IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KLK1 Ensembl ENSG00000167748 Chromosome 19 Start 56014216 End 56018855
Description Kallikrein-1 Precursor (EC 3.4.21.35)(Tissue kallikrein)(Kidney/pancreas/salivary gland kallikrein) [Source:UniProtKB/Swiss-Prot;Acc:P06870]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6357
     Entrez Gene : 3816
     UCSC : uc002ptk.1
     GeneCards : 6357
     RefSeq : NM_002257
     CCDS : CCDS12804.1
     Uniprot : P06870
     Interpro : P06870
     OMIM : 147910
     GeneTests : KLK1
     CGAP : KLK1
     PMID : 1684954

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  246_at  0.09  6.84e-1  7.65e-1  0.59  3.88e-2  7.40e-2
 HG_U133A  216699_s_at  -0.32  4.19e-6  1.01e-5  -2.36  2.90e-44  6.00e-44
 HG_U133_Plus2  216699_s_at  0.09  4.72e-1  5.60e-1  0.58  6.67e-5  1.53e-4
 Agilent_HS_21.6K  7300  0.07  1.61e-1  3.24e-1  0.08  6.75e-2  1.54e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  216699_s_at  -0.15  4.60e-1  9.17e-1  0.07  6.32e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 246_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216699_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216699_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7300    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
kallikrein ovarian cancer A multiparametric kallikrein expression profile may be a useful tool for ovarian cancer diagnosis/prognosis when used either alone or in conjunction with existing markers. 12091791 Human
kallikrein cancer Many members of the human kallikrein gene family were found to be differentially expressed in various malignancies and some are useful cancer diagnostic/prognostic markers. 11691797 Human
tissue kallikrein pancreatic adenocarcinoma The serine proteinase tissue kallikrein has been previously demonstrated in several human adenocarcinomas, and we presently report the localization of immunoreactive kallikrein and its mRNA in pancreatic adenocarcinoma. 11696440 Human
kallikrein pancreatic adenocarcinoma The serine proteinase tissue kallikrein has been previously demonstrated in several human adenocarcinomas, and we presently report the localization of immunoreactive kallikrein and its mRNA in pancreatic adenocarcinoma. 11696440 Human
tissue kallikrein oesophageal carcinoma Visualisation of tissue kallikrein and kinin receptors in oesophageal carcinoma. 10596867 Human
klk1 renal-cell carcinoma The human tissue kallikreins (KLKs 1-3) and a novel KLK1 mRNA transcript are expressed in a renal cell carcinoma cDNA library. 10614994 Human
kallikrein metaplasia The peroxidase-antiperoxidase method located (1) a large amount of kallikrein in the mucous granules which filled the goblet cells found in the mucosa showing intestinal metaplasia and (2) a small amount discharged into lumens. 2692421 Human
kallikrein glioma In Western blot analyses, a specific monoclonal antibody to tissue kallikrein (V4D11) identifies GH3-secreted kallikrein as a approximately 39,000 Da protein, slightly larger than approximately 38,000 Da kallikreins of submandibular gland, mouse anterior 3360206 Mouse
tissue kallikrein glioma In Western blot analyses, a specific monoclonal antibody to tissue kallikrein (V4D11) identifies GH3-secreted kallikrein as a approximately 39,000 Da protein, slightly larger than approximately 38,000 Da kallikreins of submandibular gland, mouse anterior 3360206 Human
kallikrein pituitary tumors This study examined glandular kallikrein levels in diethylstilbestrol (DES)-induced pituitary tumors in F344 rats and compared it to plasma and pituitary prolactin, and pituitary wet weight. 3390808 Rat
tissue kallikrein prolactin secreting adenomas Except for the localisation of tissue kallikrein (TK) in human prolactin secreting adenomas, its apparent deficiency in Alzheimer's disease and presence in human cerebrospinal fluid (CSF), the regional distribution of TK in human brain has not been d 8796264 Human
kallikrein head-and-neck cancers The effect of local radiotherapy on kallikrein activity in saliva secreted by parotid gland in patients with head and neck cancers. 9020557 Human
tissue kallikrein ductal breast carcinomas Identification of immunoreactive tissue kallikrein in human ductal breast carcinomas. 7860622 Human
kallikrein pancreatic acinar cell carcinoma Kallikrein was identified immunohistochemically and biochemically in a transplantable pancreatic acinar cell carcinoma of the rat. 2578095 Rat
kallikrein adrenal adenoma Urinary kallikrein excretion in patients with primary aldosteronism: differentiation of adrenal adenoma from idiopathic adrenal hyperplasia. 6375065 Human
kallikrein juxtaglomerular cell tumor Blood pressure, renin-angiotensin system and urinary kallikrein in a case of juxtaglomerular cell tumor. 717419 Human
kallikrein carcinoid syndrome Flushing in the carcinoid syndrome and plasma kallikrein. 2428458 Human
tissue kallikrein pituitary adenomas We therefore investigated 27 GH-immunostaining human pituitary adenomas for the presence of immunoreactive tissue kallikrein. 1500840 Human
kallikrein gastrointestinal cancer Our observations indicates that the plasma contact system is activated in ascites from patients with gastrointestinal cancer: Factor XII is activated, plasma kallikrein is present in complex with the protease inhibitor alpha 2-macroglobulin, and the plasm 1281373 Human
tissue kallikrein prolactin-secreting pituitary adenomas Tissue kallikrein may have an important role in the pathophysiology of prolactin-secreting pituitary adenomas. 1492535 Rat
kallikrein cancer BACKGROUND: Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. 12858357 Human
tissue kallikrein adenomas Immunoreactive tissue kallikrein was co-localized with prolactin in all the eleven prolactin-secreting adenomas of the human anterior pituitary gland examined in this study. 2313220 Human
kallikrein islet-cell tumors The localization of glandular pancreatic kallikrein to the beta cells of the islets was the same as that of insulin in normal human pancreas and in two islet-cell tumors. 220534 Human
kallikrein islet-cell tumors When beta cells were lacking in islet-cell tumors or in the pancreas of a patient with juvenile-onset diabetes, kallikrein antigen was not detectable. 220534 Human
tissue kallikrein renal carcinoma Experiments were designed to immunolabel tissue kallikrein, TGF-beta1, TbetaRII, TbetaRIII and kinin receptors using specific antibodies on serial sections of normal kidney and clear-cell renal carcinoma (CCRC) tissue, which included both the tumour and t 15899700 Human
tissue kallikrein metaplasia An immunohistological study demonstrated that tissue kallikrein was present in the cells showing intestinal metaplasia and goblet cells. 2232299 Human
kallikrein carcinoid The plasma and glandular kallikrein levels were determined in 20 carcinoid patients and in 17 controls. 2428458 Human
kallikrein carcinoid Twelve carcinoid patients and six controls were given alcohol and the kallikrein activity was measured before and at 2, 5, and 10 minutes after alcohol ingestion; kallikrein activity did not change significantly. 2428458 Human
kallikrein renin-secreting tumor [Renin secreting tumor and urinary excretion of kallikrein] 3916121 Human
kallikrein prolactin secreting pituitary tumours Immunoreactive kallikrein has also been reported in prolactin secreting pituitary tumours in humans. 8849579 Human
kallikrein renal tumours Cells of transplanted renal tumours of the rat, originating from the proximal tubule, had no kallikrein activity. 186028 Rat
kallikrein ovarian cancer Several members of the kallikrein (KLK) family were recently shown to be expressed in ovarian cancer and implicated in disease prognosis. 15262123 Human
kallikrein cancer BACKGROUND: All human kallikrein (KLK) genes have at least one splice variant, some of which possess clinical utility in cancer diagnostics/prognostics. 15650036 Human
kallikrein carcinoma Emerging data indicate that serine proteases of the kallikrein family (KLK) are implicated in various human diseases, including carcinoma; however, kallikrein gene expression has never been investigated in lung cancer. 15766562 Human
kallikrein cancer Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. 15893744 Human
kallikrein pheochromocytoma In this study, in order to clarify whether or not the low or high excretion rate of urinary kallikrein activity in patients with essential hypertension, primary aldosteronism, pheochromocytoma and Bartter's syndrome is caused by changes in enzyme qua 6913609 Human
kallikrein parotid tumors [Diagnostic relevance of saliva analysis in parotid tumors] The stimulated parotid saliva of 32 patients with unilateral parotid tumours was analyzed with respect to flow rate, protein and IgA content, amylase, kallikrein and peroxidase activities, as wel 2437419 Human
kallikrein parotid tumours [Diagnostic relevance of saliva analysis in parotid tumors] The stimulated parotid saliva of 32 patients with unilateral parotid tumours was analyzed with respect to flow rate, protein and IgA content, amylase, kallikrein and peroxidase activities, as wel 2437419 Human
kallikrein renin secreting tumor [Renin secreting tumor and urinary excretion of kallikrein] 3916121 Human
kallikrein idiopathic adrenal hyperplasia Urinary kallikrein excretion in patients with primary aldosteronism: differentiation of adrenal adenoma from idiopathic adrenal hyperplasia. 6375065 Human
kallikrein idiopathic adrenal hyperplasia (iha) Levels of urinary kallikrein excretion in patients with primary aldosteronism due to aldosterone-producing adenoma (APA) were greater (p less than 0.05 to p less than 0.001) than those in patients with primary aldosteronism due to idiopathic adrenal hyper 6375065 Human
tissue kallikrein cancers Now, other members of the tissue kallikrein (KLK) gene family are fast becoming of clinical interest due to their potential as prognostic biomarkers. particularly for hormone dependent cancers. 15307634 Human
kallikrein head and neck cancers The effect of local radiotherapy on kallikrein activity in saliva secreted by parotid gland in patients with head and neck cancers. 9020557 Human
kallikrein oral tumors The present findings indicate a probable biochemical role of the mixed saliva kallikrein and prokallikrein in the pathogenesis of oral tumors. 9132401 Human
kallikrein acute nonlymphoblastic leukemia (anll) The objective of the present study was to evaluate factors of the plasma kallikrein system in patients with acute nonlymphoblastic leukemia (ANLL), and compare the results to a normal control group. 9595814 Human
tissue kallikrein metastasis The expression of tissue kallikrein, kinin receptors, and TbetaRII and TbetaRIII may be relevant to the parenchymal invasion and metastasis of clear-cell renal carcinoma. 15899700 Human
tissue kallikrein ductal breast cancer By immunohistochemistry we localized tissue kallikrein in the cytoplasm of ductal breast cancer cells. 7576230 Human
kallikrein cancer There are many areas of kallikrein research that need to be further explored, including their tissue expression patterns, their regulation, identification of specific substrates, their participation in proteolytic cascades, and their clinical applicabilit 16800725 Human
kallikrein cancer Most kallikrein genes are characterized by aberrant expression patterns in various human cancers, a feature that makes them ideal cancer biomarkers. 16800742 Human
kallikrein cancers Most kallikrein genes are characterized by aberrant expression patterns in various human cancers, a feature that makes them ideal cancer biomarkers. 16800742 Human
kallikrein ovarian cancer In the present study, we investigated the effect of the epigenetic drug compound 5-aza-2'-deoxycytidine on the expression of downregulated kallikrein genes in prostate, breast, and ovarian cancer cell lines. 16800742 Human
kallikrein crohn's disease High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. 16842160 Human
tissue kallikrein neuroblastoma In Western blot analyses, a specific monoclonal antibody to tissue kallikrein (V4D11) identifies GH3-secreted kallikrein as a approximately 39,000 Da protein, slightly larger than approximately 38,000 Da kallikreins of submandibular gland, mouse anterior 3360206 Human
kallikrein polyposis [Changes of the indicators of the kallikrein-kinin system in diffuse polyposis and cancer of the large intestine before and after radical operation] 309971 Human
kallikrein acute leukemia [Kallikrein-kinin system and the hemorrhagic syndrome in acute leukemia] 6915567 Human
kallikrein fibrosarcomas Daily intralesional injections of bradykinin (250 microgram) into syngeneic SV40 virus-induced fibrosarcomas in inbred hamsters for 21 days produced marked inhibition of tumour growth, marked lymphoid cell infiltration of tumours, and significant elevatio 722404 Human
tissue kallikrein neuroblastoma Tissue kallikrein and kinin receptor expression in an angiogenic co-culture neuroblastoma model. 16865540 Human
klk1 rcc Since immunoscreening of the RCC library for expressed PSA-like proteins was unsuccessful, polymerase chain reaction (PCR) analysis of the RCC cDNA library was performed using universal KLK primers, directed to the common regions in exon 3 and exon 5 of K 10614994 Human
tissue kallikrein oesophageal squamous cell carcinoma Upregulation of tissue kallikrein, kinin B1 receptor, and kinin B2 receptor in mast and giant cells infiltrating oesophageal squamous cell carcinoma. 16126870 Human
tissue kallikrein renal carcinoma The expression of tissue kallikrein, kinin receptors, and TbetaRII and TbetaRIII may be relevant to the parenchymal invasion and metastasis of clear-cell renal carcinoma. 15899700 Human
tissue kallikrein lung cancer Here, we examined the clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis. 18316555 Human
kallikrein prostate cancer Identification of prostate cancer associated-gene expression alterations such as AMACR, Kallikrein gene family and genes associated with androgen signaling such as PDEF and STEAP were consistent with previous findings reported in prostate cancer. 17768422 Human
kallikrein non-small cell lung carcinoma A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. 18316555 Human
kallikrein breast cancer OBJECTIVES: Our aim was to examine how certain signal transduction pathways influence the regulation of hormone-dependent kallikrein (KLK) gene expression in androgen-sensitive breast cancer cell lines. 18515984 Human
kallikrein tumor The kallikrein family (KLK) has been implicated in cancer and may be useful as tumor markers. 18687310 Human
kallikrein cancer The kallikrein family (KLK) has been implicated in cancer and may be useful as tumor markers. 18687310 Human
hk1 pleural mesotheliomas However, it is not known whether hK1, hKB1, KRP/hK proteins or kinin receptors are expressed in pleural mesotheliomas. 17976017 Human
hk1 mesothelioma The expression of hK1, hKB1, KRP/hK2, 5, 6, 7, 8 and 9, and kinin B(1) and B(2) receptors was assessed in archived selected normal tissue and mesothelioma tumour sections by immunoperoxidase and immunofluorescence labelling. hK1, hKB1 and kinin B(1) and B 17976017 Human
hk1 biphasic mesothelioma The expression of hK1, hKB1, KRP/hK2, 5, 6, 7, 8 and 9, and kinin B(1) and B(2) receptors was assessed in archived selected normal tissue and mesothelioma tumour sections by immunoperoxidase and immunofluorescence labelling. hK1, hKB1 and kinin B(1) and B 17976017 Human
hk1 lung tumours Further studies are required to assess the functional significance of the expression of hK1, PK and kinin receptors in lung tumours, and whether any of these proteins may be potential biomarkers for specific subtypes of lung carcinoma. 18713009 Human
hk1 lung carcinoma Further studies are required to assess the functional significance of the expression of hK1, PK and kinin receptors in lung tumours, and whether any of these proteins may be potential biomarkers for specific subtypes of lung carcinoma. 18713009 Human

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