IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PPP1R15A Ensembl ENSG00000087074 Chromosome 19 Start 54067490 End 54071126
Description Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34)(Myeloid differentiation primary response protein MyD116 homolog) [Source:UniProtKB/Swiss-Prot;Acc:O75807]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 14375
     Entrez Gene : 23645
     UCSC : uc002pky.3
     GeneCards : 14375
     RefSeq : NM_014330
     CCDS : CCDS12738.1
     Uniprot : O75807
     Interpro : O75807
     OMIM : 611048
     GeneTests : PPP1R15A
     CGAP : PPP1R15A
     PMID : 9153226

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37028_at  -1.19  2.48e-19  1.54e-17  -1.46  2.78e-12  5.09e-11
 HG_U133A  202014_at  -1.28  1.27e-33  2.50e-32  0.93  1.68e-12  2.19e-12
 HG_U133A  37028_at  -1.47  1.02e-70  1.39e-68  -4.64  2.54e-113  2.50e-112
 HG_U133_Plus2  202014_at  -1.60  2.45e-25  1.01e-23  -1.13  1.58e-10  7.41e-10
 HG_U133_Plus2  37028_at  -1.48  1.01e-28  6.01e-27  -0.87  4.68e-8  1.62e-7
 Stanford  22092  0.46  5.70e-2  1.70e-1  0.53  8.33e-2  2.41e-1
 Agilent_HS_21.6K  7192  -0.32  3.28e-8  1.26e-6  -0.30  2.65e-9  9.77e-8

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202014_at  -0.07  7.96e-1  9.82e-1  0.06  7.86e-1  1.00e+0
 HG_U133A  37028_at  -0.09  6.74e-1  9.65e-1  0.09  5.28e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37028_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202014_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 37028_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202014_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 37028_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22092    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7192    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
gadd34 melanomas GADD34 was found in 73% of the primary melanomas investigated. 12168790 Human
gadd34 human neuroblastoma Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells. 11163539 Human
gadd34 human neuroblastoma A peroxynitrite generator, 3-morpholinosydonimine (SIN-1), was found to induce the expression of three different growth arrest and DNA damage-inducible (GADD) mRNA, GADD34, GADD45, and GADD153, at the early phase during cell death in human neuroblastoma S 11163539 Human
gadd34 melanoma The main goal of this study was to examine the expression of DNA mismatch repair genes (MLH1, MSH2, PMS1 and PMS2), the adenomatous polyposis coli (APC) gene and growth arrest DNA damage inducible (GADD) genes (GADD34, GADD45 and GADD153) in the different 11198475 Human
gadd34 metastases The main goal of this study was to examine the expression of DNA mismatch repair genes (MLH1, MSH2, PMS1 and PMS2), the adenomatous polyposis coli (APC) gene and growth arrest DNA damage inducible (GADD) genes (GADD34, GADD45 and GADD153) in the different 11198475 Human
gadd34 adenomatous polyposis coli (apc) The main goal of this study was to examine the expression of DNA mismatch repair genes (MLH1, MSH2, PMS1 and PMS2), the adenomatous polyposis coli (APC) gene and growth arrest DNA damage inducible (GADD) genes (GADD34, GADD45 and GADD153) in the different 11198475 Human
gadd34 melanomas 29 oral melanomas were stained immunohistochemically for the GADD34, GADD45 and GADD153. 10757041 Human
gadd34 melanoma GADD34 was found in 5/29 melanomas and its expression did not exceed 21%, averaging 4.1% of melanoma cells. 10757041 Human
gadd34 melanomas GADD34 was found in 5/29 melanomas and its expression did not exceed 21%, averaging 4.1% of melanoma cells. 10757041 Human
gadd34 tumor The down-regulated elements included the tumor suppressor TP53, genes related to apoptosis such as GADD34, GADD45A, GADD45B and PIG11, and the gene encoding OVGP1, a protein involved in maintenance of early pregnancy. 12579308 Human
gadd34 tumor Furthermore, gadd34/MyD116, gadd45, MyD118, and gadd153 encode acidic proteins with very similar and unusual charge characteristics; both this property and a similar pattern of induction are shared with mdm2, whic, like gadd45, has been shown previously t 8139541 Human
gadd34 myeloid leukemia The gamma(1)34.5 gene consists of an amino-terminal domain, a variable linker sequence consisting of 3 amino acids repeated 5-10 times, and a carboxyl-terminal domain homologous to the corresponding domain of MyD116, a gene expressed in myeloid leukemia c 8202476 Human
gadd34 lung tumor Ad-mda7 transduction of lung tumor cells increased expression of stress-related proteins, including BiP, GADD34, PP2A, caspases 7 and 12, and XBP-1, consistent with activation of the UPR pathway, a key sensor of endoplasmic reticulum (ER)-mediated stress. 15006602 Human
gadd34 tumor We postulated that combining use of the chemotherapy agent mitomycin C (MMC) with G207 will selectively up-regulate GADD34 in tumor that may complement the gamma134.5 gene deletion and augment viral antitumor efficacy. 15059970 Human
gadd34 cancer These data indicate that induction of GADD34 selectively restores the virulent phenotype of the deleted gene in G207 and thus provides a cellular basis for the combined use of DNA-damaging agents and gamma134.5 HSV mutants in the treatment of cancer. 15059970 Human
gadd34 cervical cancer Induction of the stress response genes GADD153, GADD34 and GADD45A, XBP-1, GRP78, GRP94, and asparagine synthase was documented by Western blot and real-time reverse transcriptase-polymerase chain reaction in C33A cervical cancer cells, and induction of a 15270080 Human
gadd34 cancer Induction of the stress response genes GADD153, GADD34 and GADD45A, XBP-1, GRP78, GRP94, and asparagine synthase was documented by Western blot and real-time reverse transcriptase-polymerase chain reaction in C33A cervical cancer cells, and induction of a 15270080 Human
gadd34 mammary tumors All of the mouse and most human mammary tumors also displayed decreased expression of genes known to inhibit cell proliferation, including NFKBIA (IKBalpha), GADD45B, and CDKN1A (p21); transcription-related genes such as CEBP, JUN, JUNB, and ELF1; and apo 15520179 Human
gadd34 tumors A majority of LMP and G1 tumors were characterized by high levels of p21/WAF1, with concomitant expression of cell growth suppressors, gadd34 and BTG-2. 15558012 Human
gadd34 tumor Sequencing of the GADD34 gene in a number of independent rat tumor cell lines revealed that in a majority of these the GADD34 gene is mutated to either PEG-3 or a PEG-3-like gene with similar C-terminal truncations. 15674324 Rat
ppp1r15a mammary tumors All of the mouse and most human mammary tumors also displayed decreased expression of genes known to inhibit cell proliferation, including NFKBIA (IKBalpha), GADD45B, and CDKN1A (p21); transcription-related genes such as CEBP, JUN, JUNB, and ELF1; and apo 15520179 Human

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