IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RRAS Ensembl ENSG00000126458 Chromosome 19 Start 54830364 End 54835212
Description Ras-related protein R-Ras Precursor (p23) [Source:UniProtKB/Swiss-Prot;Acc:P10301]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10447
     Entrez Gene : 6237
     UCSC : uc002pop.1
     GeneCards : 10447
     RefSeq : NM_006270
     CCDS : CCDS12774.1
     Uniprot : P10301
     Interpro : P10301
     OMIM : 165090
     GeneTests : RRAS
     CGAP : RRAS
     PMID : 3098437

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1879_at  -1.97  5.77e-21  4.44e-19  -2.47  4.88e-19  3.82e-17
 HG_U95  38338_at  -1.03  7.06e-26  1.10e-23  -1.29  1.89e-15  6.72e-14
 HG_U133A  212647_at  -1.50  1.01e-38  2.60e-37  -2.35  1.15e-73  4.02e-73
 HG_U133_Plus2  212647_at  -0.82  1.99e-16  3.17e-15  -1.41  9.25e-18  9.96e-17
 Agilent_HS_21.6K  10046  -0.30  1.08e-10  8.28e-9  -0.37  1.50e-14  2.87e-12

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212647_at  0.62  5.58e-2  7.13e-1  -0.23  4.49e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1879_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38338_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212647_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212647_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10046    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
r-ras pheochromocytoma We found that R-Ras GAP is down-regulated during neurite formation in rat pheochromocytoma PC12 cells by nerve growth factor (NGF), which is blocked by the transient expression of R-Ras gap or dominant negative R-ras cDNA. 17179160 Rat
r-ras oncogenic These results suggest oncogenic R-Ras has a central role in cancer progression towards a metastatic phenotype, through the activation of the PI 3-K/Akt/mTOR signaling pathway. 16862428 Human
r-ras cancer These results suggest oncogenic R-Ras has a central role in cancer progression towards a metastatic phenotype, through the activation of the PI 3-K/Akt/mTOR signaling pathway. 16862428 Human
r-ras metastasis R-Ras promotes metastasis of cervical cancer epithelial cells. 16862428 Human
r-ras cervical cancer R-Ras promotes metastasis of cervical cancer epithelial cells. 16862428 Human
r-ras invasive cancer Mutations in the small GTPase R-Ras that promote constitutive activation of this signaling molecule have been observed in a variety of invasive cancer cell types. 16862428 Human
r-ras oncogenic We previously reported that expression of an oncogenic form of R-Ras (R-Ras87L) in a cell line of cervical cancer (C33A cells) augments cell growth in vitro and tumorigenicity in vivo. 16862428 Human
r-ras cervical cancer We previously reported that expression of an oncogenic form of R-Ras (R-Ras87L) in a cell line of cervical cancer (C33A cells) augments cell growth in vitro and tumorigenicity in vivo. 16862428 Human
r-ras tumors Whereas expression of a mutant R-Ras protein (38V; analogous to the 12V activating Ras mutation) did not induce morphologic transformation of NIH3T3 cells, R-Ras(38V)-expressing cells proliferated in low serum, formed colonies in soft agar, and formed pro 7936652 Mouse
r-ras human tumors Members of the Ras subfamily of GTP-binding proteins, including Ras (H-, K-, and N-), TC21, and R-ras have been shown to display transforming activity, and activating lesions have been detected in human tumors. 9400994 Human
r-ras metastasis Furthermore, direct activation of the MEK-ERK1/2 pathway in NIH 3T3 cells by mos or a constitutively active form of MEK was sufficient to induce metastasis whereas R-Ras, which fails to activate the ERK1/2 pathway, is tumorigenic but nonmetastatic. 9671754 Human
r-ras tumor Reduced adhesiveness induced through the Eph/R-Ras pathway may explain the repulsive effect of the Eph receptors in axonal pathfinding and may facilitate tumor cell invasion and angiogenesis. 10570155 Human
r-ras breast cancer This work identifies a new potential function for p130(Cas) and a new regulatory pathway involved in the control of Ral, Rap, and R-Ras GTPases that may participate in the progression of breast cancer cells to tamoxifen resistance. 10896938 Human
r-ras cancers An activated form of Src similar to one that has been found in human cancers, Src527, shared with v-Src the ability to phosphorylate R-Ras. 11682467 Human
r-ras breast cancer Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. 12386818 Human
r-ras breast cancer A potential role for Ras-related GTPases in this process was suggested by the finding that BCAR3/AND-34, a protein isolated on the basis of its ability to convert MCF-7 and ZR-75 breast cancer cell lines to estrogen independence and tamoxifen resistance, 12386818 Human
r-ras breast cancer Moreover, because R-Ras promotes hormone-independent growth in a manner distinct from EGF receptors, it may participate in the conversion of breast cancer cells to estrogen independence when over-expression of EGF receptor family members is not involved. 12386818 Human
r-ras tumor R-Ras promotes tumor growth of cervical epithelial cells. 12548599 Human
r-ras tumor CONCLUSIONS: These data suggest that the oncogene R-Ras promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K. 12548599 Human
r-ras tumors The processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, is inhibited in tumors obtained from mice treated with GGTI-2154. 14695209 Mouse
r-ras gastric cancer Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. 15781621 Human
r-ras gastric cancers Of the 1,383 genes, 159 genes, including oncogenes ELK1, FRAT2, R-RAS, RHOB, and RHO6, were further selected as gene candidates that are silenced by DNA methylation in normal stomach mucosa but are activated by DNA demethylation in a subset of gastric can 15781621 Human
r-ras gastric cancers Next, we showed that demethylation of specific CpG sites within the first intron of R-RAS causes activation in more than half of gastric cancers. 15781621 Human
r-ras glioma EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. 16049340 Human
r-ras glioma Since R-Ras has been shown to play a critical role in EphB2 regulation of integrin activity, we explored whether the biological role of EphB2 in glioma invasion is mediated by downstream R-Ras activation. 16049340 Human
r-ras glioma Depletion of endogenous R-Ras expression by siRNA abrogated EphB2 effects on glioma cell adhesion, proliferation, and invasion in ex vivo rat brain slices. 16049340 Human
r-ras glioma Moreover, R-Ras was highly phosphorylated in the invading glioma cells. 16049340 Human
r-ras brain tumor In human brain tumor specimens, R-Ras expression and phosphorylation correlated with increasing grade of gliomas. 16049340 Human
r-ras gliomas In human brain tumor specimens, R-Ras expression and phosphorylation correlated with increasing grade of gliomas. 16049340 Human
r-ras glioblastoma Laser capture microdissection of invading glioblastoma cells revealed elevated R-Ras mRNA (1.5- to 26-fold) in 100% (eight of eight) of biopsy specimens, and immunohistochemistry revealed high R-Ras localization primarily in glioblastoma cells. 16049340 Human
r-ras glioblastoma The phosphorylation ratio of R-Ras positively correlated with the phosphorylation ratio of EphB2 in glioblastoma tissues. 16049340 Human
r-ras glioma These results demonstrate that R-Ras plays an important role in glioma pathology, further suggesting the EphB2/R-Ras signaling pathway as a potential therapeutic target. 16049340 Human
r-ras hyperplasia R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. 16286923 Mouse
r-ras tumor angiogenesis R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. 16286923 Mouse
r-ras hyperplastic In wild-type mice, R-Ras expression was greatly reduced in hyperplastic neointimal smooth muscle cells and in angiogenic endothelial cells. 16286923 Mouse
r-ras ovarian tumors SRA1 (SR-A1) gene, encoding for a human high-molecular weight SCAF protein, is located on chromosome 19, between the IRF3 and the R-RAS oncogene and it has been demonstrated from members of our group that SRA1 is constitutively expressed in most of the hu 16631123 Human
r-ras breast cancer The R-Ras GTPase Mediates Cross Talk between Estrogen and Insulin Signaling in Breast Cancer Cells. 16914723 Human
r-ras breast cancer Here we demonstrate that both R-Ras and BCAR3, a regulator of R-Ras activity that has been implicated in breast cancer, regulate the level of IRS-1 protein in estrogen-dependent MCF-7 and ZR75 breast cancer cells. 16914723 Human
r-ras breast cancer These findings show that R-Ras activity mediates inhibition of insulin signaling associated with suppression of estrogen action, implicating this GTPase in a growth-inhibitory mechanism associated with antiestrogen treatment of breast cancer. 16914723 Human
r-ras oncogenes Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. 3098437 Human
r-ras oncogenes R-ras has at least six exons, with the position of the first intron conserved relative to the Drosophila ras64B and Dictyostelium ras genes; there is no similarity in the exon-intron structure of the R-ras gene and of the mammalian H-, K-, and N-ras proto 3098437 Human
r-ras oncogenes These data suggest that human R-ras p23 has biochemical properties very similar to those of the p21 products of the H-, K-, and N-ras proto-oncogenes. 3313005 Human
r-ras oncogene Unlike the human T24 bladder oncogene-encoded p21, mutant R-ras alleles do not cause monolayer focus formation or growth in soft agar of rat fibroblasts. 3313005 Human
r-ras malignant transformation Taken together, these observations suggest that aberrant R-Ras function may stimulate malignant transformation, in the absence of morphologic transformation, via up-regulation of part of the Ras signal transduction pathway. 7936652 Human
r-ras oncogenes Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes. 8084601 Human
r-ras oncogenic Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes. 8084601 Human
r-ras oncogene Mutations were introduced into the R-ras gene at codons 38 or 87, analogous to positions 12 and 61, respectively, responsible for H-ras oncogene activation. 8084601 Human
r-ras oncogene All these findings raise the possibility that R-ras, like prototype ras genes, may be mutationally activated as an oncogene in some human malignancies. 8084601 Human
r-ras malignant transformation We have determined that two Ras-related proteins, designated R-Ras and R-Ras2/TC21, can trigger the malignant transformation of NIH 3T3 cells via activation of the Ras signal transduction pathway. 8607978 Human
r-ras oncogene BACKGROUND: The small GTPase R-Ras displays a less potent transforming activity than the closely related Ras oncogene products. 8999998 Human
r-ras oncogenes Of the 1,383 genes, 159 genes, including oncogenes ELK1, FRAT2, R-RAS, RHOB, and RHO6, were further selected as gene candidates that are silenced by DNA methylation in normal stomach mucosa but are activated by DNA demethylation in a subset of gastric can 15781621 Human
r-ras oncogenic Instead, a dominant negative mutant of phosphatidylinositol 3-kinase (PI3-K) drastically inhibited the oncogenic potential of R-Ras. 10454580 Human
r-ras oncogene Crk activation of JNK via C3G and R-Ras. v-crk is an oncogene identified originally in CT10 chicken tumor virus. 10777559 Human
r-ras oncogenic C3G, a guanine nucleotide exchange factor (GEF) for Rap1 and R-Ras, is postulated to transduce the oncogenic signal of v-Crk to c-Jun kinase (JNK). 10777559 Human
r-ras oncogenic We determined that oncogenic versions of H-, K-, and N-Ras, as well as the Ras-related proteins TC21 and R-Ras, protected RIE-1 cells from anoikis. 11463831 Human
r-ras oncogenes The functional groups and the differentially expressed genes are as follows: The cancer-related genes (nine genes) were the ets-related transcription factor activated by ras, colony-stimulating factor, A-myb, sky, cot1, c-fos, c-jun, c-myc, and R-ras prot 11568973 Human
r-ras oncogene Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. 11682467 Human
r-ras oncogene CONCLUSIONS: These data suggest that the oncogene R-Ras promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K. 12548599 Human
r-ras oncogenes We showed previously that exogenous overexpression of C3G, a guanine nucleotide releasing factor (GEF) for Rap1 and R-Ras proteins, blocks the focus-forming activity of cotransfected, activated, sis, ras and v-raf oncogenes in NIH 3T3 cells. 15077165 Human
r-ras oncogenic While oncogenic Ras GTPases and R-Ras share extensive sequence homology, R-Ras induces a distinct set of cellular behaviors. 15772154 Human
r-ras cancer Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. 15781621 Human
r-ras gastric cancer Introduction of siRNA into R-RAS-expressing cells resulted in the disappearance of the adhered cells, suggesting that functional blocking of the R-RAS-signaling pathway has great potential for gastric cancer therapy. 15781621 Human
r-ras tumor Challenging the R-Ras-null mice with arterial injury or tumor implantation showed exaggerated neointimal thickening in response to the injury and increased angiogenesis in the tumors. 16286923 Mouse
r-ras tumors Challenging the R-Ras-null mice with arterial injury or tumor implantation showed exaggerated neointimal thickening in response to the injury and increased angiogenesis in the tumors. 16286923 Human
r-ras oncogene SRA1 (SR-A1) gene, encoding for a human high-molecular weight SCAF protein, is located on chromosome 19, between the IRF3 and the R-RAS oncogene and it has been demonstrated from members of our group that SRA1 is constitutively expressed in most of the hu 16631123 Human
rras oncoprotein Phylogenetic analysis showed that TvRRas clustered with RAS oncoprotein branch and RRAS branch of human. 17094627 Human
r-ras pheochromocytoma In agreement with the reported role of RalA in exocytosis, the shRNA of either R-Ras or RalA was found to suppress calcium-triggered exocytosis in PC12 pheochromocytoma cells. 17344481 Rat
r-ras oncogenic Apart from the classic (H-, K-, and N-) Ras GTPases, only the R-Ras subfamily (R-Ras, R-Ras2/TC21, and R-Ras3/M-Ras) has significant oncogenic potential. 18676846 Human
r-ras oncogenic In this study, we show that oncogenic R-Ras transformation of EpH4 cells requires TGF-beta signaling. 18676846 Human
r-ras oncogenic Thus, TAK1 is a novel link between TGF-beta signaling and oncogenic R-Ras in the promotion of tumorigenesis. 18676846 Human
r-ras tumorigenesis Thus, TAK1 is a novel link between TGF-beta signaling and oncogenic R-Ras in the promotion of tumorigenesis. 18676846 Human

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