IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LIG1 Ensembl ENSG00000105486 Chromosome 19 Start 53310519 End 53365395
Description DNA ligase 1 (EC 6.5.1.1)(DNA ligase I)(Polydeoxyribonucleotide synthase [ATP] 1) [Source:UniProtKB/Swiss-Prot;Acc:P18858]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 6598
     Entrez Gene : 3978
     UCSC : uc002pia.1
     GeneCards : 6598
     RefSeq : NM_000234
     CCDS : CCDS12711.1
     Uniprot : P18858
     Interpro : P18858
     OMIM : 126391
     GeneTests : LIG1
     CGAP : LIG1

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1376_at  0.03  8.38e-1  8.85e-1  0.85  8.64e-4  2.73e-3
 HG_U133A  202726_at  0.65  6.52e-23  6.31e-22  2.91  8.81e-99  5.77e-98
 HG_U133_Plus2  202726_at  0.43  1.94e-5  7.05e-5  0.94  8.48e-19  1.03e-17
 Stanford  2607  -0.27  5.13e-1  6.92e-1  -0.34  2.95e-1  5.36e-1
 Stanford  6105  0.77  1.76e-1  3.59e-1  0.90  2.54e-3  2.65e-2
 Stanford  21110  -0.62  3.06e-1  5.09e-1  -0.60  1.81e-1  3.99e-1
 Agilent_HS_21.6K  450  0.05  3.70e-1  5.57e-1  0.12  1.11e-2  3.90e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202726_at  0.06  7.67e-1  9.76e-1  0.33  3.24e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1376_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202726_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202726_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2607    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6105    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21110    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 450    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dna ligase i cancer Enhancement of DNA ligase I level by gemcitabine in human cancer cells. 11948132 Human
dna ligase i human tumor In this study, we examined whether the DNA ligase I level could be modulated in human tumor cell lines by treatment with gemcitabine (2', 2'-difluoro-2'-deoxycytidine), which is a nucleoside analogue of cytidine with proven antitumor activi 11948132 NA
dna ligase i cancers In this study, we examined whether the DNA ligase I level could be modulated in human tumor cell lines by treatment with gemcitabine (2', 2'-difluoro-2'-deoxycytidine), which is a nucleoside analogue of cytidine with proven antitumor activi 11948132 NA
dna ligase i tumor RESULTS: When different types of tumor cell lines, including MiaPaCa, NGP, and SK-N-BE, were treated with gemcitabine, the level of DNA ligase I increased severalfold despite significant cell growth inhibition. 11948132 Human
dna ligase i cancer CONCLUSIONS: Our results suggest that an arrest of DNA replication caused by gemcitabine treatment through incorporation of gemcitabine triphosphate into replicating DNA and inhibition of ribonucleotide reductase would trigger an increase in DNA ligase I 11948132 Human
dna ligase i lung cancer Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis. 12009232 Human
lig1 lung cancer Because LIG1 participates in DNA repair and reduced DNA repair capacity is associated with risk of lung cancer, we evaluated in a non-population-based case-control study of 530 lung cancer cases and 570 cancer-free controls the role of this polymorphism i 12009232 Human
lig1 lung cancer The results of this large case-control study suggest that this LIG1 polymorphism may not play an important role in susceptibility to lung cancer. 12009232 Human
dna ligase i cancer Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene. 12124343 Mouse
dna ligase i cancer DNA ligase I has a key role in DNA replication in the joining together of short replication intermediates.We used gene targeting to introduce a point mutation into the mouse DNA ligase I gene that was present in a human cancer patient with immunodeficienc 12124343 Human
dna ligase i cancer The origin of the tumors from generalized genome instability, rather than the inactivation of one key control gene, should make DNA ligase I mutant mice a useful model to investigate the relationship between genome instability and cancer in humans. 12124343 Mouse
dna ligase i tumors The origin of the tumors from generalized genome instability, rather than the inactivation of one key control gene, should make DNA ligase I mutant mice a useful model to investigate the relationship between genome instability and cancer in humans. 12124343 Mouse
dna ligase i human pancreatic cancer Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells. 12372342 Human
dna ligase i human pancreatic carcinoma The effect of the broad-spectrum anticancer agent, cisplatin, on the expression of DNA ligase I in human pancreatic carcinoma MiaPaCa cells was examined in this study, since DNA ligase I is known to be involved in various DNA repair pathways. 12408985 Human
dna ligase i cancers Elevated expression of DNA ligase I in human cancers. 11751514 Human
dna ligase i human tumors In this study, we were interested in comparing DNA ligase I level in human tumors versus normal tissues and in studying whether the inhibition of DNA ligase I could lead to tumor cell death. 11751514 Human
dna ligase i tumor In this study, we were interested in comparing DNA ligase I level in human tumors versus normal tissues and in studying whether the inhibition of DNA ligase I could lead to tumor cell death. 11751514 NA
dna ligase i malignant tumor EXPERIMENTAL DESIGN: DNA ligase I level was measured by Western immunoblot assay in various human malignant tumor specimens and benign tissues obtained from patients, in peripheral blood lymphocytes obtained from healthy donors, and in human tumors grown 11751514 Human
dna ligase i human tumors EXPERIMENTAL DESIGN: DNA ligase I level was measured by Western immunoblot assay in various human malignant tumor specimens and benign tissues obtained from patients, in peripheral blood lymphocytes obtained from healthy donors, and in human tumors grown 11751514 Human
dna ligase i tumor We also have designed antisense oligonucleotides (ODNs) targeting the mRNA of DNA ligase I and tested whether DNA ligase I antisense ODNs could control tumor cell growth. 11751514 Human
dna ligase i malignant tumors RESULTS: The amount of DNA ligase I enzyme in malignant tumors was considerably higher than that in benign normal tissues and peripheral blood lymphocytes. 11751514 Human
dna ligase i human tumors The level of DNA ligase I in human tumors grown in nude mice was also very high, and the expression of DNA ligase I appears to be constitutive during in vivo tumor development. 11751514 Human
dna ligase i tumor The level of DNA ligase I in human tumors grown in nude mice was also very high, and the expression of DNA ligase I appears to be constitutive during in vivo tumor development. 11751514 Human
dna ligase i tumor We have observed that DNA ligase I antisense ODN inhibited tumor cell growth in a dose-response manner, but nonspecific control ODNs had little effect on the growth of the same cell lines. 11751514 Human
dna ligase i human tumors CONCLUSIONS: The presence of DNA ligase I at higher levels in human tumors than in benign normal tissues and normal peripheral lymphocytes suggests DNA ligase I plays more of a role in proliferating cells than in resting cells. 11751514 Human
dna ligase i tumor These results, together with our finding that DNA ligase I antisense ODNs can suppress tumor cell proliferation, warrant the design and testing of human DNA ligase I inhibitors as new anticancer agents. 11751514 Human
dna ligase i cancer DNA ligase I, Bloom's syndrome, and cancer. 3334985 Human
dna ligase i cancer A patient with altered DNA ligase I displayed a phenotype similar to Bloom's syndrome, being immunodeficient, growth retarded and predisposed to cancer. 8696349 Human
dna ligase i ascites tumor Rapidly dividing cells (mouse ascites tumor cells and calf thymus) contain higher amounts of DNA ligase I than other cells (calf liver and spleen, human placenta, and rabbit spleen), while no such correlation was observed for DNA ligase II. 1194260 Mouse
dna ligase i cancer This proneness genetic disease is characterized by several cytological abnormalities and cancer proneness and, recently, some transformed cell lines from these patients were described to present a reduced activity of DNA ligase I. 2726453 Human
dna ligase i lymphoma A cell line derived from a young woman with growth retardation, sun sensitivity, and immunodeficiencies, who died aged 19 with lymphoma, showed two different miscoding mutations at the DNA ligase I locus on chromosome 19, one in each allele. 1351188 Human
dna ligase i chromosomal breakage syndrome Thus, another factor may be responsible for the observed reduction in DNA ligase I activity associated with this chromosomal breakage syndrome. 1881902 Human
lig1 breast cancer Twelve loci of selected DNA repair genes were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (XRCC2 Arg(188)His, XRCC4 921G > T, XRCC6 1796G > T, LIG4 1977T/C, RAD51 135G > C, 172G > T, RAD52 2259C > T, LIG1 551A 15958648 Human

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