance of expression of p53 target genes, such as p21, Bax and PUMA, regulates the biological behavior and determines the fate of tumor cells. 17280505 Human
puma human colorectal cancer To understand how PUMA does so, we used homologous recombination to delete the binding sites of p53 in the promoter of PUMA in human colorectal cancer cells. 17360476 Human
puma tumor These results indicate that the binding of nuclear p53 to the specific sites within the PUMA promoter is essential for its ability to induce apoptosis and is likely to be required for its tumor suppressive capacity. 17360476 Human
puma colon cancer A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. 17363499 Human
the puma gene melanoma RESULTS: Up-regulation of the PUMA gene and protein by E2F-1 overexpression was detected by real-time PCR and Western blot analysis in the SK-MEL-2 melanoma cell line. 17263886 Human
puma colorectal cancer PUMA induces the rapid apoptosis of colorectal cancer cells. 11463391 Human
puma cancer Our studies indicate that mtCLIC, like Bax, Noxa, p53AIP1, and PUMA, participates in a stress-induced death pathway converging on mitochondria and should be considered a target for cancer therapy through genetic or pharmacologic approaches. 11997498 Human
puma colorectal cancer PUMA mediates the apoptotic response to p53 in colorectal cancer cells. 12574499 Human
puma cancer These results suggest that the balance between PUMA and p21 is pivotal in determining the responses to p53 activation and provide a model for understanding the basis of p53 mutations in human cancer. 12574499 Human
puma head and neck cancer PUMA in head and neck cancer. 12963126 Human
puma neck cancer Forced expression of wild-type PUMA in JHU-012 and JHU-013 head/neck cancer cell lines significantly inhibited colony formation. 12963126 Human
puma neck cancer Although PUMA suppresses tumor cell growth in head/neck cancer, it does not appear to be a direct target of inactivation in head and neck tumorigenesis. 12963126 Human
puma tumor Although PUMA suppresses tumor cell growth in head/neck cancer, it does not appear to be a direct target of inactivation in head and neck tumorigenesis. 12963126 Human
puma human leukemia The apoptotic effect of PUMA on the mitochondria was studied using a p53-negative, human leukemia K562 cell line. 14550297 Human
puma osteosarcoma Furthermore, osteosarcoma cells treated with cytostatic drugs showed as primary response strong up-regulation of the apoptogenic p53-inducible PUMA transcript. 14627843 Human
puma colorectal cancer p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. 15123817 Human
puma cancer The molecules and signals that act to eradicate or initiate the apoptosis cascade in cancer cells, are elucidated, and these include caspases, Fas, Bax, Bid, APC, antisense hTERT, PUMA, 15-LOX-1, ceramide, butyrate, tributyrin and PPARgamma, whereas the m 15255176 Human
puma human colon cancer Together, these findings suggest that p53 acts upstream of Bax to promote MDA-mediated cell death in a proline-rich domain-dependent manner through both transcription-dependent (by up-regulating PUMA expression) and -independent mechanisms in human colon 15262986 Human
puma colorectal adenocarcinomas We have investigated the mRNA expression of PUMA with real-time PCR in 94 colorectal adenocarcinomas and the corresponding normal mucosa. 15547745 Human
puma tumours Among them PUMA protein expression was investigated with immunohistochemistry in 23 tumours and 17 corresponding normal mucosa samples. 15547745 Human
puma tumours The mRNA expression of PUMA decreased in 4% and increased in 4% of the tumours compared with the normal mucosa. 15547745 Human
puma tumours The protein expression of PUMA decreased in 6% and increased in 29% of the tumours compared with the normal mucosa. 15547745 Human
puma tumour Decreased PUMA expression in the tumour compared with the corresponding mucosa was correlated with the distal colon and rectum (P=0.02). 15547745 Human
puma colorectal cancer We suggest that the changes in PUMA expression may be of minor importance in the development of colorectal cancer. 15547745 Human
puma cutaneous melanomas PUMA expression is significantly reduced in human cutaneous melanomas. 15690057 Human
puma melanoma In this study, we sought to determine whether PUMA (p53 upregulated modulator of apoptosis) contributes to human melanoma formation, tumor progression, and survival. 15690057 Human
puma tumor In this study, we sought to determine whether PUMA (p53 upregulated modulator of apoptosis) contributes to human melanoma formation, tumor progression, and survival. 15690057 Human
puma dysplastic nevi We used tissue microarray and immunohistochemistry to examine PUMA expression in 107 primary melanomas, 51 metastatic melanomas, and 64 dysplastic nevi. 15690057 Human
puma melanomas We used tissue microarray and immunohistochemistry to examine PUMA expression in 107 primary melanomas, 51 metastatic melanomas, and 64 dysplastic nevi. 15690057 Human
puma metastatic melanomas We used tissue microarray and immunohistochemistry to examine PUMA expression in 107 primary melanomas, 51 metastatic melanomas, and 64 dysplastic nevi. 15690057 Human
puma dysplastic nevi Here we report that PUMA expression is significantly weaker in primary melanomas compared to dysplastic nevi (P<0.0001), and is further reduced in metastatic melanomas compared to primary tumors (P=0.001). 15690057 Human
puma melanomas Here we report that PUMA expression is significantly weaker in primary melanomas compared to dysplastic nevi (P<0.0001), and is further reduced in metastatic melanomas compared to primary tumors (P=0.001). 15690057 Human
puma metastatic melanomas Here we report that PUMA expression is significantly weaker in primary melanomas compared to dysplastic nevi (P<0.0001), and is further reduced in metastatic melanomas compared to primary tumors (P=0.001). 15690057 Human
puma melanoma We show that weak PUMA expression in melanoma correlates with poorer overall and disease-specific 5-year survival (P<0.005 and P<0.001, respectively) of melanoma patients and that PUMA expression in tumor tissue is an independent predictor of both overall 15690057 Human
puma tumor We show that weak PUMA expression in melanoma correlates with poorer overall and disease-specific 5-year survival (P<0.005 and P<0.001, respectively) of melanoma patients and that PUMA expression in tumor tissue is an independent predictor of both overall 15690057 Human
puma melanoma Additionally, we show that exogenous PUMA expression in human melanoma cell lines (both wild type and mutant p53) results in significant apoptotic cell death. 15690057 Human
puma melanoma Our results suggest that PUMA expression may be an important prognostic marker for human melanoma and that adenoviral delivery of PUMA sensitizes melanoma cells to apoptosis. 15690057 Human
puma myeloma Farnesyltransferase inhibitor BMS-214662 induces apoptosis in myeloma cells through PUMA up-regulation, Bax and Bak activation, and Mcl-1 elimination. 15738311 Human
puma colorectal cancer PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. 15753358 Human
puma breast cancer In vitro MCF-7 breast cancer cells exposed to clinically achievable doxorubicin concentrations for 6 hours revealed marked induction of PUMA mRNA, as well. 15756011 Human
puma pancreatic cancer METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the expression of five genes associated with hypoxia-mediated apoptosis (PUMA, Caspase-8 [CASP8], APAF-1, BNIP3, and BNIP3L) in a panel of pancreatic cancer cell lines. 15942716 Human
puma malignant glioma Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status. 15960600 Human
puma cancer Our purpose was to elucidate a role for PUMA in p53 gene therapy and to investigate whether PUMA is an efficient substitute for p53 in cancer therapy. 15960600 Human
puma malignant glioma We demonstrated that PUMA was upregulated in mutant p53 malignant glioma cells (U373-MG and T98G) undergoing apoptosis but was not upregulated in apoptosis-resistant wild-type p53 malignant glioma cells (U87-MG and D54) after adenoviral transfer of p53. 15960600 Human
puma tumor Overexpression of PUMA resulted in massive apoptosis associated with mitochondrial damage and caspase-3 activation in all tumor cells tested. 15960600 Human
puma tumors Moreover, exogenous expression of PUMA under the hTERT promoter system significantly suppressed the growth of subcutaneous U87-MG tumors in nude mice and did not induce apoptosis in surrounding nontumor tissues. 15960600 Human
puma malignant gliomas These results indicate that PUMA, which is regulated under a tumor-specific expression system such as the hTERT promoter, may be better than p53 as a therapeutic tool for malignant gliomas. 15960600 Human
puma tumor The efficacy of chemotherapeutic agents on tumor cells has been shown to be modulated by tumor suppressor gene p53 and its target genes such as Bcl-2 family members (Bax, Noxa, and PUMA). 16202244 Human
puma sporadic colorectal cancer mRNA and protein expression of PUMA in sporadic colorectal cancer. 15547745 Human
puma cervical cancer Using RNA interference (RNAi), here, we show that targeted inhibition of E6 expression in cervical cancer cells leads to the transcriptional stimulation of the PUMA promoter, in a p53-dependent manner. 16462759 Human
puma esophageal cancer Administration of PUMA Adenovirus Increases the Sensitivity of Esophageal Cancer Cells to Anticancer Drugs. 16481741 Human
puma esophageal cancer We evaluated the therapeutic potential of PUMA adenovirus against esophageal cancer cell lines (KYSE-150, KYSE-410, KYSE-510 and YES-2). 16481741 Human
puma esophageal cancer Furthermore, we assessed the efficacy of a combined treatment with Ad-PUMA and anticancer drug (cisplatin, paclitaxel, 5-fluorouracil, respectively) for these cells and found PUMA significantly increased the chemosensitivity of esophageal cancer cells, wh 16481741 Human
puma colon cancer The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells. 16595125 Human
puma colon cancer We showed that oxaliplatin-induced PUMA expression in a time- and dose-dependent manner and suppression of PUMA expression by stable transfecting anti-sense PUMA plasmid decreased oxaliplatin-induced apoptosis in colon cancer cells. 16595125 Human
puma colon cancer Moreover, PUMA expression and apoptosis in oxaliplatin-treated colon cancer cells could be regulated partly by ERK inactivation. 16595125 Human
puma colon cancer PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. 16608847 Human
puma colon cancer In this study, we investigated how the interactions of PUMA with the antiapoptotic proteins coordinate with Bax to initiate apoptosis in HCT116 colon cancer cells. 16608847 Human
puma lung cancer PUMA Sensitizes Lung Cancer Cells to Chemotherapeutic Agents and Irradiation. 16675590 Human
puma lung cancer In this study, we investigated whether the regulation of PUMA by anticancer agents is abrogated in lung cancer cells and whether PUMA expression suppresses growth of lung cancer cells and/or sensitizes lung cancer cells to chemotherapeutic agents and irra 16675590 Human
puma lung cancer Experimental Designs: The expression of PUMA was examined in lung cancer cells with different p53 status treated with chemotherapeutic agents. 16675590 Human
puma lung cancer An adenovirus expressing PUMA (Ad-PUMA), alone or in combination with chemotherapeutic agents or gamma-irradiation, was used to treat lung cancer cells. 16675590 Human
puma cancer The cytotoxicities of PUMA on cancer and normal/nontransformed cells were compared. 16675590 Human
puma lung cancer The efficacy of PUMA and p53 in suppressing the growth of lung cancer cells was also compared. 16675590 Human
puma lung cancer RESULTS: We showed that the induction of PUMA by chemotherapeutic agents is abolished in p53-deficient lung cancer cells. 16675590 Human
puma lung cancer PUMA expression resulted in potent growth suppression of lung cancer cells and suppressed xenograft tumor growth in vivo through induction of apoptosis. 16675590 Human
puma tumor PUMA expression resulted in potent growth suppression of lung cancer cells and suppressed xenograft tumor growth in vivo through induction of apoptosis. 16675590 Human
puma cancer Furthermore, PUMA seems to be selectively toxic to cancer cells and more efficient than p53 in suppressing lung cancer cell growth. 16675590 Human
puma lung cancer Furthermore, PUMA seems to be selectively toxic to cancer cells and more efficient than p53 in suppressing lung cancer cell growth. 16675590 Human
puma lung cancer CONCLUSIONS: Our findings indicate that PUMA is an important modulator of therapeutic responses of lung cancer cells and is potentially useful as a sensitizer in lung cancer therapy. 16675590 Human
puma colon carcinoma Because p21 can protect against genotoxic stress by reducing p53-dependent transcription of the proapoptotic proteins PUMA and Bax, the current study uses genetically modified lines of HCT116 colon carcinoma cells to investigate whether p21-mediated prote 16863993 Human
bbc3 neuroblastoma BBC3 mediates fenretinide-induced cell death in neuroblastoma. 16091745 Human
puma neuroblastoma Overexpression of Bbc3/PUMA was sufficient to trigger apoptosis in SH-SY5Y neuroblastoma cells, and human cells deficient in Bbc3/PUMA showed dramatically reduced apoptosis in response to ER stress. 12913114 Human
puma tumorigenesis Although PUMA suppresses tumor cell growth in head/neck cancer, it does not appear to be a direct target of inactivation in head and neck tumorigenesis. 12963126 Human
puma human leukemia Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. 14550297 Human
puma osteosarcoma Furthermore, osteosarcoma cells treated with cytostatic drugs showed as primary response strong up-regulation of the apoptogenic p53-inducible PUMA transcript. 14627843 Human
puma tumorigenesis Suppression of tumorigenesis by the p53 target PUMA. 15192153 Human
puma oncogenic Like p53 shRNAs, PUMA shRNAs promoted oncogenic transformation of primary murine fibroblasts by the E1A/ras oncogene combination and dramatically accelerated myc-induced lymphomagenesis without disrupting p53-dependent cell-cycle arrest. 15192153 Mouse
puma lymphomagenesis Like p53 shRNAs, PUMA shRNAs promoted oncogenic transformation of primary murine fibroblasts by the E1A/ras oncogene combination and dramatically accelerated myc-induced lymphomagenesis without disrupting p53-dependent cell-cycle arrest. 15192153 Mouse
puma primary tumors Here we report that PUMA expression is significantly weaker in primary melanomas compared to dysplastic nevi (P<0.0001), and is further reduced in metastatic melanomas compared to primary tumors (P=0.001). 15690057 Human
puma neuroblastoma DeltaNp73 antisense activates PUMA and induces apoptosis in neuroblastoma cells. 15803372 Human
puma leukemia HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in leukemia cells (HL60, Jurkat, K562, and U937) through multiple mechanisms; up-regulation of DR4, DR5, Bak, Bax, Bim, Noxa and PUMA, down-regulation of IAPs, Mcl-1, Bcl-2, Bcl-XL and cFLI 16273296 Human
puma melanoma tumor Using tissue microarray analysis, we found that patients exhibiting both weak PUMA expression and strong p-Akt expression in their melanoma tumor tissue had significantly worse 5-year survival than patients with either weak PUMA or strong p-Akt expression 16982766 Human
puma primary tumor Strikingly, no patients exhibiting strong PUMA expression and weak p-Akt expression in primary tumor tissue died within 5 years of diagnosis. 16982766 Human
puma melanoma tumor We propose a two-pronged therapeutic strategy of (a) boosting PUMA expression and (b) inhibiting Akt phosphorylation in melanoma tumor tissue. 16982766 Human
puma melanoma Here, we report that a recombinant adenovirus containing human PUMA cDNA (ad-PUMA) efficiently inhibits human melanoma cell survival in vitro, rapidly induces apoptosis, and dramatically suppresses human melanoma tumor growth in a severe combined immunode 16982766 Human
puma melanoma tumor Here, we report that a recombinant adenovirus containing human PUMA cDNA (ad-PUMA) efficiently inhibits human melanoma cell survival in vitro, rapidly induces apoptosis, and dramatically suppresses human melanoma tumor growth in a severe combined immunode 16982766 Human
puma malignant melanoma Our results suggest that a strategy to correct dysregulated PUMA and p-Akt expression in malignant melanoma may be an effective therapeutic option. 16982766 Human
puma melanoma Together, these studies suggest that Phenoxodiol induces apoptosis of melanoma cells by induction of p53-dependent BH3 proteins (Bad, PUMA and Noxa) and the p53-independent Bim protein, resulting in activation of Bax and its downstream events. 17075314 Human
puma breast cancer Knockdown of p53 protein in breast cancer cells using siRNA followed by PRIMA-1 treatment resulted in decline of Bax and PUMA proteins expression. 17113036 Human
puma breast cancer We conclude that both Bax and PUMA but not JNK signaling are involved in PRIMA-1-induced apoptosis in breast cancer cells with p53 mutation. 17113036 Human
puma human colorectal cancer We used a recombinant adenovirus that carries a lethal gene [p53-up-regulated modulator of apoptosis (PUMA)] under the control of a beta-catenin/Tcf-responsive promoter (AdTOP-PUMA) to selectively target human colorectal cancer cells (SW480, HCT116, DLD-1 17121933 Human
puma hepatocellular carcinoma We used a recombinant adenovirus that carries a lethal gene [p53-up-regulated modulator of apoptosis (PUMA)] under the control of a beta-catenin/Tcf-responsive promoter (AdTOP-PUMA) to selectively target human colorectal cancer cells (SW480, HCT116, DLD-1 17121933 Human
puma gastric cancer We used a recombinant adenovirus that carries a lethal gene [p53-up-regulated modulator of apoptosis (PUMA)] under the control of a beta-catenin/Tcf-responsive promoter (AdTOP-PUMA) to selectively target human colorectal cancer cells (SW480, HCT116, DLD-1 17121933 Human
puma cancer We used a recombinant adenovirus that carries a lethal gene [p53-up-regulated modulator of apoptosis (PUMA)] under the control of a beta-catenin/Tcf-responsive promoter (AdTOP-PUMA) to selectively target human colorectal cancer cells (SW480, HCT116, DLD-1 17121933 Human
puma colorectal cancer The effect of AdTOP-PUMA on colorectal cancer cells was also examined in nude mice: SW480 cells were infected with the AdTOP-PUMA and AdFOP-PUMA, and then inoculated s.c. into nude mice. 17121933 Human

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