IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SULT2A1 Ensembl ENSG00000105398 Chromosome 19 Start 53065682 End 53081405
Description Bile salt sulfotransferase (EC 2.8.2.14)(Hydroxysteroid Sulfotransferase)(HST)(Dehydroepiandrosterone sulfotransferase)(DHEA-ST)(ST2)(ST2A3) [Source:UniProtKB/Swiss-Prot;Acc:Q06520]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11458
     Entrez Gene : 6822
     UCSC : uc002phr.2
     GeneCards : 11458
     RefSeq : NM_003167
     CCDS : CCDS12707.1
     Uniprot : Q06520
     Interpro : Q06520
     OMIM : 125263
     GeneTests : SULT2A1
     CGAP : SULT2A1
     PMID : 1588921

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  523_s_at  -0.15  4.35e-1  5.42e-1  -0.21  4.30e-1  5.35e-1
 HG_U133A  206292_s_at  -0.15  2.09e-1  2.54e-1  -0.93  1.52e-7  1.83e-7
 HG_U133A  206293_at  -0.20  1.26e-1  1.61e-1  3.26  4.20e-78  1.63e-77
 HG_U133_Plus2  206292_s_at  0.55  6.18e-3  1.33e-2  0.12  6.56e-1  7.05e-1
 HG_U133_Plus2  206293_at  0.61  7.71e-3  1.62e-2  0.26  3.52e-1  4.13e-1
 Stanford  7333  1.67  4.99e-3  4.06e-2  1.74  2.12e-3  2.33e-2
 Agilent_HS_21.6K  14237  0.03  1.37e-1  2.92e-1  0.02  3.47e-1  5.07e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206292_s_at  0.32  4.04e-1  9.02e-1  0.05  8.53e-1  1.00e+0
 HG_U133A  206293_at  1.10  1.54e-2  6.83e-1  0.09  7.69e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 523_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206292_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206293_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206292_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206293_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7333    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14237    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dhea-st tumor Dehydroepiandrosterone-sulfotransferase (DHEA-ST) immunoreactivity in nonneoplastic regions was suppressed in one case in which the tumor secreted cortisol similar to preclinical and/or overt Cushing's syndrome. 11456263 Human
dehydroepiandrosterone-sulfotransferase tumor Dehydroepiandrosterone-sulfotransferase (DHEA-ST) immunoreactivity in nonneoplastic regions was suppressed in one case in which the tumor secreted cortisol similar to preclinical and/or overt Cushing's syndrome. 11456263 Human
st2 murine neuroblastoma Expression of BCGs by stable transfection of murine neuroblastoma (F-11) cells with sialyltransferase-II (ST2) resulted in a 70% reduction of ceramide-induced apoptosis. 11574545 Mouse
dehydroepiandrosterone sulfotransferase prostate cancer Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells. 9566751 Rat
the std gene hepatoma Androgenic repression of the Std gene in rat liver can be recapitulated in androgen receptor (AR)-negative HepG2 hepatoma cells after cotransfection with an AR expression plasmid. 9705324 Human
hydroxysteroid sulfotransferase pancreatic carcinomas The effects of dehydroepiandrosterone sulfate (DHAS), a typical hydroxysteroid sulfotransferase (HSTase) inhibitor, and of 3'-phosphoadenosine 5'-phosphate (PAP), a nonspecific sulfation inhibitor on N-nitrosobis(2-oxopropyl)-amine (BOP)-induced 7697798 Human
alcohol sulfotransferase human breast carcinoma Endocrine steroid sulfotransferases: steroid alcohol sulfotransferase from human breast carcinoma cell line MCF-7. 2948075 Human
alcohol sulfotransferase human breast carcinoma Steroid alcohol sulfotransferase (SAS) has been isolated from the cytosol of a human breast carcinoma cell line, MCF-7. 2948075 Human
dehydroepiandrosterone sulfotransferase human tumors Those tumors showing the lowest conversion of testosterone to estradiol-17beta possessed the highest levels of dehydroepiandrosterone sulfotransferase which lends support to data implicating sulfurylation in the regulation of steroid metabolism in human t 137557 Human
dehydroepiandrosterone sulfotransferase tumors Those tumors showing the lowest conversion of testosterone to estradiol-17beta possessed the highest levels of dehydroepiandrosterone sulfotransferase which lends support to data implicating sulfurylation in the regulation of steroid metabolism in human t 137557 Human
dehydroepiandrosterone sulfotransferase mouse tumors In the hormone-independent mouse tumors produced from out-growth lines D1, D2, and D8, high dehydroepiandrosterone sulfotransferase activity was characteristic of the rapidity with which hyperplastic alveolar nodules developed into a neoplasms (V-max = 52 165883 Mouse
alcohol sulfotransferase mouse mammary tumor As was observed in the mouse mammary tumor, Sprague-Dawley rat neoplasms that grew in the absence of ovarian hormones contained significantly greater levels of the steroid alcohol sulfotransferase. 165883 Mouse
alcohol sulfotransferase human breast carcinomas Possible correlaion between presence of the steroid alcohol sulfotransferase and the estrogen receptor protein was observed in a limited number of human breast carcinomas. 165883 Human
dehydroepiandrosterone sulfotransferase mammary carcinoma Dehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma. 137075 Human
dhea-st adrenocortical adenoma In adrenocortical adenoma, DHEA-ST immunoreactivity was observed in all the cases of Cushing's adenoma, adenoma associated with pre-Cushing's syndrome, nonfunctioning, hormonally inactive adenoma, and two of seven cases of aldosteronoma, but dis 8751327 Human
dhea-st adenoma In adrenocortical adenoma, DHEA-ST immunoreactivity was observed in all the cases of Cushing's adenoma, adenoma associated with pre-Cushing's syndrome, nonfunctioning, hormonally inactive adenoma, and two of seven cases of aldosteronoma, but dis 8751327 Human
dhea-st adenoma In attached non-neoplastic adrenal glands of the adenoma, intense and diffuse immunoreactivity was observed in the zona reticularis cells in all the cases of aldosteronoma and five of six of the nonfunctioning hormonally inactive adenoma, but DHEA-ST immu 8751327 Human
dhea-st adrenocortical carcinoma In adrenocortical carcinoma, DHEA-ST was observed in all the cases, but the relative immunointensity of carcinoma cells was weak compared to that of the zona reticularis of the normal adrenal and adenoma. 8751327 Human
dhea-st carcinoma In adrenocortical carcinoma, DHEA-ST was observed in all the cases, but the relative immunointensity of carcinoma cells was weak compared to that of the zona reticularis of the normal adrenal and adenoma. 8751327 Human
dhea-st adenoma In adrenocortical carcinoma, DHEA-ST was observed in all the cases, but the relative immunointensity of carcinoma cells was weak compared to that of the zona reticularis of the normal adrenal and adenoma. 8751327 Human
dehydroepiandrosterone sulfotransferase mammary carcinoma MCF-7 human mammary carcinoma cells have been reported to possess beta-estradiol and dehydroepiandrosterone sulfotransferase activities. 8217878 Human
hydroxysteroid sulfotransferase negative tumors The higher concentration of C19-5-ene-steroids in ER negative cellular fractions could be due to differences in their metabolism; ER negative tumors either lack, or possess very low levels of, hydroxysteroid sulfotransferase which catalyzes formation of s 1419884 Human
hsta hyperplastic The present findings demonstrate that in the early stage of the formation of the liver hyperplastic nodules by tamoxifen, the genes of the enzymes responsible for not only detoxification but also activation of tamoxifen were activated, whereas in the late 11895865 Human
sult2a1 human hepatoma Finally, we found that both TNF and IL-1 caused a significant decrease in the mRNA level of Sult2A1 in Hep3B human hepatoma cells, suggesting that the proinflammatory cytokines TNF and IL-1 mediate the inhibitory effect of LPS on Sult2A1 mRNA level. 15198932 Human
sult2a1 tumor The lowered expression in tumor cells of SULT2A1 in HCC tissues involved in metabolism and/or inactivation of sex steroids is consistent with a regulatory role of the SULT2A1 gene product in the development and/or tumor cell differentiation and progressio 15713538 Human
dehydroepiandrosterone sulfotransferase hyperplastic In the hormone-independent mouse tumors produced from out-growth lines D1, D2, and D8, high dehydroepiandrosterone sulfotransferase activity was characteristic of the rapidity with which hyperplastic alveolar nodules developed into a neoplasms (V-max = 52 165883 Mouse
dehydroepiandrosterone sulfotransferase hepatic carcinoma Cultured human hepatic carcinoma cells (Hep G2) and intestinal carcinoma cells (Caco-2) were also used to study retinoic acid's effect on simple phenol sulfating sulfotransferase, dehydroepiandrosterone sulfotransferase and oestrogen sulfotransferase 15667595 Human
dehydroepiandrosterone sulfotransferase human hepatocellular carcinoma Down-regulation of dehydroepiandrosterone sulfotransferase gene in human hepatocellular carcinoma. 15713538 Human
dehydroepiandrosterone sulfotransferase hepatocellular carcinoma (hcc) Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; D 15713538 Human
dehydroepiandrosterone sulfotransferase hcc Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; D 15713538 Human
dehydroepiandrosterone sulfotransferase tumors A significant correlation was found between synthesis of the former and levels of estrogen sulfotransferase, but this relationship did not hold for dehydroepiandrosterone sulfotransferase, again due to low levels of this enzyme in many tumors. 137075 Human
dhea-st hepatocellular carcinoma (hcc) Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; D 15713538 Human
sult2a1 hepatocellular carcinoma (hcc) Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; D 15713538 Human
dhea-st tumor Immunoreactivity of all the steroidogenic enzymes was apparent in the tumor cells and particularly dehydroepiandrosterone sulfotransferase (DHEA-ST) immunoreactivity was markedly expressed. 17318025 Human
dehydroepiandrosterone sulfotransferase tumor Immunoreactivity of all the steroidogenic enzymes was apparent in the tumor cells and particularly dehydroepiandrosterone sulfotransferase (DHEA-ST) immunoreactivity was markedly expressed. 17318025 Human
sult2a1 prostate cancer Association of SULT2A1 allelic variants with plasma adrenal androgens and prostate cancer in African American men. 16617014 Human
alcohol sulfotransferase neoplasms As was observed in the mouse mammary tumor, Sprague-Dawley rat neoplasms that grew in the absence of ovarian hormones contained significantly greater levels of the steroid alcohol sulfotransferase. 165883 Rat
hydroxysteroid sulfotransferase hepatocarcinogenesis Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats. 8242853 Rat
dehydroepiandrosterone sulfotransferase neoplasms In the hormone-independent mouse tumors produced from out-growth lines D1, D2, and D8, high dehydroepiandrosterone sulfotransferase activity was characteristic of the rapidity with which hyperplastic alveolar nodules developed into a neoplasms (V-max = 52 165883 Mouse
st2 myeloma The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells. 9058198 Human
st2 myeloma The labeled human ST2 protein bound with myeloma-derived RPMI8226 cells among the various B-cell lines, indicating possible involvement of ST2 in T-cell/B-cell interaction. 9058198 Human
dhea-st hcc Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; D 15713538 Human
sult2a1 hcc Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; D 15713538 Human
sult2a1 hcc SULT2A1 mRNA and/or protein expression in HCC were markedly reduced in 61 of 120 (50.8%) primary unicentric HCCs. 15713538 Human
sult2a1 hccs SULT2A1 mRNA and/or protein expression in HCC were markedly reduced in 61 of 120 (50.8%) primary unicentric HCCs. 15713538 Human
sult2a1 hcc The lowered expression in tumor cells of SULT2A1 in HCC tissues involved in metabolism and/or inactivation of sex steroids is consistent with a regulatory role of the SULT2A1 gene product in the development and/or tumor cell differentiation and progressio 15713538 Human
sult2a1 hcc This suggestion is partly supported by our observations that the down-regulated SULT2A1 gene expression correlated with a higher grade and stage of HCC. 15713538 Human
sult2a1 c6 glioma Rat C6 glioma cells expressed the SULT2B1a isoform, which sulfonates pregnenolone, but, neither the SULT2B1b isoform, which catalyzes cholesterol, nor the prototypical steroid sulfotransferase SULT2A1 were expressed in these cells. 18054434 Rat

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