IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IRF3 Ensembl ENSG00000126456 Chromosome 19 Start 54854642 End 54860926
Description Interferon regulatory factor 3 (IRF-3) [Source:UniProtKB/Swiss-Prot;Acc:Q14653]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6118
     Entrez Gene : 3661
     UCSC : uc002pou.2
     GeneCards : 6118
     RefSeq : NM_001571
     CCDS : CCDS12775.1
     Uniprot : Q14653
     Interpro : Q14653
     OMIM : 603734
     GeneTests : IRF3
     CGAP : IRF3
     PMID : 8524823

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  371_at  0.47  3.68e-11  5.96e-10  0.35  1.79e-4  6.72e-4
 HG_U133A  202621_at  0.48  1.50e-17  9.81e-17  -0.81  5.08e-19  7.28e-19
 HG_U133_Plus2  202621_at  0.58  6.20e-15  8.34e-14  0.48  8.08e-7  2.40e-6
 Stanford  21951  1.04  1.57e-4  4.40e-3  0.56  6.28e-2  1.99e-1
 Agilent_HS_21.6K  3821  -0.00  8.97e-1  9.43e-1  -0.02  5.36e-1  6.79e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202621_at  0.31  1.60e-1  8.13e-1  0.22  8.95e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 371_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202621_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202621_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21951    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3821    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
interferon regulatory factor 3 b16 melanoma In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. 12234977 Mouse
interferon regulatory factor 3 tumors In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. 12234977 Mouse
interferon regulatory factor 3 tumor In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. 12234977 Mouse
irf-3 melanoma In the present study, a bicistronic retroviral vector (AP2) was used to transduce B16-F0 melanoma cells with IFN regulatory factor (IRF)-3, which has been shown to activate type I IFN genes (IFN-beta and IFN-alpha) as well as other cytokines. 12234977 Human
irf-3 b16 melanoma In animals receiving IRF-3 B16 melanoma cells, tumors grew at a 4- to 5-fold reduced rate, and tumors that developed from these mice had a moderate-to-dense infiltration of inflammatory cells, whereas only low levels of lymphocyte infiltration were observ 12234977 Mouse
irf-3 tumors In animals receiving IRF-3 B16 melanoma cells, tumors grew at a 4- to 5-fold reduced rate, and tumors that developed from these mice had a moderate-to-dense infiltration of inflammatory cells, whereas only low levels of lymphocyte infiltration were observ 12234977 Mouse
irf-3 b16 melanoma Our results demonstrate that with weakly antigenic tumors such as B16 melanoma, IRF-3 gene transfer can mediate important antitumor responses. 12234977 Mouse
irf-3 tumors Our results demonstrate that with weakly antigenic tumors such as B16 melanoma, IRF-3 gene transfer can mediate important antitumor responses. 12234977 Mouse
irf-3 cancer These findings suggest a novel role for IRF-3 as a potential molecular target for gene therapy of cancer. 12234977 Mouse
irf3 tumor These results imply that IRF3 may function as a tumor suppressor and suggest a possible role for the relative levels of IRF3 and its dominant negative mutant in tumorigenesis. 12582166 Human
irf-3 hepatoma Furthermore, dominant-negative or constitutively active IRF-3 mutants, respectively, enhanced or suppressed HCV RNA replication in hepatoma cells. 12702807 Human
irf3 hyperplastic To define the role of IRFs in lymphoid disorders, we determined the expression patterns of IRF3 and IRF7 by immunohistochemistry in 5 normal lymph nodes, 12 reactive hyperplastic lymph nodes, and 27 pediatric lymphomas. 17393359 Human
irf3 lymphoma These results suggested that IRF3 was activated principally in the histiocytes and T cells under inflammatory conditions, but IRF3 activation was attenuated in cases of lymphoma. 17393359 Human
irf3 lymphomas In the lymphomas, the number of IRF3-positive cells in the nucleus appeared to have decreased, and the cells were scattered throughout the lymphoma tissue in no specific pattern. 17393359 Human
irf3 lymphoma In the lymphomas, the number of IRF3-positive cells in the nucleus appeared to have decreased, and the cells were scattered throughout the lymphoma tissue in no specific pattern. 17393359 Human
irf3 pediatric lymphomas To define the role of IRFs in lymphoid disorders, we determined the expression patterns of IRF3 and IRF7 by immunohistochemistry in 5 normal lymph nodes, 12 reactive hyperplastic lymph nodes, and 27 pediatric lymphomas. 17393359 Human
interferon regulatory factor 3 myxoma Here we show that myxoma virus infection of primary mouse embryo fibroblasts elicited extracellular signal-regulated kinase (Erk) signaling, which was integrated to interferon regulatory factor 3 activation and type I interferon induction. 15502830 Mouse
irf-3 embryonic carcinoma First we showed in undifferentiated embryonic carcinoma cells that ectopic expression of either IRF-3 or IRF-7, but not IRF-1, was sufficient to allow virus-dependent activation of the interferon-beta promoter. 15355347 Human
irf3 tumor We conclude that IRF3 plays a crucial role in the cytotoxic activity of NS-9 against tumor cells, whereas RNA-dependent protein kinase, RNase L, or type I IFNs are not important for its activity. 15897244 Human
irf3 ovarian tumors SRA1 (SR-A1) gene, encoding for a human high-molecular weight SCAF protein, is located on chromosome 19, between the IRF3 and the R-RAS oncogene and it has been demonstrated from members of our group that SRA1 is constitutively expressed in most of the hu 16631123 Human
irf-3 murine sarcoma Thus, profiling of TAMs from a murine sarcoma revealed unexpected expression of IFN-inducible chemokines, associated with an M2 phenotype (IL-10high, IL-12low), and divergent regulation of the NF-kappaB versus the IRF-3/STAT1 pathway. 16269622 Mouse
interferon regulatory factor-3 oncoprotein Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. 9649509 Human
irf3 oncogenic Based on this negative control of cell growth by IRF3, we examined whether functional loss of IRF3 may contribute to oncogenic transformation. 12582166 Human
irf3 tumorigenesis These results imply that IRF3 may function as a tumor suppressor and suggest a possible role for the relative levels of IRF3 and its dominant negative mutant in tumorigenesis. 12582166 Human
irf3 oncogene SRA1 (SR-A1) gene, encoding for a human high-molecular weight SCAF protein, is located on chromosome 19, between the IRF3 and the R-RAS oncogene and it has been demonstrated from members of our group that SRA1 is constitutively expressed in most of the hu 16631123 Human
irf-3 oncogenic Oncogenic viral interferon regulatory factor (vIRF) encoded by KSHV ORF-K9 is a homologue of cellular interferon regulatory factor (IRF), and has been demonstrated to inhibit type I/II interferon signal transduction and transform NIH3T3 cells through the 11393281 Human
irf-3 tumor Furthermore, tumor growth was not inhibited in severe-combined immunodeficient mice after inoculation of IRF-3-expressing B16 cells, which suggested that IRF-3-mediated antitumor responses were dependent on a functional adaptive lymphocyte response. 12234977 Mouse
interferon regulatory factor 3 oncogenic Oncogenic potential of a dominant negative mutant of interferon regulatory factor 3. 12582166 Mouse
interferon regulatory factor 3 tumors The expression levels of cyclin-dependent kinase 8, phosphoinositide-3-kinase, interferon regulatory factor 3 and tubulin were significantly higher in the tumors of surviving patients with stage I lung cancer (p<0.01). 16969500 Human
interferon regulatory factor 3 stage i lung cancer The expression levels of cyclin-dependent kinase 8, phosphoinositide-3-kinase, interferon regulatory factor 3 and tubulin were significantly higher in the tumors of surviving patients with stage I lung cancer (p<0.01). 16969500 Human
interferon regulatory factor-3 choledochal cysts Experiments in vivo using tissue sections of extrahepatic bile ducts from patients with BA and controls (choledochal cysts and nonbiliary diseases) showed that the activation of NF-kappaB, interferon regulatory factor-3 (IRF-3), and PKR, and the enhanceme 17661372 Human
irf-3 choledochal cysts Experiments in vivo using tissue sections of extrahepatic bile ducts from patients with BA and controls (choledochal cysts and nonbiliary diseases) showed that the activation of NF-kappaB, interferon regulatory factor-3 (IRF-3), and PKR, and the enhanceme 17661372 Human
irf3 human hepatoma IRF3-independent ISG transcription in human hepatoma cell lines is initiated early after exposure to SNV virus particles in an entry- and replication-independent fashion. 17641046 Human
irf-3 chl Conversely, RANTES protein and mRNA were induced by the core protein in CHL cells, through the induction of the promoter.Since HCV genome modulates IRF-1 and IRF-7 in replicon system and IRF-1, IRF-3 and IRF-7 have been reported to regulate RANTES promote 17565659 Human
irf-3 human hepatoma Previously, it has been reported that the hepatitis C virus NS3-4A serine protease blocks virus-induced activation of IRF-3 in the human hepatoma cell line HuH-7, and that NS3-4A cleaves TRIF and Cardif molecules, resulting in the interruption of antivira 17651439 Human
irf3 cancer Here, we show a novel regulatory pathway connecting IRF3-promyelocytic leukemia protein (PML)-p53 in primary and cancer cell lines. 18056437 Human
irf3 cancer Overexpression of IRF3 induces p53-dependent cell growth inhibition in cancer cell lines with normal p53 activity. 18056437 Mouse
irf3 tumor In addition, doxycycline-induced expression of IRF3 in U87MG cells inhibits tumor growth in nude mice in vivo. 18056437 Mouse
irf3 tumor Taken together, the results of the present study indicate that direct transcriptional activation of PML by IRF3 results in the p53-dependent growth inhibition of normal and cancer cells in vitro and in vivo, which is suggestive of a novel regulatory netwo 18056437 Mouse
irf3 cancer Taken together, the results of the present study indicate that direct transcriptional activation of PML by IRF3 results in the p53-dependent growth inhibition of normal and cancer cells in vitro and in vivo, which is suggestive of a novel regulatory netwo 18056437 Mouse
irf-3 esophageal cancer [Relationship between polymorphism of IRF-3 gene codon 427 and esophageal cancer in Anyang population of China] OBJECTIVE:To investigate the association between the single nucleotide polymorphisms (SNPs) of interferon regulatory factor 3 (IRF-3) gene and 15303122 Human
irf-3 esophageal cancer CONCLUSION:The SNPs at codon 427 of the IRF-3 gene may relate to the susceptibility of esophageal cancer. 15303122 Human
interferon regulatory factor 3 esophageal cancer [Relationship between polymorphism of IRF-3 gene codon 427 and esophageal cancer in Anyang population of China] OBJECTIVE:To investigate the association between the single nucleotide polymorphisms (SNPs) of interferon regulatory factor 3 (IRF-3) gene and 15303122 Human
irf-3 promyelocytic leukemia P protein mediates inhibition of the IFN system by different pathways: it inhibits IFN production by impairing IFN regulatory factor-3 (IRF-3) phosphorylation and IFN signaling by blocking nuclear transport of Stat1 and alters promyelocytic leukemia (PML) 16689655 Human

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