IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SPHK2 Ensembl ENSG00000063176 Chromosome 19 Start 53814360 End 53825473
Description Sphingosine kinase 2 (SPK 2)(SK 2)(EC 2.7.1.91) [Source:UniProtKB/Swiss-Prot;Acc:Q9NRA0]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 18859
     Entrez Gene : 56848
     UCSC : uc002pjr.2
     GeneCards : 18859
     RefSeq : NM_020126
     CCDS : CCDS12727.1
     Uniprot : Q9NRA0
     Interpro : Q9NRA0
     OMIM : 607092
     GeneTests : SPHK2
     CGAP : SPHK2
     PMID : 10751414

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40273_at  0.17  1.01e-1  1.67e-1  0.15  2.30e-1  3.25e-1
 HG_U133A  209857_s_at  1.27  2.08e-21  1.80e-20  1.25  5.58e-8  6.75e-8
 HG_U133A  40273_at  0.02  7.76e-1  8.09e-1  -3.83  1.70e-91  9.16e-91
 HG_U133_Plus2  209857_s_at  0.37  4.13e-2  7.14e-2  -0.18  2.93e-1  3.52e-1
 HG_U133_Plus2  40273_at  0.45  3.96e-8  2.23e-7  0.49  4.82e-6  1.29e-5
 Stanford  4066  -0.03  9.23e-1  9.60e-1  -0.07  8.08e-1  9.12e-1
 Agilent_HS_21.6K  20846  -0.07  9.74e-3  4.50e-2  -0.09  9.99e-4  5.40e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209857_s_at  -0.38  3.12e-1  8.79e-1  0.43  5.94e-2  1.00e+0
 HG_U133A  40273_at  0.43  9.47e-2  7.69e-1  0.08  6.56e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40273_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209857_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 40273_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209857_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 40273_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4066    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20846    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
sphk2 breast cancer EGF also stimulated SphK2 in MDA-MB-453 breast cancer cells. 15951439 Human
sphk2 astrocytoma Expression of SphK1, but not SphK2, in human astrocytoma grade 4 (glioblastoma multiforme) tissue correlated with short patient survival. 16106218 Human
sphk2 glioblastoma multiforme Expression of SphK1, but not SphK2, in human astrocytoma grade 4 (glioblastoma multiforme) tissue correlated with short patient survival. 16106218 Human
sphk2 glioblastoma Surprisingly, RNA interference to knockdown SphK2 expression inhibited glioblastoma cell proliferation more potently than did SphK1 knockdown. 16106218 Human

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