IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KLK7 Ensembl ENSG00000169035 Chromosome 19 Start 56171541 End 56179106
Description Kallikrein-7 Precursor (hK7)(EC 3.4.21.117)(Stratum corneum chymotryptic enzyme)(hSCCE)(Serine protease 6) [Source:UniProtKB/Swiss-Prot;Acc:P49862]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6368
     Entrez Gene : 5650
     UCSC : uc002pup.2
     GeneCards : 6368
     RefSeq : NM_005046
     CCDS : CCDS12812.1
     Uniprot : P49862
     Interpro : P49862
     OMIM : 604438
     GeneTests : KLK7
     CGAP : KLK7
     PMID : 8034709

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38143_at  -0.16  4.54e-1  5.60e-1  -0.45  1.64e-1  2.47e-1
 HG_U133A  205778_at  -0.57  1.51e-4  3.07e-4  1.92  1.65e-46  3.54e-46
 HG_U133_Plus2  205778_at  -0.17  4.59e-1  5.48e-1  -0.39  1.90e-1  2.39e-1
 HG_U133_Plus2  239381_at  -0.14  4.44e-1  5.33e-1  0.68  5.51e-4  1.11e-3
 Agilent_HS_21.6K  17800  -0.01  8.64e-1  9.24e-1  0.09  4.34e-1  5.91e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205778_at  -0.07  8.63e-1  9.89e-1  -0.30  3.82e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38143_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205778_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205778_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239381_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17800    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
scce ovarian carcinoma We have previously reported that the stratum corneum chymotryptic enzyme (SCCE) is overexpressed in ovarian cancers and that SCCE has potential as a useful marker and/or a therapeutic target for ovarian carcinoma. 11906548 Human
scce ovarian cancers We have previously reported that the stratum corneum chymotryptic enzyme (SCCE) is overexpressed in ovarian cancers and that SCCE has potential as a useful marker and/or a therapeutic target for ovarian carcinoma. 11906548 Human
scce actinic keratosis DESIGN: Tissue samples from cases of Netherton's syndrome, congenital ichthyosiform erythroderma, ichthyosis vulgaris, actinic keratosis, squamous cell carcinoma in situ, and invasive squamous cell carcinoma were examined for expression of SCCE using 12834483 Human
scce squamous cell carcinoma in situ DESIGN: Tissue samples from cases of Netherton's syndrome, congenital ichthyosiform erythroderma, ichthyosis vulgaris, actinic keratosis, squamous cell carcinoma in situ, and invasive squamous cell carcinoma were examined for expression of SCCE using 12834483 Human
scce invasive squamous cell carcinoma DESIGN: Tissue samples from cases of Netherton's syndrome, congenital ichthyosiform erythroderma, ichthyosis vulgaris, actinic keratosis, squamous cell carcinoma in situ, and invasive squamous cell carcinoma were examined for expression of SCCE using 12834483 Human
scce metastasis The presence of SCCE on the surface of tumor cells suggests it also may contribute to the process of tumor cell shedding, resulting in early metastasis of carcinoma. 10570434 Human
scce carcinoma The presence of SCCE on the surface of tumor cells suggests it also may contribute to the process of tumor cell shedding, resulting in early metastasis of carcinoma. 10570434 Human
scce tumor The presence of SCCE on the surface of tumor cells suggests it also may contribute to the process of tumor cell shedding, resulting in early metastasis of carcinoma. 10570434 Human
scce low malignant potential tumors METHODS: Gene expression of SCCE was investigated in 44 ovarian tumors (12 low malignant potential tumors and 32 carcinomas) and 10 normal ovaries by quantitative polymerase chain reaction (PCR). 10570434 Human
scce carcinomas METHODS: Gene expression of SCCE was investigated in 44 ovarian tumors (12 low malignant potential tumors and 32 carcinomas) and 10 normal ovaries by quantitative polymerase chain reaction (PCR). 10570434 Human
scce tumor CONCLUSIONS: The results of the current study suggest that SCCE frequently is overexpressed in ovarian tumors and therefore may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells. 10570434 Human
klk7 cancer Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. 12738725 Human
klk7 epithelial ovarian cancer Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. 12738725 Human
klk7 ovarian cancer EXPERIMENTAL DESIGN: The expression of KLK5/hK5 and KLK7/hK7 was analyzed in the same cohort (n = 37) of benign (n = 4) and malignant ovarian tissue (n = 23) samples and primary cultured cells (n = 21) and in 8 ovarian cancer cell lines using semiquantita 12738725 Human
klk7 adenomas RESULTS: We showed the concordant higher expression of both KLK5/hK5 and KLK7/hK7 in ovarian carcinomas, especially late-stage serous carcinomas, compared with normal ovaries and benign adenomas. 12738725 Human
klk7 ovarian carcinomas RESULTS: We showed the concordant higher expression of both KLK5/hK5 and KLK7/hK7 in ovarian carcinomas, especially late-stage serous carcinomas, compared with normal ovaries and benign adenomas. 12738725 Human
klk7 serous carcinomas RESULTS: We showed the concordant higher expression of both KLK5/hK5 and KLK7/hK7 in ovarian carcinomas, especially late-stage serous carcinomas, compared with normal ovaries and benign adenomas. 12738725 Human
klk7 ovarian cancer We also found that one novel KLK5 transcript with a short 5'-untranslated region and a novel KLK7 transcript with a long 3'-untranslated region were highly expressed in the ovarian cancer cell lines OVCAR-3 and PEO1, respectively, but were expre 12738725 Human
klk7 tumor CONCLUSIONS: Our study demonstrated that hK5 and hK7, or more specifically, the short KLK5 and long KLK7 transcripts, may be useful as tumor markers for epithelial-derived serous carcinomas. 12738725 Human
klk7 serous carcinomas CONCLUSIONS: Our study demonstrated that hK5 and hK7, or more specifically, the short KLK5 and long KLK7 transcripts, may be useful as tumor markers for epithelial-derived serous carcinomas. 12738725 Human
scce keratosis Whereas there was essentially no expression of SCCE in normal, non-keratinized buccal mucosa, there was a strong expression in suprabasal cells in orthokeratotic and parakeratotic areas of the lesions of oral lichen planus (an inflammatory disease) and be 8800294 Human
klk7 ovarian cancer Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer. 12633763 Human
klk7 ovarian cancer Recent evidence has indicated that expression of KLK7 appears to be increased in ovarian cancer. 12633763 Human
klk7 ovarian cancer We hypothesized that overexpression of the KLK7 gene in ovarian cancer may serve as a prognostic marker of the disease. 12633763 Human
klk7 tumors KLK7 expression levels were significantly higher in patients with grade 3 than in patients with grade 1 to 2 tumors (p = 0.030). 12633763 Human
klk7 residual tumor KLK7 status also correlated with size of residual tumor postsurgery. 12633763 Human
klk7 low-grade tumors KLK7 expression is an independent predictor of both disease-free and overall survival for patients with low grade tumors. 12633763 Human
klk7 ovarian cancer CONCLUSIONS: We conclude that higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients, especially those with lower grade disease and those who have been optimally debulked. 12633763 Human
klk7 ovarian cancer We found that seven KLK genes (KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, and KLK14) are up-regulated in ovarian cancer. 12727843 Human
scce tumor draining lymph nodes Five out of five (100%) of the patients harboring SCCE-positive tumors were found to have metastatic involvement of the pelvic tumor draining lymph nodes. 15297163 Human
kallikrein 7 breast tumors Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. 14691584 Human
kallikrein 7 breast carcinoma Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. 14691584 Human
kallikrein 7 squamous cervical cancer The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells. 15297163 Human
kallikrein 7 cervical adenocarcinomas Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas. 15492784 Human
kallikrein 7 cervical adenocarcinoma To investigate the potential role of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in the development and progression of uterine cervical adenocarcinoma, we examined hK7 and ALP protein expression by immunohistochemistry in 15492784 Human
kallikrein 7 cervical adenocarcinomas To investigate the potential role of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in the development and progression of uterine cervical adenocarcinoma, we examined hK7 and ALP protein expression by immunohistochemistry in 15492784 Human
klk7 ovarian tumors METHODS: Using the LightCycler technology we quantified the level of KLK7 mRNA expression in 125 ovarian tumors. 12633763 Human
klk7 breast tumors Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. 14691584 Human
klk7 breast carcinoma Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. 14691584 Human
klk7 breast cancer KLK7 is expressed in normal breast tissue and is up-regulated in breast cancer cells by estrogens and glucocorticoids. 14691584 Human
klk7 breast cancer In the present study, expression of the KLK7 gene in 92 breast cancer tissues was analyzed by reverse transcription-PCR (RT-PCR) and direct sequencing of several samples. 14691584 Human
klk7 breast cancer KLK7 gene expression was significantly lower in breast cancer patients of low stage (I/II) (p = 0.011) and patients with positive progesterone receptors (p = 0.022). 14691584 Human
klk7 tumors Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. 14691584 Human
klk7 breast cancer Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. 14691584 Human
klk7 negative tumors Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. 14691584 Human
klk7 breast cancer These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients. 14691584 Human
klk7 lung cancer KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer. 15766562 Human
klk7 adenocarcinoma KLK5 expression is significantly more expressed in squamous cell carcinoma than in matched nonmalignant lung tissue (P=0.02), whereas expression of KLK7 was decreased in adenocarcinoma (P=0.003). 15766562 Human
klk7 squamous-cell carcinoma KLK5 expression is significantly more expressed in squamous cell carcinoma than in matched nonmalignant lung tissue (P=0.02), whereas expression of KLK7 was decreased in adenocarcinoma (P=0.003). 15766562 Human
scce oral keratosis Whereas there was essentially no expression of SCCE in normal, non-keratinized buccal mucosa, there was a strong expression in suprabasal cells in orthokeratotic and parakeratotic areas of the lesions of oral lichen planus (an inflammatory disease) and be 8800294 Human
scce ovarian tumors METHODS: Gene expression of SCCE was investigated in 44 ovarian tumors (12 low malignant potential tumors and 32 carcinomas) and 10 normal ovaries by quantitative polymerase chain reaction (PCR). 10570434 Human
scce ovarian tumors Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors. 11906548 Human
scce ovarian tumor There was significant positive correlation between SCCE and ALP mRNA overexpression status in ovarian tumor cases (P < 0.01). 11906548 Human
scce ovarian tumor Like SCCE, ALP is highly overexpressed in ovarian tumor cells, which begs the question of whether it remains an effective inhibitor of SCCE or whether it is discordant in time or space and is ineffective as an inhibitor of the SCCE enzyme. 11906548 Human
scce cervical tumors OBJECTIVE: To determine whether the Stratum Corneum Chymotryptic Enzyme (SCCE), a novel serine protease known to contribute to the cell shedding process by catalyzing the degradation of intercellular cohesive structures at the skin surface, is overexpress 15297163 Human
scce cervical cancer METHODS: SCCE expression was evaluated in 18 cervical cancer cell lines (i.e., 10 primary and 8 established cell lines) as well as in 8 normal cervical keratinocyte cultures by RT-PCR. 15297163 Human
scce paraffin-embedded tumor In addition, SCCE expression was evaluated by immunohistochemistry on paraffin-embedded tumor tissue. 15297163 Human
scce cervical cancer In contrast, 50% of the primary and 50% of the established cervical cancer cell lines expressed SCCE by RT-PCR. 15297163 Human
scce cervical tumors Eighty percent (i.e., four of five) of primary squamous cervical tumors and 20% (i.e., one of five) of primary adenocarcinomas expressed SCCE. 15297163 Human
scce primary adenocarcinomas Eighty percent (i.e., four of five) of primary squamous cervical tumors and 20% (i.e., one of five) of primary adenocarcinomas expressed SCCE. 15297163 Human
scce cervical cancer Immunohistochemistry staining of paraffin-embedded cervical cancer specimens confirmed SCCE expression in tumor cells and its absence on normal cervical epithelial cells. 15297163 Human
scce tumor Immunohistochemistry staining of paraffin-embedded cervical cancer specimens confirmed SCCE expression in tumor cells and its absence on normal cervical epithelial cells. 15297163 Human
scce squamous cervical cancer CONCLUSION: Squamous cervical cancer expressed high levels of SCCE, suggesting that this protease may play an important role in invasion and metastasis. 15297163 Human
scce metastasis CONCLUSION: Squamous cervical cancer expressed high levels of SCCE, suggesting that this protease may play an important role in invasion and metastasis. 15297163 Human
scce cervical cancer Because SCCE appears only in abundance in tumor tissue and contains a secretion signal sequence, suggesting that SCCE is secreted, it may prove to be a useful diagnostic/prognostic tool for the detection of metastatic or recurrent disease or as a novel mo 15297163 Human
scce tumor Because SCCE appears only in abundance in tumor tissue and contains a secretion signal sequence, suggesting that SCCE is secreted, it may prove to be a useful diagnostic/prognostic tool for the detection of metastatic or recurrent disease or as a novel mo 15297163 Human
scce cervical adenocarcinomas Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas. 15492784 Human
scce cervical adenocarcinoma To investigate the potential role of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in the development and progression of uterine cervical adenocarcinoma, we examined hK7 and ALP protein expression by immunohistochemistry in 15492784 Human
scce cervical adenocarcinomas To investigate the potential role of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in the development and progression of uterine cervical adenocarcinoma, we examined hK7 and ALP protein expression by immunohistochemistry in 15492784 Human
scce ovarian tumor PURPOSE: The serine protease stratum corneum chymotryptic enzyme (SCCE) is overexpressed by ovarian tumor cells, but is not expressed by normal tissues, suggesting that SCCE may be an attractive target for immunotherapy. 15867247 Human
scce ovarian tumor CD8+ CTL stimulated with peptide-loaded dendritic cells were tested against targets expressing endogenous SCCE, including HLA-A2.1-matched ovarian tumor cells. 15867247 Human
scce ovarian tumor RESULTS: CD8+ CTL specific for SCCE 123-131 lysed autologous macrophages infected with an SCCE-expressing recombinant adenovirus, and also lysed HLA-A2.1-matched, SCCE-expressing ovarian tumor cells. 15867247 Human
scce ovarian cancer CONCLUSIONS: The 110-139 region of SCCE incorporates multiple CD8+ CTL and CD4+ helper T cell epitopes, and represents an attractive target antigen for immunotherapy of ovarian cancer. 15867247 Human
scce ovarian tumor Although SCCE 110-139-loaded dendritic cells processed and presented the 123-131 epitope, the dominant CD8(+) CTL response was directed against alternative epitopes within SCCE 110-139.CONCLUSIONS: The 110-139 region of SCCE incorporates multiple CD8(+) C 15867247 Human
scce carcinomas RESULTS: mRNA expression levels of SCCE were elevated significantly in 66.7% of 12 low malignant potential tumors and 78.1% of 32 carcinomas. 10570434 Human
scce tumor Furthermore, SCCE protein was abundant in tumor cells and tumor cell lines that overexpressed the mRNA transcript. 10570434 Human
scce ovarian tumor CONCLUSIONS: The results of the current study suggest that SCCE frequently is overexpressed in ovarian tumors and therefore may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells. 10570434 Human
scce ovarian tumors CONCLUSIONS: The results of the current study suggest that SCCE frequently is overexpressed in ovarian tumors and therefore may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells. 10570434 Human
klk7 squamous cell carcinoma KLK5 expression is significantly more expressed in squamous cell carcinoma than in matched nonmalignant lung tissue (P=0.02), whereas expression of KLK7 was decreased in adenocarcinoma (P=0.003). 15766562 Human
scce low malignant potential tumors RESULTS: mRNA expression levels of SCCE were elevated significantly in 66.7% of 12 low malignant potential tumors and 78.1% of 32 carcinomas. 10570434 Human
klk7 low grade tumors KLK7 expression is an independent predictor of both disease-free and overall survival for patients with low grade tumors. 12633763 Human
klk7 breast cancer Quantitative Reverse Transcription-PCR Assay for Detection of mRNA Encoding Full-Length Human Tissue Kallikrein 7: Prognostic Relevance of KLK7 mRNA Expression in Breast Cancer. 16627559 Human
klk7 breast cancer METHODS: We established a specific quantitative reverse transcription-PCR assay for full-length KLK7 mRNA that excluded amplification of the exon 2 deletion splice variant (the latter does not encode a functional protease), and evaluated full-length KLK7 16627559 Human
klk7 tumor METHODS: We established a specific quantitative reverse transcription-PCR assay for full-length KLK7 mRNA that excluded amplification of the exon 2 deletion splice variant (the latter does not encode a functional protease), and evaluated full-length KLK7 16627559 Human
klk7 breast cancer disease This subgroup was least influenced by postoperative treatment and thus best showed the impact of KLK7 expression on the natural course of breast cancer disease. 16627559 Human
klk7 breast cancer disease CONCLUSION: Expression of full-length KLK7 mRNA may represent a new prognostic marker in breast cancer disease. 16627559 Human
scce tumors Five out of five (100%) of the patients harboring SCCE-positive tumors were found to have metastatic involvement of the pelvic tumor draining lymph nodes. 15297163 Human
klk7 tumors RESULTS: We here report that patients with KLK7-negative tumors have a significantly higher disease-free survival than patients with KLK7-positive tumors. 12633763 Human
klk7 tumors Similarly, patients who had undergone optimal debulking but harbored KLK7-positive tumors had a high hazard ratio (HR) for relapse (HR = 8.2) and death (HR = 4.6). 12633763 Human
klk7 tumorigenesis Altogether, our results suggest that variability in KLK5 and KLK7 gene expression might be involved in lung tumorigenesis and useful for clinical purposes. 15766562 Human
klk7 ovarian cancer Reports indicate that in ovarian cancer, KLK7 is significantly up-regulated at the mRNA level. 16916986 Human
klk7 intracranial tumors In this study, we examined the level of mRNA expression of the KLK7 and KLK8 genes in 73 intracranial tumors using qualitative RT-PCR. 17132107 Human

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