IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SPIB Ensembl ENSG00000142539 Chromosome 19 Start 55614010 End 55626117
Description Transcription factor Spi-B [Source:UniProtKB/Swiss-Prot;Acc:Q01892]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11242
     Entrez Gene : 6689
     UCSC : uc002psd.2
     GeneCards : 11242
     RefSeq : NM_003121
     CCDS : CCDS33080.1
     Uniprot : Q01892
     Interpro : Q01892
     OMIM : 606802
     GeneTests : SPIB
     CGAP : SPIB
     PMID : 1406622

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35883_at  0.41  1.25e-4  4.98e-4  0.78  9.94e-5  3.97e-4
 HG_U133A  205861_at  -0.02  8.48e-1  8.72e-1  2.25  8.23e-66  2.47e-65
 HG_U133_Plus2  205861_at  0.72  1.80e-4  5.46e-4  0.62  1.83e-3  3.38e-3
 HG_U133_Plus2  232739_at  0.04  8.30e-1  8.73e-1  0.12  6.05e-1  6.59e-1
 Stanford  4788  0.11  8.01e-1  8.89e-1  -0.16  7.03e-1  8.51e-1
 Agilent_HS_21.6K  11918  -0.06  3.81e-1  5.68e-1  0.14  8.84e-2  1.90e-1
 Agilent_HS_21.6K  17753  0.13  4.21e-1  6.05e-1  0.04  6.09e-1  7.36e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205861_at  0.60  1.44e-1  8.03e-1  0.61  6.26e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35883_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205861_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205861_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232739_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4788    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11918    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17753    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
spi-b multiple myeloma Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. 11841448 Human
spi-b multiple myeloma Using reverse transcription polymerase chain reaction, we studied the expression of five TFs (octamer binding factor oct-2, ets family members PU.1 and Spi-B, pax gene family member BSAP, and Blimp-1) in (1) human cell lines with a plasma cell phenotype, 11841448 Human
spi-b plasma-cell leukaemia (pcl) Using reverse transcription polymerase chain reaction, we studied the expression of five TFs (octamer binding factor oct-2, ets family members PU.1 and Spi-B, pax gene family member BSAP, and Blimp-1) in (1) human cell lines with a plasma cell phenotype, 11841448 Human
spi-b erythroleukemia In the erythroleukemia cell line K562, due to the absence of Spi-B, only PU.1 bound to the Btk promoter. 8934542 Human

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