IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CARD8 Ensembl ENSG00000105483 Chromosome 19 Start 53403325 End 53444737
Description Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1)(DACAR)(CARD-inhibitor of NF-kappa-B-activating ligand)(CARDINAL)(Tumor up-regulated CARD-containing antagonist of CASP9)(TUCAN) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2G2]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17057
     Entrez Gene : 22900
     UCSC : uc002pie.3
     GeneCards : 17057
     RefSeq : NM_001184900
     CCDS : CCDS12712.1
     Uniprot : Q9Y2G2
     Interpro : Q9Y2G2
     OMIM : 609051
     GeneTests : CARD8
     CGAP : CARD8
     PMID : 10231032

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41100_at  -0.58  8.38e-5  3.49e-4  -1.09  1.80e-7  1.30e-6
 HG_U133A  204950_at  -0.59  1.86e-23  1.88e-22  -3.79  3.04e-44  6.30e-44
 HG_U133_Plus2  1554479_a_at  -0.15  1.06e-1  1.61e-1  -0.71  7.86e-10  3.40e-9
 HG_U133_Plus2  204950_at  -0.48  1.97e-8  1.16e-7  -0.70  7.78e-13  4.79e-12
 HG_U133_Plus2  228641_at  -0.65  9.06e-10  6.36e-9  -0.95  1.39e-12  8.36e-12
 HG_U133_Plus2  232969_at  -0.33  8.63e-2  1.35e-1  -0.20  3.35e-1  3.96e-1
 Agilent_HS_21.6K  13458  -0.22  4.02e-2  1.24e-1  -0.27  1.14e-2  3.99e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204950_at  0.20  4.25e-1  9.10e-1  -0.04  7.57e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41100_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204950_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1554479_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204950_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228641_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232969_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13458    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tucan cancer TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. 11408476 Human
tucan cancer A novel CARD-containing protein was identified that is overexpressed in some types of cancer and that binds and suppresses activation of procaspase-9, which we term TUCAN (tumor-up-regulated CARD-containing antagonist of caspase nine). 11408476 Human
tucan colon cancer High levels of endogenous TUCAN protein were detected in several tumor cell lines and in colon cancer specimens, correlating with shorter patient survival. 11408476 Human
tucan tumor High levels of endogenous TUCAN protein were detected in several tumor cell lines and in colon cancer specimens, correlating with shorter patient survival. 11408476 Human

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