IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTOV1 Ensembl ENSG00000104960 Chromosome 19 Start 55045950 End 55055802
Description Prostate tumor overexpressed gene 1 protein (PTOV-1)(Activator interaction domain-containing protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q86YD1]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9632
     Entrez Gene : 53635
     UCSC : uc002pqf.1
     GeneCards : 9632
     RefSeq : NM_017432
     CCDS : CCDS12782.1
     Uniprot : Q86YD1
     Interpro : Q86YD1
     OMIM : 610195
     GeneTests : PTOV1
     CGAP : PTOV1
     PMID : 12598323

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40955_at  0.24  8.77e-4  2.80e-3  0.21  3.54e-2  6.86e-2
 HG_U133A  212032_s_at  0.29  1.85e-5  4.17e-5  -2.96  1.45e-45  3.07e-45
 HG_U133_Plus2  212032_s_at  0.44  3.65e-6  1.51e-5  0.63  1.97e-5  4.86e-5
 HG_U133_Plus2  235665_at  0.09  5.96e-1  6.75e-1  0.35  7.51e-2  1.04e-1
 Stanford  7625  0.95  1.18e-3  1.62e-2  0.55  3.96e-2  1.45e-1
 Agilent_HS_21.6K  4048  -0.16  7.54e-6  1.37e-4  -0.15  7.27e-4  4.17e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212032_s_at  0.12  5.16e-1  9.34e-1  0.18  1.96e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40955_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212032_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212032_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235665_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7625    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4048    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ptov1 prostate cancer PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks. 11313889 Human
ptov1 prostate cancer In a search for molecular markers of progression in prostate cancer by means of differential display, we have identified a new gene, which we have designated PTOV1. 11313889 Human
ptov1 tumors Semiquantitative RT-PCR has established that nine out of 11 tumors overexpress PTOV1 at levels significantly higher than benign prostatic hyperplasia or normal prostate tissue. 11313889 Human
ptov1 benign prostatic hyperplasia Semiquantitative RT-PCR has established that nine out of 11 tumors overexpress PTOV1 at levels significantly higher than benign prostatic hyperplasia or normal prostate tissue. 11313889 Human
ptov1 prostatic intraepithelial neoplasia In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adenocarcinomas showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepi 11313889 Human
ptov1 prostate adenomas In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adenocarcinomas showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepi 11313889 Human
ptov1 carcinoma In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adenocarcinomas showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepi 11313889 Human
ptov1 prostate adenocarcinomas In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adenocarcinomas showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepi 11313889 Human
ptov1 prostate cancer Therefore, PTOV1 is a previously unknown gene, overexpressed in early and late stages of prostate cancer. 11313889 Human
ptov-1 prostate cancer PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. 12598323 Human
ptov1 prostate cancer PTOV1 was recently identified as a novel gene and protein during a differential display screening for genes overexpressed in prostate cancer. 12598323 Human
ptov1 intraepithelial neoplasia By immunohistochemical analysis, we have found that PTOV1 is overexpressed in 71% of 38 prostate carcinomas and in 80% of samples with prostate intraepithelial neoplasia. 12598323 Human
ptov1 prostate carcinomas By immunohistochemical analysis, we have found that PTOV1 is overexpressed in 71% of 38 prostate carcinomas and in 80% of samples with prostate intraepithelial neoplasia. 12598323 Human
ptov1 tumors High levels of PTOV1 in tumors correlated significantly with proliferative index, as assessed by Ki67 immunoreactivity, and associated with a nuclear localization of the protein, suggesting a functional relationship between PTOV1 overexpression, prolifera 12598323 Human
ptov1 tumor In quiescent cultured prostate tumor cells, PTOV1 localized to the cytoplasm, being excluded from nuclei. 12598323 Human
ptov1 tumor These observations suggest that overexpression of PTOV1 can contribute to the proliferative status of prostate tumor cells and thus to their biological behavior. 12598323 Human
ptov1 prostate tumor In quiescent cultured prostate tumor cells, PTOV1 localized to the cytoplasm, being excluded from nuclei. 12598323 Human
ptov1 prostate tumor These observations suggest that overexpression of PTOV1 can contribute to the proliferative status of prostate tumor cells and thus to their biological behavior. 12598323 Human

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