IGDB.NSCLC Gene View
Gene Information Microarray Gene Expression Result Treatment Result Microarray Sample Data Cancer Gene Index
 
Gene Information        (help)
Gene PLA2G4C Ensembl ENSG00000105499 Chromosome 19 Start 53242916 End 53305865
Description Cytosolic phospholipase A2 gamma Precursor (cPLA2-gamma)(EC 3.1.1.4)(Phospholipase A2 group IVC) [Source:UniProtKB/Swiss-Prot;Acc:Q9UP65]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9037
     Entrez Gene : 8605
     UCSC : uc002phx.2
     GeneCards : 9037
     RefSeq : NM_001159322
     CCDS : CCDS12710.1
     Uniprot : Q9UP65
     Interpro : Q9UP65
     OMIM : 603602
     GeneTests : PLA2G4C
     CGAP : PLA2G4C
     PMID : 9705332

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33707_at  -0.34  1.62e-3  4.80e-3  -0.37  1.23e-2  2.77e-2
 HG_U133A  209785_s_at  -1.28  1.69e-35  3.66e-34  0.92  2.47e-26  3.93e-26
 HG_U133_Plus2  1554810_at  -0.14  4.99e-1  5.86e-1  -0.10  6.59e-1  7.08e-1
 HG_U133_Plus2  209785_s_at  -1.09  2.07e-20  5.05e-19  -1.47  1.19e-20  1.78e-19
 Agilent_HS_21.6K  1002  -0.13  1.09e-5  1.88e-4  -0.17  9.96e-8  2.19e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209785_s_at  1.02  1.04e-2  6.82e-1  0.08  7.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33707_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209785_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1554810_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209785_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1002    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cpla2-gamma tumor PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative glioma tumor suppressor gene region. 11958371 Human
pla2g4c tumor PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative glioma tumor suppressor gene region. 11958371 Human
cpla2-gamma glioma PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative glioma tumor suppressor gene region. 11958371 Human
pla2g4c glioma PLA2G4C, encoding cytosolic phospholipase A2-gamma (cPLA2-gamma), is a 17-exon gene located on chromosome 19q13.3 within the putative glioma tumor suppressor gene region. 11958371 Human
pla2g4c tumor The relatively large size of the repeats allows detection of allelic variants with standard ethidium bromide-stained agarose gels and the PLA2G4C marker is the closest polymorphism to the smallest common deletion area in the putative glioma tumor suppress 11958371 Human
pla2g4c glioma The relatively large size of the repeats allows detection of allelic variants with standard ethidium bromide-stained agarose gels and the PLA2G4C marker is the closest polymorphism to the smallest common deletion area in the putative glioma tumor suppress 11958371 Human
cytosolic calcium-independent insulinoma Evidence that group VIA cytosolic calcium-independent phospholipase A(2) (iPLA(2)beta) participates in beta-cell signal transduction includes the observations that inhibition of iPLA(2)beta with the bromoenol lactone suicide substrate suppresses glucose-s 14749286 Human
pla2g4c gliomas Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas. 11958371 Human
pla2g4c gliomas These characteristics suggest that the PLA2G4C polymorphism will be a convenient and practical assay for clinical and research evaluation of 19q status in human gliomas. 11958371 Human
pla2g4c anaplastic oligodendrogliomas In addition, we found that the cytosolic phospholipase A2 (PLA2G4C) gene at 19q13.3 demonstrated significantly lower expression in anaplastic oligodendrogliomas (WHO grade III) when compared to well-differentiated oligodendrogliomas (WHO grade II). 16550607 Human
pla2g4c well-differentiated oligodendrogliomas In addition, we found that the cytosolic phospholipase A2 (PLA2G4C) gene at 19q13.3 demonstrated significantly lower expression in anaplastic oligodendrogliomas (WHO grade III) when compared to well-differentiated oligodendrogliomas (WHO grade II). 16550607 Human
pla2g4c tumor One tumor demonstrated small interstitial deletions at 1p36 (at D1S1612 and D1S513, but not at D1S548 or D1S1592) and a small interstitial deletion at 19q13 (at D19S219 and D19S412, but not at PLA2G4C). 17667543 Human

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