IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KLK8 Ensembl ENSG00000129455 Chromosome 19 Start 56191076 End 56196770
Description Kallikrein-8 Precursor (hK8)(EC 3.4.21.118)(Neuropsin)(NP)(Ovasin)(Serine protease TADG-14)(Tumor-associated differentially expressed gene 14 protein)(Serine protease 19) [Source:UniProtKB/Swiss-Prot;Acc:O60259]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6369
     Entrez Gene : 11202
     UCSC : uc002pur.1
     GeneCards : 6369
     RefSeq : NM_007196
     CCDS : CCDS12813.1
     Uniprot : Q9UQ47
     Interpro : Q9UQ47
     OMIM : 605644
     GeneTests : KLK8
     CGAP : KLK8
     PMID : 10102990

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37131_at  0.30  1.06e-1  1.74e-1  0.89  8.43e-4  2.67e-3
 HG_U133A  206125_s_at  0.17  1.31e-1  1.67e-1  -1.31  4.97e-18  7.01e-18
 HG_U133_Plus2  1552319_a_at  0.98  2.11e-6  9.07e-6  1.35  3.34e-10  1.51e-9
 HG_U133_Plus2  206125_s_at  0.78  1.20e-3  3.06e-3  1.66  2.77e-14  2.00e-13
 HG_U133_Plus2  233687_s_at  0.15  3.11e-1  3.99e-1  1.08  6.24e-7  1.88e-6
 Agilent_HS_21.6K  11225  0.08  4.16e-1  6.01e-1  0.35  3.35e-2  9.13e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206125_s_at  0.61  1.08e-1  7.80e-1  -0.27  4.53e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37131_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206125_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1552319_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206125_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233687_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11225    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hnp inflammatory bowel disease The aim of this study was to investigate the expression of HNP 1-3 and lysozyme in normal and active inflammatory bowel disease (IBD) mucosa. 11919217 Human
klk8 seborrheic keratosis Psoriasis vulgaris, seborrheic keratosis, lichen planus, and squamous cell carcinoma skin samples, which show severe hyperkeratosis, displayed a high density of KLK8 mRNA on northern and in situ hybridisation analyses. 12147714 Human
klk8 squamous-cell carcinoma Psoriasis vulgaris, seborrheic keratosis, lichen planus, and squamous cell carcinoma skin samples, which show severe hyperkeratosis, displayed a high density of KLK8 mRNA on northern and in situ hybridisation analyses. 12147714 Human
klk8 ovarian cancer The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. 11309326 Human
ovasin ovarian cancer The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. 11309326 Human
neuropsin ovarian cancer The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. 11309326 Human
klk8 ovarian cancer Recent reports have implicated KLK8 in ovarian cancer. 11309326 Human
klk8 ovarian carcinoma PURPOSE: We undertook this study to evaluate the prognostic value of KLK8 in ovarian carcinoma by examining its expression in ovarian tumors. 11309326 NA
klk8 ovarian tumors Study of the expression of the KLK8 gene and its spliced variants in ovarian tumors indicated that the new variants were expressed very frequently and that full-length KLK8 expression is an independent and favorable prognostic marker for ovarian cancer. 11309326 Human
klk8 ovarian cancer Study of the expression of the KLK8 gene and its spliced variants in ovarian tumors indicated that the new variants were expressed very frequently and that full-length KLK8 expression is an independent and favorable prognostic marker for ovarian cancer. 11309326 Human
klk8 residual tumor Patients with higher KLK8 expression in the tumor have lower grade disease, lower residual tumor left after surgery, live longer, and relapse less frequently. 11309326 Human
klk8 tumor Patients with higher KLK8 expression in the tumor have lower grade disease, lower residual tumor left after surgery, live longer, and relapse less frequently. 11309326 Human
klk8 ovarian cancer CONCLUSIONS: These results suggest that KLK8 is a novel, favorable prognostic marker in ovarian cancer. 11309326 Human
klk8 ovarian cancer Because KLK8 encodes for a predicted secreted protein, its detection in serum may aid in ovarian cancer diagnosis. 11309326 Human
tumor-associated differentially expressed gene-14 cervical cancer The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer. 14749636 Human
tadg-14 ovarian carcinomas Tumor-associated differentially expressed gene-14 (TADG-14) is a novel transmembrane serine protease recently reported by our group to be highly overexpressed in ovarian carcinomas. 14749636 Human
tumor-associated differentially expressed gene-14 ovarian carcinomas Tumor-associated differentially expressed gene-14 (TADG-14) is a novel transmembrane serine protease recently reported by our group to be highly overexpressed in ovarian carcinomas. 14749636 Human
tadg-14 tumors The goal of this study was to investigate the frequency of expression of the TADG-14 gene in human cervical tumors. 14749636 Human
tadg-14 cervical cancer STUDY DESIGN: TADG-14 expression was evaluated in 19 cervical cancer cell lines (11 primary and 8 established cell lines) as well as in 8 normal cervical keratinocyte cultures by reverse transcriptase polymerase chain reaction. 14749636 Human
tadg-14 cervical cancer RESULTS: TADG-14 was found to be highly expressed in 82% (9/11) primary cervical cancer cell lines and in 87% (7/8) established cervical cancer cell lines by reverse transcriptase-polymerase chain reaction. 14749636 Human
tadg-14 primary cervical cancer RESULTS: TADG-14 was found to be highly expressed in 82% (9/11) primary cervical cancer cell lines and in 87% (7/8) established cervical cancer cell lines by reverse transcriptase-polymerase chain reaction. 14749636 Human
tadg-14 primary adenocarcinomas Expression of TADG-14 by primary squamous cervical tumors was 100% (6/6), whereas 60% (3/5) of primary adenocarcinomas expressed TADG-14. 14749636 Human
tadg-14 tumors Expression of TADG-14 by primary squamous cervical tumors was 100% (6/6), whereas 60% (3/5) of primary adenocarcinomas expressed TADG-14. 14749636 Human
tadg-14 cervical cancer Immunohistochemistry staining of paraffin-embedded cervical cancer specimens confirmed TADG-14 expression in tumor cells and its absence on normal cervical epithelial cells. 14749636 Human
tadg-14 tumor Immunohistochemistry staining of paraffin-embedded cervical cancer specimens confirmed TADG-14 expression in tumor cells and its absence on normal cervical epithelial cells. 14749636 Human
tadg-14 metastasis CONCLUSION: Cervical cancer expressed a high level of TADG-14, suggesting that this protease may play an important role in invasion and metastasis. 14749636 Human
tadg-14 cervical cancer CONCLUSION: Cervical cancer expressed a high level of TADG-14, suggesting that this protease may play an important role in invasion and metastasis. 14749636 Human
tadg-14 cervical cancer Because TADG-14 appears only in abundance in tumor tissue and contains a secretion signal sequence, suggesting that TADG-14 is secreted, it may prove to be a useful diagnostic tool for the early detection of recurrent/persistent cervical cancer after stan 14749636 Human
tadg-14 tumor Because TADG-14 appears only in abundance in tumor tissue and contains a secretion signal sequence, suggesting that TADG-14 is secreted, it may prove to be a useful diagnostic tool for the early detection of recurrent/persistent cervical cancer after stan 14749636 Human
klk8 breast cancer These data were verified by screening the EST databases, where all mRNA clones isolated for these genes, except for one in each, were from normal breast libraries, with no clones detected from breast cancer tissues or cell lines (with the exception of KLK 14710225 Human
neuropsin hyperplasia A single topical application of 12-O-tetradecanoyl-phorbol 13-acetate induced epidermal hyperplasia and simultaneously induced an extensive increase in neuropsin mRNA in the suprabasal cells. 10421059 Human
tumor-associated differentially expressed gene-14 ovarian carcinoma Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma. 10485494 Human
tadg14 ovarian carcinoma Northern blot analysis indicated that the mRNA for TADG14 is 1.4 kb long and that it is highly overexpressed in ovarian carcinoma compared with normal ovary. 10485494 Human
tadg14 tumors Semiquantitative PCR indicates that TADG14 is overexpressed in 24 of 40 tumors studied. 10485494 Human
klk8 breast cancer Several lines of evidence suggest that members of the kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14). 12633763 Human
klk8 ovarian cancer We found that seven KLK genes (KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, and KLK14) are up-regulated in ovarian cancer. 12727843 Human
hnp tumor This study describes a mutation screen of SDHB, SDHC, and SDHD in blood and tumor samples of 14 sporadic and three familial cases of head and neck PGL (HNP). 15479192 NA
klk8 ovarian tumors PURPOSE: We undertook this study to evaluate the prognostic value of KLK8 in ovarian carcinoma by examining its expression in ovarian tumors. 11309326 NA
klk8 ovarian tumors Human kallikrein 8 gene (KLK8) mRNA expression was examined by semi-quantitative PCR in 35 ovarian tumors and 7 normal ovaries. 15138549 Human
tadg-14 cervical tumors The goal of this study was to investigate the frequency of expression of the TADG-14 gene in human cervical tumors. 14749636 Human
tadg-14 primary tumor In addition, to validate gene expression data at the protein level, TADG-14 expression was evaluated by immunohistochemistry on paraffin-embedded tissue from which all 11 primary tumor cell lines were established. 14749636 Human
tadg-14 cervical tumors Expression of TADG-14 by primary squamous cervical tumors was 100% (6/6), whereas 60% (3/5) of primary adenocarcinomas expressed TADG-14. 14749636 Human

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